-
公开(公告)号：EP1599201B1
公开(公告)日：2010-04-14
申请号：EP04713398.8
申请日：2004-02-20
发明人： ALI, Amjad , BERESIS, Richard , COLLETTI, Steven, L. , GRAHAM, Donald, W. , TATA, James, R. , THOMPSON, Christopher, F.
IPC分类号： C07D231/54 , C07D403/12 , C07D401/12 , C07D409/12 , C07D409/04 , A61K31/41 , A61P29/00
CPC分类号： C07D409/12 , C07D231/54 , C07D401/12 , C07D403/06 , C07D403/12 , C07D409/04
摘要： The present invention encompasses compounds of Formula (I) or pharmaceutically acceptable salts or hydrates thereof, which are useful as novel non-steroidal selective glucocorticoid receptor modulators for treating a variety of autoimmune and inflammatory diseases or conditions, and possess advantages over steroidal glucocorticoid ligands with respect to undesireable side-effects, efficacy, toxicity and/or metabolism. Pharmaceutical compositions and methods of use are also included.
-
42.发明授权D-HOMOANDROSTA-17-YL-CARBAMATE DERIVATIVES AS SELECTIVE GLUCOCORTICOID RECEPTOR LIGANDS 有权D-HOMOANDROSTA -17-基氨基甲酸酯衍生物作为选择性糖皮质激素受体配体
公开(公告)号：EP1883624B1
公开(公告)日：2010-04-07
申请号：EP06770329.8
申请日：2006-05-15
IPC分类号： C07C261/00 , C07J63/00 , A61K31/56
CPC分类号： C07J63/008
-
公开(公告)号：EP3883575A1
公开(公告)日：2021-09-29
申请号：EP19886307.8
申请日：2019-11-15
发明人： BRILL, Zachary, G. , ALI, Amjad , CUMMING, Jared , DEMONG, Duane , DENG, Qiaolin , GRAHAM, Thomas, H. , KUANG, Rongze , LIM, Yeon-Hee , PLUMMER, Christopher, W. , RICO DUQUE, Jenny Lorena , WANG, Huijun , ZHANG, Yonglian , ZHAO, Kake
IPC分类号： A61K31/519 , A61P35/00 , C07D487/04
-
公开(公告)号：EP3723754A1
公开(公告)日：2020-10-21
申请号：EP18887555.3
申请日：2018-12-10
发明人： ALI, Amjad , LIM, Yeon-Hee , GALLO-ETIENNE, Gioconda, V. , KELLY, Joseph, Michael , BERLIN, Michael , TING, Pauline , TAGAT, Jayaram, R. , XIAO, Dong , KUANG, Rongze , WU, Heping , WANG, Hongwu
IPC分类号： A61K31/4188 , A61K31/505 , A61K31/519 , C07D247/00 , C07D247/02 , C07D255/00
-
公开(公告)号：EP3134408B1
公开(公告)日：2020-08-12
申请号：EP15783339.3
申请日：2015-04-21
发明人： LIM, Yeon-Hee , GUO, Zhuyan , ALI, Amjad , EDMONDSON, Scott D. , LIU, Weiguo , GALLO-ETIENNE, Gioconda V. , WU, Heping , GAO, Ying-Duo , STAMFORD, Andrew M. , YU, Younong , KEVIN, Nancy J. , ANAND, Rajan , SHA, Deyou , NEELAMKAVIL, Santhosh F. , HUSSAIN, Zahid , KUMAR, Puneet , MONINGKA, Remond , DUFFY, Joseph L. , XU, Jiayi , JIANG, Yu , SONE, Hiroki , CHAKRABARTI, Anjan
IPC分类号： C07D471/10 , A61K31/438 , C07D498/20
-
公开(公告)号：EP3220910B1
公开(公告)日：2020-01-15
申请号：EP15861650.8
申请日：2015-11-13
发明人： KUANG, Rongze , TING, Pauline , ALI, Amjad , WU, Heping , BERLIN, Michael , STAMFORD, Andrew , WANG, Hongwu , ZHOU, Gang , KIM, David , DENG, Qiaolin , LIM, Yeon-Hee , YU, Younong
IPC分类号： A61K31/497 , C07D241/26 , C07D413/04
-
公开(公告)号：EP3180325B1
公开(公告)日：2019-03-20
申请号：EP15827513.1
申请日：2015-07-23
发明人： MERTZ, Eric , EDMONDSON, Scott D. , GUO, Zhuyan , HRUZA, Alan, W. , HE, Jiafang , SO, Sung-Sau , ALI, Amjad , GAO, Ying-Duo
IPC分类号： C07D401/10 , C07D405/14 , C07D401/14 , A61P7/02 , A61K31/4439
-
公开(公告)号：EP2706852B1
公开(公告)日：2018-08-22
申请号：EP12782391.2
申请日：2012-05-04
发明人： DESCHENES, Denis , ALTMAN, Michael D. , ELLIS, John Michael , FISCHER, Christian , HAIDLE, Andrew M. , KATTAR, Solomon D. , NORTHRUP, Alan B. , SCHELL, Adam J. , SMITH, Graham F. , TAOKA, Brandon M. , BIENSTOCK, Corey , DI FRANCESCO, Maria Emilia , DONOFRIO, Anthony , PETERSON, Scott , SPENCER, Kerrie B. , JEWELL, James Patrick , ALI, Amjad , BENNETT, David Jonathan , DANG, Qun , WAI, John
IPC分类号： A01N43/40 , A61K31/44 , C07D213/04
CPC分类号： C07D401/14 , C07D401/12 , C07D409/14 , C07D417/14 , C07D471/04
摘要： The present invention provides novel pyrimidine amines of formula I which are potent inhibitors of spleen tyrosine kinase, or are prodrugs thereof, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis and cancer.
-
公开(公告)号：EP3038466B1
公开(公告)日：2018-05-23
申请号：EP14840648.1
申请日：2014-08-25
发明人： ALI, Amjad , GALLO, Gioconda, V. , HENDERSON, Timothy, J. , KUANG, Rongze , LIM, Yeon-Hee , LO, Michael Man-Chu , METZGER, Edward , RUIZ, Manuel de Lera , STAMFORD, Andrew , TEMPEST, Paul , WHITEHEAD, Brent , WU, Heping
IPC分类号： C07D519/00 , C07D491/147 , A61K31/519 , A61P25/00 , A61P25/16 , A61P25/28
CPC分类号： C07D519/00 , C07D491/147
摘要： The present invention is directed to 2,2-difluorodioxolo compounds that are antagonists of A2A receptor. The present invention is also directed to uses of the 2,2-difluorodioxolo compounds described herein in the potential treatment or prevention of neurological disorders and diseases in which A2A receptor are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds and to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which A2A receptors are involved.
-
公开(公告)号：EP3253390A1
公开(公告)日：2017-12-13
申请号：EP16747041.8
申请日：2016-02-01
发明人： ALI, Amjad , ZHOU, Gang , KUANG, Rongze , LIM, Yeon-Hee , LO, Michael Man-Chu , TING, Pauline C. , BIJU, Purakkattle , RUIZ, Manuel de Lera , DEGRADO, Sylvia J. , TUNG, Alexander L. , HENDERSON, Timothy J. , HONG, Liwu , KIM, Jae-Hun , KIM, David Won-Shik , LEE, Joe F. , WU, Jie , WU, Heping , XIAO, Yushi , YU, Tao , ZHU, Xiaohong , MCCORMICK, Kevin D. , TAGAT, Jayaram R. , XIAO, Dong , KHAN, Tanweer , CAO, Jianhua , BERLIN, Michael , ZHANG, Yonglian
IPC分类号： A61K31/517 , C07D239/84 , C07D403/12
CPC分类号： C07D239/84 , A61K31/517 , A61P25/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention is directed to compounds of generic formula I: or pharmaceutically acceptable salts thereof that are believed to be useful as an A2A-receptor antagonist.
-
-
-
-
-
-
-
-
-
搜索结果
80 条记录 (耗时 0.028 秒)
