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公开(公告)号：EP2524260A4
公开(公告)日：2013-07-24
申请号：EP10808625
申请日：2010-08-10
Applicant: CHROMX LLC
Inventor： FAY THEODORE DENIS JR
CPC classification number: G01N21/6458 , G01J3/14 , G01J2003/2826 , G01N21/64 , G01N21/6486 , G01N21/65 , G01N2021/6463 , G01N2201/061 , G01N2201/0683 , G02B21/10 , G02B21/16
Abstract: A fluorescence microscope includes a nearly monochromatic light source, a Brewster angle wedge, and an optical system for irradiating a sample with a light beam from the light source and directing fluorescence light from said sample onto the Brewster angle wedge. Collection optics are provided for focusing a hyper-spectral, wide angle and dark field image of the sample from the Brewster angle wedge onto recording optics.
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公开(公告)号：EP2524260A1
公开(公告)日：2012-11-21
申请号：EP10808625.7
申请日：2010-08-10
Applicant: CHROMX, LLC
Inventor： FAY, Theodore, Denis, Jr.
IPC: G02B21/10
CPC classification number: G01N21/6458 , G01J3/14 , G01J2003/2826 , G01N21/64 , G01N21/6486 , G01N21/65 , G01N2021/6463 , G01N2201/061 , G01N2201/0683 , G02B21/10 , G02B21/16
Abstract: A fluorescence microscope includes a nearly monochromatic light source, a Brewster angle wedge, and an optical system for irradiating a sample with a light beam from the light source and directing fluorescence light from said sample onto the Brewster angle wedge. Collection optics are provided for focusing a hyper-spectral, wide angle and dark field image of the sample from the Brewster angle wedge onto recording optics.
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公开(公告)号：EP3187856A4
公开(公告)日：2018-04-25
申请号：EP15835242
申请日：2015-08-11
Applicant: THE DOSHISHA , NAT INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE
Inventor： EMOTO AKIRA , OTANI NAOKI , FUKUDA TAKASHI
IPC: G01N21/23
CPC classification number: G01N21/23 , G01N2201/0683
Abstract: The present invention has a problem aiming to provide a birefringence measurement device capable of measuring a two-dimensional distribution of birefringence in a measurement target in real time and in detail using a simple configuration without a rotating mechanism. A birefringence measurement device 1A according to the present invention includes light flux generating means 2 for generating light flux L1, light flux irradiating means 3, 4, or 5 for irradiating a measurement target 20 with the light flux L1 in a predetermined polarization state, an imaging optical system 10 for forming an image from light flux L4 transmitted through the measurement target 20, a polarization/diffraction grating 8 disposed in a position within the imaging optical system 10, image pickup means 12 for generating a light-dark signal related to brightness of the image formed by the imaging optical system 10, and output means for outputting information regarding a phase difference for the light flux L4, the phase difference resulting from the transmission through the measurement target 20 and being determined on the basis of the light-dark signal, and the image pickup means 12 generates the light-dark signal for an image based on at least one beam of diffracted light L7 from among a plurality of beams of diffracted light produced by the polarization/diffraction grating 8.
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24.发明公开
公开(公告)号：EP3153843A4
公开(公告)日：2018-02-14
申请号：EP15802877
申请日：2015-06-03
Applicant: UNIV TSUKUBA
Inventor： YASUNO YOSHIAKI , KASARAGOD DEEPA KAMATH
CPC classification number: G01N21/21 , A61B3/102 , G01B9/02044 , G01B9/02083 , G01B9/02091 , G01B2290/70 , G01N21/17 , G01N21/4795 , G01N2201/0683 , G01N2201/12
Abstract: Polarization-sensitive optical image measurement is subject to a non-negligible bias, and consequent deviation in birefringence, in a surrounding range of low SN ratios (signal-to-noise ratios) and low signal strengths; however, this deviation in birefringence is removed to make accurate quantitative measurement possible. Noise-containing OCT signals obtained by polarization OCT are processed using a birefringence calculation algorithm, to obtain measured birefringence, after which noise is statistically adjusted to simulate a measured birefringence distribution and determine the noise characteristics of the measured birefringence values, and then Monte Carlo calculations are repeated by assuming different values for the noise level and the true birefringence value, respectively, to form three-dimensional histogram of combinations of true birefringence values, SN ratios, and measured birefringence values, after which specified measured birefringence values and SN ratios are assumed from the three-dimensional histogram information to obtain a true birefringence probability density distribution, and true birefringence values are estimated from the true birefringence probability density distribution.
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25.发明公开METHODS FOR DETERMINING PROTEIN STRUCTURE USING A SURFACE-SELECTIVE NONLINEAR OPTICAL TECHNIQUE 审中-公开使用表面选择性非线性光学技术确定蛋白质结构的方法
公开(公告)号：EP3278087A1
公开(公告)日：2018-02-07
申请号：EP16774379.8
申请日：2016-04-01
Applicant: Biodesy, Inc.
Inventor： SALAFSKY, Joshua, S.
CPC classification number: G06F19/16 , G01B11/14 , G01N21/21 , G01N21/636 , G01N33/542 , G01N33/54373 , G01N33/582 , G01N33/6803 , G01N2201/06113 , G01N2201/0683
Abstract: Methods, devices, and systems are disclosed for determining protein structure and dynamics using second harmonic generation (SHG) and related surface-selective nonlinear optical techniques.
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Patent Agency Ranking
公开(公告)号：EP3221897A1
公开(公告)日：2017-09-27
申请号：EP15839312.4
申请日：2015-09-08
Inventor： O'MULLANE, Sam , DIEBOLD, Alain , PETERSON, Brennan , KELLER, Nicholas
IPC: H01L29/78 , H01L21/28 , H01L21/768
CPC classification number: G01N21/211 , G01B11/02 , G01N21/9501 , G01N21/956 , G01N2021/213 , G01N2201/0683
Abstract: There is set forth herein in one embodiment, a structure including a metallic grating having a grating pattern, the metallic grating including a critical dimension. The metallic grating can output a spectral profile when exposed to electromagnetic radiation, the spectral profile having a feature. The grating pattern can be configured so that a change of the critical dimension produces a shift in a value of the feature of the spectral profile. A method can include propagating input electromagnetic radiation onto a metallic grating having a two dimensional periodic grating pattern and measuring a critical dimension of the metallic grating using output electromagnetic radiation from the metallic grating.
Abstract translation: 这里在一个实施例中阐述了一种包括具有光栅图案的金属光栅的结构，金属光栅包括临界尺寸。 当暴露于电磁辐射时，金属光栅可以输出光谱分布，光谱分布具有特征。 光栅图案可以被配置为使得临界尺寸的变化产生光谱轮廓的特征值的偏移。 一种方法可包括将输入电磁辐射传播到具有二维周期性光栅图案的金属光栅上，并使用来自金属光栅的输出电磁辐射测量金属光栅的临界尺寸。
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27.发明公开
公开(公告)号：EP3187856A1
公开(公告)日：2017-07-05
申请号：EP15835242.7
申请日：2015-08-11
Inventor： EMOTO, Akira , OTANI, Naoki , FUKUDA, Takashi
IPC: G01N21/23
CPC classification number: G01N21/23 , G01N2201/0683
Abstract: The present invention has a problem aiming to provide a birefringence measurement device capable of measuring a two-dimensional distribution of birefringence in a measurement target in real time and in detail using a simple configuration without a rotating mechanism. A birefringence measurement device 1A according to the present invention includes light flux generating means 2 for generating light flux L1, light flux irradiating means 3, 4, or 5 for irradiating a measurement target 20 with the light flux L1 in a predetermined polarization state, an imaging optical system 10 for forming an image from light flux L4 transmitted through the measurement target 20, a polarization/diffraction grating 8 disposed in a position within the imaging optical system 10, image pickup means 12 for generating a light-dark signal related to brightness of the image formed by the imaging optical system 10, and output means for outputting information regarding a phase difference for the light flux L4, the phase difference resulting from the transmission through the measurement target 20 and being determined on the basis of the light-dark signal, and the image pickup means 12 generates the light-dark signal for an image based on at least one beam of diffracted light L7 from among a plurality of beams of diffracted light produced by the polarization/diffraction grating 8.
Abstract translation: 本发明的目的在于提供一种双折射测定装置，该双折射测定装置能够使用不具有旋转机构的简单的结构，实时且详细地测定测定对象中的双折射的二维分布。 根据本发明的双折射测量设备1A包括用于产生光束L1的光束产生装置2，用于以预定偏振状态的光束L1照射测量目标20的光束照射装置3,4或5， 成像光学系统10，用于根据透过测量目标20的光束L4形成图像;偏振/衍射光栅8，设置在成像光学系统10内的位置;图像拾取装置12，用于产生与亮度有关的明暗信号 ，以及用于输出关于光束L4的相位差的信息的输出装置，该信息是通过透过测量目标20的透射产生的并且基于明暗来确定的相位差 信号，并且图像拾取装置12基于至少一束衍射光束L7f产生用于图像的明暗信号 由偏振/衍射光栅8产生的多个衍射光束中的光。
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28.发明公开CHIPS, DETECTION SYSTEMS, AND METHODS FOR MULTIPLEX PNEUMOCOCCUS SEROLOGY 审中-公开CHIPS，NACHWEISSYSTEME UND VERFAHRENFÜRMULTIPLEX-PNEUMOKOKKEN-SEROLOGIE
公开(公告)号：EP3055433A4
公开(公告)日：2017-05-03
申请号：EP14851985
申请日：2014-10-09
Applicant: UNIV ROCHESTER , UAB RES FOUND
Inventor： MILLER BENJAMIN L , NAHM MOON H
IPC: G01N33/569 , G01N21/21 , G01N21/55 , G01N33/543
CPC classification number: G01N33/56944 , G01N21/211 , G01N21/55 , G01N33/54373 , G01N2201/06113 , G01N2201/0683 , G01N2333/3156
Abstract: According to aspects illustrated herein, there are provided a sensor chip suitable for serological detection of Streptococcus pneumoniae, a method for detecting serotypes of Streptococcus pneumoniae using the sensor chip, a detection system that includes the sensor chip, and a method for detecting serotypes of Streptococcus pneumoniae using the detection system described herein.
Abstract translation: 根据本文所示的方面，提供了一种适用于肺炎链球菌血清学检测的传感器芯片，一种使用传感器芯片检测肺炎链球菌血清型的方法，一种包括传感器芯片的检测系统以及一种用于检测链球菌血清型的方法 使用本文所述的检测系统进行肺炎。
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29.发明公开
公开(公告)号：EP2993460A4
公开(公告)日：2017-04-26
申请号：EP14804538
申请日：2014-05-30
Applicant: UNIV OSAKA PREFECT PUBLIC CORP
Inventor： IIDA TAKUYA , TOKONAMI SHIHO
IPC: G01N21/17 , C12Q1/68 , G01N21/3577 , G01N21/41 , G01N21/552 , G01N21/65 , G01N33/53 , G01N33/543 , G01N33/553
CPC classification number: G01N33/54346 , C12Q1/6834 , C12Q2563/155 , C12Q2565/628 , G01N21/21 , G01N21/554 , G01N21/658 , G01N33/5308 , G01N33/553 , G01N2201/061 , G01N2201/0683
Abstract: A detection device (100) detects an analyte that may be contained in a specimen. The detection device (100) includes a plurality of gold nanoparticles, an optical trapping light source (101), an illumination light source (102), an objective lens (103), an image pick-up device (108), and a computation unit (106). The plurality of gold nanoparticles are each modified with a probe DNA allowing the analyte to specifically adhere thereto. The optical trapping light source (101) emits polarized light for assembling the plurality of gold nanoparticles together. The objective lens (103) focuses and introduces the polarized light into a liquid containing a specimen and the plurality of gold nanoparticles. The image pick-up device (108) receives light from the liquid. The computation unit (106) detects an analyte based on a signal received from the image pick-up device (108).
Abstract translation: 检测装置（100）检测可能包含在样本中的分析物。 检测装置（100）包括多个金纳米粒子，光俘获光源（101），照明光源（102），物镜（103），图像拾取装置（108）和计算机 单元（106）。 多个金纳米颗粒各自用允许分析物特异性粘附于其上的探针DNA修饰。 光俘获光源（101）发射用于将多个金纳米颗粒组装在一起的偏振光。 物镜（103）聚焦并将偏振光引入含有样本和多个金纳米颗粒的液体中。 图像拾取装置（108）接收来自液体的光。 计算单元（106）基于从图像拾取装置（108）接收的信号来检测分析物。
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公开(公告)号：EP3149451A1
公开(公告)日：2017-04-05
申请号：EP15727049.7
申请日：2015-05-28
Applicant: The University Of Birmingham
Inventor： DAFFORN, Timothy , HICKS, Matthew
CPC classification number: G01N21/19 , C12Q1/6825 , G01N21/05 , G01N21/21 , G01N33/56916 , G01N2201/061 , G01N2201/0683 , G01N2333/245 , G01N2333/255 , G01N2469/10 , C12Q2563/107
Abstract: A molecular sensor that utilises dichroism can be used to identify the presence of specific molecules in a substance. The molecular sensor includes a sensor element comprising (i) a scaffold moiety and (ii) one or more receptor molecules for the target molecule attached to the scaffold moiety to form a scaffold/receptor complex, wherein the scaffold/receptor complex is modified to incorporate a chromophore and the modified scaffold/receptor complex has a high aspect ratio.
Abstract translation: 利用二色性的分子传感器可用于识别物质中特定分子的存在。 分子传感器包括传感器元件，其包括（i）支架部分和（ii）用于靶分子的一个或多个受体分子，所述受体分子连接到所述支架部分以形成支架/受体复合物，其中所述支架/受体复合体被修饰为掺入 发色团和修饰的支架/受体复合物具有高的纵横比。
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