公开(公告)号：EP0861263A4

公开(公告)日：1999-09-29

申请号：EP96940512

申请日：1996-11-18

申请人： TULARIK INC

发明人： DE LA BROUSSE FABIENNE CHARLES ,  CHEN JIN-LONG

IPC分类号： C12N15/09 ,  A61K38/00 ,  C07K14/575 ,  C12Q1/68 ,  C07H21/04

CPC分类号： C07K14/5759 ,  A61K38/00

公开(公告)号：EP0939627A1

公开(公告)日：1999-09-08

申请号：EP97936133.0

申请日：1997-07-18

申请人： TULARIK, INC.

发明人： FLYGARE, John ,  MEDINA, Julio ,  SHAN, Bei ,  CLARK, David ,  ROSEN, Terry

IPC分类号： C07D295 ,  A61K31 ,  A61P35 ,  C07C309 ,  C07C311 ,  C07C313 ,  C07C323 ,  C07D209 ,  C07D213 ,  C07D231 ,  C07D317 ,  C07D319 ,  C07K14

CPC分类号： C07K14/47 ,  A61K31/18 ,  A61K31/255 ,  A61K31/357 ,  A61K31/36 ,  A61K31/404 ,  A61K31/415 ,  A61K31/416 ,  A61K31/44 ,  A61K31/47 ,  A61K31/5375 ,  C07C309/73 ,  C07C311/21 ,  C07C313/06 ,  C07C323/49 ,  C07D209/08 ,  C07D213/76 ,  C07D231/56 ,  C07D295/135 ,  C07D317/66 ,  C07D319/18 ,  Y02A50/411

摘要： The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, vascular restenosis, microbial infections, and psoriasis, or as lead compounds for the development of such agents. The compositions include compounds of the general formula I:

摘要翻译： 本发明提供涉及新型五氟苯基磺酰胺衍生物和类似物的方法和组合物及其作为药理活性剂的用途。 该组合物特别用作治疗疾病，特别是癌症，血管再狭窄，微生物感染和牛皮癣的药理学试剂，或作为开发这些试剂的先导化合物。 该组合物包括通式（I）的化合物。

公开(公告)号：EP0929665A1

公开(公告)日：1999-07-21

申请号：EP97940763.0

申请日：1997-09-02

申请人： TULARIK, INC.

发明人： SHAN, Bei ,  LEARNED, R., Marc ,  AMARAL, M., Catherine ,  MCKNIGHT, Steven, L. ,  DE LA BROUSSE, Fabienne, C. ,  CHEN, Jin-Long

IPC分类号： C12N15 ,  C12N5 ,  C12Q1 ,  G01N33

CPC分类号： G01N33/5023 ,  A01K2217/072 ,  C12N15/8509 ,  C12N2510/00 ,  C12N2830/008 ,  C12Q1/6897 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5044 ,  G01N2500/00

摘要： The invention provides methods and compositions for screening for pharmacological agents which regulate gene expression in mammals. An exemplary assay involves (a) contacting a mammalian cell comprising a knock-in mutant of a targeted native allele encoding a reporter of gene expression, as shown in the figure, wherein the expression of the reporter is under the control of the gene expression regulatory sequences of the native allele, with a candidate agent under conditions whereby but for the presence of the agent, the reporter is expressed at a first expression level; and (b) measuring the expression of the reporter to obtain a second expression level, wherein a difference between the first and second expressions levels indicates that the candidate agent modulates gene expression.

公开(公告)号：EP1476423A4

公开(公告)日：2005-12-14

申请号：EP03735124

申请日：2003-01-29

申请人： TULARIK INC

发明人： JIAO XIAN YUN ,  KAYSER FRANK ,  KOPECKY DAVID J ,  MCKENDRY SHARON ,  PIPER DEREK E ,  SHIAU ANDREW K

IPC分类号： C07D233/64 ,  A61K31/18 ,  A61K31/196 ,  A61K31/216 ,  A61K31/277 ,  A61K31/381 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4174 ,  A61K31/4184 ,  A61K31/426 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/50 ,  A61K31/505 ,  A61K31/695 ,  A61K45/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P35/04 ,  A61P43/00 ,  C07C311/21 ,  C07C317/32 ,  C07D207/32 ,  C07D207/33 ,  C07D207/333 ,  C07D207/335 ,  C07D213/30 ,  C07D231/12 ,  C07D233/54 ,  C07D235/12 ,  C07D237/02 ,  C07D239/26 ,  C07D257/04 ,  C07D263/02 ,  C07D277/22 ,  C07D277/24 ,  C07D333/34 ,  C07F7/08 ,  C07F7/10 ,  C07C311/08 ,  A61K31/625 ,  A61K31/63 ,  C07C311/13 ,  C07C311/15 ,  C07C311/16 ,  C07C311/20

CPC分类号： C07D207/33 ,  C07C311/21 ,  C07C317/32 ,  C07C2601/08 ,  C07C2601/16 ,  C07D207/333 ,  C07D207/335 ,  C07D213/30 ,  C07D213/42 ,  C07D231/12 ,  C07D233/61 ,  C07D233/64 ,  C07D235/12 ,  C07D235/14 ,  C07D239/26 ,  C07D257/04 ,  C07D277/24 ,  C07D277/28 ,  C07D333/34 ,  C07F7/0818

公开(公告)号：EP1572709A3

公开(公告)日：2005-11-23

申请号：EP03766015.6

申请日：2003-07-23

申请人： PTC Therapeutics, Inc. ,  Tularik Inc.

发明人： WILDE, Richard, G. ,  ALMSTEAD, Neil, G. ,  WELCH, Ellen, M. ,  BECKMANN, Holger

IPC分类号： C07H19/00

CPC分类号： A61K31/506 ,  A61K31/7072 ,  C07H19/00

公开(公告)号：EP1562956A2

公开(公告)日：2005-08-17

申请号：EP03789996.0

申请日：2003-11-21

申请人： Tularik Inc. ,  Japan Tobacco, Inc.

发明人： FOX, Brian, M. ,  FURUKAWA, N.,Japan Tobacco, Inc. ,  HAO, Xiaolin ,  IIO, K.,Japan Tobacco, Inc. ,  INABA, T.,Japan Tobacco, Inc. ,  JACKSON, Simon, M. ,  KAYSER, Frank ,  LABELLE, Marc ,  LI, Kexue ,  MATSUI, T.,Japan Tobacco, Inc. ,  MCMINN, Dustin, L. ,  OGAWA, N.,Japan Tobacco, Inc. ,  RUBENSTEIN, Steven, M. ,  SAGAWA, S.,Japan Tobacco, Inc. ,  SUGIMOTO, K.,Japan Tobacco, Inc. ,  SUZUKI, M.,Japan Tobacco, Inc. ,  TANAKA, M.,Japan Tobacco, Inc. ,  YE, Guosen ,  YOSHIDA, A.,Japan Tobacco, Inc. ,  ZHANG, Jian

IPC分类号： C07D491/052

CPC分类号： C07D491/04

摘要： Compounds, pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the activity of proteins involved in lipid metabolism and cell proliferation.

公开(公告)号：EP0845005B1

公开(公告)日：2005-03-23

申请号：EP96927409.1

申请日：1996-08-14

申请人： Genentech, Inc. ,  TULARIK, INC.

发明人： GOEDDEL, David, V. ,  ROTHE, Mike

IPC分类号： C07K14/47 ,  C12N15/12 ,  C12N15/63 ,  C07K16/18 ,  C12P21/02 ,  A61K38/17 ,  A61K48/00

CPC分类号： C07K14/7151 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4703

摘要： The invention concerns novel inhibitors of tumor necrosis factor receptor associated factor-(TRAF) mediated signal transduction. The invention encompasses the novel inhibitor proteins (I-TRAFs), nucleic acid encoding them, methods for their recombinant production, and their use in screening assays and as pharmaceuticals.

公开(公告)号：EP1497642A2

公开(公告)日：2005-01-19

申请号：EP03716689.9

申请日：2003-03-18

申请人： Tularik, Inc.

发明人： LI, Jing ,  POWERS, Scott ,  YANG, Jianxin

IPC分类号： G01N33/00

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156 ,  Y10T436/143333

摘要： There are disclosed methods and compositions for the diagnosis, prevention, and treatment of tumors and cancers in mammals, for example, humans, utilizing the CTSZ and CD24 genes, which are amplified colon cancer and/or ovarian cancer and/or breast cancer genes. The CTSZ and CD24 genes, their expressed protein products and antibodies are used diagnostically or as targets for cancer therapy or vaccine; they also are used to identify compounds and reagents useful in cancer diagnosis, prevention, and therapy.

公开(公告)号：EP1476423A2

公开(公告)日：2004-11-17

申请号：EP03735124.4

申请日：2003-01-29

申请人： Tularik Inc.

发明人： JIAO, Xian, Yun ,  KAYSER, Frank ,  KOPECKY, David, J. ,  MCKENDRY, Sharon ,  PIPER, Derek, E. ,  SHIAU, Andrew, K.

IPC分类号： C07C311/08 ,  C07C311/13 ,  C07C311/15 ,  C07C311/16 ,  C07C311/20 ,  C07C311/21 ,  A61K31/18 ,  A61K31/625 ,  A61K31/63 ,  A61P3/04 ,  A61P3/06

CPC分类号： C07D207/33 ,  C07C311/21 ,  C07C317/32 ,  C07C2601/08 ,  C07C2601/16 ,  C07D207/333 ,  C07D207/335 ,  C07D213/30 ,  C07D213/42 ,  C07D231/12 ,  C07D233/61 ,  C07D233/64 ,  C07D235/12 ,  C07D235/14 ,  C07D239/26 ,  C07D257/04 ,  C07D277/24 ,  C07D277/28 ,  C07D333/34 ,  C07F7/0818

摘要： Arylsulfonamidobenzyl alcohols, amines and sulfonamides are provided which are useful in treating lipid disorders, metabolic diseases and cell-proliferative diseases.

公开(公告)号：EP1005453B1

公开(公告)日：2004-10-27

申请号：EP98939384.8

申请日：1998-08-13

申请人： TULARIK, INC.

发明人： MEDINA, Julio, Cesar ,  CLARK, David, Louis ,  FLYGARE, John, A. ,  ROSEN, Terry, J. ,  SHAN, Bei

IPC分类号： C07C311/21 ,  A61K31/18

CPC分类号： C07C311/21

摘要： The invention provides compounds, compositions and methods relating to novel electrophilic aromatic derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, psoriasis, vascular restenosis, infections, atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents. The compositions include compounds of general Formula (I).