公开(公告)号：EP2606048A4

公开(公告)日：2014-01-15

申请号：EP11818823

申请日：2011-08-19

Applicant: UNIV ILLINOIS

Inventor： HARTWIG JOHN F ,  MORIMOTO HIROYUKI ,  FIER PATRICK

IPC: C07D471/04 ,  C07C29/32 ,  C07C41/30 ,  C07C45/68

CPC classification number: C07C17/32 ,  B01J31/0231 ,  B01J31/0235 ,  B01J31/0244 ,  C07B39/00 ,  C07C17/263 ,  C07C22/08 ,  C07C29/32 ,  C07C37/11 ,  C07C41/30 ,  C07C41/48 ,  C07C45/63 ,  C07C45/68 ,  C07C67/293 ,  C07C67/343 ,  C07C201/12 ,  C07C209/68 ,  C07C231/12 ,  C07C253/30 ,  C07D209/08 ,  C07D209/10 ,  C07D213/26 ,  C07D213/61 ,  C07D215/12 ,  C07D215/18 ,  C07D239/22 ,  C07D239/54 ,  C07F1/08 ,  C07C43/225 ,  C07C33/46 ,  C07C47/55 ,  C07C49/80 ,  C07C69/63 ,  C07C43/1742 ,  C07C69/76 ,  C07C43/313 ,  C07C255/50 ,  C07C25/13 ,  C07C205/11 ,  C07C211/52 ,  C07C233/15

Abstract: A method of forming a fluorinated molecular entity includes reacting in a reaction mixture an aromatic halide, copper, a fluoroalkyl group, and a ligand. The aromatic halide includes an aromatic group and a halogen substituent bonded to the aromatic group. The ligand includes at least one group-V donor selected from phosphorus and an amine. The overall molar ratio of copper to aromatic halide in the reaction mixture is from 0.2 to 3. The method further includes forming a fluoroalkylarene including the aromatic group and the fluoroalkyl group bonded to the aromatic group. A composition, which may be used in the method, consists essentially of copper, the fluoroalkyl group, and the ligand, where the molar ratio of copper to the fluoroalkyl group is approximately 1.

公开(公告)号：EP2681185A1

公开(公告)日：2014-01-08

申请号：EP12706245.3

申请日：2012-02-27

Applicant: Bayer Intellectual Property GmbH

Inventor： HIMMLER, Thomas ,  GOOSSEN, Lukas J. ,  RUDOLPHI, Felix ,  SONG, Bingrui

IPC: C07C205/56 ,  C07C253/30 ,  C07C319/20 ,  C07C67/343 ,  C07C333/24 ,  C07C69/612 ,  C07C69/734 ,  C07C69/616 ,  C07C69/75 ,  C07C69/76

CPC classification number: C07D333/24 ,  C07C67/343 ,  C07C201/12 ,  C07C253/30 ,  C07C319/20 ,  C07C255/57 ,  C07C323/62 ,  C07C205/56 ,  C07C69/612 ,  C07C69/734 ,  C07C69/616 ,  C07C69/738 ,  C07C69/65 ,  C07C69/76 ,  C07C323/52

Abstract: The invention relates to a process for preparing aryl- and heteroaryl­acetic acids and derivatives thereof by reaction of aryl or heteroaryl halides with malonic diesters in the presence of a palladium catalyst, one or more bases and optionally a phase transfer catalyst. This process enables the preparation of a multitude of functionalized aryl- and heteroarylacetic acids and derivatives thereof, and more particularly also the preparation of arylacetic acids with sterically demanding substituents.

Abstract translation: 本发明涉及通过芳基或杂芳基卤化物与丙二酸二酯在钯催化剂存在下，一种或多种碱和任选的相转移催化剂的反应制备芳基和杂芳基乙酸及其衍生物的方法。 该方法能够制备大量官能化的芳基和杂芳基乙酸及其衍生物，特别是制备具有空间要求取代基的芳基乙酸。

公开(公告)号：EP2576486A4

公开(公告)日：2014-01-01

申请号：EP11787494

申请日：2011-05-27

Applicant: GRAPHEA INC

Inventor： BIELAWSKI CHRISTOPHER W ,  DREYER DANIEL R ,  JIA HONG-PENG

IPC: C07B41/00 ,  B01J21/18 ,  C07C29/09 ,  C07C45/42 ,  C07C51/093

CPC classification number: B01J31/04 ,  B01J8/067 ,  B01J8/382 ,  B01J19/00 ,  B01J21/18 ,  B01J21/185 ,  B01J35/002 ,  B01J35/023 ,  B01J37/12 ,  B01J37/349 ,  B01J2208/00176 ,  B01J2208/00212 ,  B01J2219/00006 ,  B01J2219/00031 ,  B01J2219/00033 ,  B01J2219/00038 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/194 ,  C01B32/23 ,  C07C45/28 ,  C07C45/29 ,  C07C45/30 ,  C07C201/12 ,  C07C315/02 ,  C07C319/24 ,  C07D333/22

公开(公告)号：EP2576048A4

公开(公告)日：2014-01-01

申请号：EP11787491

申请日：2011-05-27

Applicant: GRAPHEA INC

Inventor： BIELAWSKI CHRISTOPHER W ,  DREYER DANIEL R

IPC: B01J21/18 ,  B01J8/18 ,  B01J19/24 ,  B01J37/02 ,  C01B31/04

CPC classification number: B01J31/04 ,  B01J8/067 ,  B01J8/382 ,  B01J19/00 ,  B01J21/18 ,  B01J21/185 ,  B01J35/002 ,  B01J35/023 ,  B01J37/12 ,  B01J37/349 ,  B01J2208/00176 ,  B01J2208/00212 ,  B01J2219/00006 ,  B01J2219/00031 ,  B01J2219/00033 ,  B01J2219/00038 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/194 ,  C01B32/23 ,  C07C45/28 ,  C07C45/29 ,  C07C45/30 ,  C07C201/12 ,  C07C315/02 ,  C07C319/24 ,  C07D333/22

公开(公告)号：EP2174927B1

公开(公告)日：2013-09-11

申请号：EP08791756.3

申请日：2008-07-28

Applicant: Sumitomo Chemical Company, Limited

Inventor： TAKEDA, Masahiro ,  KADONO, Hiroshi ,  MURAKAMI, Kazuo

IPC: C07C201/12 ,  C07C205/09

CPC classification number: C07C201/12 ,  C07C205/09

公开(公告)号：EP2576486A2

公开(公告)日：2013-04-10

申请号：EP11787494.1

申请日：2011-05-27

Applicant: Graphea, Inc.

Inventor： BIELAWSKI, Christopher W. ,  DREYER, Daniel R. ,  JIA, Hong-Peng

IPC: C07B41/00 ,  B01J21/18 ,  C07C45/42 ,  C07C51/093 ,  C07C29/09

CPC classification number: B01J31/04 ,  B01J8/067 ,  B01J8/382 ,  B01J19/00 ,  B01J21/18 ,  B01J21/185 ,  B01J35/002 ,  B01J35/023 ,  B01J37/12 ,  B01J37/349 ,  B01J2208/00176 ,  B01J2208/00212 ,  B01J2219/00006 ,  B01J2219/00031 ,  B01J2219/00033 ,  B01J2219/00038 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/194 ,  C01B32/23 ,  C07C45/28 ,  C07C45/29 ,  C07C45/30 ,  C07C201/12 ,  C07C315/02 ,  C07C319/24 ,  C07D333/22

Abstract: The disclosure relates to catalytically active carbocatalysts, e.g., a graphene oxide or graphite oxide catalyst suitable for use in a variety of chemical transformations. In one embodiment, it relates to a method of catalyzing a chemical reaction of an organic molecule by reacting the organic molecule in the presence of a sufficient amount of graphene oxide or graphite oxide for a time and at a temperature sufficient to allow catalysis of a chemical reaction. According to other embodiments, the reaction may be an oxidation reaction, a hydration reaction, a dehydrogenation reaction, a condensation reaction, or a polymerization reaction. Some reactions may include auto-tandem reactions. The disclosure further provides reaction mixtures containing an organic molecule and graphene oxide or graphite oxide in an amount sufficient to catalyze a reaction of the organic molecule.

公开(公告)号：EP2418204A4

公开(公告)日：2012-07-18

申请号：EP10761763

申请日：2010-04-09

Applicant: UNIV KYOTO ,  SUMITOMO CHEMICAL CO

Inventor： TAKEMOTO YOSHIJI ,  MURAKAMI KAZUO

IPC: C07D235/30 ,  C07B53/00 ,  C07B61/00 ,  C07C201/12 ,  C07C205/53 ,  C07C253/30 ,  C07C255/41 ,  C07C281/02 ,  C07D239/88

CPC classification number: C07C253/30 ,  C07B53/00 ,  C07B2200/07 ,  C07C67/343 ,  C07C201/12 ,  C07C205/53 ,  C07C231/08 ,  C07C231/14 ,  C07C241/02 ,  C07C281/02 ,  C07C2602/10 ,  C07D233/88 ,  C07D235/30 ,  C07D239/95 ,  C07C69/757 ,  C07C233/92 ,  C07C255/41

公开(公告)号：EP2474536A1

公开(公告)日：2012-07-11

申请号：EP10811488.5

申请日：2010-08-23

Applicant: Ihara Chemical Industry Co., Ltd.

Inventor： KAWAZOE, Kentaro

IPC: C07D239/52 ,  C07C201/08 ,  C07C201/12 ,  C07C205/26 ,  C07C205/34 ,  C07C205/58

CPC classification number: C07D239/52 ,  C07C201/08 ,  C07C201/12 ,  C07C205/19 ,  C07C205/34 ,  C07C205/58

Abstract: Provided is a process by which pyrimidinylacetonitrile derivatives can be prepared easily and efficiently from industrially available raw materials. Also provided are intermediates for the synthesis of the derivatives. A process for the preparation of pyrimidinylacetonitrile derivatives represented by general formula (3) [wherein X is a halogen atom, and R is an alkoxymethyl group], characterized by reacting a 2,4-dihalogeno-6-nitrobenzene derivative represented by general formula (1) [wherein X and R are each as defined above] with 4,6-dimethoxy-2-cyanomethylpyrimidine represented by general formula (2) [wherein Me represents a methyl group] in the presence of a base; and intermediates for the synthesis of the pyrimidinylacetonitrile derivatives.

Abstract translation: 提供了通过该pyrimidinylacetonitrile衍生物可以容易且有效地从工业上获得的原料来制备的方法。 这样提供了用于该衍生物的合成中间体。 一种衍生物的制备过程pyrimidinylacetonitrile由通式（3）表示[worin X为卤素原子，R是烷氧基甲基]，通过使由通式表示的2,4-二卤代-6-硝基苯衍生物为特征的（ 1）[式中，X和R分别如上定义]与通式4,6-二甲氧基-2-氰基甲基（2）[其中，Me darstellt甲基〕在碱的存在; 和用于pyrimidinylacetonitrile衍生物的合成中间体。

公开(公告)号：EP2460789A1

公开(公告)日：2012-06-06

申请号：EP10804580.8

申请日：2010-07-26

Applicant: Sumitomo Chemical Company, Limited

Inventor： HIDA, Noriyuki ,  HIBINO, Hiroaki

IPC: C07C303/32 ,  C07C201/12 ,  C07C205/06 ,  C07C309/39 ,  C07B61/00

CPC classification number: C07C303/32 ,  C07B37/04 ,  C07C201/12 ,  C07C309/39 ,  C07C205/06

Abstract: A method for producing a biaryl compound represented by the formula (2)

        Ar-Ar     (2)

wherein Ar represents an aromatic group which can have a substituent, comprising conducting a coupling reaction of a compound represented by the formula (1)

        Ar-Cl     (1)

wherein Ar represents the same meaning as defined above, in the presence of copper metal and a copper salt.

公开(公告)号：EP1858837B1

公开(公告)日：2012-05-16

申请号：EP06707090.4

申请日：2006-02-20

Applicant: Syngenta Participations AG

Inventor： WALTER, Harald, Syngenta Crop Protection AG ,  CORSI, Camilla, Syngenta Crop Protection AG ,  EHRENFREUND, Josef, Syngenta Crop Protection AG ,  LAMBERTH, Clemens, Syngenta Crop Protection AG ,  SCHNEIDER, Hermann ,  TOBLER, Hans, Syngenta Crop Protection AG

IPC: C07C209/36

CPC classification number: C07C209/36 ,  C07C201/12 ,  C07C303/28 ,  C07C309/66 ,  C07C309/67 ,  C07C2601/02 ,  C07C211/45 ,  C07C205/06 ,  C07C205/11

Abstract: The present invention relates to a process fo the preparation of compounds of formula (I) wherein the substituents are as defined in claim 1, by a) reaction of a compound of formula (II) to form a compound of formula (III) b) reaction of that compound in the presence of a base to form a compound of formula (IV) c) conversion of that compound in the presence ofa reducing agent into a compound of formula (I).

Abstract translation: 本发明涉及式（I）化合物的制备方法，其中取代基如权利要求1所定义，通过a）式（II）化合物与式（III）化合物的反应b） 该化合物在碱存在下反应形成式（Ⅳ）化合物，c）将化合物在还原剂存在下转化成式（Ⅰ）化合物。