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公开(公告)号：EP3294333B1
公开(公告)日：2020-09-02
申请号：EP16721176.2
申请日：2016-05-09
申请人： Biontech Cell&Gene Therapies GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , SIMON, Petra , OMOKOKO, Tana , BREITKREUZ, Andrea , MROZ, Karolina Anna , HEBICH, Lisa
IPC分类号： C12N9/12 , A61K39/00 , C07K14/705 , C07K16/28 , C07K14/725 , C07K7/06 , A61P35/00 , A61P37/04
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公开(公告)号：EP2847225B1
公开(公告)日：2019-11-27
申请号：EP13721596.8
申请日：2013-05-06
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , MITNACHT-KRAUS, Rita , WÖLL, Stefan
IPC分类号： C07K16/30
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公开(公告)号：EP3421496A1
公开(公告)日：2019-01-02
申请号：EP18179328.2
申请日：2012-04-20
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , WALTER, Korden , WÖLL, Stefan , KREUZBERG, Maria , HUBNER, Bernd , ERDELJAN, Michael , WEICHEL, Michael
IPC分类号： C07K16/30 , A61K39/395 , C07K16/28 , A61K39/00
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLDN6, including tumor- related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
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公开(公告)号：EP2152754B8
公开(公告)日：2018-07-04
申请号：EP08758782.0
申请日：2008-05-27
申请人： Ganymed Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , BRANDENBURG, Gunda , USENER, Dirk
IPC分类号： C07K16/30 , A61K39/395 , A61P35/00 , C12N5/12
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/30 , C07K16/3046 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, cancer of the gallbladder, and the metastases thereof.
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公开(公告)号：EP3283521A1
公开(公告)日：2018-02-21
申请号：EP16715583.7
申请日：2016-04-13
申请人： Ganymed Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , WALTER, Korden , KREUZBERG, Maria , MITNACHT-KRAUS, Rita , LE GALL, Fabrice , JACOBS, Stefan
CPC分类号： A61K47/6859 , A61K31/40 , A61K47/6803 , A61K47/6849 , A61K47/6863 , A61K2039/505 , A61K2039/627 , A61P35/00 , A61P35/04 , C07K16/28 , C07K16/303 , C07K16/3046 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要： The present invention provides anti-CLDN18.2 antibody-drug conjugates which are effective for treating and/or preventing cancer diseases associated with cells expressing CLDN18.2, including gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.
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公开(公告)号：EP3213765A3
公开(公告)日：2017-09-20
申请号：EP17165403.1
申请日：2011-09-19
申请人： BioNTech Cell & Gene Therapies GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , SIMON, Petra , OMOKOKO, Tana
IPC分类号： A61K39/00 , C07K14/705 , C07K14/47 , C07K14/045
CPC分类号： A61K39/0011 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/4748 , C07K14/705 , C07K14/70503 , C07K14/7051 , C12N5/0636 , C12N9/16 , C12N15/85 , C12N2510/00 , C12N2710/16134 , C12Y301/03048 , G01N33/5017 , G01N2333/916
摘要： The present invention relates to efficient methods for providing antigen- specific lymphoid cells. These lymphoid cells may be used to provide antigen specific T cell receptors having a defined MHC restriction and to identify immunologically relevant T cell epitopes. Furthermore, the present invention relates to antigen-specific T cell receptors and T cell epitopes and their use in immunotherapy.
摘要翻译： 本发明涉及用于提供抗原特异性淋巴细胞的有效方法。 这些淋巴细胞可用于提供具有限定的MHC限制的抗原特异性T细胞受体并鉴定免疫学相关的T细胞表位。 此外，本发明涉及抗原特异性T细胞受体和T细胞表位及其在免疫治疗中的用途。
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57.发明公开TUMOR VACCINATION INVOLVING A HUMORAL IMMUNE RESPONSE AGAINST SELF-PROTEINS 有权TUMORIMFPUNG麻醉师EINER HUMORALEN免疫GEGEN SELBSTPROTEINE
公开(公告)号：EP2547695A1
公开(公告)日：2013-01-23
申请号：EP11707355.1
申请日：2011-03-09
发明人： KLAMP, Thorsten , SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , HILLER, Thomas , SCHUMACHER, Jens
CPC分类号： C07K14/4748 , A61K39/0011 , A61K2039/5156 , A61K2039/523 , A61K2039/5258 , A61K2039/53 , A61K2039/57 , A61K2039/575 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N7/00 , C12N2730/10123 , C12N2730/10134 , C12N2730/10143 , C12N2730/10171
摘要： The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.
摘要翻译： 本发明涉及使用包含全部或部分乙型肝炎病毒核心抗原蛋白的嵌合蛋白和包含衍生自肿瘤相关抗原的细胞外部分的表位的氨基酸序列的肿瘤免疫治疗，特别是肿瘤免疫治疗。 特别地，本发明提供了包含所述嵌合蛋白的病毒样颗粒，其可用于在受试者中针对肿瘤相关抗原，特别是针对在其表面上携带所述肿瘤相关抗原的细胞引起体液免疫应答，其中 肿瘤相关抗原是所述受试者的自身蛋白质。
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58.发明公开VERWENDUNG VON FLT3-LIGAND ZUR VERSTÄRKUNG VON IMMUNREAKTIONEN BEI RNA-IMMUNISIERUNG 有权FLT3配体对增强免疫反应RNA免疫的使用
公开(公告)号：EP2370101A1
公开(公告)日：2011-10-05
申请号：EP09796949.7
申请日：2009-12-09
IPC分类号： A61K39/39 , C07K14/475
CPC分类号： A61K39/39 , A61K2039/53 , A61K2039/55516 , C07K14/475 , C07K2319/00
摘要： The invention relates to supplying vaccine RNA to cells. The invention relates in particular to a common use of vaccine RNA and Flt3 ligand for inducing, creating or enhancing an immune response when administered to animals (including humans).
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59.发明公开
公开(公告)号：EP4364756A3
公开(公告)日：2024-07-31
申请号：EP24150410.9
申请日：2013-05-21
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , MITNACHT-KRAUS, Rita , JACOBS, Denis Stefan , UTSCH, Magdalena Jadwiga , HEINZ, Cornelia Adriana Maria , STADLER, Christiane Regina
IPC分类号： A61K39/395 , C07K16/30 , A61K45/06 , A61P35/00
CPC分类号： A61K39/39558 , A61K45/06 , C07K16/30 , C07K16/3046 , A61K2039/50520130101 , A61P35/00 , C07K2317/73220130101 , C07K2317/7320130101 , C07K2317/73420130101
摘要： The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.
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公开(公告)号：EP4285911A2
公开(公告)日：2023-12-06
申请号：EP23200924.1
申请日：2010-02-19
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , HELFTENBEIN, Gerd , KORDEN, Walter , WÖLL, Stefan , OPREA, Gabriela-Elena
IPC分类号： A61K31/7088
摘要： The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of tumor tissues such as ovarian tumor and lung tumor tissues and which represent targets for therapy or diagnosis of tumor diseases in a subject.
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