公开(公告)号：EP0119031A3

公开(公告)日：1985-09-18

申请号：EP84301278

申请日：1984-02-28

申请人： THE UNIVERSITY OF MARYLAND AT BALTIMORE

发明人： Kaper, James B. ,  Levine, Myron M.

IPC分类号： C12N15/00 ,  C12N01/20 ,  A61K39/106 ,  C12R01/63

CPC分类号： A61K39/107 ,  A61K2039/522 ,  C07K14/28 ,  C12N15/01 ,  C12R1/63 ,  Y02A50/472 ,  Y10S435/909

摘要： This invention relates to a method of isolating deletion mutants of Vibrio cholerae ,wherein the deletion is predetermined by digestion with restriction endonucleases of known specificity. The deletions are inserted into the Vibrio cholerae chromosone by in vivo recombination between a plasmid carrying the desired deletion, with adjacent flanking sequences, and the Vibrio cholerae chromosome. The invention includes the isolation and characterization of a new Vibrio cholerae strain having a deletion in the tox gene, as defined by Acc I, Xba I, C/a I and/or restriction endonuclease sites.

公开(公告)号：EP4104854A3

公开(公告)日：2023-03-08

申请号：EP22171378.7

申请日：2017-03-31

申请人： The United States of America as represented by the Secretary of the Department of Health and Human Services ,  The University Of Maryland ,  Thomas Jefferson University

发明人： JOHNSON, Reed, F. ,  SCHNELL, Matthias ,  HENSLEY, Lisa, E. ,  WIRBLICH, Christoph ,  COLEMAN, Christopher, M. ,  FRIEMAN, Matthew, B.

IPC分类号： A61K39/12 ,  A61K39/205 ,  A61K39/215 ,  C12N7/04 ,  C12N15/86

摘要： The present disclosure provides methods and compositions for inducing an immune response that confers dual protection against infections by either or both of a rabies virus and a coronavirus, and/or which can be used therapeutically for an existing infection with rabies virus and/or a coronavirus to treat at least one symptom thereof and/or to neutralize or clear the infecting agents. In particular, the present disclosure provides a recombinant rabies virus vector comprising a nucleotide sequence encoding at least one coronavirus immunogenic glycoprotein fragment, as well as pharmaceutical compositions comprising the vaccine vectors.

公开(公告)号：EP3439695A1

公开(公告)日：2019-02-13

申请号：EP17718216.9

申请日：2017-03-31

申请人： The U.S.A. as represented by the Secretary, Department of Health and Human Services ,  The University Of Maryland ,  Thomas Jefferson University

发明人： JOHNSON, Reed F. ,  SCHNELL, Matthias ,  HENSLEY, Lisa E. ,  WIRBLICH, Christoph ,  COLEMAN, Christopher M. ,  FRIEMAN, Matthew B.

IPC分类号： A61K39/12 ,  A61K39/205 ,  A61K39/215 ,  C12N7/04 ,  C12N15/86

公开(公告)号：EP2970731A1

公开(公告)日：2016-01-20

申请号：EP14773437.0

申请日：2014-03-13

申请人： The University Of Maryland Office of Technology Commercialization

发明人： DIEHN, Kevin ,  DOWLING, Matthew ,  RAGHAVAN, Srinivasa R. ,  KING, David R.

IPC分类号： C09K3/00

摘要： A hemostatic putty for treatment of a variety of wounds topographies, including but not limited to highly three dimensional wounds, for example gunshot wounds and impalements, is disclosed. The putty is comprised of a matrix polymer weakly crosslinked or not crosslinked such that a viscoelastic matrix is formed. The viscoelastic nature of the putty is tunable by the composition and enables the putty to conform to a variety of wound topographies. Likewise, a hemostatic polymer, for example chitosan or hydrophobically modified chitosan, is included in this matrix to impart hemostatic properties and tissue adhesive on the putty. The hemostatic polymers disclosed prevent microbial infection and are suitable for oxygen transfer required during normal wound metabolism.

公开(公告)号：EP1977248A2

公开(公告)日：2008-10-08

申请号：EP07762499.7

申请日：2007-01-23

申请人： THE UNIVERSITY OF MARYLAND AT BALTIMORE

发明人： FRANKLIN, Renty, B. ,  COSTELLO, Leslie, C.

IPC分类号： G01N33/574 ,  C12N5/06 ,  C12N5/16

CPC分类号： C12Q1/6886 ,  C12Q2600/158 ,  Y10T436/201666

摘要： The present invention provides methods of detecting prostate cancer employing biomarkers, including hZIPl, zinc and citrate. Also provided are antibodies to detect hZIPl protein or peptides and an expression vector comprising a genetic sequence effective to increase uptake of zinc into a prostate cell upon expression thereof. Furthermore, methods of treating prostate cancer and of increasing uptake of zinc into a prostate cell are provided.

公开(公告)号：EP1871419A2

公开(公告)日：2008-01-02

申请号：EP06751239.2

申请日：2006-04-24

申请人： THE UNIVERSITY OF MARYLAND AT BALTIMORE

发明人： EL-ASADY, Riham ,  HADLEY, Gregg

IPC分类号： A61K39/395

CPC分类号： G01N33/566 ,  A61K47/6825 ,  A61K47/6849

摘要： The present invention relates to methods for treating or preventing graft versus host disease (GVHD) in a host subject, with the methods comprising treating either the graft or the host subject or both to reduce the interaction of graft-origin, CD103-expressing cells with cells in the host. The present invention also relates to methods of screening a graft to determine the likelihood of the graft to generate GVHD.

公开(公告)号：EP1439667A3

公开(公告)日：2007-12-26

申请号：EP04000636.3

申请日：2004-01-14

申请人： SAMSUNG ELECTRONICS CO., LTD. ,  THE UNIVERSITY OF MARYLAND COLLEGE PARK

发明人： Lee, In-Sun ,  Jang, Kyung-Hun ,  Shin, Min-Ho ,  Arbaugh, William Albert ,  Mishra, Arunesh

IPC分类号： H04L12/28 ,  H04L12/56

CPC分类号： H04W12/04 ,  H04L9/0836 ,  H04L9/0844 ,  H04L63/062 ,  H04L63/0823 ,  H04L2209/80 ,  H04L2463/061 ,  H04W12/06 ,  H04W84/12 ,  H04W88/08

摘要： A roaming service method for a fast and secure wireless network is provided. In an embodiment of the present invention, an AP, which an STA associates with, transmits security keys needed for roaming to neighbor APs of the AP. When the STA moves to one of the neighbor APs, a reassociation is carried out between the STA and the neighbor AP using the already provided security key. In another embodiment of the present invention, an authentication server transmits security keys needed for roaming to neighbor APs to which the STA is likely to move, so that when the STA moves to one of the neighbor APs, a reassociation is carried out between the STA and the neighbor AP using the already provided security key.

公开(公告)号：EP0982988B1

公开(公告)日：2003-09-24

申请号：EP98919778.5

申请日：1998-04-28

申请人： THE UNIVERSITY OF MARYLAND AT BALTIMORE

发明人： FASANO, Alessio

IPC分类号： C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  C07K14/47 ,  A61K47/48

CPC分类号： C07K14/4716 ,  A61K38/28 ,  A61K47/62 ,  C07K14/4705 ,  Y10S530/839 ,  Y10S530/844

摘要： A substantially pure mammalian protein, hereinafter "zonulin", that is a physiological modulator of mammalian tight junctions is disclosed, as well as methods for the use of the same.

公开(公告)号：EP1305019A2

公开(公告)日：2003-05-02

申请号：EP01975702.0

申请日：2001-07-31

申请人： THE UNIVERSITY OF MARYLAND AT BALTIMORE

发明人： HAYASHI, Jun ,  MACKERELL, Alexander, D.

IPC分类号： A61K31/215 ,  A61K31/12

CPC分类号： A61K31/16 ,  A61K31/17 ,  A61K31/192 ,  A61K31/195 ,  A61K31/21 ,  A61K31/222 ,  A61K31/265 ,  A61K31/4402 ,  A61K31/47 ,  A61K31/66

摘要： Compounds are described which modulate the tzrosine kinase activity of p56lck and signal transduction pathways in which this enzyme is involved. The invention also relates to compounds which have immunomodulatory activity, e.g., which have immunosuppressant or immunostimulatory activity, and/or which have an antineoplastic effect. The invention further relates to compositions comprising these compounds, and methods of using them.

公开(公告)号：EP1185682A1

公开(公告)日：2002-03-13

申请号：EP99925596.1

申请日：1999-05-21

申请人： THE UNIVERSITY OF MARYLAND

发明人： CUNNINGHAM, Francis, X.

IPC分类号： C12P23/00 ,  C12P7/26 ,  C12N9/02 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04 ,  C07K14/00

CPC分类号： C12N9/0071 ,  C12N9/00 ,  C12N9/0004 ,  C12P23/00 ,  Y10S435/822 ,  Y10S435/946

摘要： A purified nucleic acid sequence which encodes for a protein having ketolase enzyme activity and has the nucleic acid sequence of SEQ ID NO: 1 or 3, or has a sequence which encodes the amino acid sequence of SEQ ID NO: 2 or 4, as well as vectors and host cells containing them. Methods of use of the nucleic acid sequences to produce ketocarotenoid in host cells and methods of use of the nucleic acid sequences to modify the production of carotenoids in a host cell are included.

摘要翻译： 一种纯化的核酸序列，其编码具有酮酶的酶活性的蛋白质，并具有SEQ ID NO：1或3的核酸序列，或具有编码SEQ ID NO：2或4的氨基酸序列的序列 作为载体和含有它们的宿主细胞。 包括在宿主细胞中产生酮类胡萝卜素的核酸序列的使用方法和使用该核酸序列改变宿主细胞中类胡萝卜素产生的方法。