公开(公告)号：EP1783139B8

公开(公告)日：2009-09-23

申请号：EP06117664.0

申请日：1997-10-01

申请人： GERON CORPORATION ,  The Regents of the University of Colorado

发明人： Cech, Thomas R ,  Lingner, Joachim ,  Nakamura, Toru ,  Chapman, Karen B. ,  Morin, Gregg, B ,  Harley, Calvin B. ,  Andrews, William H.

IPC分类号： C07K4/12

CPC分类号： C12N15/113 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N9/1241 ,  C12N9/1276 ,  C12N15/1137 ,  C12N2310/15 ,  C12N2310/315 ,  C12Y207/07049 ,  Y10S530/827 ,  Y10S530/828

公开(公告)号：EP0876610B1

公开(公告)日：2007-08-15

申请号：EP97901914.8

申请日：1997-01-06

申请人： THE PENN STATE RESEARCH FOUNDATION

发明人： HAMMERSTEDT, Roy, H. ,  CRAMER, Palmer, G. ,  BARBATO, Guy, F.

IPC分类号： G01N33/53 ,  A61K38/10 ,  A61K38/17 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/705 ,  Y10S530/827 ,  Y10S530/85 ,  Y10S530/851 ,  Y10S530/852 ,  Y10S530/853

摘要： A purified polypeptide which provides for initial binding of sperm to oocyte investments and has an active amino acid sequence of SEQ ID NO:12 (Cys-Gln-Ser-Leu-Gln-Glu-Tyr-Leu-Ala-Glu-Gln-Asn-Gln-Arg-Gln-Leu-Glu-Ser-Asn-Lys-Ile-Pro-Glu-Val-Asp-Leu-Ala-Arg-Val-Val-Ala-Pro-Phe-Met-Ser-Asn-Ile-Pro-Leu-Leu-Leu-Tyr-Pro-Gln-Asp-Arg-Pro-Arg-Ser-Gln-Pro-Gln-Pro-Lys-Ala-Asn-Glu-Asp-Val-Cys); or SEQ ID NO:13 (Cys-Glu-Ser-Leu-Gln-Lys-His-Leu-Ala-Glu-Leu-Asn-His-Gln-Lys-Gln-Leu-Glu-Ser-Asn-Lys-Ile-Pro-Glu-Leu-Asp-Met-Thr-Glu-Val-Val-Ala-Pro-Phe-Met-Ala-Asn-Ile-Pro-Leu-Leu-Leu-Tyr-Pro-Gln-Asp-Gly-Pro-Arg-Ser-Lys-Pro-Gln-Pro-Lys-Asp-Asn-Gly-Asp-Val-Cys); or the shorter but biologically active SEQ ID NO:1 and SEQ ID NO:9 (Tyr-Pro-Gln-Asp-Arg-X-Arg-Ser-Gln-Pro-Gln-Pro-Lys-Ala-Asn, where X is Thr or Pro). The polypeptide is useful in improving sperm-egg binding by fresh sperm, restoring sperm-egg binding following a cryopreservation cycle, enhancing fertilizing potential, and producing antibodies to determine fertilizing potential of sperm, determining sperm-binding sites on egg investments, and contraception.

公开(公告)号：EP0920501B1

公开(公告)日：2003-10-29

申请号：EP97935335.6

申请日：1997-08-07

申请人： Amgen Inc., ,  YEDA RESEARCH & DEVELOPMENT CO. LTD.

发明人： THEILL, Lars, Eyde ,  NAEVE, Gregory, Scott ,  CITRI, Yoav

IPC分类号： C12N15/12 ,  C07K14/475 ,  C07K16/22

CPC分类号： C07K14/475 ,  A61K38/00 ,  Y10S530/827 ,  Y10S530/839 ,  Y10S530/855

摘要： Disclosed are DNA and amino acid sequences for a novel polypeptide termed Neuritin which is expressed primarily in selected regions of the brain.

摘要翻译： 公开了称为Neuritin的新多肽的DNA和氨基酸序列，其主要在脑的选定区域中表达。

公开(公告)号：EP1224200A4

公开(公告)日：2003-01-08

申请号：EP00970546

申请日：2000-10-03

申请人： HUMAN GENOME SCIENCES INC

发明人： MOORE PAUL A ,  RUBEN STEVEN M ,  EBNER REINHARD

IPC分类号： C12N15/09 ,  A61K31/711 ,  A61K35/76 ,  A61K38/00 ,  A61K38/46 ,  A61K39/395 ,  A61K48/00 ,  A61P1/00 ,  A61P1/02 ,  A61P1/04 ,  A61P1/16 ,  A61P1/18 ,  A61P3/10 ,  A61P5/14 ,  A61P7/02 ,  A61P9/00 ,  A61P9/02 ,  A61P9/10 ,  A61P9/14 ,  A61P11/00 ,  A61P11/04 ,  A61P13/08 ,  A61P13/10 ,  A61P13/12 ,  A61P15/00 ,  A61P15/08 ,  A61P15/14 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61P17/16 ,  A61P19/02 ,  A61P21/00 ,  A61P25/00 ,  A61P27/02 ,  A61P27/06 ,  A61P29/00 ,  A61P31/12 ,  A61P31/18 ,  A61P35/02 ,  A61P35/04 ,  C07K16/40 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/64 ,  C12N9/72 ,  C12N15/55 ,  C07H21/04 ,  C12N15/63

CPC分类号： C12N9/6456 ,  A61K38/00 ,  C07K2319/00 ,  C12N9/6421 ,  C12N2799/026 ,  Y10S530/827 ,  Y10S530/828

公开(公告)号：EP1224200A1

公开(公告)日：2002-07-24

申请号：EP00970546.8

申请日：2000-10-03

申请人： Human Genome Sciences, Inc.

发明人： MOORE, Paul, A. ,  RUBEN, Steven, M. ,  EBNER, Reinhard

IPC分类号： C07H21/04 ,  C12N9/64 ,  C12N15/55 ,  C12N15/63

CPC分类号： C12N9/6456 ,  A61K38/00 ,  C07K2319/00 ,  C12N9/6421 ,  C12N2799/026 ,  Y10S530/827 ,  Y10S530/828

摘要： The present invention relates to a novel t-PALP protein which is a member of the serine protease family. In particular, isolated nucleic acid molecules are provided encoding the human t-PALP protein. t-PALP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of t-PALP activity. Also provided are diagnostic methods for detecting circulatory system-related disorders and therapeutic methods for treating circulatory system-related disorders.

公开(公告)号：EP1024701A4

公开(公告)日：2000-12-06

申请号：EP98953509

申请日：1998-10-14

申请人： UNIV FORDHAM

发明人： SRIVASTAVA PRAMOD K ,  CHANDAWARKAR RAJIV Y

IPC分类号： C12N15/09 ,  A61K35/12 ,  A61K38/00 ,  A61K38/17 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P13/12 ,  A61P29/00 ,  A61P37/02 ,  A61P37/06 ,  A61P43/00 ,  C07K14/47 ,  A01N63/00 ,  A61K39/00 ,  A61P37/00 ,  A61K45/05

CPC分类号： A61K38/1709 ,  Y10S424/81 ,  Y10S514/825 ,  Y10S514/866 ,  Y10S514/903 ,  Y10S530/806 ,  Y10S530/827 ,  Y10S530/868

摘要： The invention relates to methods and compositions for the treatment of autoimmune disease. Specifically, compositions comprising heat shock proteins, including gp96, hsp90, and hsp70, are disclosed. Immunotherapeutic methods for administering the hsp-containing compositions are disclosed. Furthermore, methods for preventing rejection of organs transplanted to treat autoimmune disease are disclosed. The disclosed methods are useful for treating a variety of autoimmune diseases, including insulin dependent diabetes mellitus.

公开(公告)号：EP0988056A2

公开(公告)日：2000-03-29

申请号：EP98902634.9

申请日：1998-01-20

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： THORPE, Philip, E. ,  KING, Steven, W. ,  GAO, Boning

IPC分类号： A61K47/48

CPC分类号： A61K47/6813 ,  A61K47/6435 ,  Y10S514/834 ,  Y10S530/827 ,  Y10S530/829

摘要： The invention embodies the surprising discovery that Tissue Factor (TF) compositions and variants thereof specifically localize to the blood vessels within a vascularized tumor following systemic administration. The invention therefore provides methods and compositions comprising coagulant-deficient Tissue Factor for use in effecting specific coagulation and for use in tumor treatment. The TF compositions and methods of present invention may be used alone, as TF conjugates with improved half-life, or in combination with other agents, such as conventional chemotherapeutic drugs, targeted immunotoxins, targeted coaguligands, and/or in combination with Factor VIIa(FVIIa) or FBVIIa activators.

公开(公告)号：EP0722275A4

公开(公告)日：1998-04-15

申请号：EP94926038

申请日：1994-08-24

申请人： UNIV WASHINGTON

发明人： KORSMEYER STANLEY J

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K48/00 ,  A61P35/00 ,  C07K14/47 ,  C07K14/82 ,  C12N1/15 ,  C12N5/02 ,  C12N5/10 ,  C12N9/99 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/68 ,  A23J1/00 ,  C07H17/00 ,  C07K1/00 ,  C12P21/06 ,  C12Q1/00 ,  G01N33/53

CPC分类号： C07K14/82 ,  A01K2217/05 ,  C07K14/4747 ,  Y10S435/81 ,  Y10S530/827

公开(公告)号：EP0828512A1

公开(公告)日：1998-03-18

申请号：EP96913924.0

申请日：1996-05-02

申请人： THE WISTAR INSTITUTE OF ANATOMY & BIOLOGY

发明人： PRENDERGAST, George, C. ,  SAKAMURO, Daitoku

IPC分类号： C07K14 ,  C07K16 ,  C12N15 ,  A61K38

CPC分类号： C07K14/4703 ,  A61K38/00 ,  C07K16/18 ,  Y10S530/827 ,  Y10S530/828

摘要： A partial murine cDNA clone, a human cDNA clone, and a partial human genomic clone, each encoding a Box-dependent myc-interacting polypeptide termed Bin1, are provided. Also provided are methods of using the nucleic acid sequences, polypeptides, and antibodies directed against same in the diagnosis and treatment of cancers and hyperplastic disease states.

公开(公告)号：EP0332651B2

公开(公告)日：1996-12-27

申请号：EP87908082.8

申请日：1987-11-20

申请人： CENTOCOR, INC.

发明人： DAVIS, Hugh, M. ,  KLUG, Thomas, L. ,  ZURAWSKI, Vincent, R., Jr.

IPC分类号： C12P21/00 ,  C07K14/435 ,  A61K39/00

CPC分类号： C07K14/705 ,  A61K38/00 ,  Y10S530/827 ,  Y10S530/832 ,  Y10S530/853

摘要： A procedure for isolating CA 125 antigen and an isolated specie of the antigen.