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公开(公告)号：EP2968251B1
公开(公告)日：2020-02-12
申请号：EP14717027.8
申请日：2014-03-14
IPC分类号： A61K31/337 , A61K31/397 , A61K31/439 , A61K31/445 , A61K31/4545 , C07D205/06 , A61P35/00 , A61P29/00 , A61P25/30 , A61P37/00 , A61P25/28 , A61P31/04 , A61P31/12
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42.发明公开
公开(公告)号：EP3461503A1
公开(公告)日：2019-04-03
申请号：EP18205446.0
申请日：2008-04-11
发明人： Oppenheimer, Daniel I. , Dorenbaum, Alejandro , Okhamafe, Augustus , Foehr, Erik , Castillo, Sianna , Kostel, Paul John
摘要： The present invention is directed to treatment methods of administering tetrahydrobiopterin, including in oral dosage forms, in intravenous formulations, and with food. Also disclosed herein are biopterin assays for measuring the amount of biopterin and metabolites of biopterin in a sample.
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公开(公告)号：EP2900831B1
公开(公告)日：2018-11-21
申请号：EP13840682.2
申请日：2013-09-26
发明人： CRAWFORD, Brett, E. , BROWN, Jillian, R. , GLASS, Charles, A. , BEITEL, Jim, R. , JACKMAN, Robin, M.
IPC分类号： G01N33/68
CPC分类号： C12Q1/34 , C12Q1/48 , C12Q1/527 , G01N33/66 , G01N33/6893
摘要： Provided herein are methods of diagnosing or monitoring the treatment of abnormal glycan accumulation or a disorder associated with abnormal glycan accumulation.
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公开(公告)号：EP3175863A1
公开(公告)日：2017-06-07
申请号：EP16192229.9
申请日：2010-05-20
发明人： WENDT, Daniel, J. , AOYAGI-SCHARBER, Mika , LONG, Shinong , VELLARD, Michel, Claude , CASTILLO, Sianna , OKHAMAFE, Augustus, O. , PRICE, Christopher, P.
IPC分类号： A61K38/16 , A61K49/00 , G01N33/53 , C12Q1/42 , C12P21/06 , C12N1/21 , G01N33/68 , A61K38/00 , A61K38/10 , C07K14/00 , C07K7/00 , A61P9/00 , A61P9/12 , A61P13/12 , A61P19/00 , C07K14/58
CPC分类号： C07K14/58 , A61K9/08 , A61K38/00 , A61K38/22 , A61K38/2242 , A61K47/10 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/60 , G01N2333/58 , G01N2800/10 , G01N2800/105 , G01N2800/385 , G01N2800/52
摘要： The present disclosure provides variants of C-type natriuretic peptide (CNP), pharmaceutical compositions comprising CNP variants, and methods of making CNP variants. The CNP variants are useful as therapeutic agents for the treatment of diseases responsive to CNP, including but not limited to bone-related disorders, such as skeletal dysplasias (e.g., achondroplasia), and vascular smooth muscle disorders (e.g., restenosis and arteriosclerosis).
摘要翻译： 本公开提供C型利钠肽（CNP）的变体，包含CNP变体的药物组合物，以及制备CNP变体的方法。 CNP变体可用作治疗剂，用于治疗对CNP有反应的疾病，包括但不限于骨相关病症如骨骼发育不良（例如软骨发育不全）和血管平滑肌障碍（例如再狭窄和动脉硬化）。
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45.发明授权COMPOSITIONS INCLUDING 6-AMINOHEXANOIC ACID DERIVATIVES AS HDAC INHIBITORS 有权ZUSAMMENSETZUNGEN MIT 6-AMINOHEXANSAUREDERIVATEN ALS HDAC-HEMMER
公开(公告)号：EP2330894B8
公开(公告)日：2017-04-19
申请号：EP09812248.4
申请日：2009-09-03
IPC分类号： C07C235/16 , C07C237/22 , C07C255/57 , C07C311/16 , C07C311/19 , C07C317/44 , C07C323/62 , C07D209/48 , C07D213/30 , C07D231/56 , C07D277/56 , C07D295/14 , C07D307/84 , C07D409/12 , A01N37/18 , A61K31/00 , A61K31/16
CPC分类号： C07C233/80 , A61K31/00 , A61K31/16 , C07C235/16 , C07C237/22 , C07C255/57 , C07C311/16 , C07C311/19 , C07C317/44 , C07C323/62 , C07C2601/02 , C07C2601/14 , C07D209/48 , C07D213/30 , C07D213/81 , C07D217/24 , C07D231/12 , C07D231/56 , C07D237/24 , C07D241/24 , C07D241/44 , C07D271/12 , C07D277/56 , C07D295/14 , C07D295/15 , C07D307/84 , C07D307/85 , C07D333/38 , C07D409/12 , Y02A50/411
摘要： This invention relates to compounds of Formula (I) wherein Cy1, L1, Y, R1, L2, and Ar2 are defined herein, for the treatment of cancers, inflammatory disorders, and neurological conditions.
摘要翻译： 本发明涉及式（I）化合物，其中Cy1，L1，Y，R1，L2和Ar2在本文中定义，用于治疗癌症，炎症性疾病和神经病症。
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公开(公告)号：EP3138566A1
公开(公告)日：2017-03-08
申请号：EP16178739.5
申请日：2004-11-17
IPC分类号： A61K31/519 , A61P3/00
CPC分类号： A61K31/519 , A23L33/15 , A23L33/155 , A23L33/16 , A23L33/17 , A23L33/175 , A61K9/0053 , A61K31/00 , A61K31/198 , A61K31/5025
摘要： The present invention is directed to a novel methods and compositions for the therapeutic intervention in hyperphenylalaninemia. More specifically, the specification describes methods and compositions for treating various types of phenylketonurias using compositions comprising BH4. Combination therapies of BH4 and other therapeutic regimens are contemplated.
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公开(公告)号：EP2432489B1
公开(公告)日：2016-10-05
申请号：EP10778389.6
申请日：2010-05-20
发明人： WENDT, Daniel, J. , AOYAGI-SCHARBER, Mika , LONG, Shinong , VELLARD, Michel, Claude , CASTILLO, Sianna , OKHAMAFE, Augustus, O. , PRICE, Christopher, P.
IPC分类号： A61K38/16 , A61K49/00 , G01N33/53 , C12Q1/42 , C12P21/06 , C12N1/21 , G01N33/68 , A61K38/00 , A61K38/10 , C07K14/00 , C07K7/00 , A61P9/00 , A61P9/12 , A61P13/12 , A61P19/00 , C07K14/58 , A61K47/48
CPC分类号： C07K14/58 , A61K9/08 , A61K38/00 , A61K38/22 , A61K38/2242 , A61K47/10 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/60 , G01N2333/58 , G01N2800/10 , G01N2800/105 , G01N2800/385 , G01N2800/52
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公开(公告)号：EP3046920A1
公开(公告)日：2016-07-27
申请号：EP14789439.8
申请日：2014-09-19
IPC分类号： C07D405/14 , C07D319/18 , C07D405/12 , C07D407/12 , C07D417/12 , C07D307/79 , C07D409/12 , C07D213/64 , C07D295/12 , C07D309/10 , C07D311/12 , C07D413/12 , C07D265/30 , C07D205/04 , C07D333/16
CPC分类号： C07D319/18 , C07B59/002 , C07B2200/05 , C07B2200/07 , C07D205/04 , C07D209/04 , C07D211/46 , C07D213/46 , C07D213/56 , C07D213/61 , C07D213/64 , C07D215/06 , C07D231/56 , C07D235/06 , C07D235/08 , C07D265/30 , C07D277/22 , C07D277/30 , C07D277/62 , C07D295/12 , C07D295/13 , C07D305/08 , C07D307/79 , C07D307/81 , C07D309/10 , C07D309/12 , C07D311/12 , C07D311/58 , C07D333/16 , C07D333/24 , C07D333/60 , C07D333/62 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D471/08 , C07D487/08 , C07D491/056
摘要： Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).
摘要翻译： 本文描述了式I的化合物，制备此类化合物的方法，含有此类化合物的药物组合物和药物，以及使用此类化合物治疗或预防与葡糖基神经酰胺合酶（GCS）相关的疾病或病症的方法。
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49.发明公开Methods of administering tetrahydrobiopterin, associated compositions, and methods of measuring 审中-公开施用四氢生物蝶呤的方法，相关的组合物和测量方法
公开(公告)号：EP2545939A3
公开(公告)日：2013-06-12
申请号：EP12005352.5
申请日：2008-04-11
发明人： Oppenheimer, Daniel I. , Dorenbaum, Alejandro , Okhamafe, Augustus , Foehr, Erik , Castillo, Sianna , Kostel, Paul John
CPC分类号： A61K31/519 , A61K9/0019 , A61K9/0053 , A61K9/0065 , A61K9/0095 , A61K9/08 , A61K9/1652 , A61K9/2027 , A61K9/2054 , A61K9/2086 , A61K9/4808 , A61K9/4858 , A61K9/4891 , A61K45/06 , C07B63/00 , C07D487/04 , G01N27/62 , G01N30/7233 , G01N33/6848 , H01J49/004 , Y10T436/147777 , A61K2300/00
摘要： The present invention is directed to treatment methods of administering tetrahydrobiopterin, including in oral dosage forms, in intravenous formulations, and with food. Also disclosed herein are biopterin assays for measuring the amount of biopterin and metabolites of biopterin in a sample.
摘要翻译： 本发明涉及四氢生物喋呤管理，包括口服剂型，在静脉内式蒸发散的治疗方法，并用食品。 因此，在生物蝶呤是用于测量在一游离缺失样品盘生物蝶呤和生物喋呤的代谢物的量测定。
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50.发明公开Methods of administering tetrahydrobiopterin, associated compositions, and methods of measuring 审中-公开施用四氢生物蝶呤的方法，相关组合物和测量方法
公开(公告)号：EP2545939A2
公开(公告)日：2013-01-16
申请号：EP12005352.5
申请日：2008-04-11
发明人： Oppenheimer, Daniel I. , Dorenbaum, Alejandro , Okhamafe, Augustus , Foehr, Erik , Castillo, Sianna , Kostel, Paul John
CPC分类号： A61K31/519 , A61K9/0019 , A61K9/0053 , A61K9/0065 , A61K9/0095 , A61K9/08 , A61K9/1652 , A61K9/2027 , A61K9/2054 , A61K9/2086 , A61K9/4808 , A61K9/4858 , A61K9/4891 , A61K45/06 , C07B63/00 , C07D487/04 , G01N27/62 , G01N30/7233 , G01N33/6848 , H01J49/004 , Y10T436/147777 , A61K2300/00
摘要： The present invention is directed to treatment methods of administering tetrahydrobiopterin, including in oral dosage forms, in intravenous formulations, and with food. Also disclosed herein are biopterin assays for measuring the amount of biopterin and metabolites of biopterin in a sample.
摘要翻译： 本发明涉及给予四氢生物蝶呤的治疗方法，包括口服剂型，静脉内制剂和食物。 本文还公开了用于测量样品中生物蝶呤和生物蝶呤代谢物的量的生物蝶呤测定法。
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