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公开(公告)号：EP2342224A2
公开(公告)日：2011-07-13
申请号：EP09815462.8
申请日：2009-09-25
申请人： TransGenRx, Inc. , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
IPC分类号： C07K14/555 , C12N15/63 , C07H21/04 , C12P21/06
CPC分类号： C07K14/555 , A01K2217/052 , A01K2227/30 , A01K2267/01 , C07K14/465 , C07K2319/43 , C07K2319/50 , C12N15/85 , C12N15/8509 , C12N2800/90 , C12N2830/15 , C12N2830/40 , C12N2830/46 , C12N2830/60 , C12N2830/90 , C12N2840/105
摘要： Novel compositions for the production of interferons such as interferon-α 2a, interferon-α 2b, or interferon-β 1a (IFN-α 2a, IFN-α 2b, or IFN-β 1a) are provided. The compositions comprise components of vectors, such as a vector backbone, a promoter, and a gene of interest that encodes an interferon such as IFN-α 2a, IFN-α 2b, or IFN-β 1a, and the vectors comprising these components. In certain embodiments, these vectors are transposon-based vectors. Also provided are methods of making these compositions and methods of using these compositions for the production of an interferon such as IFN-α 2a, IFN-α 2b, or IFN-β 1a.
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42.发明公开POLYPEPTIDE-NUCLEIC ACID CONJUGATE FOR IMMUNOPROPHYLAXIS OR IMMUNOTHERAPY FOR NEOPLASTIC OR INFECTIOUS DISORDERS 审中-公开多肽 - 核酸结合免疫预防或免疫治疗肿瘤或感染性疾病
公开(公告)号：EP2178896A1
公开(公告)日：2010-04-28
申请号：EP08797017.4
申请日：2008-07-31
申请人： The Johns Hopkins University , The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
发明人： BEDI, Atul , RAVI, Rajani , LI, Shulin
CPC分类号： A61K47/6863 , A61K47/6807 , A61K47/6849 , A61K47/6851 , A61K47/6855
摘要： The present invention discloses compositions which induce cross-activation of immune mediated and direct death signaling in targeted cells by exploiting the properties of a antibody/peptide-nucleic acid conjugate. The conjugate is able to simultaneously activate multiple death signaling mechanisms. Methods of using the conjugate of the present invention as an immunotherapeutic modality for the treatment or prevention of infectious disease, neoplastic diseases or other disorders.
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43.发明公开
公开(公告)号：EP1745278A2
公开(公告)日：2007-01-24
申请号：EP05755572.4
申请日：2005-04-27
发明人： STRONGIN, Robert, M. , WANG, Weihua , RUSIN, Oleksandr , ST. LUCE, Nadia, N. , ESCOBEDO CORDOVA, Jorge, O.
IPC分类号： G01N21/76
CPC分类号： G01N33/6815 , G01N21/78 , G01N33/52 , G01N2021/7769 , G01N2021/7786 , Y10T436/17 , Y10T436/182
摘要： Colorimetric and fluorometric methods are disclosed for the rapid, accurate, selective, and inexpensive detection of homocysteine, or of homocysteine and cysteine, or of cysteine. The methods may be employed with materials that are readily available commercially. The novel methods are selective for homocysteine, for cysteine, or for total homocysteine and cysteine, and do not cross-react substantially with chemically-related species such as glutathione. The homocysteine-selective method does not have substantial cross-reactivity to the very closely related species cysteine. The cysteine-selective method does not have substantial cross-reactivity to the very closely related species homocysteine. The methods may be used, for example, in a direct assay of human blood plasma for homocysteine levels.
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公开(公告)号：EP1330533B1
公开(公告)日：2006-02-08
申请号：EP01972383.2
申请日：2001-10-03
申请人： SA Bioproducts (PTY) Ltd. , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
CPC分类号： C12Y301/03008 , A23J1/16 , A23K20/147 , A23K20/174 , A23V2002/00 , B01J39/05 , B01J39/26 , C12P7/02 , A23V2300/34
摘要： A method of preparing a modified corn steep liquor product from a corn steep liquor which includes suspended solids, high molecular weight compounds, phytic acid, and metal values includes the steps of: subjecting the corn steep liquor to ultrafiltration to remove the suspended solids and high molecular weight compounds; treating the product of step (a) with a phytase enzyme to convert the phytic acid to inositol-mono-phosphate; treating the product of step (b) with an acid phosphatase enzyme to convert the inositol-mono-phosphate to myo-inositol; adjusting the pH of the product of step (c) to from 7 to 9 inclusive using a soluble base which causes most or all of the Mg values to precipitate, and removing the precipitate; and contacting the product of step (d) with a strong acid cation chromatographic resin to produce a first fraction containing most of the remaining metal values, and a second fraction containing most of the myo-inositol, the second fraction being the modified corn steep liquor product.
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公开(公告)号：EP1597378A2
公开(公告)日：2005-11-23
申请号：EP03808563.5
申请日：2003-12-24
申请人： Transgenrx, Inc. , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
IPC分类号： C12P21/00 , A01K67/027 , A01K67/033 , C07H21/04 , C12N15/00
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2227/30 , A01K2267/01 , A23L15/00 , A23V2002/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C07K14/62 , C07K16/00 , C07K16/02 , C07K16/1063 , C07K16/26 , C07K2317/23 , C07K2317/34 , C12N15/85 , C12N2800/90 , C12N2830/003 , C12N2830/008 , C12N2830/90 , C12N2840/20 , Y02A50/407 , Y02A50/469 , A23V2300/21
摘要： Administration of modified transposon-based vectors has been used to achieve stable incorporation of exogenous genes into animals. These transgenic animals produce transgenic progeny. Further, these transgenic animals produce large quantities of desired molecules encoded by the transgene. Transgenic egg-laying animals produce large quantities of desired molecules encoded by the transgene and deposit these molecules in the egg.
摘要翻译： 本发明提供了一种在个体中产生多聚体蛋白质的新的，有效的和有效的方法。 多聚体蛋白质包括相关的多聚体蛋白质（两种或更多种相关多肽）和多价多聚体蛋白质（由多于一种目的基因编码的单一多肽）。 个体中多聚蛋白的表达和/或形成是通过将含有编码部分多聚蛋白的感兴趣基因的多核苷酸盒给予个体来实现的。 多核苷酸盒可另外含有一个或多个pro序列，prepro序列，cecropin前原序列和/或切割位点序列。
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46.发明公开Prolactin inhibiting or stimulating compounds to regulate the immune function 失效催乳素抑制性化合物或-stimulating调节免疫功能
公开(公告)号：EP1275392A3
公开(公告)日：2003-05-21
申请号：EP02017154.2
申请日：1995-07-07
申请人： The General Hospital doing business as Massachusetts General Hospital , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
IPC分类号： A61K31/4985 , A61K31/454 , A61P37/02
CPC分类号： A61K38/225 , A61K31/00 , A61K31/137 , A61K31/166 , A61K31/40 , A61K31/405 , A61K31/445 , A61K31/4515 , A61K31/454 , A61K31/475 , A61K31/48 , A61K31/4985 , A61K31/5415 , A61K38/2257 , A61K45/06 , A61K2300/00
摘要： Methods for rectifying or ameliorating abnormal responses of mammalian immune systems is provided. Also provided are methods for modifying normal responses of the mammalian immune system. Further provided is a method for treating a mammal having an immune dysfunction by administering to the mammal a prolactin reducer and/or enhancer at a predetermined time or times during a 24-hour period that results in modification of the mammal's abnormal prolactin profile so that it approaches or conforms to the prolactin profile of a young mammal of the same species, thereby ameliorating said immune dysfunction. Also provided is a method of upregulating or augmenting an immune response in a mammal.
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47.发明公开METHOD FOR REGULATING METABOLISM WITH DOPAMINE BETA HYDROXYLASE INHIBITORS 失效方法调节代谢与多巴胺BETA HYDROXYLASEINHIBITOREN的
公开(公告)号：EP0836445A1
公开(公告)日：1998-04-22
申请号：EP96922476.0
申请日：1996-06-05
申请人： THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE , ERGO SCIENCE INCORPORATED
CPC分类号： A61K31/135 , A61K31/00 , A61K31/015 , A61K31/03 , A61K31/05 , A61K31/137 , A61K31/145 , A61K31/27 , A61K31/275 , A61K31/277 , A61K31/325 , A61K31/381 , A61K31/44 , Y10S514/824 , Y10S514/866
摘要： Disclosed herein are methods for regulating or ameliorating lipid and glucose metabolism and reducing in a vertebrate animal body fat stores, insulin resistance, hyperinsulinemia, hyperglycemia, hyperlipidemia, elevated blood lipoproteins (such as triglycerides and cholesterol including chylomicrons, VLDL and LDL) and/or increasing in the subject the plasma HDL. The methods comprise administration or timed administration of inhibitors or dopamine beta hydroxylase (DBH).
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公开(公告)号：EP0833658A1
公开(公告)日：1998-04-08
申请号：EP96918234.0
申请日：1996-06-06
申请人： Agritech Technologies, Ltd. , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2227/30 , A01K2267/02 , A61K38/00 , A61K39/00 , A61K39/0005 , A61K2039/6068 , C07K14/575 , C07K2319/00
摘要： The present invention relates, in general, to a method of enhancing the production performance of avians, by administering to a bird a heterologous protein comprised of inhibin protein, or a fragment thereof, and a carrier protein. The present invention also relates to a method of enhancing the production performance of avians, by administering to a bird a fusion gene product comprising a gene encoded for the expression of alpha-subunit avian inhibin protein, or a fragment thereof, and a gene encoded for the expression of a carrier protein. An effective amount of the heterologous protein or fusion gene product is administered to an animal such that an immunological response occurs in the animal against the heterologous protein. The present invention further relates to the above heterologous protein and fusion gene product, and to methods of producing the same.
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公开(公告)号：EP0833636A1
公开(公告)日：1998-04-08
申请号：EP96922478.0
申请日：1996-06-05
申请人： ERGO SCIENCE INCORPORATED , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
CPC分类号： A61K31/166 , A61K31/4045 , A61K31/405 , A61K31/454 , A61K31/48 , A61K38/2257 , A61K31/40 , A61K2300/00
摘要： This invention relates to a method for inhibiting the growth of neoplasms, in a mammal having a prolactin profile. This method involves comparing the prolactin profile of the afflicted mammal to a standard prolactin profile for healthy mammals of the same species and sex and adjusting the prolactin profile of the afflicted mammal to conform to or approach the standard prolactin profile for a mammal of the same species and sex of the afflicted mammal, thereby inhibiting the neoplastic growth.
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公开(公告)号：EP0833625A1
公开(公告)日：1998-04-08
申请号：EP96919438.0
申请日：1996-06-05
申请人： ERGO SCIENCE INCORPORATED , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
CPC分类号： A61K31/13 , A61K31/16 , Y10S514/866
摘要： This invention relates to a method for modifying metabolism in a vertebrate animal which entails the administration of pantethine or cysteamine at a predetermined time daily. The method is useful in the treatment of hyperglycemia, glucose intolerance, insulin resistance, and hyperinsulinemia.
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