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公开(公告)号：EP0179338B1
公开(公告)日：1993-08-11
申请号：EP85112621.9
申请日：1985-10-04
申请人： AJINOMOTO CO., INC.
CPC分类号： C12N15/52 , C12N15/77 , C12P13/08 , C12P13/22 , Y10S435/84
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42.发明授权Process for producing L-glutamic acid by fermentation and mutant microorganisms for use therein 失效通过发酵和突变微生物生产L-谷氨酸的方法
公开(公告)号：EP0350971B1
公开(公告)日：1993-06-16
申请号：EP89115776.0
申请日：1984-02-24
发明人： Hattori, Kiyoji c/o Patent Department , Kotani, Yukinobu c/o Patent Department , Kino, Kuniki c/o Patent Department
CPC分类号： C12R1/14 , C12P13/14 , C12R1/15 , Y10S435/84 , Y10S435/843
摘要： A fermentation process is disclosed for producing L-glutamic acid in high yield using microorganisms belonging to the genus Corynebacterium or Brevibacterium having the ability to produce L-glutamic acid and which have or have been endowed with a resistance to one or more antibiotics of the type which inhibit energy metabolism and selected from oligomycin, antimycin A, rutamycin, and valinomycin.
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43.发明授权Recombinant DNA, bacteria carrying said recombinant DNA and a process for producing l-threonine or l-isoleucine using said bacteria 失效重组DNA，携带重组DNA的细菌和使用真菌细菌产生L-苏氨酸或L-精氨酸的方法
公开(公告)号：EP0137348B1
公开(公告)日：1991-12-04
申请号：EP84111003.4
申请日：1984-09-14
申请人： AJINOMOTO CO., INC.
发明人： Nakamori, Shigeru , Takagi, Hiroshi , Ishida, Masaaki , Sato, Takaaki , Miwa, Kiyoshi , Sano, Konosuke
CPC分类号： C12P13/08 , C12N9/12 , C12N15/77 , C12P13/06 , Y10S435/84 , Y10S435/843
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公开(公告)号：EP0215414B1
公开(公告)日：1991-11-21
申请号：EP86112399.0
申请日：1986-09-08
申请人： Kuraray Co., Ltd.
IPC分类号： C12P13/22
CPC分类号： C12P13/222 , Y10S435/84 , Y10S435/843 , Y10S435/872
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45.发明公开
公开(公告)号：EP0430555A1
公开(公告)日：1991-06-05
申请号：EP90312647.2
申请日：1990-11-21
发明人： Kise, Shoichi, c/o Mitsui Petrochemical Ind. Ltd. , Hayashida, Mikio, c/o Mitsui Petrochemical Ind. , Ori, Aiichiro, c/o Mitsui Petrochemical Ind. , Hiratsuka, Junzou, c/o Mitsui Petrochemical Ind. , Yamada, Hideaki
CPC分类号： C12P41/005 , C12P17/04 , Y10S435/822 , Y10S435/839 , Y10S435/84 , Y10S435/939
摘要： A process for preparing (+)-homopilopic acid and the salts thereof which comprises hydrolyzing a mixture of (+)-homopilopic acid ester of the general formula (I):
wherein R₁ denotes a straight or branched C₁-C₁₀ hydrocarbon, and (-)-homopilopic acid ester of the general formula (II):
wherein R₂ denotes a straight or branched C₁-C₁₀ hydrocarbon, in the presence of a culture, cells, culture supernatant or treated matter of a microorganism belonging to the genus Arthrobacter , Aspergillus , Escherichia , Cunninghamella , Xanthomonas , Candida , Pseudomonas , Serratia , Cellulomonas , Nocardia , Bacillus , Brevibacterium , Flavobacterium , Mycobacterium , Rhizomucor , Rhodotorula or Rhodococcus .摘要翻译： 制备（+） - 均二酸及其盐的方法，其包括水解通式（I）的（+） - 高二酸酯的混合物：其中R 1表示直链或支链C 1 -C 10烃， 和（ - ） - 通式（II）的高磷酸酯：
其中R2表示直链或支链C1-C10烃，在培养物存在下，细胞，培养物上清液或属于 节杆菌属，曲霉属，埃希氏杆菌属，坎宁汉菌属，黄单胞菌属，假丝酵母属，假单胞菌属，沙雷氏菌属，纤维单胞菌属，诺卡氏菌属，芽孢杆菌属，短杆菌属，黄杆菌属，分枝杆菌属，根霉属，红酵母属或红球菌属。 -
公开(公告)号：EP0312089A3
公开(公告)日：1990-04-25
申请号：EP88117119.3
申请日：1988-10-14
发明人： Terasawa, Masato c/o Central Research Lab. , Nara, Terukazu c/o Central Research Lab. , Fukushima, Makiko c/o Central Research Lab. , Satoo, Yukie c/o Central Research Lab. , Shimazu, Mitsunobu c/o Central Research Lab. , Yukawa, Hideaki c/o Central Research Lab. , Kurusu, Yasurou c/o Central Research Lab. , Kohama, Keiko c/o Central Research Lab.
CPC分类号： C12P13/08 , C12N15/52 , C12N15/77 , Y10S435/84
摘要： A method for producing L-threonine, which comprises subjecting at least L- or DL-aspartic acid or a salt thereof to enzymatic reaction according to the reaction system not accompanied with growth of microorganism cells in an aqueous solution in the presence of a microorganism and collecting L-threonine formed, wherein the microorganism is a biotin-requiring microorganism for the growth belonging to coryneform bacterium; a plasmid comprising a DNA fragment containing at least a gene encoding biosynthesis of threonine which can be expressed within a biotin-requiring microorganism cell for the growth belonging to coryneform bacterium and a DNA fragment containing a gene encoding autonomous replication within coryneform bacterium cell; and a biotin-requiring microorganism for the growth belonging to coryneform bacterium which has been transformed with the plasmid described above, both of which are employed in the present method. According to the present invention, L-threonine can be produced with good yield, and further since production management becomes extremely easy without requiring cumbersome operation such as sterilization of the medium, etc. as in the fermentation method, L-threonine can be produced inexpensively in industry.
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47.发明公开Process for producing L-glutamic acid by fermentation and mutant microorganisms for use therein 失效一种用于通过发酵生产L-谷氨酸和使用，突变微生物处理。
公开(公告)号：EP0350970A1
公开(公告)日：1990-01-17
申请号：EP89115775.2
申请日：1984-02-24
发明人： Hattori, Kiyoji c/o Patent Department , Kotani, Yukinobu c/o Patent Department , Kino, Kuniki c/o Patent Department
CPC分类号： C12R1/14 , C12P13/14 , C12R1/15 , Y10S435/84 , Y10S435/843
摘要： A fermentation process is disclosed for producing L-glutamic acid in high yield using microorganisms belonging to the genus Corynebacterium or Brevibacterium having the ability to produce L-glutamic acid and which have or have been endowed with a resistance to one or more antibiotics of the type which inhibit energy metabolism and selected from oligomycin, antimycin A, rutamycin, and valinomycin.
摘要翻译： 发酵方法是圆盘游离缺失利用属于棒杆菌属或短杆菌具有生产L-谷氨酸并具有或已被赋予了阻力的类型的一种或多种抗生素的能力的微生物以高收率生产L-谷氨酸 抑制能量代谢和寡，抗霉素A，rutamycin和真菌霉素选择。
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48.发明公开Verfahren zur fermentativen Herstellung von L-Isoleucin aus D,L-alpha-Hydroxybutyrat 失效通过从D，L-ALPHA-羟基丁酸酯发酵L-精氨酸制备的方法
公开(公告)号：EP0248238A3
公开(公告)日：1989-06-14
申请号：EP87106872.2
申请日：1987-05-12
发明人： Scheer, Elisabeth , Sahm, Hermann, Prof. , Eggeling, Lothar, Dr. , Kircher, Manfred, Dr. , Leuchtenberger, Wolfgang, Dr.
CPC分类号： C12R1/15 , C12P13/06 , Y10S435/84 , Y10S435/843
摘要： Die Erfindung betrifft ein Verfahren zur fermentativen Herstellung von L-Isoleucin aus D,L-α-Hydroxybutyrat durch D-Lactat verwertende Mutanten der Gattung Corynebacterium.
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49.发明公开Method for the production of ribavirin using high ribose donor concentrations 失效Verfahren zur Herstellung von Ribavirin unter Verwendung von hohen Ribose-Donor-Konzentrationen。
公开(公告)号：EP0307853A2
公开(公告)日：1989-03-22
申请号：EP88114937.1
申请日：1988-09-13
IPC分类号： C12P19/28
CPC分类号： C12P19/38 , Y10S435/84
摘要： A method for the production of a 1,2,4-triazole nucleoside comprising the step of reacting a ribose donor with a triazole compound in the presence of an enzyme preparation derived from Brevibacterium acetylicum is disclosed. The method is characterized in that the ribose donor is guanosine; the concentration of the donor is above 100 mM; and the enzyme preparation is added before the reaction mixture gells. The method is capable of high production rates and high concentrations of the final product.
摘要翻译： 公开了一种制备1,2,4-三唑核苷的方法，包括在衍生自乙酰微小杆菌的酶制剂存在下使核糖供体与三唑化合物反应的步骤。 该方法的特征在于核糖供体是鸟苷; 供体的浓度高于100mM; 在反应混合物凝胶化之前加入酶制剂。 该方法具有高生产率和高浓度的最终产品。
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50.发明公开
公开(公告)号：EP0248622A2
公开(公告)日：1987-12-09
申请号：EP87304829.2
申请日：1987-06-01
发明人： Terasawa, Masato , Satoo, Yukie , Yukawa, Hideaki
CPC分类号： C12P13/08 , C12N9/90 , C12P13/06 , Y10S435/84
摘要： An aqueous culture medium is prepared containing preferably ethanol and/or glucose as carbon sources and inorganic salts and 0-l-20 w/v of L- or DL-homoserine; cells of biotin requiring microorganism of genus Brevibacterium , exemplified as 4 strains of Brevibacterium flavum, ammonigenes or divaricatum ,or an immobilized form of these cells are added and they provide enzyme to convert the homoserine to L-threonine by racemization during cultivation at 20 to 50°C for l0 to 72 hours; L-threonine is separated and purified.
The homoserine can be obtained as residue from enzymatic racemization of DL-homoserine using e.g. a Pseudomonas putida strain.摘要翻译： 制备的水性培养基优选含有乙醇和/或葡萄糖作为碳源和无机盐和0-120w / v的L-或DL-高丝氨酸; 添加需要微生物的生物素的细胞，例如作为4种黄色短杆菌，氨基酸或裂殖酵母或这些细胞的固定形式，并且它们提供酶，以在20至50培养期间通过外消旋将高丝氨酸转化为L-苏氨酸 DEG为10〜72小时; L-苏氨酸被分离和纯化。 高丝氨酸可以通过DL-高丝氨酸的酶外消旋化获得作为残基。 恶臭假单胞菌（Pseudomonas putida）菌株。
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