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公开(公告)号：EP2485713B1
公开(公告)日：2018-09-26
申请号：EP10784350.0
申请日：2010-10-05
发明人： FRIEDMAN, Michael , STEINBERG, Doron , GATI, Irith
CPC分类号： A61Q11/00 , A61K8/347 , A61K8/43 , A61K8/4926 , A61K8/731 , A61K8/86 , A61K9/0063 , A61K9/08 , A61K9/7007 , A61K47/32 , A61K47/36 , A61K47/38 , A61K2800/31 , A61K2800/594
摘要： The present invention discloses liquid precursor compositions adapted for application on a hard surface in the oral cavity, comprising at least one therapeutic agent suitable for the treatment of oral disorders, at least one acidic-pH sensitive polymer, at least one hydrophobic polymer, and a pharmaceutically acceptable volatile carrier, wherein a weight ratio between said at least one hydrophobic polymer and said at least one acidic-pH sensitive polymer is larger than 1. The invention also discloses formulations formed of the solidification of these compositions, and methods for treating oral disorders by applying these compositions on hard surfaces in the oral cavity or to be placed in the oral cavity.
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公开(公告)号：EP3344658A1
公开(公告)日：2018-07-11
申请号：EP16775866.3
申请日：2016-09-01
申请人： Yissum Research Development Company of The Hebrew University of Jerusalem Ltd. , University Of Rijeka Faculty Of Medicine
CPC分类号： A61K39/39558 , A61K2039/505 , A61P35/00 , C07K16/28 , C07K16/2803 , C07K2317/24 , C07K2317/76 , C07K2317/92 , G01N33/577
摘要： Provided is a natural killer (NK) cell killing of various tumors is inhibited in the presence of ligands of TIGIT, an inhibitory receptor present on all human NK cells and on various T cells. Monoclonal antibodies that recognize TIGIT and inhibit its suppressive activity on T-cells are provided as well as pharmaceutical compositions including them and methods for their use in cancer immunotherapy and in diagnosis and treatment of immune disorders.
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公开(公告)号：EP3097540B1
公开(公告)日：2018-07-11
申请号：EP15708891.5
申请日：2015-01-22
发明人： JOSKOWICZ, Leo , MEDAN, Guy , KRONMAN, Achia
IPC分类号： G06T11/00
CPC分类号： G06T11/008 , G06T11/005 , G06T2207/10081 , G06T2207/20048 , G06T2207/30016 , G06T2211/408 , G06T2211/428 , G06T2211/436
摘要： There are provided a method of CT volume reconstruction based on a baseline sinogram obtained by a prior scanning an object in B directions, and a system thereof. The method comprises: a) obtaining initial partial sinogram by initial repeat scanning the object in b directions out of B directions, b being substantially less than B; b) comparing the baseline sinogram and the initial partial sinogram to assess, for each voxel associated with the object, a likelihood of change; e) using the assessed likelihood of change for generating configuration data informative, at least, of rays to be cast in a further repeat scan in an un-scanned direction; d) performing a repeat scan in the un-scanned direction in accordance with the generated configuration data, thereby obtaining partial sinogram, and using the partial sinogram for updating the assessed likelihood of change; e) repeating operations c) and d) until all directions have been scanned to yield respective partial sinograms; f) composing the baseline and the partial sinograms into a composed sinogram; and g) processing the composed sinograms into an image of the object.
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公开(公告)号：EP3331877A1
公开(公告)日：2018-06-13
申请号：EP16753709.1
申请日：2016-08-04
发明人： BEN NERIAH, Yinon , BRACHYA, Guy , BURSTAIN, Ido , MINZEL, Waleed , SNIR-ALKALAY, Irit , VACCA, Joseph , LI, Dansu
IPC分类号： C07D405/14 , C07D413/14 , C07D403/04 , A61K31/506 , A61P35/00
CPC分类号： A61K31/506 , A61P35/02 , C07D403/04 , C07D405/14 , C07D413/14
摘要： The present invention provides pyrazole pyrimidine derivatives which inhibit Casein kinase I (CKI) and/or Interleukin-1 receptor-associated kinase 1 (IRAKI) and methods of their manufacture, compositions comprising them and uses thereof in methods of treating malignant disease and disorders and methods for treating inflammatory diseases and disorders.
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35.发明公开
公开(公告)号：EP3328993A1
公开(公告)日：2018-06-06
申请号：EP16750572.6
申请日：2016-07-28
申请人： New York Stem Cell Foundation, Inc. , Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
IPC分类号： C12N5/0735 , C12N5/075
CPC分类号： C12N5/0606 , C12N5/0609 , C12N5/0612 , C12N2501/115 , C12N2501/727 , C12N2501/999 , C12N2506/04 , C12N2517/04 , C12N2517/10
摘要： Haploid human embryonic stem cells and cell lines, haploid multipotent human cells, and haploid differentiated human cells are provided. In addition, methods of making and using the haploid human cells are provided.
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公开(公告)号：EP2498754B1
公开(公告)日：2018-06-06
申请号：EP10738041.2
申请日：2010-06-24
发明人： GARTI, Nissim , ASERIN, Abraham , LIBSTER, Dima , MISHRAKI, Tehila , AMAR-YULI, Idit , BITAN-CHERVKOVSKY, Liron
CPC分类号： A61K9/1274 , A61K9/0014 , A61K9/0053 , A61K38/13 , A61K38/28 , A61K38/31 , A61K2300/00
摘要： Reverse hexagonal mesophase (HII) liquid crystals provide multi-component hexagonal systems for use in solubilizing and/or protecting from degradation one or more bio-macromolecule and/or active material, and relates to therapeutic and non-therapeutic applications, such as an oral delivery system, where the mesophase is adapted for oral administration. The present invention provides the formation of mesophase systems of ternary glycerol monooleate (GMO)/water combinations which comprise at least one triglyceride or an equivalent thereof. At least one biomacromolecule or drug is incorporated in the mesophase of a pharmaceutical composition or oral delivery system.
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37.发明公开NEW INDOLE COMPOUNDS HAVING ANTIPROTOZOAL ACTIVITY AND ITS USE AS WELL AS METHODS FOR PRODUCING THE SAME 审中-公开具有抗原活性的新吲哚化合物及其用途以及生产相同物质的方法
公开(公告)号：EP3319940A1
公开(公告)日：2018-05-16
申请号：EP15736269.0
申请日：2015-07-10
申请人： Technische Universität Braunschweig , Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
IPC分类号： C07D209/12
CPC分类号： C07D403/08 , A61P33/06 , C07D209/12 , C07D401/08 , C07D471/04
摘要： In a first aspect, the present invention relates to new compounds as depicted in formula (I). In particular, compounds according to the present invention are bisindolylcyclobuten-dione-based structures having antiprotozoal activity. In a further aspect, pharmaceutical compositions containing the same are provided as well as the use of the compounds and pharmaceutical compositions for the prophylaxis and treatment of parasite based diseases including malaria. Finally, methods for the treatment of parasite diseases including malaria are provided.
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公开(公告)号：EP3297272A1
公开(公告)日：2018-03-21
申请号：EP17152868.0
申请日：2007-12-09
IPC分类号： H04N5/32 , G06F17/30 , G11B27/28 , G11B27/034
CPC分类号： G11B27/28 , G06F17/3079 , G06F17/30843 , G11B27/034
摘要： In a system and method for generating a synopsis video from a source video, at least three different source objects are selected according to one or more defined constraints, each source object being a connected subset of image points from at least three different frames of the source video. One or more synopsis objects are sampled from each selected source object by temporal sampling using image points derived from specified time periods. For each synopsis object a respective time for starting its display in the synopsis video is determined, and for each synopsis objects and each frame a respective colour transformation for displaying the synopsis object may be determined. The synopsis video is displayed by displaying selected synopsis objects at their respective time and colour transformation, such that in the synopsis video at least three points that each derive from different respective times in the source video are displayed simultaneously.
摘要翻译： 在用于从源视频生成概要视频的系统和方法中，根据一个或多个定义的约束来选择至少三个不同的源对象，每个源对象是来自源的至少三个不同帧的图像点的连接子集 视频。 通过使用从指定的时间段导出的图像点的时间采样，从每个选择的源对象采样一个或多个提要对象。 对于每个提要对象，确定在提要视频中开始其显示的相应时间，并且对于每个提要对象和每个帧，可以确定用于显示提要对象的相应颜色变换。 简要视频通过在各自的时间和颜色变换下显示选定的简要目标来显示，使得在简要视频中同时显示源自源视频中的不同相应时间的至少三个点。
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公开(公告)号：EP2996549B1
公开(公告)日：2018-03-07
申请号：EP14732408.1
申请日：2014-05-16
申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. , Hadasit Medical Research Services and Development Ltd.
CPC分类号： A61B1/06 , A61B1/00009 , A61B1/04 , A61B1/0661 , A61B1/267 , A61M16/0488
摘要： A guided tracheal intubation system using an autonomous modulated light source, outputting modulated illumination at a constant level, and externally applied to the subject's larynx region. An optical imaging system receives a video stream from within the subject's throat, including modulated illumination from the subject's trachea. A display control system performs signal processing on the modulated content of the images, and outputs frames of those images in which the intensity level of illumination from the trachea can be controlled without any need to change the illumination output from the modulated light source. The light source has no connection with the rest of the system, and need contain no more than a battery, a power supply circuit and a light source. It can therefore be of low cost and can be made disposable, such as in the form of an adhesive patch applied to the subject's neck.
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公开(公告)号：EP3277079A1
公开(公告)日：2018-02-07
申请号：EP16771507.7
申请日：2016-03-31
发明人： ELKIND, Yonatan
摘要： The present invention relates to novel plants, in particular to pepper plants capable of producing fruits which can be kept a longer period of time on the plant as well as being stored after harvesting under refrigerated conditions without exhibiting excessive softening. The invention thus refers to pepper plant which produces fruits with significantly increased fruit firmness at the harvesting stage, wherein said increased fruit firmness is controlled by a genetic determinant, monogenic, wherein said increased fruit firmness is defined as a fruit deformation under a 1 kg load force that is lower than that of a fruit from a control pepper plant which does not have the said genetic determinant
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