公开(公告)号：EP4399317A1

公开(公告)日：2024-07-17

申请号：EP22868298.5

申请日：2022-09-08

申请人： BioConsortia, Inc.

发明人： MALIN, John ,  CURTIS, Damian ,  WILLIAMS, Thomas

IPC分类号： C12N15/90 ,  C12P19/34 ,  C12N5/10 ,  C12N15/63

CPC分类号： C12N15/90 ,  C12N15/70 ,  C12N15/102 ,  C12N15/74

公开(公告)号：EP4399313A1

公开(公告)日：2024-07-17

申请号：EP22782860.5

申请日：2022-09-08

申请人： Docquier, Jean-Denis

发明人： DEVENTE, Savannah ,  DOCQUIER, Jean-Denis

IPC分类号： C12N15/81 ,  A61K36/064 ,  A61P1/00 ,  C12N15/70 ,  C12N15/90

CPC分类号： C12N15/81 ,  A61P1/00 ,  C12N15/70 ,  C12N2830/4220130101

公开(公告)号：EP3549954B1

公开(公告)日：2024-07-03

申请号：EP17875487.5

申请日：2017-11-29

IPC分类号： C07K14/725 ,  C12N15/12 ,  C12N15/63 ,  C12N5/10 ,  A61K38/17 ,  A61P35/00

CPC分类号： A61P35/00 ,  A61K38/00 ,  C07K14/7051 ,  C12N15/70 ,  C12N2740/1604320130101 ,  A61K39/464488 ,  A61K2239/5720230501 ,  A61K39/4611 ,  A61K2239/3120230501 ,  A61K39/4632 ,  A61K2239/3820230501

公开(公告)号：EP4375379A1

公开(公告)日：2024-05-29

申请号：EP22306737.2

申请日：2022-11-24

申请人： BIOC3

发明人： LACHAUX, Cléa ,  GRONDIN, Eric

IPC分类号： C12P7/42 ,  C12N15/70

CPC分类号： C12Y402/0113 ,  C12P7/42 ,  C12N15/70

摘要： The invention relates to a method for the biochemical production of glycolic acid or its derivatives comprising a step of culturing a whole cell biocatalyst comprising or consisting of modified microorganisms cells producing an enzyme converting glyoxal into glycolic acid, in a suitable culture medium comprising glyoxal as substrate, and optionally recovering glycolic acid from the culture medium.

公开(公告)号：EP4375378A1

公开(公告)日：2024-05-29

申请号：EP22845990.5

申请日：2022-02-28

申请人： POSTECH Research and Business Development Foundation

发明人： JUNG, Gyoo Yeol ,  YE, Dae Yeol ,  NOH, Myung Hyun ,  MIN, Myeong Won

IPC分类号： C12N15/70 ,  C12N9/10 ,  C12N9/90 ,  C12P7/44

CPC分类号： C12N9/90 ,  C12P7/44 ,  C12N9/10 ,  C12N15/70

摘要： The present invention relates to a novel metabolic pathway for producing itaconic acid and a recombinant microorganism, for producing itaconic acid, into which the metabolic pathway is introduced. It has been confirmed that the recombinant microorganism, for producing itaconic acid, into which the novel itaconic acid metabolic pathway is introduced, according to the present invention, significantly increases the production and yield of itaconic acid. In addition, as the recombinant microorganism for producing itaconic acid of the present invention uses an intermediate material of glycolysis rather than an intermediate material of the TCA cycle, the recombinant microorganism can further increase the production yield of itaconic acid through further improvement. Accordingly, the novel metabolic pathway for producing itaconic acid and the recombinant microorganism into which the metabolic pathway is introduced can increase the economic feasibility of itaconic acid, and thus can be variously used in industrial fields for synthetic resins, latexes, food additives, and the like in which itaconic acid is utilized.

公开(公告)号：EP4371997A1

公开(公告)日：2024-05-22

申请号：EP21953717.2

申请日：2021-08-18

申请人： Qitan Technology Ltd., Chengdu

发明人： LIU, Shaowei ,  XIE, Fuli ,  HE, Jingxiong ,  YUE, Feifei ,  LI, Qianwen

IPC分类号： C07K14/21 ,  C12N15/31 ,  C12Q1/6869 ,  C12N1/21 ,  C12N15/70

CPC分类号： C07K14/195 ,  C07K14/21 ,  C12N15/70 ,  C12Q1/6869 ,  C12N15/74

摘要： The present invention belongs to the technical field of characterization of target analyte properties, and particularly provides a mutant of a porin monomer, a protein pore comprising same, and use thereof in the detection of a target analyte, wherein an amino acid of the mutant of the porin monomer comprises a sequence set forth in SEQ ID NO: 1 or a sequence having at least 99%, 98%, 97%, 96%, 95%, 90%, 80%, 70%, 60%, or 50% identity thereto, and the amino acid of the mutant of the porin monomer comprises mutations at one or more positions corresponding to T71, S75, or F76 of SEQ ID NO: 1.

公开(公告)号：EP4361260A1

公开(公告)日：2024-05-01

申请号：EP22827500.4

申请日：2022-06-20

申请人： Porton Pharma Solutions Ltd.

发明人： CHEN, Zecong

IPC分类号： C12N9/06 ,  C12N15/53 ,  C12N11/089 ,  C12N1/21 ,  C12P17/16

CPC分类号： C12P17/16 ,  C12N15/66 ,  C12N9/0004 ,  C12R2001/1920210501 ,  C12N15/70 ,  C12P41/00 ,  C12N15/74 ,  C12N11/089

摘要： Disclosed in the present invention are an imine reductase mutant, and a method for preparing (S)-nicotine using the imine reductase mutant. The first objective of the invention is to provide an imine reductase mutant, for solving the problems in the prior art that no nicotine of S configuration can be obtained by using an enzyme and the enzyme activity is low, and this mutant can implement catalytic reduction of a substrate myosmine or 4-(Methylamino)-1-(pyridin-3-yl)butanone to (S)-nicotine. The second objective of the present invention is to provide a coexpressed enzyme of the imine reductase and a glucose dehydrogenase, specifically being a coexpressed enzyme of an imine reductase mutant enzyme and the glucose dehydrogenase. The co-expressed enzyme is used to prepare (S)-nicotine, and the cost of enzymatically preparing (S)-nicotine is lowered.

公开(公告)号：EP4357357A1

公开(公告)日：2024-04-24

申请号：EP22848285.7

申请日：2022-07-14

申请人： Yunquan Biotechnology (Beijing) Co., Ltd.

发明人： DONG, Minghui ,  LU, Yongtao

IPC分类号： C07K14/55 ,  C12N15/70 ,  C12N15/81 ,  C07K19/00 ,  C12N15/62 ,  C12N15/64 ,  A61K38/20 ,  A61P35/00 ,  A61P37/00 ,  A61K47/68

CPC分类号： A61K38/20 ,  A61K47/68 ,  A61P35/00 ,  A61P37/00 ,  C07K14/55 ,  C07K19/00 ,  C12N15/62 ,  C12N15/64 ,  C12N15/70 ,  C12N15/81

摘要： Provided are a human interleukin-2 variant and the use thereof. Specifically, provided is an IL-2 variant (or a derivative thereof) having eliminated or reduced affinity with a high-affinity receptor IL-2Rα/β/γ and retaining affinity with a medium-affinity receptor IL-2Rβ/γ. Also provided is a recombinant protein/fusion protein comprising an IL-2 variant and a human antibody fragment. The activity of the IL-2 variant is improved, and is close to the activity of a wild human IL-2.

公开(公告)号：EP4351604A1

公开(公告)日：2024-04-17

申请号：EP22821011.8

申请日：2022-06-09

申请人： Microbial Machines, Inc.

发明人： WAGNER, Jeffrey ,  MERMELSTEIN, Fred ,  NOVINA, Carl ,  DISTEL, Robert ,  NEIER, Steven ,  POLISKY, Barry

IPC分类号： A61K35/74 ,  A61P29/00 ,  A61P35/00 ,  A61P37/08 ,  C12N15/65 ,  C12N15/70 ,  C12N15/75 ,  A61K38/00 ,  A61K39/00 ,  A61P31/04

CPC分类号： A61K35/74 ,  A61K38/00 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P37/08 ,  C12N15/70 ,  C12N15/65 ,  A61K48/005 ,  A61K48/0083 ,  A61K48/0041 ,  A61K48/0075 ,  G01N2800/0620130101 ,  G01N33/57446 ,  G01N33/57419 ,  G01N33/5091 ,  G01N33/5088 ,  G01N2800/5220130101 ,  C07K14/24 ,  C07K14/195 ,  C07K14/59 ,  C12R2001/1920210501 ,  C12N9/0069

公开(公告)号：EP3066206B1

公开(公告)日：2018-12-12

申请号：EP14802286.6

申请日：2014-11-04

申请人： BGN Tech LLC

发明人： ZHOU, Rui ,  YU, Xiaodan

IPC分类号： C12P7/42 ,  C12P7/40 ,  C12P7/24 ,  C12P7/22 ,  C12N15/70 ,  C07C47/58

CPC分类号： C12P7/24 ,  C12N15/70 ,  C12P7/22 ,  C12P7/40 ,  C12P7/42

摘要： A bioconversion method of making vanillin including expressing VaoA gene in a mixture, expressing MtSAD1 gene in the mixture, feeding eugenol to the mixture, and converting ferulic acid to vanillin by incubating with a microbial Amycolalopsis sp. strain (Zhp06) and/or a recombinant E. coli strain.