公开(公告)号：EP3581917A1

公开(公告)日：2019-12-18

申请号：EP18751637.2

申请日：2018-02-13

申请人： Tosoh Corporation ,  National University Corporation Chiba University

发明人： IIJIMA, Kazuki ,  TOYOSHIMA, Toshinobu ,  FURUKAWA, Kotohiro ,  KATAYAMA, Koji ,  JIN, Naotaka ,  SEKI, Minoru

IPC分类号： G01N15/12 ,  B03B5/00

摘要： The objective of the present invention is to provide a particle detection device and a particle detection method that can individually and continuously detect a wide range of particles. The objective is achieved by a particle detection device including: a particle separation channel through which particles are separated according to particle sizes in a perpendicular direction to the flow of fluid; and two or more particle recovery channels that are connected to and branched from the particle separation channel, in which each of the particle recovery channels includes a particle detection unit that includes an aperture and an electric detector.

公开(公告)号：EP2638393B1

公开(公告)日：2019-03-06

申请号：EP11839117.6

申请日：2011-11-09

申请人： The General Hospital Corporation ,  Massachusetts Institute of Technology ,  The Board of Trustees of the University of Illinois ,  Daktari Diagnostics, Inc.

发明人： WATKINS, Nicholas ,  BASHIR, Rashid ,  RODRIGUEZ, William ,  CHENG, Xuanhong ,  TONER, Mehmet ,  CHEN, Grace ,  OPPENHEIMER, Aaron

IPC分类号： G01N33/53 ,  G01N33/52 ,  G01N21/17 ,  C12M1/34 ,  G01N15/12 ,  G01N33/569 ,  G01N33/543 ,  G01N15/10 ,  G01N15/14

公开(公告)号：EP3255408B1

公开(公告)日：2019-01-23

申请号：EP17182219.0

申请日：2014-05-08

申请人： Masterrind GmbH

发明人： RATH, Detlef

IPC分类号： G01N15/14 ,  G01N15/12 ,  G01N15/10 ,  C12M1/00 ,  G01N33/487

公开(公告)号：EP3403066A1

公开(公告)日：2018-11-21

申请号：EP17738912.9

申请日：2017-01-12

申请人： The Board of Trustees of the University of Illinois

发明人： BASHIR, Rashid ,  REDDY, Bobby, Jr. ,  GHONGE, Tanmay ,  HASSAN, Umer ,  DURACK, Gary ,  DAMHORST, Gregory

IPC分类号： G01N15/12 ,  G01N27/02 ,  G01N27/27 ,  C12M1/34

CPC分类号： G01N15/10 ,  C12M41/36 ,  G01N27/745 ,  G01N33/48721 ,  G01N2015/1006 ,  G01N2015/1486

摘要： Provided are methods and systems that characterize a property of a particle suspended in a fluid sample in a label-free manner. Detection elements are provided fluidically adjacent upstream and downstream from a modulation element. Fluid sample containing particles flows across a first detection element and a first particle parameter detected for each particle that passes the first detection element or a first aggregate particle parameter for a plurality of particles that pass the first detection element. The particles flow from the first detection element to a first modulation element, wherein the first modulation element effects a change in a property of the particles flowing past the first modulation element. A second detection element then detects the particle parameter again or a second aggregate particle parameter for a plurality of particles that pass the second detection element. Comparing the first and second particle or aggregate parameters thereby characterizes the particle property.

公开(公告)号：EP3348992A1

公开(公告)日：2018-07-18

申请号：EP17178172.7

申请日：2005-02-25

申请人： Novelis, Inc.

发明人： MARCOTTE, Jacques ,  SLUSARENKO, Yuhil

IPC分类号： G01N15/02 ,  G01N27/403 ,  G01N33/20 ,  G01N15/12

摘要： The present invention relates to a liquid metal cleanliness analyzer comprising: an insulating wall comprising a passage; a first electrode disposed proximate to a first side of the insulating wall; at least one additional electrode proximate to a second side of the insulating wall, wherein the second side is opposite of the first side; a computation apparatus; and a current supply system connected to the first electrode and to the at least one additional electrode, wherein: the computation apparatus is configured to measure a voltage between the first electrode and the at least one additional electrode while liquid metal flows through the passage; when a current measured falls below a predetermined level, the liquid metal cleanliness analyzer is configured to suspend measurement of the voltage while the current supply system is adjusted to return the current to an initial value; and the measurement is restarted after the current is returned to the initial value. Furthermore, the invention relates to a method of operating a liquid metal cleanliness analyser.

公开(公告)号：EP1417481B1

公开(公告)日：2017-12-20

申请号：EP02748164.7

申请日：2002-07-15

申请人： Beckman Coulter, Inc.

发明人： HUO, Ziling ,  PARK, Jaesang ,  YAO, Wei ,  ZHANG, Shuliang ,  ZHENG, Min

IPC分类号： G01N31/00 ,  G01N15/12 ,  G01N33/49 ,  G01N33/50

CPC分类号： G01N15/12 ,  G01N15/1456 ,  G01N21/47 ,  G01N33/491 ,  G01N2015/1037 ,  Y10T436/10 ,  Y10T436/101666 ,  Y10T436/107497

摘要： A method of analyzing nucleated red blood cells (NRBCs) in a blood sample and further enumerating NRBCs is disclosed. The method includes lysing a first aliquot and a second aliquot of a blood sample separately with a first lysing reagent system and a second lysing reagent system; measuring the first sample mixture in a flow cell by DC, RF, and light scatter measurements; measuring cell distributions and counting remaining blood cells in the second sample mixture by DC impedance measurements in a non-focused flow aperture; analyzing blood cell distribution patterns obtained from measuring the first sample mixture and from measuring the second sample mixture respectively; and further performing a combined analysis to differentiate NRBCs from other cell types and determine numbers of NRBCs in the blood sample.

公开(公告)号：EP3236233A1

公开(公告)日：2017-10-25

申请号：EP17160299.8

申请日：2005-12-02

申请人： XY, LLC ,  Chata Biosystems, Inc.

发明人： NEAS, Edwin Dean ,  KUIKEN, Jerald Edward ,  SCHENK, John Louis ,  GILLIGAN, Thomas Boyd

IPC分类号： G01N15/10 ,  G01N15/12 ,  G01N15/14 ,  B01L3/02 ,  B01L3/00 ,  G01N35/10

CPC分类号： G01N15/1484 ,  B01L3/0296 ,  B01L3/5027 ,  B01L2200/027 ,  B01L2200/0684 ,  B01L2200/141 ,  B01L2400/0481 ,  G01N35/1095 ,  G01N2015/1409 ,  G01N2015/1481 ,  G01N2015/149 ,  Y10T137/0318 ,  Y10T137/1624 ,  Y10T436/11 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/2575

摘要： A fluid handling and delivery system useful in generating a fluid stream (7) in the flow path (8) of microfluidic device (16). The system comprises a variable volume container (1) having a flexible wall (2) which acts on an amount of fluid (3) within the variable volume container (1) in response to an amount of pressure (4) exerted on the exterior surface (5) of the flexible wall (2) by an amount of gas (6). The amount of pressure (4) exerted on the exterior surface (5) of flexible wall (2) continuously adjusts the volume of the variable volume container (1) to act on the amount of fluid (3) to generate a fluid stream (7) in the flow path (8).

摘要翻译： 流体处理和输送系统可用于在微流体装置（16）的流动路径（8）中产生流体流（7）。 该系统包括具有柔性壁（2）的可变容积容器（1），柔性壁（2）响应于施加在外部表面上的压力（4）的量而作用于可变容积容器（1）内的一定量的流体 （6）的所述柔性壁（2）的所述内壁（5）上。 施加在柔性壁（2）的外表面（5）上的压力量（4）连续调节可变容积容器（1）的体积以作用于流体量（3）以产生流体流（7 ）在流路（8）中。

公开(公告)号：EP2002256B1

公开(公告)日：2017-10-18

申请号：EP07757394.7

申请日：2007-02-23

申请人： Beckman Coulter, Inc.

发明人： ORTIZ, Nery ,  GERULA, Theodore, J. ,  SOCARRAS, Sandra

IPC分类号： G01N31/00 ,  G01N33/96 ,  G01N15/10 ,  G01N15/12 ,  G01N15/14

CPC分类号： G01N33/96 ,  G01N15/1012 ,  G01N15/12 ,  G01N15/147 ,  G01N2015/1037 ,  G01N2496/05 ,  Y10T436/10 ,  Y10T436/101666 ,  Y10T436/107497 ,  Y10T436/25 ,  Y10T436/2525

公开(公告)号：EP2378283A4

公开(公告)日：2017-02-22

申请号：EP10729262

申请日：2010-01-07

申请人： SONY CORP

发明人： KATSUMOTO YOICHI ,  OMORI SHINJI

IPC分类号： G01N27/22 ,  C12M1/34 ,  G01N15/12 ,  G01N27/02

CPC分类号： G01N15/12 ,  G01N15/1031 ,  G01N15/1056 ,  G01N2015/1006 ,  G01N2015/1254

公开(公告)号：EP1953525B1

公开(公告)日：2016-12-14

申请号：EP08001586.0

申请日：2008-01-29

申请人： SYSMEX CORPORATION

发明人： Narisada, Noriyuki

IPC分类号： G01N15/12 ,  G01N15/14 ,  G01N35/00 ,  G01N33/49

CPC分类号： G01N15/1459 ,  G01N15/12 ,  G01N35/00594 ,  G01N2015/0073 ,  G01N2015/0076 ,  G01N2015/008 ,  G01N2015/1486