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11.发明公开Attenuated virus and vaccine therefrom for use against infections in fowl caused by Turkey rhinotracheitis virus 失效用于防止感染由土耳其恶毒病毒引起的感染的灭活病毒和疫苗
公开(公告)号：EP0292210A3
公开(公告)日：1990-01-24
申请号：EP88304359.8
申请日：1988-05-13
发明人： Cook, Jane Kathleen Alexandra , Frazier, Judith A. , Mockett, Albert Philip Adrian , Binns, Matthew McKinley , Dolby, Christine Ann , Box, Philip
IPC分类号： A61K39/155 , C12N7/08
CPC分类号： A61K39/155 , A61K39/12 , A61K2039/5254 , A61K2039/543 , A61K2039/544 , A61K2039/552 , C12N2760/18334 , Y10S424/816
摘要： An attenuated strain of the virus of contagious turkey rhinotracheitis is obtained by alternate embryonic egg and tracheal organ culture passaging of the virus of contagious turkey rhinotracheitis. Turkeys may be vaccinated to prevent them getting turkey rhinotracheitis, and chickens may be vaccinated to prevent them getting swollen head syndrome.
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公开(公告)号：EP2811027A1
公开(公告)日：2014-12-10
申请号：EP14160481.9
申请日：2005-05-20
发明人： Perri, Silvia , Polo, John , Uematsu, Yasushi , Greer, Catherine
IPC分类号： C12N15/86 , A61K39/145 , A61K39/155 , A61K39/215 , A61K39/12 , A61K39/02 , A61K39/00 , A61K39/295
CPC分类号： A61K39/12 , A61K39/145 , A61K39/155 , A61K2039/5252 , A61K2039/5256 , A61K2039/53 , A61K2039/543 , A61K2039/545 , A61K2039/55544 , A61K2039/55566 , A61K2039/70 , C12N15/86 , C12N2760/16122 , C12N2760/16134 , C12N2760/18322 , C12N2760/18334 , C12N2760/18522 , C12N2760/18534 , C12N2760/18622 , C12N2760/18634 , C12N2770/20022 , C12N2770/20034 , C12N2770/36143 , C12N2830/20 , C12N2830/60 , C12N2840/20 , C12N2840/203
摘要： Described herein are compositions and methods for stimulating an immune response to one or more proteins derived from one or more respiratory pathogens. In particular, the invention relates to alphavirus replicons, alphavirus vector constructs, alphavirus replicon particles expressing one or more antigens derived from one or more respiratory pathogens as well as to method of making and using these immunogenic compositions.
摘要翻译： 本文描述了用于刺激来自一种或多种呼吸道病原体的一种或多种蛋白质的免疫应答的组合物和方法。 特别地，本发明涉及甲病毒复制子，甲病毒载体构建体，表达一种或多种源自一种或多种呼吸道病原体的抗原的甲病毒属复制子颗粒以及制备和使用这些免疫原性组合物的方法。
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13.发明公开Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences and methods for propagating virus 审中-公开Metapneumovirusstämme以及它们在疫苗制剂和作为载体使用对抗原序列和方法的表达对病毒的传播
公开(公告)号：EP2494986A1
公开(公告)日：2012-09-05
申请号：EP11192988.1
申请日：2004-04-23
发明人： Haller, Aurelia , Tang, Roderick , Fouchier, Ronaldus Adrianus Maria , Van Den Hoogen, Bernadetta Gerarda , Osterhaus, Albertus Dominicus M.
IPC分类号： A61K39/155 , C12N7/00 , C12Q1/70 , C07K16/10
CPC分类号： C07K16/1027 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/505 , A61K2039/543 , A61K2039/544 , A61K2039/70 , C07K14/005 , C07K2317/21 , C07K2317/23 , C12N7/00 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18351 , C12N2760/18361 , C12N2760/18534 , G01N2333/115
摘要： The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention also provides isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular the invention provides a mammalian MPV, subgroups and variants thereof. The invention relates to genomic nucleotide sequences of different isolates of mammalian metapneumoviruses, in particular human metapneumoviruses. The invention relates to the use of the sequence information of different isolates of mammalian metapneumoviruses for diagnostic and therapeutic methods. The present invention relates to nucleotide sequences encoding the genome of a metapneumovirus or a portion thereof, including both mammalian and avian metapneumovirus. The invention further encompasses chimeric or recombinant viruses encoded by said nucleotide sequences. The invention also relates to chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. The invention further relates to vaccine formulations comprising mammalian or avian metapneumovirus, including recombinant and chimeric forms of said viruses. The vaccine preparations of the invention encompass multivalent vaccines, including bivalent and trivalent vaccine preparations. The invention also provide methods for propagating virus.
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14.发明公开RECOVERY OF RECOMBINANT HUMAN PARAINFLUENZA VIRUS TYPE 2 (HPIV2) FROM cDNA AND USE OF RECOMBINANT HPIV2 IN IMMUNOGENIC COMPOSITIONS AND AS VECTORS TO ELICIT IMMUNE RESPONSES AGAINST PIV AND OTHER HUMAN PATHOGENS 有权获得重组人流感病毒2型PARA（HPIV2）的cDNA和在免疫原性组合物重组HPIV2的用途，和作为矢量引发针对PIV和其他人类病原体免疫反应的
公开(公告)号：EP1572947A4
公开(公告)日：2008-09-03
申请号：EP03752537
申请日：2003-09-18
申请人： US HEALTH
IPC分类号： A61K39/00 , A61K39/155 , C07K14/115 , C07K14/135 , C12N7/04 , C12N7/00 , A01N63/00 , C12N7/01 , C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N2760/18334 , C12N2760/18634 , C12N2760/18643 , C12N2760/18722 , C12N2760/18734 , C12N2760/18743 , C12N2760/18762
摘要： Recombinant human parainfluenza virus type 2 (HPIV2) viruses and related immunogenic compositions and methods are provided. The recombinant HPIV2 viruses, including HPIV2 chimeric and chimeric vector viruses, provided according to the invention are infectious and attenuated in permissive mammalian subjects, including humans, and are useful in immunogenic compositions for eliciting an immune responses against one or more PIVs, against one or more non-PIV pathogens, or against a PIV and a non-PIV pathogen. Also provided are isolated polynucleotide molecules and vectors incorporating a recombinant HPIV2 genome or antigenome.
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公开(公告)号：EP1765385A1
公开(公告)日：2007-03-28
申请号：EP05750245.2
申请日：2005-06-16
IPC分类号： A61K39/00 , A61K39/39 , A61K47/48 , A61K39/02 , A61K39/118 , A61K39/12 , A61P31/00 , A61P35/00 , A61P39/00 , A61P43/00
CPC分类号： A61K39/12 , A61K9/0024 , A61K9/0092 , A61K39/02 , A61K39/0258 , A61K39/0275 , A61K39/08 , A61K39/39 , A61K47/24 , A61K2039/521 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , A61K2039/55505 , A61K2039/55577 , C12N2710/16734 , C12N2720/12334 , C12N2750/14334 , C12N2760/18334 , C12N2770/20034 , Y02A50/474 , Y02A50/482
摘要： A non-liquid vaccine composition including one or more antigen component(s); a pharmaceutically acceptable non-liquid adjuvant therefor; and optionally a non-liquid vaccine protection agent.
摘要翻译： 包含一种或多种抗原组分的非液体疫苗组合物; 其药学上可接受的非液体佐剂; 和任选的非液体疫苗保护剂。
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16.发明公开METAPNEUMOVIRUS STRAINS AND THEIR USE IN VACCINE FORMULATIONS AND AS VECTORS FOR EXPRESSION OF ANTIGENIC SEQUENCES AND METHODS FOR PROPAGATING VIRUS 审中-公开偏肺病毒菌株和它们在疫苗制剂，并作为为VIRUSPROPAGIERUNG表达抗原序列和方法向量
公开(公告)号：EP1623006A2
公开(公告)日：2006-02-08
申请号：EP04750614.2
申请日：2004-04-23
发明人： HALLER, Aurelia , TANG, Roderick , FOUCHIER, Ronaldus, Adrianus, Maria , VAN DEN HOOGEN, Bernadetta, Gerarda , OSTERHAUS, Albertus, Dominicus, Marcellinus, E.
IPC分类号： C12N1/00
CPC分类号： C07K16/1027 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/505 , A61K2039/543 , A61K2039/544 , A61K2039/70 , C07K14/005 , C07K2317/21 , C07K2317/23 , C12N7/00 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18351 , C12N2760/18361 , C12N2760/18534 , G01N2333/115
摘要： The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention also provides isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular the invention provides a mammalian MPV, subgroups and variants thereof. The invention relates to genomic nucleotide sequences of different isolates of mammalian metapneumoviruses, in particular human metapneumoviruses. The invention relates to the use of the sequence information of different isolates of mammalian metapneumoviruses for diagnostic and therapeutic methods. The present invention relates to nucleotide sequences encoding the genome of a metapneumovirus or a portion thereof, including both mammalian and avian metapneumovirus. The invention further encompasses chimeric or recombinant viruses encoded by said nucleotide sequences. The invention also relates to chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. The invention further relates to vaccine formulations comprising mammalian or avian metapneumovirus, including recombinant and chimeric forms said viruses. The vaccine preparations of the invention encompass multivalent vaccines, including bivalent and trivalent vaccine preparations. The invention also provide methods for propagating virus.
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公开(公告)号：EP1603939A2
公开(公告)日：2005-12-14
申请号：EP04775808.1
申请日：2004-02-27
发明人： COLLINS, Peter, L. , BIACCHESI, Stephane , BUCHHOLZ, Ursula , SKIADOPOULOS, Mario, H. , MURPHY, Brian, R.
IPC分类号： C07K14/115 , C12N7/04 , C12N15/86 , A61K39/155
CPC分类号： A61K39/155 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/70 , C12N7/00 , C12N15/86 , C12N2760/18334 , C12N2760/18343 , C12N2760/18351 , C12N2760/18361 , C12N2760/18362 , C12N2760/18634 , C12N2760/18643
摘要： Recombinant HMPV (rHMPV) and related immunogenic compositions and methods are provided. The rHMPVs, including chimeric and HMPV vector viruses, provided according to the current disclosure are infectious and attenuated in permissive mammalian subjects, including humans. The rHMPVs are useful in immunogenic compositions for eliciting an immune response against HPIV, against one or more non-HMPV pathogens, or against a HMPV and a non-HMPV pathogen. Also provided are isolated polynucloetide molecules and vectors incorporating a recombinant HMPV genome or antigenome.
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公开(公告)号：EP1503792A2
公开(公告)日：2005-02-09
申请号：EP03730063.9
申请日：2003-05-16
发明人： NAYLOR, Clive, J.
IPC分类号： A61K39/155 , C12N15/45 , C12N15/85 , C12N7/04 , C07K14/115 , C07K14/11
CPC分类号： C07K7/06 , A61K39/12 , A61K39/155 , A61K2039/525 , C07K5/1013 , C07K5/1019 , C07K14/005 , C12N7/00 , C12N2760/18322 , C12N2760/18334 , C12N2760/18362 , C12N2760/18522 , C12N2760/18534 , C12N2760/18562
摘要： The invention relates to a vaccine against members of the genus metapneumovirus or RSV or a virus that comprises a significant genetic homology in the F protein to members of the genus metapneumovirus, whereby the vaccine is an attenuated live vaccine. In particular, the vaccine is directed against metapneumovirus of avian or human origin.
摘要翻译： 本发明涉及针对偏亚型肺病毒或RSV的成员的疫苗或包含F蛋白与偏肺病毒的成员的显着遗传同源性的病毒，其中疫苗是减毒活疫苗。 特别地，疫苗针对禽或人源的偏肺病毒。
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公开(公告)号：EP0914442A1
公开(公告)日：1999-05-12
申请号：EP97934579.0
申请日：1997-07-16
申请人： MERIAL
CPC分类号： C07K14/005 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/17 , A61K39/215 , A61K39/245 , A61K39/255 , A61K2039/51 , A61K2039/53 , A61K2039/552 , A61K2039/70 , C12N2710/16034 , C12N2710/16334 , C12N2720/10034 , C12N2750/10034 , C12N2760/16134 , C12N2760/18134 , C12N2760/18334 , C12N2770/20034 , C12N2770/22034 , C12N2770/32034 , C12N2770/32434
摘要： An avian vaccine formula including at least three polynucleotide vaccine valencies that each include a plasmid containing an avian pathogen valency gene capable of being expressed in vivo in host cells. Said valencies are selected from the group which consists of Marek's disease virus, Newcastle disease virus, infectious bursal disease virus, infectious bronchitis virus and infectious anaemia virus. The plasmids include one or more genes per valency, and said genes are selected from the group which consists of gB and gD for Marek's disease virus, HN and F for Newcastle disease virus, VP2 for infectious bursal disease virus, S, M and N for infectious bronchitis virus and C + NS1 for infectious anaemia virus.
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20.发明公开Procédé de culture du virus de la rhinotrachéite infectieuse notamment de la dinde, et vaccin préparé à partir du virus ainsi obtenu 失效一种用于病毒和牛的培养方法制备鼻气管炎疫苗Truthahnes从其。
公开(公告)号：EP0263048A1
公开(公告)日：1988-04-06
申请号：EP87460013.3
申请日：1987-07-16
申请人： Ministère de l'Agriculture, Direction de la Qualité, Services Vétérinaires, Laboratoire National de Pathologie Aviaire , RHONE MERIEUX
CPC分类号： C12N7/00 , A61K39/12 , A61K39/155 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , C12N2760/18334 , C12N2760/18364 , Y10S424/816
摘要： L'invention concerne un procédé de culture du virus de la rhinotrachéite infectieuse de la dinde qui est responsable également d'affections d'autres espèces aviaires telles que le syndrome infectieux des grosses têtes (ou de gonflement de la tête) de la poule et de la pintade.
Selon l'invention, on prélève des échantillons sur des animaux malades, que l'on inocule sur des cultures cellulaires constituées par une lignée continue de cellules de rein de singe.
On obtient ainsi une grande quantité de virus utilisable comme antigène dans la fabrication d'un vaccin pouvant être indifféremment utilisé pour l'immunisation de toutes espèces aviaires.
L'invention s'applique également à la fabrication de vaccins à partir des souches virales obtenues par ce procédé.
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