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    DUAL WAVELENGTH SOURCE GAS DETECTOR
    11.
    发明公开
    DUAL WAVELENGTH SOURCE GAS DETECTOR 审中-公开
    双波长气源探测器

    公开(公告)号：EP3236238A1

    公开(公告)日：2017-10-25

    申请号：EP17165601.0

    申请日：2017-04-07

    Applicant: Honeywell International Inc.

    Inventor： MARTA, Teresa M. ,  WILLETT, Martin ,  FRITZ, Bernard

    IPC: G01N21/31 ,  G01N21/35 ,  G01N21/39 ,  G01N21/3504

    CPC classification number: G01N21/31 ,  G01N21/314 ,  G01N21/3151 ,  G01N21/3504 ,  G01N21/39 ,  G01N2021/3148 ,  G01N2021/3181 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/10

    Abstract: Devices, methods, systems, and computer-readable media for a dual wavelength source gas sensor are described herein. One or more embodiments include a gas sensor, comprising: a dual wavelength source (102-1), (102-2) to transmit a first wavelength (104-1) within an absorption range of the gas and a second wavelength (104-2) that is outside the absorption range of the gas via an optical path, wherein a gas (106) is present through the optical path, a detector (114) to receive the first wavelength (104-1) and the second wavelength (104-2) via the optical path, and a computing device coupled to the detector (114) to determine a signal intensity for the first wavelength (104-1) and the second wavelength (104-2), wherein the second wavelength (104-2) is a reference wavelength and can be used for montoring of the laser power, for detection of the presence and/or concentration of particulate matter in the gas (106) and for identification of a system failure, such as a false alam.

    Abstract translation: 本文描述了用于双波长源气体传感器的设备，方法，系统和计算机可读介质。 一个或多个实施例包括气体传感器，其包括：在气体的吸收范围内传输第一波长（104-1）的双波长源（102-1），（102-2） 通过光路存在气体（106），接收第一波长（104-1）和第二波长（104）的检测器（114） -2）;以及耦合到所述检测器（114）的计算设备，以确定所述第一波长（104-1）和所述第二波长（104-2）的信号强度，其中所述第二波长（104- 2）是参考波长，并且可以用于监测激光功率，用于检测气体（106）中颗粒物质的存在和/或浓度，以及用于识别系统故障，例如假阿拉姆。

    IMAGING APPARATUS AND IMAGING METHOD
    12.
    发明公开
    IMAGING APPARATUS AND IMAGING METHOD 审中-公开
    成像装置和成像方法

    公开(公告)号：EP3214427A1

    公开(公告)日：2017-09-06

    申请号：EP16186606.6

    申请日：2016-08-31

    Applicant: SCREEN Holdings Co., Ltd.

    Inventor： Kokubo, Masahiko

    IPC: G01N21/25

    CPC classification number: H04N5/2256 ,  G01N21/253 ,  G01N33/487 ,  G01N2201/061 ,  G01N2201/10 ,  G02B21/0032 ,  G02B21/362 ,  G06K9/00134

    Abstract: An imaging apparatus (1) for imaging an imaging object carried together with liquid (M) in a sample container (W) with a bottom surface having optical transparency comprises: a holder (12) for holding the sample container; an imaging optical system (131, 132, 133, 135) having an object-side hypercentric property; a two-dimensional imaging element (136) for imaging an image of the imaging object focused by the imaging optical system; an illuminator (10) for illuminating the imaging object from a side opposite to the imaging optical system across the sample container held by the holder; a mover (15) for relatively integrally moving the imaging optical system, the two-dimensional imaging element and the illuminator with respect to the imaging object in a direction orthogonal to an optical axis of the imaging optical system; and a controller (14), wherein: the illuminator includes a plurality of illumination optical systems (100, 110) that have mutually different exit pupil positions and coaxially emit lights toward the imaging object; the controller is configured to cause one of the plurality of illumination optical systems to emit light and to cause the two-dimensional imaging element to image the imaging object when a relative position of the imaging optical system with respect to the imaging object reaches any one of a plurality of imaging positions determined in advance while causing the mover to relatively move the imaging optical system, the two-dimensional imaging element and the illuminator with respect to the imaging object, and to switch the illumination optical system for emitting the light according to the imaging position.

    Abstract translation: 一种成像装置（1），用于将具有液体（M）的成像对象在具有光学透明性的底面的样本容器（W）中成像，所述成像装置包括：保持器（12），用于保持所述样本容器; 具有物侧超心形特性的成像光学系统（131,132,133,135） 二维成像元件（136），用于对由成像光学系统聚焦的成像对象的图像进行成像; 照明器（10），其用于从保持在所述保持器上的所述检体容器的相对于所述摄像光学系统的相反侧照射所述摄像对象物; 移动器（15），用于使所述成像光学系统，所述二维成像元件和所述照明器相对于所述成像对象在与所述成像光学系统的光轴正交的方向上相对地整体移动; 和控制器（14），其中：所述照明器包括多个照明光学系统（100,110），所述多个照明光学系统具有相互不同的出射光瞳位置并且朝向所述成像对象同轴发光; 所述控制器被配置为当所述成像光学系统相对于所述成像对象的相对位置达到所述成像对象中的任何一个时，使所述多个照明光学系统中的一个发光并且使所述二维成像元件对所述成像对象成像。 在使所述动子相对于所述摄像对象物使所述摄像光学系统，所述二维摄像元件及所述照明装置相对移动的同时预先决定的多个摄像位置，以及根据所述摄像光学系统，所述二维摄像元件及所述照明装置， 成像位置。

    SYSTEM AND METHOD FOR CONFOCAL RAMAN-SPECTROSCOPIC MEASUREMENTS OF BIOLOGICAL SAMPLES
    13.
    发明公开
    SYSTEM AND METHOD FOR CONFOCAL RAMAN-SPECTROSCOPIC MEASUREMENTS OF BIOLOGICAL SAMPLES 审中-公开
    用于生物样本的共焦拉曼光谱测量的系统和方法

    公开(公告)号：EP3182099A1

    公开(公告)日：2017-06-21

    申请号：EP15200489.1

    申请日：2015-12-16

    Applicant: rap.ID Particle Systems GmbH

    Inventor： GOEDE, Karsten ,  HOLZ, Lothar ,  LANKERS, Markus ,  VALET, Oliver K.

    IPC: G01N21/65 ,  G01J3/44

    CPC classification number: G01N21/03 ,  G01J3/44 ,  G01N21/65 ,  G01N33/483 ,  G01N2021/0385 ,  G01N2021/0389 ,  G01N2201/0846 ,  G01N2201/10

    Abstract: The invention relates to a system (1) for confocal Raman-spectroscopic measurements, comprising at least the following components:
    - a sample chamber (10), wherein said sample chamber (10) is configured to house a sample (2) in a closed chamber volume (12) of the sample chamber (10),
    - an excitation light source (3),
    - an objective lens (4), configured to focus excitation light (32) of the excitation light source (3) through a ceiling portion (11) of the sample chamber (10) in a focal volume (31) in the chamber volume (12) and to collect inelastically scattered light (33) stemming from the focal volume (31),
    - a confocal detection arrangement (20), comprising means for a confocal detection (22, 23) of a Raman signal comprised in the inelastically scattered light (33) from the focal volume (31), and a detector (21) that is configured to detect and to record said Raman signal,
    wherein the distance (5) between the ceiling portion (11) of the sample chamber (10) and the focal volume (31) is greater than one millimetre during operation of the system (1).

    Abstract translation: 本发明涉及用于共焦拉曼光谱测量的系统（1），其至少包括以下组件： - 样品室（10），其中所述样品室（10）被配置为将样品（2） （10）的腔室容积（12）， - 激励光源（3）， - 物镜（4），其配置为将激励光源（3）的激励光（32）聚焦通过天花板部分 （12）中的聚焦体积（31）中的样本室（10）的样本（11），并且收集源自所述聚焦容积（31）的非弹性散射光（33）， - 共焦检测装置（20） ，包括用于包括在来自所述聚焦容积（31）的所述非弹性散射光（33）中的拉曼信号的共焦检测（22,23）的装置，以及配置成检测并记录所述拉曼信号 ，其中样品室（10）的顶部（11）与聚焦体积（31）之间的距离（5）为i 在系统（1）的操作期间大于1毫米。

    PROCÉDÉ DE DÉTECTION ET DE QUANTIFICATION DE LA FIBROSE
    14.
    发明公开
    PROCÉDÉ DE DÉTECTION ET DE QUANTIFICATION DE LA FIBROSE 有权
    PROC DE D DETÉTECTIONET DE数量DE LA FIBROSE

    公开(公告)号：EP3175224A1

    公开(公告)日：2017-06-07

    申请号：EP15756961.7

    申请日：2015-07-02

    Applicant: Université De Reims Champagne-Ardenne

    Inventor： VUIBLET, Vincent ,  PIOT, Olivier ,  RIEU, Philippe ,  FERE, Michael ,  GOBINET, Cyril

    IPC: G01N21/3563 ,  G01N21/359 ,  G01N21/35 ,  G01N21/31

    CPC classification number: G01N21/3563 ,  G01N21/359 ,  G01N33/5091 ,  G01N2021/3196 ,  G01N2021/3595 ,  G01N2201/10 ,  G01N2201/129

    Abstract: A method for detecting and quantifying fibrosis, which involves at least; positioning a non-coloured fixed tissue sample on a support; carrying out infrared acquisition, by scanning, of points of said sample; converting the infrared spectrum produced by each acquired point into at least one spectral image; carrying out a digital processing operation on said spectral image by distinguishing between at least physiological collagen and pathological collagen from fibrosis, attributing, to each point, a spectral class defined by an algorithm classifying the spectra according to the spectral similarities % thereof, then attributing a status to each class by statistically comparing with a digital model of spectra; quantifying the relative surface area occupied by the points of each status and recording the result.

    Abstract translation: 一种检测和定量纤维化的方法，至少涉及; 将无色固定的组织样本定位在支撑件上; 通过扫描来进行所述样本的点的红外采集; 将由每个获取的点产生的红外光谱转换为至少一个光谱图像; 通过区分至少生理胶原蛋白和病理性胶原蛋白与纤维化来对所述光谱图像执行数字处理操作，从而将每个点归因于由根据其光谱相似度％对光谱进行分类的算法定义的光谱类别，然后归因于 通过与光谱的数字模型进行统计比较来确定每个类别的状态; 量化每个状态的点所占据的相对表面积并记录结果。

    INHIBITORS OF ALPHA-CRYSTALLIN AGGREGATION FOR THE TREATMENT FOR CATARACT
    18.
    发明公开
    INHIBITORS OF ALPHA-CRYSTALLIN AGGREGATION FOR THE TREATMENT FOR CATARACT 审中-公开
    ALPHA-KRISTALLIN-AGGREGATION SHEMMER ZUR KATARAKTBEHANDLUNG

    公开(公告)号：EP2874709A2

    公开(公告)日：2015-05-27

    申请号：EP13742133.5

    申请日：2013-07-17

    Applicant: The Regents of The University of Michigan

    Inventor： GESTWICKI, Jason, E.

    IPC: A61P27/12 ,  A61K31/575 ,  A61K31/045 ,  G01N33/68 ,  A61K47/48

    CPC classification number: A61K31/575 ,  A61K9/0048 ,  A61K31/045 ,  A61K47/6951 ,  B82Y5/00 ,  C07J9/00 ,  C12Q1/34 ,  G01N21/6428 ,  G01N33/68 ,  G01N2201/10 ,  G01N2333/4709 ,  G01N2500/20

    Abstract: The invention provides inhibitors of α-crystallin aggregation and methods of using α-crystallin aggregation inhibitors to, e.g., treat or prevent cataracts in a subject having or at risk of developing cataracts. The invention further provides high throughput methods of screening compounds for modulation of protein thermal stability, the method comprising contacting a protein with each of a plurality of test compounds; and (b) measuring the melting transition (Tm) of the protein in the presence of each of the plurality of test compounds, wherein a compound that decreases or increases the apparent Tm by at least 2 standard deviations is identified as a pharmacological protein chaperone.

    Abstract translation: 本发明提供了α-晶状体蛋白聚集的抑制剂和使用α-晶状蛋白聚集抑制剂的方法，例如治疗或预防具有或有发生白内障风险的受试者的白内障。 本发明还提供了筛选化合物用于调节蛋白质热稳定性的高通量方法，所述方法包括使蛋白质与多种测试化合物中的每一种接触; 并且（b）测量在多种测试化合物中存在的蛋白质的熔融转变（Tm），其中将表观Tm降低或增加至少2个标准偏差的化合物被鉴定为药理学蛋白质分子伴侣。

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