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21.发明公开NAPHTHYLMETHYLIMIDIZOLES FOR THE TREATMENT OF STRESS URINARY INCONTINENCE 审中-公开NAPHTHYLMETHYLIMIDIZOLE压力性尿失禁的治疗
公开(公告)号：EP2296648A1
公开(公告)日：2011-03-23
申请号：EP09747222.9
申请日：2009-05-07
申请人： Allergan, Inc.
IPC分类号： A61K31/4174 , A61P13/00
CPC分类号： A61K31/4174
摘要： Disclosed herein is a method of treating stress urinary incontinence comprising administering a compound to a mammal in need thereof, wherein said compound has the formula (I). Compositions and medicaments related thereto are also disclosed.
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22.发明公开SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF 审中-公开选择性肾上腺素能活性成分从SUBTYP ALPHA 2及使用方法
公开(公告)号：EP2285372A2
公开(公告)日：2011-02-23
申请号：EP09747288.0
申请日：2009-05-11
申请人： Allergan, Inc.
IPC分类号： A61K31/415 , A61P27/02 , A61P27/06 , A61P1/12 , A61P1/04 , A61P9/12 , A61P9/10 , A61P11/02 , A61P19/02 , A61P25/14 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00
CPC分类号： A61K31/4168
摘要： The invention provides methods for treating disorders associated with selective subtype modulation of alpha 2 adrenergic receptors. In particular, the invention provides methods employing well-defined N- [1- (2 and/or 3-substituted-phenyl) -alkyl] - (4, 5-dihydro-1H-imidazol-2-yl) -amines and pharmaceutical compositions thereof to treat disorders associated with selective subtype alpha 2 adrenergic receptor modulation, such as ocular disorders, pain and central nervous system (CNS) motor disorders.
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23.发明公开OXAZOLIDINE AND THIAZOLIDINE SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF 有权恶唑烷OR 噻唑烷衍生物有关使用AS亚型选择性α-2肾上腺素受体激动剂，
公开(公告)号：EP2242753A1
公开(公告)日：2010-10-27
申请号：EP09703035.7
申请日：2009-01-14
申请人： ALLERGAN, INC.
发明人： HEIDELBAUGH, Todd, M. , CHOW, Ken , SINHA, Santosh, C. , NGUYEN, Phong, X. , FANG, Wenkui, K. , LI, Ling , TAKEUCHI, Janet, A. , BHAT, Smita, S.
IPC分类号： C07D413/12 , C07D417/12 , A61K31/422 , A61K31/427 , A61P29/00
CPC分类号： C07D401/12 , A61K31/422 , A61K31/497 , C07D213/18 , C07D241/12 , C07D263/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： The invention provides oxazolidine and thiazolidine derivatives that are useful as subtype selective alpha 2 adrenergic agonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with selective subtype modulation of alpha 2 adrenergic receptors.
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24.发明公开SUBSTITUTED-ARYL-2-PHENYLETHYL-1H-IMIDAZOLE COMPOUNDS AS SUBTYPE SELECTIVE MODULATORS OF ALPHA 2B AND/OR ALPHA 2C ADRENERGIC RECEPTORS 审中-公开取代的芳基-2-苯乙基-1H-咪唑AS调节剂的亚型选择性肾上腺素能α-2B和/或α-2C受体
公开(公告)号：EP2240453A1
公开(公告)日：2010-10-20
申请号：EP09700891.6
申请日：2009-01-05
申请人： ALLERGAN, INC.
IPC分类号： C07D233/58 , C07D233/64 , C07D401/06 , A61K31/4164 , A61K31/4427 , A61P29/00
CPC分类号： C07D401/06 , C07D233/58 , C07D233/64
摘要： A compound having selective modulating activity at the alpha 2B and/or alpha 2C adrenergic receptor subtypes is represented by the general Formula (1) wherein n=1-4; X is C or N; R1-R6 can be the same or different and are independently selected from the group consisting of H, C1-6 alkyl, OCH3, OH, F, Cl, Br, CH2OH, CH2N(R7)2, C(O)R8, CH2CN, CF3; wherein R7 is H or C1-6 alkyl; and R8 is C1-6 alkyl or aryl. The compounds of Formula (1) can be incorporated in pharmaceutical compositions and used in methods of treatment of alpha 2 receptor mediated diseases and conditions.
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公开(公告)号：EP2188261A1
公开(公告)日：2010-05-26
申请号：EP08797858.1
申请日：2008-08-14
申请人： ALLERGAN, INC.
发明人： CHOW, Ken , FANG, Wenkui, K. , CORPUZ, Evelyn, G. , GOMEZ, Dario, G. , SINHA, Santosh, C. , BHAT, Smita, S. , HEIDELBAUGH, Todd, M. , GIL, Daniel, W.
IPC分类号： C07D233/50 , C07D263/28 , C07D277/18 , A61K31/4168 , A61K31/421 , A61K31/426 , A61P25/04
CPC分类号： C07D233/50 , C07D263/28 , C07D277/18
摘要： Disclosed herein is a compound having a structure (I), compositions, methods, and medicaments related thereto are also disclosed.
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26.发明公开4-(CONDENSED CYCLICMETHYL)-IMIDAZOLE-2-THIONES ACTING AS ALPHA2 ADRENERGIC AGONISTS 审中-公开4-（稠环）咪唑-2-硫酮ASα2-肾上腺素能激动剂作用
公开(公告)号：EP1791833A2
公开(公告)日：2007-06-06
申请号：EP05796239.1
申请日：2005-09-07
申请人： ALLERGAN, INC.
发明人： HEIDELBAUGH, Todd, M. , CHOW, Ken , NGUYEN, Phong, X. , GIL, Daniel , DONELLO, John, E. , GARST, Michael, E. , WHEELER, Larry, A.
IPC分类号： C07D405/06 , C07D401/06 , C07D233/84 , C07D409/06 , C07D417/06 , A61K31/4164 , A61K31/4178 , A61P29/02
CPC分类号： C07D405/06 , C07D233/84 , C07D401/06 , C07D409/06 , C07D417/06
摘要： Compounds of Formula 1 (I) where the variables have the meaning defined in the specification are agonists of alpha2 adrenergic receptors. Several compounds of the disclosure are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors. Additionally some of the claimed compounds have no or only minimal cardivascular and/or sedatory activity. The compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2 adrenergic receptors. Compounds of Formula 1 which have no significant cardiovascular and/or sedatory activity are useful for treating pain and other conditions with minimal side effects.
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27.发明公开4-(HETEROARYL-METHYL AND SUBSTITUTED HETEROARYL-METHYL)-IMIDAZOLE-2-THIONES ACTING AS ALPHA2 ADRENERGIC AGONISTS 审中-公开4-（杂芳基和取代杂芳基）咪唑-2-硫酮ASα2-肾上腺素能激动剂作用
公开(公告)号：EP1791832A1
公开(公告)日：2007-06-06
申请号：EP05796248.2
申请日：2005-09-07
申请人： ALLERGAN, INC.
发明人： HEIDELBAUGH, Todd, M. , CHOW, Ken , NGUYEN, Phong, X. , GIL, Daniel, W. , DONELLO, John, E. , GARST, Michael, E. , WHEELER, Larry, A.
IPC分类号： C07D403/06 , C07D401/06 , C07D409/06 , C07D405/06 , A61K31/4178 , A61K31/437 , A61K31/4439 , A61P1/12 , A61P7/12 , A61P9/12 , A61P29/00 , A61P37/00
CPC分类号： C07D471/04 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06
摘要： Compounds of formula (I) where the variables have the meaning defined in the specification are agonists of alpha2 adrenergic receptors. Several compounds of the disclosure are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors. Additionally some of the claimed compounds have no or only minimal cardivascular and/or sedatory activity. The compounds of formula (I) are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2 adrenergic receptors. Compounds of formula (I) which have no significant cardiovascular and/or sedatory activity are useful for treating pain and other conditions with minimal side effects.
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28.发明授权OXAZOLIDINE AND THIAZOLIDINE SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF 有权恶唑烷OR 噻唑烷衍生物有关使用AS亚型选择性α-2肾上腺素受体激动剂，
公开(公告)号：EP2242753B1
公开(公告)日：2015-04-08
申请号：EP09703035.7
申请日：2009-01-14
申请人： ALLERGAN, INC.
发明人： HEIDELBAUGH, Todd, M. , CHOW, Ken , SINHA, Santosh, C. , NGUYEN, Phong, X. , FANG, Wenkui, K. , LI, Ling , TAKEUCHI, Janet, A. , BHAT, Smita, S.
IPC分类号： C07D413/12 , C07D417/12 , A61K31/422 , A61K31/427 , A61P29/00
CPC分类号： C07D401/12 , A61K31/422 , A61K31/497 , C07D213/18 , C07D241/12 , C07D263/12 , C07D403/12 , C07D413/12 , C07D417/12
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29.发明授权((BICYLICHETEROARYL) IMIDAZOLYL) METHYLHETEROARYL COMPOUNDS AS ADRENERGIC RECEPTOR AGONISTS 有权（（二环杂芳基）咪唑基）METHYLHETEROARYLVERBINDUNGEN AS肾上腺素能受体的激动剂
公开(公告)号：EP2162450B1
公开(公告)日：2015-02-25
申请号：EP08755994.4
申请日：2008-05-21
申请人： ALLERGAN, INC.
发明人： SINHA, Santosh, C. , HEIDELBAUGH, Todd, M. , CHOW, Ken , BHAT, Smita, S. , NGUYEN, Phong, X. , GARST, Michael, E.
IPC分类号： C07D401/14 , C07D405/14 , A61K31/4709 , A61P29/02
CPC分类号： C07D401/14 , C07D405/14
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公开(公告)号：EP2155715B1
公开(公告)日：2013-03-13
申请号：EP08769462.6
申请日：2008-05-13
申请人： ALLERGAN, INC.
发明人： SINHA, Santosh, C. , HEIDELBAUGH, Todd, M. , CHOW, Ken , BHAT, Smita, S. , NGUYEN, Phong, X. , GARST, Michael, E.
IPC分类号： C07D401/06 , C07D409/06 , A61K31/4178 , A61P29/00
CPC分类号： C07D401/06 , C07D409/06
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