公开(公告)号：EP1535074A1

公开(公告)日：2005-06-01

申请号：EP03735191.3

申请日：2003-07-10

申请人： Cryptome Pharmaceuticals Ltd.

发明人： SMITH, Alexander, Ian ,  BERNDT, Michael ,  AUTELITANO, Dominic ,  CSAR, Xavier ,  TALBO, Gert, Hoy

IPC分类号： G01N33/68 ,  G01N33/86 ,  C12N9/76 ,  C12Q1/66 ,  C12Q1/56 ,  C07K1/36 ,  C07K17/02 ,  C07K14/75

CPC分类号： C40B30/04 ,  C07K14/75 ,  C07K14/765

摘要： A method for the detection of bioactive peptides derived from a precursor protein or protein-containing biological extract, comprising the steps of: (i) providing a library of peptides derived from said precursor protein or protein-containing biological extract; (ii) optionally screening said library to confirm that it includes peptides exhibiting one or more biological activities; (iii) separating said library to provide fractions of the library; (iv) screening said fractions to identify active fractions which include peptides exhibiting said one or more biological activities; (v) optionally separating each said active fraction to provide sub-fractions thereof, and screening said sub-fractions to identify active sub-fractions which include peptides exhibiting said one or more biological activities; and (vi) isolating from said active fractions or active sub-fractions one or more peptides exhibiting said one or more biological activities.

公开(公告)号：EP1530571A1

公开(公告)日：2005-05-18

申请号：EP03751901.4

申请日：2003-08-25

申请人： Gambro, Inc.

发明人： LOCKERBIE, Robert, Owen ,  KUMAR, Vijay ,  KEIL, Shawn, D. ,  GOODRICH, Raymond, P.

IPC分类号： C07D475/14 ,  A61L2/00 ,  A61L2/08 ,  A61L2/10

CPC分类号： A61L2/0082 ,  A61K41/0019 ,  A61L2/0011 ,  A61M1/3681 ,  A61M1/3683

摘要： A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process comprises adding to the blood or blood component containing pathogens an effective amount of riboflavin, and exposing the fluid to light of an appropriate wavelength to damage the nucleic acid of the pathogen and to substantially maintain the damage to the pathogenic nucleic acids to allow for subsequent transfusion into a recipient.

摘要翻译： 一种损害和维护病原体核酸如血液或血液成分中可能含有的白细胞，细菌和病毒的损害的方法。 该方法包括向含有病原体的血液或血液成分中加入有效量的核黄素，并将该液体暴露于适当波长的光以损害病原体的核酸，并基本维持致病性核酸的损伤，以允许 随后输血到接受者。

公开(公告)号：EP1470164A1

公开(公告)日：2004-10-27

申请号：EP03700080.9

申请日：2003-01-08

申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION ,  Orica Australia Pty Ltd

发明人： ELDRIDGE, Robert, James ,  NORRET, Marck ,  DAHLKE, Thomas, W. ,  BALLARD, Mathew, John ,  ADAMS, Beryn, John

IPC分类号： C08F2/44 ,  C08K3/22

CPC分类号： C08K3/22 ,  C08F2/08 ,  C08F2/44 ,  C08F8/32 ,  C08F220/32

摘要： The invention provides a process for preparing polymeric beads of complexing resin incorporating magnetic particles, which process comprises: producing a dispersion having a continuous aqueous phase and a dispersed organic phase, said organic phase comprising one or more polymerisable monomers, magnetic particles and a dispersing agent for dispersing said magnetic particles in the organic phase; polymerising said one or more polymerisable monomers to form polymeric beads incorporating said magnetic particles, wherein said polymeric beads include amine groups capable of complexing a transition metal cation, or wherein said polymeric beads are reacted with one or more compounds to provide amine groups capable of complexing a transition metal cation, complexing resins prepared by this process, and polymeric beads of complexing resin comprising a polymer matrix having magnetic particles dispersed substantially uniformly therein, wherein the polymer matrix incorporates amine groups capable of complexing a transition metal cation.

公开(公告)号：EP1456359A2

公开(公告)日：2004-09-15

申请号：EP02805649.7

申请日：2002-12-20

申请人： Gambro, Inc.

发明人： GOODRICH, Raymond, P.

IPC分类号： C12N7/04 ,  A61K39/00 ,  A61K39/02 ,  A61K39/12 ,  A61L2/08 ,  A61L2/16

CPC分类号： A61K41/0019 ,  A61K39/00 ,  A61K2039/521 ,  A61K2039/5252

摘要： Methods are provided for treating a vaccine containing infectious particles which may be viral, bacterial, and/or cellular in nature. Preferred methods include the steps of adding an effective, non-toxic amount of an endogenous photosensitizer to the fluid and exposing the fluid to photoradiation sufficient to inactivate the infectious particles but not enough to damage the antigenic characteristics of the infectious particles.

公开(公告)号：EP2909175B1

公开(公告)日：2017-06-07

申请号：EP13783363.8

申请日：2013-10-15

申请人： MACROPHAGE PHARMA LIMITED

发明人： PINTAT, Stéphane ,  DAVIES, Stephen, John ,  MOFFAT, David, Festus, Charles

IPC分类号： C07D213/73 ,  A61K31/4412 ,  A61P35/00 ,  A61P29/00

CPC分类号： C07D213/73

摘要： The present invention provides a metabolite produced by hydrolysis of the ester compound tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl)-L-alaninate, which is useful for inhibiting the activity of a p38 MAP kinase enzyme.

摘要翻译： 本发明提供的化合物是：N- [2- {4- [6-氨基-5-（2,4-二氟苯甲酰基）-2-氧代吡啶-1（2H） - 基] -3,5 - 二氟苯基}乙基）-L-丙氨酸酯或其盐，水合物或溶剂合物。 本发明还提供了包含该化合物以及一种或多种药学上可接受的载体和/或赋形剂的药物组合物。 该化合物和组合物可用于抑制p38 MAP激酶的活性。 如此，它们可用于治疗自身免疫性或炎性疾病或细胞增殖性疾病。 另外，本发明提供了通过水解本发明化合物的酯基产生的酸。 该酸是N- [2- {4- [6-氨基-5-（2,4-二氟苯甲酰基）-2-氧代吡啶-1（2H） - 基] -3,5-二氟苯基}乙基）-L-丙氨酸 。

公开(公告)号：EP2669297B1

公开(公告)日：2017-05-10

申请号：EP11857028.2

申请日：2011-03-25

申请人： Hefei TaiRui Biotechnology co., ltd.

发明人： JIN, Yanwen ,  WEAVER, David ,  RYNKIEWICZ, Michael ,  CAO, Cheng

IPC分类号： C07K16/28 ,  C12N15/13 ,  C12N5/10 ,  A61K39/395 ,  A61K48/00 ,  A61P35/00 ,  A61P43/00

CPC分类号： C07K16/30 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92

公开(公告)号：EP2283151B1

公开(公告)日：2017-03-08

申请号：EP09738409.3

申请日：2009-05-01

申请人： F2G Limited

发明人： OLIVER, Jason, David ,  THAIN, John, Leslie ,  BROMLEY, Michael, John ,  SIBLEY, Graham, Edward, Morris ,  BIRCH, Michael

IPC分类号： C12Q1/32 ,  C12N9/02 ,  C07D239/95 ,  A61P31/10

CPC分类号： C12Q1/32 ,  C07D239/95 ,  C12N9/001 ,  C12Y103/05002 ,  G01N2333/90206 ,  G01N2500/02

公开(公告)号：EP3102106A1

公开(公告)日：2016-12-14

申请号：EP15704080.9

申请日：2015-02-03

申请人： LIGHTSHIP MEDICAL LIMITED

发明人： CRANE, Barry Colin ,  BARWELL, Nicholas Paul ,  PATERSON, William

IPC分类号： A61B5/1495 ,  A61B5/145 ,  A61B5/1459

CPC分类号： A61B5/1495 ,  A61B5/14532 ,  A61B5/1459 ,  A61B2560/0233

摘要： A process for calibrating a glucose sensor under sterile conditions includes providing separate, sterile, glucose-containing calibration fluids, each having a different glucose concentration, and in turn providing these fluids to a sensing zone containing a sensing probe of a glucose sensor. Each solution is typically, in turn, propelled into the sensing zone, thus flushing out used fluid already present in the sensing zone. The process provides rapid calibration of a glucose sensor in a sterile fashion and is therefore appropriate for point-of-use calibration.

公开(公告)号：EP3071183A1

公开(公告)日：2016-09-28

申请号：EP14803195.8

申请日：2014-11-19

申请人： Oxford University Innovation Limited

发明人： KWAN, James ,  MYERS, Rachel ,  COUSSIOS, Constantin-Cassios ,  SHAH, Apurva

IPC分类号： A61K9/00 ,  A61K51/00 ,  A61K31/00

CPC分类号： A61K9/0009 ,  A61B8/0841 ,  A61K9/5138 ,  A61M37/0092 ,  C08L25/06 ,  C08L2203/02

摘要： The invention disclosed herein relates to a nanoparticle comprising: a cup having a cavity, and a gas pocket present in the cavity, wherein the gas pocket is partially encapsulated by the cup. Typical uses of the nanocups include initiating inertial cavitation during simultaneous exposure to ultrasound, and/or as drug carriers to achieve targeted drug delivery in response to ultrasound excitation.

公开(公告)号：EP3060255A1

公开(公告)日：2016-08-31

申请号：EP14790262.1

申请日：2014-10-21

申请人： Oxford University Innovation Limited

发明人： MO, Steven ,  CARLISLE, Robert Crispin ,  SEYMOUR, Leonard W. ,  COUSSIOS, Constantin-Cassios

IPC分类号： A61K41/00 ,  A61K47/48 ,  A61P35/00

CPC分类号： A61K41/0047 ,  A61K33/24 ,  A61K41/0028 ,  A61K47/48215 ,  A61K47/48884 ,  A61K47/60 ,  A61K47/6923 ,  A61K47/6929 ,  A61M37/0092 ,  A61M2037/0007

摘要： The invention disclosed herein relates to a method of cavitation-induced delivery of a therapeutic or diagnostic agent to a human or animal subject. In particular the invention provides an agent for use in a method of diagnosis or treatment of a human or animal subject, the method comprising exposing the subject to ultrasound, wherein the agent comprises a therapeutic or diagnostic component which is covalently bound to a dense component, the dense component having a density greater than that of the therapeutic or diagnostic component, and wherein either the dense component is a cavitation initiator or the method comprises administering to the subject a further agent which is a cavitation initiator. Binding of the dense component enhances cavitation-induced transport of the therapeutic or diagnostic component.