公开(公告)号：EP0997147A4

公开(公告)日：2000-10-11

申请号：EP98929830

申请日：1998-07-03

Applicant: ONO PHARMACEUTICAL CO

Inventor： SEKO TAKUYA ,  KATO MASASHI

IPC: A61K38/00 ,  C07C233/46 ,  C07C233/47 ,  C07C233/51 ,  C07C233/83 ,  C07C235/52 ,  C07C235/84 ,  C07C237/08 ,  C07C237/22 ,  C07C237/36 ,  C07C271/22 ,  C07C309/18 ,  C07C311/06 ,  C07C311/13 ,  C07C311/14 ,  C07C311/19 ,  C07C311/29 ,  C07C311/46 ,  C07C317/50 ,  C07C323/59 ,  C07C323/60 ,  C07C323/62 ,  C07D207/16 ,  C07D211/14 ,  C07D211/20 ,  C07D211/58 ,  C07D211/62 ,  C07D213/30 ,  C07D213/32 ,  C07D213/64 ,  C07D213/643 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D215/06 ,  C07D215/08 ,  C07D215/12 ,  C07D217/06 ,  C07D233/54 ,  C07D233/90 ,  C07D263/34 ,  C07D277/04 ,  C07D277/06 ,  C07D277/14 ,  C07D277/16 ,  C07D277/56 ,  C07D279/06 ,  C07D279/12 ,  C07D295/135 ,  C07D295/185 ,  C07D307/14 ,  C07D307/24 ,  C07D307/42 ,  C07D307/52 ,  C07D307/68 ,  C07D309/04 ,  C07D309/06 ,  C07D333/16 ,  C07D333/20 ,  C07D333/38 ,  C07D417/12 ,  C07K5/072 ,  C07K5/078 ,  A61K31/165 ,  A61K31/18 ,  A61K31/215 ,  A61K31/27 ,  A61K31/34 ,  A61K31/38 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/445

CPC classification number: C07D213/30 ,  A61K38/00 ,  C07C233/46 ,  C07C233/47 ,  C07C233/51 ,  C07C233/83 ,  C07C235/52 ,  C07C235/84 ,  C07C237/08 ,  C07C237/22 ,  C07C237/36 ,  C07C271/22 ,  C07C309/18 ,  C07C311/06 ,  C07C311/13 ,  C07C311/14 ,  C07C311/19 ,  C07C311/29 ,  C07C311/46 ,  C07C317/50 ,  C07C323/59 ,  C07C323/60 ,  C07C323/62 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/18 ,  C07C2602/42 ,  C07C2603/74 ,  C07D207/16 ,  C07D211/14 ,  C07D211/20 ,  C07D211/58 ,  C07D211/62 ,  C07D213/32 ,  C07D213/64 ,  C07D213/643 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D215/06 ,  C07D215/08 ,  C07D215/12 ,  C07D217/06 ,  C07D233/64 ,  C07D233/90 ,  C07D263/34 ,  C07D277/04 ,  C07D277/06 ,  C07D277/14 ,  C07D277/16 ,  C07D277/56 ,  C07D279/06 ,  C07D279/12 ,  C07D295/135 ,  C07D295/185 ,  C07D307/14 ,  C07D307/24 ,  C07D307/42 ,  C07D307/52 ,  C07D307/68 ,  C07D309/04 ,  C07D309/06 ,  C07D333/16 ,  C07D333/20 ,  C07D333/38 ,  C07D417/12 ,  C07K5/06113 ,  C07K5/06139

Abstract: Compounds represented by general formula (I), salts thereof and type N calcium channel inhibitors containing the same as the active ingredient, wherein R1 represents optionally substituted alkyl, alkoxy or phenyl, a heterocyclic group, etc.; A represents a single bond, CO or SO¿2; R?2 represents H, optionally substituted alkyl, etc.; D represents alkylene, etc.; E represents COO, OCO, O, S, SO, SO¿2?, etc.; R?3¿ represents optionally substituted alkyl, a carbocyclic group or a heterocycle group; J represents O or NR16 (wherein R16 represents H or optionally substituted alkyl); and R4 represents optionally substituted alkyl, a carbocyclic group or a heterocyclic group. Because of inhibiting the type N calcium channel, the compounds (I) are useful as preventives and/or remedies for cerebral infarction, transient cerebral ischemic attack, cerebrospinal disorders following heart operations, spinal vascular lesion, stress hypertension, neurosis, epilepsy, etc. or remdies for pains.

Abstract translation: 通式（I）表示的化合物，其盐以及含有它们作为活性成分的N型钙通道抑制剂，其中R 1表示任选取代的烷基，烷氧基或苯基，杂环基等; A代表单键，CO或SO 2; R 2表示H，任选取代的烷基等; D代表亚烷基等; E表示COO，OCO，O，S，SO，SO 2等; R 3'代表任意取代的烷基，碳环基团或杂环基团; J表示O或NR 16（其中R 16表示H或任选取代的烷基）; 并且R4代表任选取代的烷基，碳环基团或杂环基团。 由于抑制N型钙通道，化合物（I）可用作脑梗塞，短暂性脑缺血发作，心脏手术后的脑脊髓疾病，脊髓血管病变，压力性高血压，神经官能症，癫痫等的预防和/或治疗。 或改变痛苦。

公开(公告)号：EP0713859B1

公开(公告)日：2000-08-30

申请号：EP95118164.3

申请日：1995-11-17

Applicant: SEIKAGAKU KOGYO KABUSHIKI KAISHA (SEIKAGAKU CORPORATION)

Inventor： Waki, Michinori ,  Miyamoto, Kenji ,  Motani, Yoshihiro

IPC: C07C219/10 ,  C07C217/08 ,  C07C229/22 ,  C07C237/08 ,  C07C233/51 ,  C07C237/04 ,  C07K5/06 ,  C07K5/08 ,  C08B37/00 ,  C08B37/08

CPC classification number: C07K5/06026 ,  C07C217/08 ,  C07C219/10 ,  C07C229/22 ,  C07C233/51 ,  C07C237/08 ,  C07C237/12 ,  C07K5/0806 ,  C08B37/003 ,  C08B37/0063

公开(公告)号：EP0502595A2

公开(公告)日：1992-09-09

申请号：EP92250052.5

申请日：1992-03-05

Applicant: INSTITUT FÜR DIAGNOSTIKFORSCHUNG GmbH AN DER FREIEN UNIVERSITÄT BERLIN

Inventor： Neumeier, Reinhard, Dr. ,  Kramp, Wolfgang, Dr. ,  Rohlfs, Gerhard, Dr.

IPC: C07C331/28 ,  A61K43/00 ,  A61K49/02 ,  C07C233/51 ,  C07C237/20 ,  C07D309/12 ,  C07D207/33 ,  C07C233/20 ,  C07D213/70 ,  C07C323/41 ,  C07J51/00

CPC classification number: C07D213/70 ,  A61K47/6887 ,  C07C233/20 ,  C07C237/20 ,  C07C323/41 ,  C07C323/52 ,  C07C331/28 ,  C07D495/04 ,  C07J41/0044 ,  C07J41/0072

Abstract: Die Erfindung betrifft Verbindungen der allgemeinen Formel I

worin A eine funktionelle Gruppe beinhaltet, die für die Kopplung an sich selektiv anreichernde Verbindungen geeignet ist und R 1 , R 2 , R 3 , R 4 und R 5 unterschiedliche Bedeutung haben können. B ist eine Gruppe, die für die koordinative Bindung von Metallionen geeignet ist. Die neuen Verbindungen dienen zur Komplexierung von radioaktiven Metallionen, insbesondere Rhenium- und Technetium-Isotopen, und werden in der medizinischen Diagnostik und Therapie eingesetzt.

Abstract translation: 本发明涉及通式Ⅰ“IMAGE”的化合物，其中A包含适于与经历选择性积累的化合物偶合的官能团，R 1，R 2，R 3，R 3， 4>和R 5可以具有各种含义。 B是适合金属离子的配位键合的基团。 这些化合物用于放射性金属离子，特别是铼和锝同位素的络合，并用于医学诊断和治疗。

公开(公告)号：EP0492171A1

公开(公告)日：1992-07-01

申请号：EP91120369.3

申请日：1991-11-28

Applicant: AMERICAN CYANAMID COMPANY

Inventor： Kameswaran, Venkataraman ,  Doehner, Robert Francis, Jr. ,  Barton, Jerry Michael ,  Kuhn, David George

IPC: C07D207/22 ,  C07C233/51 ,  A01N43/36

CPC classification number: C07D207/416 ,  A01N43/36 ,  C07C233/51 ,  C07D207/22 ,  C07D207/34

Abstract: There are provided important pyrroline and glycine intermediates, methods for the preparation of said intermediates and the use thereof in the manufacture of arylpyrrole insecticidal agents.

Abstract translation: 提供重要的吡咯啉和甘氨酸中间体，制备所述中间体的方法及其在制备芳基吡咯杀虫剂中的用途。

公开(公告)号：EP0351382A3

公开(公告)日：1991-10-09

申请号：EP89830317.7

申请日：1989-07-07

Applicant: MINISTERO DELL' UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA

Inventor： Cannata, Vincenzo ,  Tamerlani, Giancarlo ,  Calzolari, Claudio

IPC: C07C227/34 ,  C07C255/44 ,  C07C233/47 ,  C07C233/51 ,  C07C271/22 ,  C07C231/10 ,  C07C231/20

CPC classification number: C07C255/44 ,  C07C227/34 ,  C07C233/51 ,  C07C233/87 ,  C07C237/20 ,  C07C271/22

Abstract: New process for the synthesis of optically active aminoacids of formula
wherein R and R₁, equal or different,represent a hydrogen atom or an alkyl radical, straight or branched, containing from 1 to 6 carbon atoms, by reacting compounds of formula
wherein R and R₁ have the above seen meanings, R₂ represent a nitrile group or a COR₄ group wherein R₄ represents hydroxy or halogen or alkoxy, straight or branched,containing from 1 to 6 carbon atoms,or a OCOR₅ wherein R₅ represents an alkyl or an alkoxy group, straight or branched, containing from 1 to 6 carbon atoms and R₃ represents hydrogen, an alkyl or an alkoxy radical, straight or branched, containing from 1 to 6 carbon atoms or an aryl or aralkyl radical, with an optically active alcohol of formula R₆-OH      (III) d or l
wherein R₆ represents an alkyl or cycloalkyl group, substituted or unsubstituted, containing from 3 to 12 carbon atoms, to obtain a pair of diastereoisomer esters of formula
which is resolved in basic medium into the single diastereoisomer esters of formula
from which the desired optically active aminoacid of formula (I) is obtained by treatment in acid medium.

公开(公告)号：EP0218622B1

公开(公告)日：1991-07-10

申请号：EP86901914.1

申请日：1986-03-28

Applicant: Robert, Dominique ,  Jung, Louis

Inventor： Robert, Dominique ,  Jung, Louis

IPC: C07C233/11 ,  C07C233/51 ,  C07C323/59 ,  C07D233/64 ,  C07D295/18 ,  A61K7/42

CPC classification number: A61Q17/04 ,  A61K8/37 ,  A61K8/4946 ,  C07D233/64 ,  C07D295/185

Abstract: Derivatives with amide function obtained by reaction between derivatives of linear, branched or cyclic amines having an amino acid or peptidic structure and para-methoxycinnamic acid or urocanic acid. Application of said compounds as specific solar filters, absorbing about 310 nm and avoiding erythematous phenomena during exposures to the sun and as active principles of dermo-pharmaceutical and cosmetological preparations.

公开(公告)号：EP2935205B1

公开(公告)日：2017-03-01

申请号：EP13818745.5

申请日：2013-12-20

Applicant: LEK Pharmaceuticals d.d.

Inventor： STARCEVIC, Stefan ,  MRAK, Peter ,  KOPITAR, Gregor

IPC: C07C233/51 ,  C12P13/04

CPC classification number: C12P41/007 ,  A61K31/4985 ,  A61K45/06 ,  C07B2200/07 ,  C07C231/18 ,  C07C233/51 ,  C12P13/04

公开(公告)号：EP2303830B1

公开(公告)日：2014-02-19

申请号：EP09772647.5

申请日：2009-06-05

Applicant: Institut de Recherche pour le Développement

Inventor： LORQUIN, Jean

IPC: C07C231/02 ,  C07C233/51 ,  C07C235/34 ,  C12P13/00 ,  A61K31/165 ,  A61K8/44 ,  A61P39/06 ,  A61Q90/00

CPC classification number: C07C231/02 ,  C07C233/51 ,  C07C235/34 ,  C12P13/02

公开(公告)号：EP2208721B1

公开(公告)日：2013-12-25

申请号：EP08854528.0

申请日：2008-10-27

Applicant: Zhejiang Hisun Pharmaceutical Co. Ltd. ,  Central South University

Inventor： YU, Niefang ,  LIU, Xiaoyu ,  HU, Xiaodong

IPC: C07C259/06 ,  C07C233/51 ,  A61K31/16 ,  A61P35/00

CPC classification number: C07C323/63 ,  C07C259/06 ,  C07C275/42 ,  C07C311/07 ,  C07C335/22 ,  C07D213/53 ,  C07D333/20

Abstract: The present invention relates to compounds represented by formula (I) or composition comprising at least one of such compounds, which are inhibitors of histone deacetylase. The detailed description of these compounds is disclosed in the Description. These compounds and the composition comprising the same may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase (HDAC) activities.

公开(公告)号：EP2308868A4

公开(公告)日：2013-01-16

申请号：EP09765374

申请日：2009-06-09

Applicant: JIANGSU GOWORTH INVEST CO LTD ,  SHANGHAI INST PHARM INDUSTRY

Inventor： LI JIANQI ,  FENG JUAN ,  CAI WANGPING

IPC: C07D401/10 ,  A61K31/165 ,  A61K31/4406 ,  A61P17/06 ,  A61P35/00 ,  C07C233/51 ,  C07C233/56 ,  C07D277/38 ,  C07D401/12 ,  C07D409/12 ,  C07D417/12

CPC classification number: A61K31/165 ,  A61K31/44 ,  A61K31/4406 ,  C07D213/73 ,  C07D213/75 ,  C07D213/76