公开(公告)号：EP1089776B1

公开(公告)日：2002-05-29

申请号：EP99931880.1

申请日：1999-06-23

申请人： International Heart Institute of Montana Foundation

发明人： DURAN, Carlos, M., G. ,  CHEUNG, David, T. ,  PANG, David, C.

IPC分类号： A61L27/00

CPC分类号： A61L27/3691 ,  A61L27/3604 ,  A61L27/3687 ,  Y10S623/915 ,  Y10S623/917

摘要： A process for preparing pliable soft tissue specimen which are resistant to cracking and devoid of viable cells includes the steps of treating native soft tissue obtained from a donor by a gradually increasing gradient of aliphatic alcohol or other suitable water miscible polar organic solvent until the last alcohol (or other solvent) solution has at least 25 % by volume of the organic liquid. Thereafter, the tissue specimen is treated with a solution containing glycerol or low molecular weight (

公开(公告)号：EP1098024A1

公开(公告)日：2001-05-09

申请号：EP99923930.4

申请日：1999-06-07

申请人： Shimizu, Yasuhiko ,  Tapic International Co., Ltd.

发明人： SHIMIZU, Yasuhiko

IPC分类号： D04H1/42 ,  A61L27/00 ,  C08L89/06

CPC分类号： A61L15/325 ,  A61L17/08 ,  A61L26/0033 ,  A61L27/24 ,  A61L27/60 ,  A61L31/044 ,  D04H1/4266 ,  Y10S514/801 ,  Y10S623/915 ,  Y10S623/917 ,  Y10T442/2525 ,  Y10T442/608 ,  Y10T442/614

摘要： The objective of the present invention is to provide a collagen material that possesses physical properties to an extent that allows suturing while still maintaining the biochemical properties inherently possessed by collagen, and retains its shape for a certain amount of time even after application to the body; its production process; and, a medical material on which it is based, examples of which include a artificial tube for nerve, artificial tube for spinal cord, artificial esophagus, artificial trachea, artificial blood vessel, artificial valve or alternative medical membranes such as artificial endocranium, artificial ligamenta, artificial tendons, surgical sutures, surgical prostheses, surgical reinforcement, wound protecting materials, artificial skin and artificial cornea, characterized by filling or having inside a substance having biocompatibility that can be degraded and absorbed in the body into a matrix of a non-woven fabric-like multi-element structure of collagen fibers having ultra-fine fibers of collagen as its basic unit.

摘要翻译： 本发明的目的是提供一种胶原材料，其具有允许缝合同时仍然保持胶原固有的生物化学性质的物理性能，并且即使在施用到身体之后也保持其形状一定量的时间; 其生产工艺; 以及其所基于的医疗材料，其实例包括人造神经管，脊髓人造管，人造食道，人造气管，人造血管，人造瓣膜或人造内膜，人造韧带等替代医用膜 ，人造筋，手术缝合线，手术假体，手术加强件，伤口保护材料，人造皮肤和人造角膜，其特征在于，在具有生物相容性的物质内部填充或具有能够在身体中降解和吸收到无纺布基质中的物质 具有胶原纤维超细纤维作为其基本单位的胶原纤维的织物状多元素结构。

公开(公告)号：EP1018979A1

公开(公告)日：2000-07-19

申请号：EP98920349.2

申请日：1998-05-08

申请人： ORGANOGENESIS INC.

发明人： ABRAHAM, Ginger, A. ,  CARR, Robert, M., Jr. ,  KEMP, Paul, D. ,  MERCER, Ryan ,  BAKER, Linda

IPC分类号： A61F2/00 ,  A61F2/02 ,  A61F2/24 ,  A61F13/00 ,  A01N1/02

CPC分类号： A61L27/3687 ,  A61K35/12 ,  A61K38/39 ,  A61L27/24 ,  A61L27/3695 ,  A61L2430/40 ,  Y10S623/917 ,  Y10S623/92

摘要： The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.

公开(公告)号：EP0156740B1

公开(公告)日：1988-10-12

申请号：EP85420025.0

申请日：1985-02-19

申请人： BIOETICA, Société Anonyme

发明人： Huc, Alain ,  Gimeno, René

IPC分类号： A61F2/06 ,  A61L27/00

CPC分类号： B29C47/8895 ,  A61F2/062 ,  A61F2310/00365 ,  A61L27/24 ,  B29C47/0023 ,  Y10S128/08 ,  Y10S623/917

公开(公告)号：EP0212933A1

公开(公告)日：1987-03-04

申请号：EP86306231.1

申请日：1986-08-12

申请人： KOKEN CO. LTD.

发明人： Noishiki, Yasuharu ,  Kodaira, Kazuhiko ,  Furuse, Masayasu ,  Miyata, Teruo

IPC分类号： A61L33/00 ,  C08B37/10

CPC分类号： C08L5/10 ,  A61L27/507 ,  A61L33/0029 ,  Y10S514/822 ,  Y10S623/917

摘要： In a method of preparing an antithrombogenic medical material having a heparinized collagen as an antithrombogenic component, there is provided a method comprising the steps of fixing a protamine to a collagen through a polyepoxy compound, and heparinizing the collagen by fixing heparin to the protamine.

公开(公告)号：EP0110966B1

公开(公告)日：1987-01-28

申请号：EP83902165.6

申请日：1983-05-25

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY

发明人： BELL, Eugene

IPC分类号： A61F2/28 ,  A61L27/00 ,  C12N5/00

CPC分类号： A61L27/3608 ,  A61F2/00 ,  A61F2/28 ,  A61F2310/00365 ,  A61L27/24 ,  A61L27/365 ,  A61L27/38 ,  A61L27/44 ,  A61L2430/02 ,  Y10S514/80 ,  Y10S623/915 ,  Y10S623/917

摘要： A bone-equivalent, useful in the fabrication of prostheses, which is prepared from a hydrated collagen lattice contracted by fibroblast cells and containing demineralized bone powder.

公开(公告)号：EP0156740A1

公开(公告)日：1985-10-02

申请号：EP85420025.0

申请日：1985-02-19

申请人： BIOETICA, Société Anonyme

发明人： Huc, Alain ,  Gimeno, René

IPC分类号： A61F2/06 ,  A61L27/00

CPC分类号： B29C47/8895 ,  A61F2/062 ,  A61F2310/00365 ,  A61L27/24 ,  B29C47/0023 ,  Y10S128/08 ,  Y10S623/917

摘要： Ce procédé de fabrication comporte les étapes suivantes: extrusion dans une filière cylindrique (2) équipée d'un tube central concentrique (3) destiné à recevoir une partie du bain de coagulation (5), d'un gel acide aqueux (4) contenant 1,5 % environ de collagène natif, suivie d'une coagulation des parois interne et externe du tube sortant de la filière dans un bain de coagulation (5) constitué d'environ 70% d'acétone pour 30% d'ammoniaque, et d'un séchage.
Une fois séché, le tube de collagène (8) est soumis à une réticulation par déshydratation poussée en étuve à environ 80°C sous un vide d'environ 0,1 mm de mercure pendant environ 24 heures.
Le tube de collagène (8) réticulé est éventuellement soumis à un traitement permettant d'introduire des groupes azides dans la molécule sans toutefois occasionner le couplage du collagène avec quelque molécule que ce soit.

公开(公告)号：EP1098024A4

公开(公告)日：2008-04-02

申请号：EP99923930

申请日：1999-06-07

申请人： SHIMIZU YASUHIKO ,  TAPIC INT CO LTD

发明人： SHIMIZU YASUHIKO

IPC分类号： A61L15/32 ,  A61L17/08 ,  A61L26/00 ,  A61L27/24 ,  A61L31/04 ,  D04H1/42 ,  D04H1/64 ,  A61L27/00 ,  C08L89/06

CPC分类号： A61L15/325 ,  A61L17/08 ,  A61L26/0033 ,  A61L27/24 ,  A61L27/60 ,  A61L31/044 ,  D04H1/4266 ,  Y10S514/801 ,  Y10S623/915 ,  Y10S623/917 ,  Y10T442/2525 ,  Y10T442/608 ,  Y10T442/614

摘要： A collagen material which has such physical properties as enabling suture while maintaining the biochemical characteristics inherent to collagen and can sustain its shape over a certain period of time after the application to a living body; and materials for medical use based thereon, for example, artificial nerve tubes, artificial spinal cords, artificial gullets, artificial tracheae, artificial blood vessels, artificial valves, artificial membranes for medical use such as artificial scleromeninx, artificial ligaments, artificial tendons, surgical suture threads, surgical loading materials, surgical reinforcing materials, wound protectors, artificial skin and artificial cornea. The above collagen material is characterized by comprising a biocompatible and biodegradable/absorbable substance filled in or sandwiched between matrices of a multidimensional nonwoven structure consisting of collagen fibers having ultrafine collagen fibers as the fundamental constituting unit.

公开(公告)号：EP1217101B8

公开(公告)日：2006-02-01

申请号：EP01125379.6

申请日：1995-04-26

申请人： Boston Scientific Scimed, Inc.

发明人： Buirge, Andrew W. ,  Buscemi, Paul J. ,  Burmeister, Paul H.

IPC分类号： C25D13/00 ,  C25D9/00 ,  A61F2/06 ,  A61L27/00 ,  A61L31/00

CPC分类号： A61M29/02 ,  A61F2/0022 ,  A61F2/07 ,  A61F2/86 ,  A61F2/885 ,  A61F2/89 ,  A61F2/90 ,  A61F2/91 ,  A61F2/915 ,  A61F2/95 ,  A61F2/958 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2002/828 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2002/9583 ,  A61F2210/0076 ,  A61F2220/0025 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2220/0091 ,  A61F2250/0067 ,  A61L31/10 ,  A61M25/0045 ,  Y10S623/917 ,  C08L89/06

公开(公告)号：EP1452150A1

公开(公告)日：2004-09-01

申请号：EP04076470.6

申请日：1998-05-08

申请人： ORGANOGENESIS INC.

发明人： Abraham, Ginger A ,  Carr, Robert M. Jnr. ,  Kemp, Paul D. ,  Mercer, Ryan ,  Baker, Linda

IPC分类号： A61F2/00 ,  A61F2/02 ,  A61F2/24 ,  A61F13/00 ,  A01N1/02 ,  A61L27/24 ,  A61L27/36

CPC分类号： A61L27/3687 ,  A61K35/12 ,  A61K38/39 ,  A61L27/24 ,  A61L27/3695 ,  A61L2430/40 ,  Y10S623/917 ,  Y10S623/92

摘要： The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.

摘要翻译： 本发明涉及已被处理以除去非胶原成分如胶原组织的细胞，细胞碎片和其它细胞外基质成分，例如通常存在于天然组织中的蛋白聚糖和糖胺聚糖。 用碱，螯合剂，酸和盐处理组织可以从胶原组织基质中去除非胶原成分，同时控制溶胀和溶解的量，使得所得胶原蛋白基质保持其结构组织，完整性和生物可重构性质。 该方法避免了使用有害地影响胶原基质的细胞相容性，强度和生物可塑性的洗涤剂和酶的需要。 胶原组织基质用于哺乳动物宿主植入，修复或使用。