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公开(公告)号：EP2055325B1
公开(公告)日：2019-07-17
申请号：EP09152183.1
申请日：2000-12-20
申请人： Acell, Inc.
发明人： Spievack, Alan R
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23.发明公开
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公开(公告)号：EP3448396A1
公开(公告)日：2019-03-06
申请号：EP18784786.8
申请日：2018-04-13
发明人： YI, Tingfang , WAGNER, Gerhard
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公开(公告)号：EP3427726A1
公开(公告)日：2019-01-16
申请号：EP17763162.9
申请日：2017-03-06
申请人： Osaka University , National Institute for Materials Science , Nippon Zoki Pharmaceutical Co., Ltd.
IPC分类号： A61K9/70 , A61K31/714 , A61K35/36 , A61K38/18 , A61K45/00 , A61K47/34 , A61K47/36 , A61P25/00 , A61P25/02
摘要： Provided is a sustained release sheet that includes a drug for treating nerve injury, wherein the sheet is applied to a nerve injury site, can maintain a high concentration of the drug over a long period, and promotes nerve regeneration without stimulating the nerves, even when the sheet is implanted in the periphery of the nerve injury site. Also provided is a production method for the sheet. This sustained drug release sheet for treating nerve injury is a sheet comprising a non-woven fabric that is formed from nanofibers containing a drug such as vitamin B12 and a biocompatible polymer such as a biodegradable aliphatic polyester, and is implanted in the periphery of the nerve injury site to promote nerve regeneration.
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公开(公告)号：EP2956543B1
公开(公告)日：2018-09-05
申请号：EP14706762.3
申请日：2014-02-12
IPC分类号： A61K38/18 , A61K38/30 , C12N5/077 , C12N5/0775 , A61K35/36
CPC分类号： A61K35/36 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/1858 , A61K38/193 , A61K38/204 , A61K38/30 , A61K45/06 , C12N5/0628 , C12N5/066 , C12N5/0666 , C12N2501/113 , C12N2501/905 , A61K2300/00
摘要： The present invention relates to compositions and methods utilizing hair follicle derived Non-Bulbar Dermal Sheath cells for use in the treatment or prevention of the tendon injuries.
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公开(公告)号：EP3365037A1
公开(公告)日：2018-08-29
申请号：EP16858318.5
申请日：2016-10-21
发明人： KOEHLER, Karl, R. , LEE, Jiyoon
CPC分类号： C12N5/0698 , A61K35/36 , A61L27/362 , A61L27/3633 , A61L27/3641 , A61L27/3687 , A61L27/3813 , A61L27/3834 , A61L27/3839 , A61L27/3891 , A61L27/3895 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/58 , A61L27/60 , A61L2300/412 , A61L2300/604 , A61L2300/64 , A61L2430/34 , A61L2430/40 , C12N5/0606 , C12N5/0629 , C12N2501/155 , C12N2501/999 , C12N2506/03 , C12N2506/1346 , C12N2513/00 , C12N2533/76 , C12Q1/6876 , C12Q2600/136
摘要： Provided herein are methods for directing differentiation of human pluripotent stem cells into a three-dimensional multilayered skin composition comprising an epidermal layer, a dermal layer, and a plurality of cells capable of forming a functional hair follicle. Also provided herein are three-dimensional, multilayered engineered skin compositions and methods of using the same for drug screening, for screening compounds for effects on hair growth, and for other applications.
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公开(公告)号：EP3176256B1
公开(公告)日：2018-08-15
申请号：EP17150457.4
申请日：2006-05-16
发明人： FERNANDEZ MIGUEL, Maria Gema , GONZALEZ DE LA PENA, Manuel Angel , GARCIA CASTRO, Rosa Ana , GARCIA ARRANZ, Mariano , GARCIA OLMO, Damian
IPC分类号： C12N5/0775 , A61K35/36 , A61L27/38 , A61P17/02
CPC分类号： A61K35/35 , A61B17/1659 , A61B17/32 , A61B2017/320008 , A61K35/12 , A61K45/06 , A61L24/0015 , A61L24/106 , A61L27/3604 , A61L27/3834 , A61L27/3839 , A61L27/3869 , A61L27/3895 , A61L2300/64 , C12N5/0667 , C12N2509/00 , C12N2510/00 , C12N2533/56
摘要： Provided herein are novel methods and compositions utilizing adipose tissue-derived stromal stem cells for treating fistulae.
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公开(公告)号：EP3350312A1
公开(公告)日：2018-07-25
申请号：EP15779014.8
申请日：2015-09-15
CPC分类号： C12M3/04 , A61F2002/048 , A61K35/36 , A61L27/3813 , A61L27/3895 , A61L27/60 , A61P17/02 , C12M23/20 , C12M23/34 , C12N5/0629 , C12N2502/115 , C12N2533/20
摘要： A method of culturing autogenous cells as well as a method of treating a mammalian patient is described. The cells are cultured on a substrate material having a surface treated with a fatty acid ester so as to have a strong hydrophobic surface and autogenous plasma obtained from a blood sample of the patient is used as a growth medium in order to culture the cells. The substrate material is also used as a transfer dressing for transferring the cultured cells to the patient and as a wound cover dressing. The invention also describes a kit as well as a system for culturing autogenous cells using the culture method.
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公开(公告)号：EP3331488A1
公开(公告)日：2018-06-13
申请号：EP16835601.2
申请日：2016-07-19
申请人： CHL Industries, LLC
IPC分类号： A61K8/19 , A61K8/36 , A61K31/728 , A61K35/36 , A61Q19/08
CPC分类号： A61K8/19 , A61K8/494 , A61K8/735 , A61K9/0014 , A61K9/0019 , A61K31/409 , A61K31/555 , A61K31/728 , A61K2800/58 , A61K2800/91 , A61Q19/08
摘要： Disclosed are methods and compositions for reducing the rate and/or extent of degradation of endogenously-generated and/or exogenous hyaluronic acid (HA), or a modified-HA composition, by the administration, topically and/or by injection, of sodium copper isochlorin e4 or oxidized sodium copper isochlorin e4. The methods and compositions extend the shelf-life of HA or modified-HA (i.e., prior to therapeutic use) and improve therapeutic outcomes including (i) improving the appearance of the skin exhibiting rhytids, grooves, furrows, creping, sagging, or otherwise appearing hollow, (b) reducing skeletal pain in and around the knees, ankles, shoulders, elbows, wrists, distal phalanges, and spine (including facet joints and intervertebral discs), and extending the duration of such improvement in skin appearance and reduction of pain.
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