公开(公告)号：EP0182152A3

公开(公告)日：1987-08-05

申请号：EP85113751

申请日：1985-10-29

申请人： AMERICAN CYANAMID COMPANY

发明人： Lee, May Dean-Ming ,  Greenstein, Michael ,  Labeda, David Paul

IPC分类号： C12P01/06 ,  C07G11/00 ,  A61K35/66 ,  C12N01/20 ,  C12R01/29

CPC分类号： C12P1/06 ,  C12R1/29

摘要： Antibacterial and antitumor agents designated LL-E33288 complex and their production by new strains of Micromonospora, Micromonospora echinospora ssp. calichensis, NRRL-15839 and NRRL-15975, are disclosed.

公开(公告)号：EP0164207A1

公开(公告)日：1985-12-11

申请号：EP85302921.3

申请日：1985-04-25

申请人： Celino, Martin S. (Deceased), legally represented by Celino, Cecilio G.

发明人： Celino, Martin S.

IPC分类号： C07D493/04 ,  A61K31/35 ,  C12P17/18 ,  C12P1/06

CPC分类号： C07D493/04 ,  C12P17/181 ,  C12R1/29

摘要： A novel Micromonospora strain is provided which produces Crisamicin, a complex having gram positive antibacterial, antiviral and antitumor activities. Crisamicin contains as major components compounds Crisamicin A and Crisamicin B, and minor amounts of compounds Crisamicin C, D and E.

公开(公告)号：EP1521765B1

公开(公告)日：2016-02-24

申请号：EP03762689.2

申请日：2003-06-30

申请人： Janssen Pharmaceutica NV

发明人： VAN DUN, Jacobus, A., J., Janssen Pharmaceutica NV ,  WOUTERS, Walter, B., L., Janssen Pharmaceutica NV ,  JANICOT, Michel, M., F., Janssen Pharmaceutica NV ,  MOCEK, Ursula, Maria ,  LAAKSO, Jodi, Ann

IPC分类号： C07H17/04 ,  C07D313/00 ,  A61K31/70

CPC分类号： A61K31/70 ,  C07D313/00 ,  C07H17/04 ,  C12P17/162 ,  C12R1/29

公开(公告)号：EP2013329A4

公开(公告)日：2010-12-29

申请号：EP07719556

申请日：2007-04-16

申请人： THALLION PHARMACEUTICALS INC

发明人： PIRAEE MAHMOOD ,  YEBOAH FAUSTINUS

IPC分类号： C12N1/20 ,  B01D1/00 ,  B01D15/02 ,  B01D21/26 ,  B01D61/14 ,  C12P17/10

CPC分类号： C12P17/10 ,  B01D15/00 ,  B01D61/145 ,  C07D243/38 ,  C12N1/20 ,  C12P17/12 ,  C12R1/29

公开(公告)号：EP1585814A1

公开(公告)日：2005-10-19

申请号：EP04703733.8

申请日：2004-01-21

申请人： Ecopia Biosciences Inc.

发明人： BACHMANN, Brian, O. ,  MCALPINE, James, B. ,  ZAZOPOULOS, Emmanuel ,  FARNET, Chris, M. ,  PIRAEE, Mahmood

IPC分类号： C12N9/02 ,  C12N9/12 ,  C12N9/88 ,  C12N9/10 ,  C12N9/14 ,  C12N9/90 ,  C07D243/38 ,  A61K31/5513 ,  C12N1/20 ,  C12R1/29 ,  C12P17/10 ,  C12P17/16 ,  C12N15/74 ,  C12N15/03 ,  C07K14/195

CPC分类号： C12N9/93 ,  A61K38/00 ,  C07D243/38 ,  C07D405/06 ,  C07D405/14 ,  C12N9/0004 ,  C12N9/10 ,  C12N9/12 ,  C12N9/14 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12P17/10 ,  C12R1/29 ,  Y02A50/473

摘要： The invention relates to biologically active dibenzodiazepinone analogs represented by Formula I, to methods of producing them, to pharmaceutical compositions comprising them and to methods of treating neoplastic conditions.

公开(公告)号：EP1001957B8

公开(公告)日：2003-10-22

申请号：EP98937654.6

申请日：1998-08-04

申请人： Instituto Biomar S.A.

发明人： CANEDO, Librada Maria, Instituto Biomar S.A. ,  ROMERO, Francisco, Instituto Biomar S.A. ,  ESPLIEGO, Fernando, Instituto Biomar S.A. ,  FERNANDEZ-PUENTES Jose Luis, Instituto Biomar S.A. ,  FERNANDEZ-CHIMENO, Rosa I., Instituto Biomar S.A. ,  PEREZ-BAZ, Julia, Instituto Biomar S.A.

IPC分类号： C07D493/20 ,  A61K31/365 ,  C12R1/29 ,  C12P17/18

CPC分类号： C07D493/20 ,  C12P17/181 ,  C12R1/29 ,  Y10S435/867

公开(公告)号：EP1215212A3

公开(公告)日：2003-05-21

申请号：EP01123067.9

申请日：1987-12-30

申请人： Wyeth Holdings Corporation

发明人： Lee, May Dean-Ming ,  Greenstein, Michael ,  Labeda, David Paul ,  Fantini, Amedeo Alexander

IPC分类号： C07H15/203 ,  C07H5/10 ,  C12N1/20 ,  C12P19/64

CPC分类号： C07H15/203 ,  C12P19/60 ,  C12R1/29

摘要： Antibacterial and antitumor agents designated pseudoaglycone and dihydro derivatives of LL-E33288 complex and their production by new strains of Micromonospora echinospora ssp. calichensis and NRRL-18149; and their preparation are disclosed.

公开(公告)号：EP1198448A2

公开(公告)日：2002-04-24

申请号：EP00950379.8

申请日：2000-07-11

申请人： Ivax Corporation

发明人： JEKKEL, Antonia ,  AMBRUS, Gabor ,  ILKOY, Eva ,  HORVATH, Ildiko ,  KONYA, Attila ,  SZABO, Istvan, Mihaly ,  NAGY, Zsuzsanna ,  HORVATH, Gyula ,  MOZES, Julianna ,  BARTA, Istvan ,  SOMOGYI, Gyorgy ,  SALAT, Janos ,  BOROS, Sandor

IPC分类号： C07C69/74 ,  C07C61/12 ,  C07C67/02

CPC分类号： C12R1/29 ,  C12P7/42 ,  C12P17/06

摘要： The present invention relates to a new microbial process for the preparation of the compound of formula (I) from a compound of general formula (II) wherein R+ stands for an alkali metal or ammonium ion, by the submerged cultivation of the strain able to 6β-hydroxylate a compound of formula (II) in aerobic fermentation and by the separation and purification of the product of formula (I) formed in the course of the bioconversion, which comprises cultivating a strain of the genera Micromonospora able to 6β-hydroxylate a compound of the general formula (II), wherein R+ is as defined above, on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts at 25-32 °C, thereafter feeding the substrate to be transformed into the developed culture, then fermenting the substrate until the end of bioconversion, then separating the compound of formula (I) from the culture broth and, if desired, purifying the same.

公开(公告)号：EP0702691B1

公开(公告)日：2000-07-05

申请号：EP95914502.0

申请日：1995-04-06

申请人： PHARMA MAR, S.A.

发明人： BAZ, Julia, Perez ,  MILLAN, Francisco, Romero ,  DE QUESADA, Theresa, Garcia ,  GRAVALOS, Dolores, Garcia

IPC分类号： C07K5/10 ,  C07K14/36 ,  C12N1/20 ,  A61K38/07

CPC分类号： C12R1/29 ,  A61K38/00 ,  C07K7/06

摘要： The present invention is directed to a novel depsipeptide which has been isolated from a new marine strain L-13-ACM2-092 belonging to the family Micromonosporaceae. Its production by aerobic fermentation under controlled conditions of the strain, and the isolation and purification of PM-93135 are described herein. The compound and the fermentation broth demonstrate significant activity against several cancer cell lines. The compound also shows activity against several gram positive bacteria.

摘要翻译： 本发明涉及从属于小单孢菌科的新海洋菌株L-13-ACM2-092分离的新型缩肽。 本文描述了其在菌株的受控条件下通过好氧发酵进行的生产以及PM-93135的分离和纯化。 该化合物和发酵液对几种癌细胞系表现出显着的活性。 该化合物还显示对几种革兰氏阳性细菌的活性。

公开(公告)号：EP0350623A2

公开(公告)日：1990-01-17

申请号：EP89110487.9

申请日：1989-06-09

申请人： Bristol-Myers Squibb Company

发明人： Ohkuma, Hiroaki ,  Konishi, Masataka ,  Matsumoto, Kiyoshi ,  Oki, Toshikazu ,  Hoshino, Yutaka

IPC分类号： C07D491/08 ,  C12P17/16 ,  A61K31/435

CPC分类号： C07D491/08 ,  C12P17/18 ,  C12R1/29 ,  Y10S435/867

摘要： The novel antitumor antibiotic designated herein as BU-3420T is produced by fermentation of Micromonospora chersina strain M956-1 (ATCC 53710). BU-3420T and its triacetate derivative possess antibacterial and antifungal activity and also inhibit the growth of mammalian tumors such as P388 leukemia in mice.

摘要翻译： 本文命名为“CHEM”的BU-3420T的新型抗肿瘤抗生素是通过发酵黑麦草细菌菌株M956-1（ATCC 53710）产生的。 BU-3420T及其三醋酸酯衍生物具有抗菌和抗真菌活性，并且还抑制小鼠中哺乳动物肿瘤如P388白血病的生长。