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公开(公告)号：EP2162436A1
公开(公告)日：2010-03-17
申请号：EP08757142.8
申请日：2008-05-23
发明人： WU, Tom, Yao-Hsiang , JUTEAU, Helene , GALLANT, Michel , DUBE, Daniel , ROY, Patrick , ASPIOTIS, Renee , GRIMM, Erich, L. , LALIBERTE, Sebastien , CHEN, Austin
IPC分类号： C07D211/60 , A61K31/451 , A61K31/4523 , A61K31/5377 , A61P13/10 , A61P9/00 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
CPC分类号： C07D211/60 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D417/12
摘要： The present invention relates to piperidine-based renin inhibitor compounds having carboxylate or carboxylic acid terminal groups. The disclosed low molecular weight, orally active renin inhibitors are of non-peptide nature and have long duration of action. The compounds can be used in the treatment of cardiovascular events and renal insufficiency.
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42.发明公开[1,2,3]TRIAZOLYL SUBSTITUTED QUINOLINES AND COUMARINS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS 有权[1,2,3] - 三唑基 - 取代CHINO LINE AND AS香豆素白三烯生物合成抑制剂
公开(公告)号：EP2118093A4
公开(公告)日：2010-03-17
申请号：EP08714553
申请日：2008-02-05
发明人： DUCHARME YVES , FRENETTE RICHARD , FRIESEN RICHARD , GAGNON MARC , GAREAU YVES , GRIMM ERICH L , JUTEAU HELENE , LALIBERTE SEBASTIEN , MACKAY BRUCE
IPC分类号： C07D405/06 , A61K31/4192 , A61K31/422 , A61K31/427 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61P9/10 , A61P11/06 , A61P29/00 , A61P37/08 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
CPC分类号： C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
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公开(公告)号：EP2144871A1
公开(公告)日：2010-01-20
申请号：EP08733702.8
申请日：2008-03-31
发明人： O'SHEA, Paul , GOSSELIN, Francis
IPC分类号： C07C315/04 , C07B43/06 , C07C317/32 , A61P19/10 , A61K31/277 , A61P35/04
CPC分类号： C07C315/04 , C07C2601/02 , C07C317/32
摘要： This invention describes an amidation process whereby amino acids of the Formulae IIA or IIB can be activated and treated with an amine in the presence of a base to yield amides of the Formula (I), without loss of optical purity.
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公开(公告)号：EP2132173A1
公开(公告)日：2009-12-16
申请号：EP08725987.5
申请日：2008-02-22
发明人： PARENT, Wayne , AFAGHI, Mahtab , BRESLIN, David , GRANGER, Mireille , WANG, Lei , ZIMMERMAN, Jeff
IPC分类号： C07D209/42
CPC分类号： A61K31/277 , A61K9/0019 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K9/4866 , A61K31/165 , C07D209/42
摘要： The instant invention relates to pharmaceutical compositions comprising cathepsin K inhibitors as the active ingredient with excipients which include binders, diluents, lubricants, and disintegrants. Also disclosed are processes for making said pharmaceutical compositions for oral and intravenous delivery.
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公开(公告)号：EP1912977A4
公开(公告)日：2009-10-21
申请号：EP06761196
申请日：2006-07-28
发明人： COLUCCI JOHN , HAN YONGXIN , FARAND JULIE A
IPC分类号： C07D413/06 , A61K31/5355 , A61P19/00 , A61P19/08 , A61P19/10 , A61P27/02
CPC分类号： C07D413/06
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46.发明公开2-(PHENYL OR HETEROCYCLIC)-1H-PHENANTRHO[9,10-D]IMIDAZOLES AS MPGES-1 INHIBITORS 有权2-（苯基或杂环基）-1H- PHENANTRO [9,10，D〕咪唑ALS的mPGES-1抑制剂
公开(公告)号：EP1828143A4
公开(公告)日：2009-08-26
申请号：EP05823957
申请日：2005-12-15
发明人： CHAU ANH , COTE BERNARD , DUCHARME YVES , FRENETTE RICHARD , FRIESEN RICHARD , GAGNON MARC , GIROUX ANDRE , MARTINS EVELYN , YU HONGPING , WU TOM
IPC分类号： C07D235/02 , A61K31/4164 , A61K31/4439 , C07D401/04 , C07D403/04
CPC分类号： C07D401/14 , C07D235/02 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/06 , C07D413/06
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47.发明公开AZETIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE 审中-公开氮杂环丁烷，硬脂酰辅酶AΔ9去饱和酶的抑制剂
公开(公告)号：EP2032566A4
公开(公告)日：2009-07-08
申请号：EP07719942
申请日：2007-06-08
发明人： ISABEL ELISE , OBALLA RENATA , POWELL DAVID , ROBICHAUD JOEL
IPC分类号： C07D413/14 , A61K31/427 , A61K31/501 , A61P3/06 , C07D403/04 , C07D417/04
CPC分类号： C07D401/04 , C07D403/04 , C07D403/14 , C07D413/14 , C07D417/04
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48.发明公开
公开(公告)号：EP1989187A4
公开(公告)日：2009-07-08
申请号：EP07719387
申请日：2007-02-22
发明人： CHAU ANH , COTE BERNARD , DUCHARME YVES , FRENETTE RICHARD , FRIESEN RICHARD , GAGNON MARC , GIROUX ANDRE , MARTINS EVELYN , YU HONGPING , HAMEL PIERRE
IPC分类号： C07D235/02 , A61K31/4184 , A61P29/00
CPC分类号： C07D235/02 , C07D401/04 , C07D403/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
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公开(公告)号：EP1487797B1
公开(公告)日：2009-05-27
申请号：EP03744288.6
申请日：2003-03-17
发明人： GALLANT, Michel , LACOMBE, Patrick , DUBE, Daniel , DESCHENES, Denis , MACDONALD, Dwight , DUBE, Laurence
IPC分类号： C07D215/04 , C07D215/12 , C07D215/14 , C07D401/06 , C07D409/14 , C07D401/12 , C07D417/12 , C07D409/12 , C07D401/14 , C07D413/12 , C07D487/04 , A61K31/47 , A61K31/4709 , A61P11/00 , A61P25/00
CPC分类号： C07D215/04 , C07D215/12 , C07D215/14 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D487/04
摘要： 8-arylquinolines wherein the aryl group at the 8-position contains a meta one or two atom bridge to a phenyl, 5 or 6 member heteroaryl or fused bicyclic heteroaryl group, and wherein at least one of the bridge atoms is not carbon, are PDE4 inhibitors.
摘要翻译： 其中8-位上的芳基包含与苯基，5或6元杂芳基或稠合双环杂芳基的间位一个或两个原子桥，并且其中至少一个桥原子不是碳，是PDE4 抑制剂。
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50.发明公开
公开(公告)号：EP1989187A1
公开(公告)日：2008-11-12
申请号：EP07719387.8
申请日：2007-02-22
发明人： CHAU, Anh , COTE, Bernard , DUCHARME, Yves , FRENETTE, Richard , FRIESEN, Richard , GAGNON, Marc , GIROUX, Andre , MARTINS, Evelyn , YU, Hongping , HAMEL, Pierre
IPC分类号： C07D235/02 , A61K31/4184
CPC分类号： C07D235/02 , C07D401/04 , C07D403/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要： The invention encompasses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
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