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    VERFAHREN ZUR BESTIMMUNG EINER ANALYTKONZENTRATION
    36.
    发明公开
    VERFAHREN ZUR BESTIMMUNG EINER ANALYTKONZENTRATION 审中-公开
    方法用于确定分析物浓度

    公开(公告)号：EP2794909A1

    公开(公告)日：2014-10-29

    申请号：EP12805708.0

    申请日：2012-12-20

    申请人： Roche Diagnostics GmbH ,  F.Hoffmann-La Roche AG

    发明人： HORN, Carina ,  UNKRIG, Volker

    IPC分类号： C12Q1/54 ,  G01N33/52 ,  A61B5/145

    CPC分类号： C12Q1/54 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1486 ,  A61B2562/0295 ,  G01N21/78 ,  G01N21/8483 ,  G01N33/525 ,  G01N2021/7786 ,  G01N2035/00108

    摘要： The invention relates to a method, to a test element (50), and to a device (190) for determining at least one concentration of at least one analyte in a sample (110), in particular for detecting at least one metabolite in a sample (110) of a bodily fluid, wherein at least one test element (50) having at least one test chemistry (102) is used, wherein at least one reaction of the test chemistry (102) with the analyte is detected. The invention further relates to at least one marker (104, 104'), wherein the marker (104, 104') is different from the analyte (117), wherein at least one diffusion of the marker (104, 104') in the sample (110) or at least one component of the sample (110) is detected. At least one piece of correction information is produced from the diffusion of the marker (104, 104'), wherein the concentration of the analyte is determined from the reaction of the test chemistry (102) with the analyte while taking into account the correction information.

    VERFAHREN UND VORRICHTUNGEN ZUR ELEKTROCHEMISCHEN BESTIMMUNG VON FAKTOR XA-INHIBITOREN IN BLUTPROBEN
    38.
    发明公开
    VERFAHREN UND VORRICHTUNGEN ZUR ELEKTROCHEMISCHEN BESTIMMUNG VON FAKTOR XA-INHIBITOREN IN BLUTPROBEN 有权
    方法和设备电化学测定Xa因子抑制剂在血液样本

    公开(公告)号：EP2079849A1

    公开(公告)日：2009-07-22

    申请号：EP07819390.1

    申请日：2007-10-27

    申请人： Roche Diagnostics GmbH ,  F.HOFFMANN-LA ROCHE AG

    发明人： HORN, Carina ,  DOERGE, Liesel ,  KRZYSIUK, Margarete

    IPC分类号： C12Q1/56 ,  G01N33/86

    CPC分类号： G01N27/26 ,  C12Q1/005 ,  C12Q1/56 ,  G01N33/86

    摘要： The invention relates to methods and apparatuses for determining factor Xa inhibitors, especially heparins and fractionated or low molecular weight heparins, and direct FXa inhibitors, in blood samples, which are characterized in that in a first step the blood sample is brought into contact with a detection reagent which comprises at least one thrombin substrate which consists of a peptide residue which can be eliminated by thrombin and which is amidically linked via the carboxyl end to an electrogenic substance, and with a known amount of factor X reagent and an activator reagent which brings about conversion of factor X into factor Xa, subsequently in a second step the amount or activity of the electrogenic substance which is eliminated from the thrombin substrate through the factor Xa-mediated thrombin activation, and/or the time course thereof, is determined as measured signal using electrochemical methods, and finally in a third step, by means of this measured signal, the amount of the factor Xa inhibitor in the sample of the blood to be investigated, or a measured quantity correlating therewith, in particular a clotting time correlating therewith, is ascertained.