公开(公告)号：EP0938307A1

公开(公告)日：1999-09-01

申请号：EP97941585.0

申请日：1997-09-15

申请人： MERCK & CO., INC.

发明人： BILLS, Gerald, F. ,  DOMBROWSKI, Anne, W. ,  HORN, Wendy, S. ,  JANSSON, Richard, K. ,  RATTRAY, Mark ,  SCHMATZ, Dennis ,  SCHWARTZ, Robert, E.

IPC分类号： A01N45 ,  A01N63 ,  C07H15 ,  C12N1 ,  C12P17 ,  C12P19 ,  C12R1

CPC分类号： C07H15/18 ,  A01N45/00 ,  A01N63/04 ,  C12N1/14 ,  C12P17/06 ,  C12P17/18 ,  C12P17/185 ,  C12P19/56

摘要： Sordarin and derivatives thereof have protective and systemic effects against phytopathogenic fungi in crops.

公开(公告)号：EP0931082A1

公开(公告)日：1999-07-28

申请号：EP97941580.0

申请日：1997-09-15

申请人： Merck & Co., Inc. (a New Jersey corp.)

发明人： MEINKE, Peter, T. ,  SHIH, Thomas ,  FISHER, Michael, H.

IPC分类号： A23K1 ,  A01N43 ,  A01N49 ,  A61K31 ,  A61P33 ,  C07D491

CPC分类号： C07D491/14 ,  A01N49/00 ,  A61K31/405 ,  A61K31/415 ,  A61K31/44 ,  A61K31/165 ,  A61K2300/00

摘要： The present invention relates to novel nodulisporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.

摘要翻译： 本发明涉及新颖的球孢子酸衍生物，其为杀螨剂，抗寄生虫剂，杀虫剂和驱虫剂。

公开(公告)号：EP0931066A1

公开(公告)日：1999-07-28

申请号：EP97942446.0

申请日：1997-09-12

申请人： MERCK & CO., INC.

发明人： DORZIOTIS, Ilias, K. ,  HOUPIS, Ioannis, N. ,  LEE, Jaemoon ,  VOLANTE, Ralph, P.

IPC分类号： B01J31 ,  C07B61 ,  C07D213

CPC分类号： C07D213/16 ,  C07D213/30

摘要： This invention is concerned with a novel process for the preparation of a compound of structural formula (I) wherein R?1 and R2¿ independently are aryl, C¿2-15? alkenyl or C1-15 alkyl, either unsubstituted or substituted with one or three substituents, which can be the same or different, selected from the group consisting of Ra, wherein Ra belongs to a group consisting of C1-6 alkyl, aryl, halo, -N(R?3)¿2, -NO2, -CN, -OR3, -C¿3-6? cycloalkoxy, -CO(R?3¿), -COOR3, SO2R3 and -SR3; wherein R3 is selected from the group consisting of hydrogen, C¿1-6? alkyl, C2-6 alkenyl and aryl, said alkyl, alkenyl or aryl optionally substituted with 1 to 3 groups of R?a¿, which is an important antiasthmatic agent.

公开(公告)号：EP0896628A1

公开(公告)日：1999-02-17

申请号：EP97920222.0

申请日：1997-04-07

申请人： MERCK & CO., INC.

发明人： ZHANG, Jinyou ,  GREASHAM, Randolph, L.

IPC分类号： C12N1 ,  C12N15

CPC分类号： C12N1/18 ,  C12N1/16 ,  C12N15/81

摘要： Yields in yeast recombinant expression systems are improved by identifying bad lots of yeast extract that are to be used in the culture medium and supplementing the lots of yeast extract with the appropriate combination of adenine, trehalose, and/or lactate.

公开(公告)号：EP0871481A1

公开(公告)日：1998-10-21

申请号：EP96940252.0

申请日：1996-10-23

申请人： MERCK & CO., INC.

发明人： HICKEY, Gerard, J. ,  MOHN, Kenneth, L.

IPC分类号： A61K39 ,  A61K31 ,  A61K47 ,  A61K51 ,  A61P15 ,  A61P35 ,  C07K7 ,  C07K14 ,  C07K16

CPC分类号： C07K14/21 ,  A61K39/00 ,  A61K47/646 ,  C07K7/23

摘要： Pseudomonas exotoxin and variants thereof are potent immunogenic carrier proteins for GnRH. Vaccines containing a GnRH associated with Pseudomonas exotoxin are capable of eliciting high titres of anti-GnRH antibodies in animals, and are therefore useful for controlling fertility, reducing undesirable reproductive hormone driven behaviors, and treating sex steroid responsive tumors.

公开(公告)号：EP0861025A1

公开(公告)日：1998-09-02

申请号：EP96938745.0

申请日：1996-11-04

申请人： MERCK & CO., INC.

发明人： LESCOTA, Regina, D. ,  MOOKERJEE, Pradip, K. ,  PETERSON, Robert, F.

IPC分类号： A01N25 ,  A01N43

CPC分类号： A01N25/12 ,  A01N43/90 ,  A01N25/30 ,  A01N25/08 ,  A01N2300/00

摘要： The present invention is directed to a pesticidal composition of a water-soluble pesticide and processes for its manufacture. More specifically, the invention relates to a soluble granule (SG) pesticidal formulation comprising a water-soluble pesticide and a water-soluble filler. The present invention provides a pesticidal formulation with efficacy equal to the corresponding liquid formulation, yet with improved handler safety, such as lower eye irritation.

公开(公告)号：EP0859624A1

公开(公告)日：1998-08-26

申请号：EP96936921.0

申请日：1996-10-23

申请人： MERCK & CO., INC.

发明人： TOLMAN, Richard, L. ,  LOMBARDO, Victoria, K.

IPC分类号： A61K38 ,  A61K31 ,  A61K39 ,  A61K47 ,  A61P15 ,  A61P35 ,  C07K1 ,  C07K7 ,  C07K14 ,  C07K17 ,  C07K19

CPC分类号： A61K39/0006 ,  A61K38/00 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/6037 ,  A61K2039/627 ,  C07K7/23 ,  C07K14/21

摘要： Conjugates of GnRH are constructed from GnRH or an analog thereof, a reduced Pseudomonas exotoxin, or a variant thereof, and a unique linking group. The conjugates are administered to male and female animals to sterilize said animals or to reduce tumors that require sex steroids for growth. The instant conjugates are therefore useful as sterilizing agents and anticancer agents.

公开(公告)号：EP0858444A1

公开(公告)日：1998-08-19

申请号：EP96941315.0

申请日：1996-10-15

申请人： MERCK & CO., INC.

发明人： FINKE, Paul, E. ,  MacCOSS, Malcom ,  MEURER, Laura, C. ,  MILLS, Sander, G. ,  CALDWELL, Charles, G. ,  CHEN, Ping ,  DURETTE, Philippe, L. ,  HALE, Jeffery ,  HOLSON, Edward ,  KOPKA, Ihor ,  ROBICHAUD, Albert

IPC分类号： A61K31 ,  A61P1 ,  A61P11 ,  A61P25 ,  A61P29 ,  A61P43 ,  C07C43 ,  C07C62 ,  C07C69 ,  C07C217 ,  C07C229 ,  C07C233 ,  C07C237 ,  C07C265 ,  C07C271 ,  C07C275 ,  C07D207 ,  C07D209 ,  C07D211 ,  C07D213 ,  C07D215 ,  C07D233 ,  C07D239 ,  C07D249 ,  C07D257 ,  C07D261 ,  C07D263 ,  C07D271 ,  C07D277 ,  C07D295 ,  C07D307 ,  C07D333 ,  C07D401 ,  C07D403 ,  C07D405 ,  C07D413 ,  C07D417 ,  C07D513 ,  C07D521 ,  C07J73

CPC分类号： C07J73/006 ,  C07C69/757 ,  C07C217/52 ,  C07C229/48 ,  C07C233/81 ,  C07C237/06 ,  C07C2601/08 ,  C07D207/16 ,  C07D207/26 ,  C07D209/08 ,  C07D211/14 ,  C07D211/58 ,  C07D211/62 ,  C07D213/38 ,  C07D213/61 ,  C07D215/18 ,  C07D215/20 ,  C07D231/12 ,  C07D233/56 ,  C07D233/86 ,  C07D239/26 ,  C07D249/08 ,  C07D249/12 ,  C07D257/04 ,  C07D261/08 ,  C07D271/06 ,  C07D271/10 ,  C07D277/28 ,  C07D277/64 ,  C07D307/52 ,  C07D307/64 ,  C07D307/92 ,  C07D333/20 ,  C07D333/32 ,  C07D333/38 ,  C07D401/04 ,  C07D403/12 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D513/04

摘要： The present invention is directed to certain novel compounds represented by structural formula (I) or a pharmaceutically acceptable salt thereof, wherein R?3, R6, R7, R8, R11, R12, R13¿, A, Q, W, X, Y, Z and n are defined herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulation in the treatment of certain disorders. The compounds of this invention are tachykinin receptor antagonists and are useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis.

摘要翻译： 本发明涉及由结构式（I）表示的某些新化合物或其药学上可接受的盐，其中R 3，R 6，R 7，R 8，R 11，R 12，R 13，A，Q，W，X，Y Z和n在本文中定义。 本发明还涉及包含这些新化合物作为活性成分的药物制剂以及该新化合物及其制剂在治疗某些病症中的用途。 本发明化合物是速激肽受体拮抗剂，可用于治疗炎性疾病，疼痛或偏头痛，哮喘和呕吐。

公开(公告)号：EP0840733A1

公开(公告)日：1998-05-13

申请号：EP96925277.0

申请日：1996-07-08

申请人： MERCK & CO., INC.

发明人： CHENG, Chen, Y. ,  LARSEN, Robert, D. ,  McCAULEY, James, A. ,  VANDRILLA, Jennifer, L. ,  VERHOEVEN, Thomas, R.

IPC分类号： C07D403 ,  A61K31 ,  A61P25 ,  A61P43 ,  C07D521

CPC分类号： C07D249/08 ,  A61K31/4196 ,  C07D231/12 ,  C07D233/56

摘要： The bisulfate salt of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine is a selective agonist of 5-HT1-like receptors and is useful in the treatment of migraine and associated disorders.

公开(公告)号：EP0837863A1

公开(公告)日：1998-04-29

申请号：EP96919036.0

申请日：1996-06-03

申请人： MERCK & CO., INC.

发明人： BRENNER, Gerald, S. ,  OBERHOLTZER, Earl, R., Jr. ,  THIES, J., Eric

IPC分类号： A61K31 ,  A61P43 ,  C07F9

CPC分类号： A61K31/663 ,  C07F9/3873

摘要： Disclosed is a method for treating and for preventing bone loss in patients by administering a formulation of 4-amino-1-hydroxy-butylidene-1,1-bisphophonic acid, disodium salt, or its hydrates. Also described is a pharmaceutical composition containing said disodium salt in a pharmaceutically acceptable excipient.

摘要翻译： 本发明公开了通过给予4-氨基-1-羟基 - 亚丁基-1,1-双膦酸，二钠盐或其水合物的制剂来治疗和预防患者骨丢失的方法。 还描述了在药学上可接受的赋形剂中含有所述二钠盐的药物组合物。