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55 条记录 (耗时 0.029 秒)

    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    21.
    发明公开
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
    VERFAHREN UND ZUSAMMENSETZUNGEN ZUR DIAGNOSE UND PROGNOSE VON NIERENVERLETZUNGEN UND NIERENINSUFFIZIENZ

    公开(公告)号：EP2585827A4

    公开(公告)日：2013-12-04

    申请号：EP11798516

    申请日：2011-06-23

    申请人： ASTUTE MEDICAL INC

    发明人： ANDERBERG JOSEPH ,  GRAY JEFF ,  MCPHERSON PAUL ,  NAKAMURA KEVIN ,  KAMPF JAMES PATRICK

    IPC分类号： G01N33/48 ,  G01N33/53 ,  G01N33/68

    CPC分类号： G01N33/6893 ,  G01N2333/475 ,  G01N2333/49 ,  G01N2333/52 ,  G01N2333/521 ,  G01N2333/54 ,  G01N2333/5418 ,  G01N2333/71 ,  G01N2333/7155 ,  G01N2333/96494 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect MMP9:TIMP2 complex and optionally further a kidney injury marker of Thymic stromal lymphopoietin, Vascular endothelial growth factor receptor 1, C-C motif chemokine 1, C-C motif chemokine 17, C-C motif chemokine 21, C-C motif chemokine 27, FLT-3 Ligand, Immunoglobulin G subclass 3, Interleukin-1 receptor type I, Interleukin-20, Interleukin-29, Interleukin-7, Platelet-derived growth factor A/B dimer, Platelet-derived growth factor A/A dimer, and as diagnostic and prognostic biomarkers in renal injuries.

    摘要翻译： 本发明涉及用于监测，诊断，预后和确定患有或怀疑患有肾损伤的受试者的治疗方案的方法和组合物。 特别地，本发明涉及使用一种或多种配置为检测选自胸腺基质淋巴细胞生成素，血管内皮生长因子受体1，CC基序趋化因子1，CC基元趋化因子17，CC基序趋化因子 21，CC基序趋化因子27，FLT-3配体，免疫球蛋白G亚类3，白细胞介素-1受体I型，白细胞介素-20，白细胞介素-29，白细胞介素-7，血小板衍生生长因子A / B二聚体，血小板衍生生长 因子A / A二聚体和MMP9：TIMP2复合体作为肾损伤中的诊断和预后生物标志物。

    Methods of producing biologically active peptide dimers
    26.
    发明公开
    Methods of producing biologically active peptide dimers 失效
    Verfahren zur herstellung von biologisch-aktive Dimerpeptiden

    公开(公告)号：EP0721983A1

    公开(公告)日：1996-07-17

    申请号：EP95118567.7

    申请日：1989-01-18

    申请人： ZymoGenetics, Inc.

    发明人： Sledziewski, Andrzej Z. ,  Bell, Lillian A. ,  Kindsvogel, Wayne R.

    IPC分类号： C12N15/62 ,  C12N15/13 ,  C07K16/46

    CPC分类号： C07K14/71 ,  A61K38/00 ,  C07K16/18 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/036 ,  C07K2319/32 ,  C12N15/62 ,  C12N15/625 ,  C12N15/67 ,  C12N15/81 ,  G01N33/6863 ,  G01N33/74 ,  G01N2333/49 ,  G01N2333/71

    摘要： Methods for producing secreted biologically active peptide dimers are disclosed. The methods for producing secreted biologically active peptide dimers utilize a DNA sequence encoding a peptide requiring dimerization for biological activity joined to a dimerizing protein. Polypeptides comprising essentially the extracellular domain of a human PDGF receptor fused to dimerizing proteins, the portion being capable of binding human PDGF or an isoform thereof, are also disclosed. The polypeptides may be used within methods for determining the presence of and for purifying human PDGF or isoforms thereof. Pharmaceutical and diagnostic compositions utilizing the polypeptides are also disclosed.

    摘要翻译： 公开了生产分泌的生物活性肽二聚体的方法。 用于生产分泌的生物活性肽二聚体的方法利用编码需要二聚化的肽的DNA序列用于与二聚化蛋白结合的生物活性。 还公开了包含与二聚化蛋白融合的人PDGF受体的基本上胞外结构域的多肽，该部分能够结合人PDGF或其同种型。 多肽可用于确定人PDGF或其同种型的存在和用于纯化人PDGF或其同种型的方法。 还公开了利用多肽的药物和诊断组合物。

    Methods of producing secreted receptor analogs and biologically active peptide dimers.
    28.
    发明公开
    Methods of producing secreted receptor analogs and biologically active peptide dimers. 失效
    Verfahren zur Herstellung von sekretierten Rezeptoranalogen和biologisch-aktive Dimerpeptiden。

    公开(公告)号：EP0325224A2

    公开(公告)日：1989-07-26

    申请号：EP89100787.4

    申请日：1989-01-18

    申请人： ZymoGenetics, Inc.

    发明人： Sledziewski, Andrzej Z. ,  Bell, Lillian A. ,  Kindsvogel, Wayne R.

    IPC分类号： C12N15/12 ,  C12P21/00 ,  G01N33/68 ,  A61K38/17

    CPC分类号： C07K14/71 ,  A61K38/00 ,  C07K16/18 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/036 ,  C07K2319/32 ,  C12N15/62 ,  C12N15/625 ,  C12N15/67 ,  C12N15/81 ,  G01N33/6863 ,  G01N33/74 ,  G01N2333/49 ,  G01N2333/71

    摘要： Methods for producing a secreted receptor analogs and biologically active peptide dimers are disclosed. The methods for producing secreted receptor analogs and biologi­cally active peptide dimers utilize a DNA sequence encoding a receptor analog or a peptide requiring dimerization for biological activity joined to a dimerizing protein. The receptor analog includes a ligand-binding domain. Polypep­tides comprising essentially the extracellular domain of a human PDGF receptor fused to dimerizing proteins, the portion being capable of binding human PDGF or an isoform thereof, are also disclosed. The polypeptides may be used within methods for determining the presence of and for puri­fying human PDGF or isoforms thereof. Pharmaceutical and diagnostic compositions utilizing the polypeptides are also disclosed.

    摘要翻译： 公开了生产分泌受体类似物和生物活性肽二聚体的方法。 用于产生分泌的受体类似物和生物活性肽二聚体的方法利用编码受体类似物的DNA序列或需要二聚化用于与二聚化蛋白结合的生物活性的肽。 受体类似物包括配体结合结构域。 还公开了包含与二聚化蛋白融合的人PDGF受体的基本上胞外结构域的多肽，该部分能够结合人PDGF或其同种型。 多肽可用于确定人PDGF或其同种型的存在和用于纯化人PDGF或其同种型的方法。 还公开了利用多肽的药物和诊断组合物。