公开(公告)号：EP1042000A4

公开(公告)日：2005-03-02

申请号：EP98963026

申请日：1998-12-15

申请人： CELL GENESYS INC

发明人： SNYDER RICHARD O ,  RENDAHL KATHERINE ,  LEFF STUART ,  MANDEL RONALD ,  COHEN LAWRENCE ,  DANOS OLIVIER

IPC分类号： C12N15/09 ,  A61K31/711 ,  A61K35/76 ,  A61K38/22 ,  A61K38/46 ,  A61K48/00 ,  C12N5/10 ,  C12N7/00 ,  C12N15/864 ,  A61K39/00 ,  C12N15/85

CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N2750/14143 ,  C12N2830/006 ,  C12N2830/42 ,  C12N2840/44

公开(公告)号：EP0452484B2

公开(公告)日：2004-07-28

申请号：EP91900640.3

申请日：1990-11-06

申请人： CELL GENESYS, INC.

发明人： SKOULTCHI, Arthur, I.

IPC分类号： C12P21/06 ,  C12P21/02 ,  C12N15/00

CPC分类号： C12N15/81 ,  C07K14/505 ,  C07K14/535 ,  C07K14/59 ,  C12N15/85 ,  C12N15/86 ,  C12N15/902 ,  C12N2795/00011 ,  C12N2800/206 ,  C12N2840/20 ,  C12N2840/44

摘要： Methods and compositions are provided for expression of mammalian genes in culture. An amplifiable gene is introduced by homologous recombination in juxtaposition to a target gene, the resulting combination of amplifiable gene and target gene transferred to a convenient host and the target gene amplified by means of the amplifiable gene. The resulting expression host may then be grown in culture with enhanced expression of the target gene.

公开(公告)号：EP1437938A2

公开(公告)日：2004-07-21

申请号：EP02725849.0

申请日：2002-04-29

申请人： CELL GENESYS, INC.

发明人： CHANG, Betty ,  WU, Wei Wei ,  MACARTHUR, James ,  PATEL, Salil ,  JOOSS, Karin ,  MENDEZ, Michael

IPC分类号： A01N43/04 ,  A61K31/70 ,  C12N15/00 ,  C12N15/09 ,  C12N15/63 ,  C12N15/70 ,  C12N15/74

CPC分类号： C12N9/6435 ,  A61K48/00 ,  C07K14/78 ,  C12N2799/022 ,  C12N2799/025 ,  C12Y304/21007

摘要： The present invention provides anti-angiogenic compositions and methods, based on gene delivery vectors that include the coding sequence for an anti-angiogenic compound.

公开(公告)号：EP1318839A2

公开(公告)日：2003-06-18

申请号：EP01916717.0

申请日：2001-03-21

申请人： CELL GENESYS, INC.

发明人： YU, De-Chao ,  CHEN, Yu ,  HENDERSON, Daniel, R.

IPC分类号： A61K48/00 ,  C12N15/861 ,  A61P35/00

CPC分类号： A61K31/7048 ,  A61K38/09 ,  A61K38/212 ,  A61K48/0058 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2830/00 ,  C12N2830/001 ,  C12N2830/008 ,  C12N2830/85 ,  C12N2840/20 ,  C12N2840/203 ,  A61K2300/00

摘要： The invention provides methods of treating neoplasia using combinations of target cell-specific replication competent adenoviral vectors and chemotherapy, radiation therapy or combinations thereof. The adenoviral vectors are target cell-specific for the particular type of neoplasia for which treatment is necessary and the combination with the chemotherapy and/or radiation leads to synergistic treatment over existing adenoviral therapy or traditional chemotherapy and radiation therapy.

公开(公告)号：EP1129100A4

公开(公告)日：2003-01-15

申请号：EP99962651

申请日：1999-11-12

申请人： CELL GENESYS INC

发明人： MCGUINNESS RYAN ,  NALDINI LUIGI

IPC分类号： C12N15/09 ,  C12N7/00 ,  C12N15/867 ,  C07H21/00 ,  C07H21/04 ,  C12N5/10 ,  C12N15/00 ,  C12N15/63 ,  C12N15/70 ,  C12N15/74 ,  C12N15/86

CPC分类号： C12N15/86 ,  C12N2740/16052

公开(公告)号：EP1005534A4

公开(公告)日：2002-08-28

申请号：EP98939892

申请日：1998-08-07

申请人： CELL GENESYS INC

发明人： SYNDER RICHARD

IPC分类号： C12N15/09 ,  C12N5/10 ,  C12N15/864 ,  C07K14/015 ,  C12N15/10 ,  C12N15/63 ,  C12N15/64 ,  C12N15/86

CPC分类号： C12N15/86 ,  C12N2750/14143

摘要： The present invention relates to methods and compositions for increasing the production of high titer stocks or recombinant AAV (rAAV) through regulation of expression of the AAV REP and CAP proteins. The methods and compositions of the invention are based on the observation that the low level expression of the AAV REP 78/68 protein increases the production of AAV viral capsid protein and efficiency of packaging resulting in production of higher titer recombinant viral stocks. The invention encompasses recombinant AAV vectors that direct the expression of AAV REP and CAP proteins and the use of such vectors for the production of novel stable cell lines capable of generating high titer rAAV vectors. The invention provides methods for regulating the expression of the AAV REP 78/68, REP 40/52 and CAP gene at the transcriptional and post-transcriptional level.

公开(公告)号：EP1171624A4

公开(公告)日：2002-06-26

申请号：EP00926354

申请日：2000-04-26

申请人： CELL GENESYS INC

发明人： NALDINI LUIGI ,  DULL THOMAS ,  BUKOVSKY ANATOLY ,  FARSON DEBORAH ,  WITT ROCHELLE

IPC分类号： C12N15/09 ,  A61K35/76 ,  C12N7/00 ,  C12N15/48 ,  C12N15/867 ,  C12R1/93 ,  C12N15/63 ,  C12N15/64 ,  C12N15/86

CPC分类号： C12N15/86 ,  C12N2740/16043 ,  C12N2740/16045 ,  C12N2810/6081 ,  C12N2830/003

公开(公告)号：EP0904031A4

公开(公告)日：2002-05-02

申请号：EP97928725

申请日：1997-05-29

申请人： CELL GENESYS INC

发明人： SULLIVAN SEAN M ,  MENG XIAO-YING

IPC分类号： C12N15/09 ,  A61K9/127 ,  A61K31/26 ,  A61K31/74 ,  A61K31/785 ,  A61K47/48 ,  A61K48/00 ,  C08G69/26 ,  C08G73/02 ,  C08G85/00 ,  C12N15/88 ,  A61F2/00 ,  A61K31/795 ,  C08K5/09 ,  C08K5/10

CPC分类号： A61K9/1272 ,  A61K47/59 ,  A61K47/595 ,  A61K48/00 ,  C08G73/02 ,  C08G73/0213 ,  C12N15/88

摘要： Novel cationic polymers and cationic lipids, and methods of making and using the same, are provided. The cationic polymers and cationic lipids are useful for the delivery of nucleic acid polymers and oligomers to cells in vitro and in vivo.

公开(公告)号：EP1007637A4

公开(公告)日：2002-04-03

申请号：EP98915603

申请日：1998-04-14

申请人： CELL GENESYS INC ,  UNIV NORTH CAROLINA

发明人： SAMULSKI RICHARD J ,  XIAO XIAO ,  SNYDER RICHARD

IPC分类号： C12N15/09 ,  A61K48/00 ,  C07K14/075 ,  C12N5/10 ,  C12N7/00 ,  C12N7/01 ,  C12N15/864 ,  C12N15/10 ,  C12N15/63 ,  C12N15/64 ,  C12N15/86

CPC分类号： C12N15/86 ,  A61K48/00 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/10322 ,  C12N2710/10343 ,  C12N2750/14121 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14152

公开(公告)号：EP1171624A1

公开(公告)日：2002-01-16

申请号：EP00926354.2

申请日：2000-04-26

申请人： CELL GENESYS, INC.

发明人： NALDINI, Luigi ,  DULL, Thomas ,  BUKOVSKY, Anatoly ,  FARSON, Deborah ,  WITT, Rochelle

IPC分类号： C12N15/867 ,  C12N15/63 ,  C12N15/64 ,  C12N15/48

CPC分类号： C12N15/86 ,  C12N2740/16043 ,  C12N2740/16045 ,  C12N2810/6081 ,  C12N2830/003

摘要： Lentiviral vectors modified at the 5' LTR or both the 5' and 3' LTR are useful in the production of recombinant lentivirus vectors (See the Figure). Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the vector carrying the transgene enhances virus production. The vectors can contain inducible or conditional promoters.