公开(公告)号：EP3458155A1

公开(公告)日：2019-03-27

申请号：EP17798468.9

申请日：2017-05-19

申请人： University Health Network ,  The Governing Council of the University of Toronto

发明人： WILSON, Brian ,  ALLEN, Christine

IPC分类号： A61N5/06 ,  A61K41/00 ,  C12N13/00 ,  C12N15/00

公开(公告)号：EP3004124B1

公开(公告)日：2018-12-26

申请号：EP14726580.5

申请日：2014-05-23

申请人： ARLANXEO Deutschland GmbH ,  The Governing Council of the University of Toronto

发明人： LUND, Clinton ,  STEPHAN, Douglas Wade ,  MCKINTY, Adam ,  ONG, Christopher ,  BOONE, Michael

IPC分类号： C07F15/00 ,  B01J31/00

CPC分类号： C07F15/0046 ,  B01J31/00 ,  B01J31/2265 ,  B01J31/2278 ,  B01J2231/324 ,  B01J2231/543 ,  B01J2231/641 ,  B01J2531/821 ,  C08F136/20 ,  C08J3/00 ,  C08J2309/02

摘要： Novel transition metal complexes are provided which represent viable catalysts for a broad variety of reactions such as hydrogenation reactions and metathesis reactions. Novel preparation processes are made available via unprecedented routes inter alia not involving structures according to Grubbs I or Grubbs II catalysts.

公开(公告)号：EP3411391A1

公开(公告)日：2018-12-12

申请号：EP17746656.2

申请日：2017-01-31

申请人： The Governing Council Of The University Of Toronto ,  Sinai Health System

发明人： DUROCHER, Daniel ,  SIDHU, Sachdev ,  ZHANG, Wei ,  SICHERI, Frank ,  CANNY, Marella

IPC分类号： C07K14/47 ,  A61K38/17 ,  C12N15/00 ,  C12N15/12

CPC分类号： C12N15/00 ,  A61K38/00 ,  C07K14/47

摘要： 53BP1 inhibitors, derived from the modification of wild-type ubiquitin, as well as compositions comprising the inhibitors and methods of using same are provided. The inhibitors can be used in combination with gene editing systems.

公开(公告)号：EP2949089B1

公开(公告)日：2018-11-28

申请号：EP14742786.8

申请日：2014-01-24

申请人： Huawei Technologies Co., Ltd. ,  The Governing Council Of The University Of Toronto

发明人： YU, Wei ,  ZHOU, Yuhan ,  MA, Jianglei ,  ZHU, Peiying ,  BALIGH, Mohammadhadi

IPC分类号： H04L25/03 ,  H04B7/15

CPC分类号： H04L5/0032 ,  H04B7/00 ,  H04B7/024 ,  H04L5/0035 ,  H04L25/0204 ,  H04W72/0413

摘要： Embodiments are provided for a compress and forward relaying scheme in joint multi-cell processing. A plurality of base stations receive similar combinations of user signals from a plurality of users, compress the signals using quantization, and relay the signals over respective backhaul links to a processor in the network for decoding the signal. The processor determines suitable quantization noise levels for the backhaul links according to a weighted sum-rate maximization function for optimizing the quantization noise levels, subject to a backhaul sum capacity constraint on the backhaul links. The determined quantization noise levels are sent to the base stations, which then quantize the received combinations of user signals according to the quantization noise levels and relay the quantized signals to the processor. The quantization is according to a Wyner-Ziv coding or a single user compression algorithm that excludes statistical correlations between the user signals at the base stations.

公开(公告)号：EP3366697A1

公开(公告)日：2018-08-29

申请号：EP17209579.6

申请日：2011-06-08

申请人： The Governing Council of the University of Toronto

发明人： SIDHU, Sachdev ,  BEATTY, Linda ,  ERNST, Andreas

IPC分类号： C07K14/435

CPC分类号： C07K14/435 ,  A61K38/17 ,  C07K14/47

摘要： The present disclosure provides a method of producing enzyme-specific inhibitors or substrate binding partners comprising: identifying active site residues of the substrate in the enzyme substrate complex or in substrate binding partner-substrate complex; randomizing the active site residues to produce a combinatorial library of substrate variants; and selecting substrate variants that inhibit enzyme activity or bind substrate as substrate-specific binding partners. The present disclosure also provides ubiquitin enzyme specific inhibitors and ubiquitin variants that bind ubiquitin interaction motifs.

公开(公告)号：EP3204014A1

公开(公告)日：2017-08-16

申请号：EP15848249.7

申请日：2015-10-09

申请人： The Governing Council of the University of Toronto

发明人： GRAY-OWEN, Scott ,  GAUDET, Ryan ,  MALOTT, Rebecca

IPC分类号： A61K31/7024 ,  A61K39/39 ,  A61P29/00 ,  A61P31/00 ,  A61P31/18 ,  A61P33/00 ,  A61P35/00 ,  A61P37/02 ,  C12Q1/00 ,  G01N33/48 ,  C07H11/04

CPC分类号： A61K39/39 ,  A61K31/7024 ,  A61K39/095 ,  A61K45/06 ,  A61K2039/55511 ,  C07H11/04 ,  C12Q1/6876 ,  C12Q1/6897 ,  C12Q2600/136 ,  C12Q2600/178 ,  G01N33/502 ,  Y02A50/403 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/423 ,  A61K2300/00

摘要： Novel methods and uses for modulating immune responses are provided. The methods and uses involve the use of a TIFA activator such heptose-1,7-5 bisphosphate or an analogue or derivative thereof. The methods may be used to activate, inhibit or otherwise modify an immune response so as to either prevent or treat infectious or inflammatory diseases or cancer. Also provided are methods to identify compounds capable of modulating immune responses.

摘要翻译： 提供了调节免疫应答的新方法和用途。 所述方法和用途涉及使用TIFA活化剂，例如庚糖-1,7-5二磷酸或其类似物或衍生物。 该方法可用于激活，抑制或以其他方式修饰免疫应答，从而预防或治疗传染性或炎性疾病或癌症。 还提供了鉴定能够调节免疫应答的化合物的方法。 -69-

公开(公告)号：EP2814498B1

公开(公告)日：2017-05-10

申请号：EP13758208.6

申请日：2013-02-15

申请人： The Governing Council of the University of Toronto ,  Hospital For Sick Children

发明人： HEGELE, Richard George ,  MASTRANGELO, Peter ,  MORAES, Theo

IPC分类号： C12N15/115 ,  A61K31/711 ,  A61P31/14

CPC分类号： C12N15/1131 ,  A61K31/711 ,  C12N2310/16

公开(公告)号：EP3147372A3

公开(公告)日：2017-04-26

申请号：EP16185746.1

申请日：2012-11-21

申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

发明人： KELLEY, Shana, O. ,  ZARAGOZA, Alexandre ,  SARGENT, Edward, Hartley ,  DAS, Jagotamoy ,  CEDERQUIST, Kristin

IPC分类号： C12Q1/68 ,  G01N33/543

CPC分类号： G01N27/3275 ,  C12Q1/6818 ,  C12Q1/6825 ,  C12Q2525/107 ,  C12Q2527/146 ,  G01N27/327 ,  G01N27/3277 ,  G01N27/4145 ,  G01N33/54373 ,  G01N33/5438 ,  G01N33/94

摘要： Contemplated methods and devices comprise use of a charged probe and a pseudoligand in the electrochemical detection of a wide range of analytes, including nucleic acids, proteins and small molecules. In certain embodiments, the pseudoligand forms a complex with the probe that has a reduced charge magnitude compared to the probe itself, and is displaced from the probe when the complex is exposed to the analyte.

摘要翻译： 考虑的方法和装置包括在电化学检测广泛范围的分析物（包括核酸，蛋白质和小分子）中使用带电探针和伪配体。 在某些实施方案中，伪配体与探针形成复合物，其与探针本身相比具有降低的电荷量，并且当复合物暴露于分析物时，其与探针置换。

公开(公告)号：EP3156938A1

公开(公告)日：2017-04-19

申请号：EP16180114.7

申请日：2016-07-19

申请人： Samsung Electronics Co., Ltd. ,  The Governing Council of the University of Toronto

发明人： KIM, Jungbae ,  SALAKHUTDINOV, Ruslan ,  HAN, Jaejoon ,  YOO, Byungin

IPC分类号： G06K9/00 ,  G06K9/46 ,  G06K9/62

CPC分类号： G06K9/00275 ,  G06K9/00241 ,  G06K9/00288 ,  G06K9/4628 ,  G06K9/4661 ,  G06K9/6262 ,  G06K9/6272

摘要： A training method of training an illumination compensation model includes extracting, from a training image, an albedo image of a face area, a surface normal image of the face area, and an illumination feature, the extracting being based on an illumination compensation model; generating an illumination restoration image based on the albedo image, the surface normal image, and the illumination feature; and training the illumination compensation model based on the training image and the illumination restoration image.

摘要翻译： 一种训练照度补偿模型的训练方法，包括从训练图像中提取面部区域的反照率图像，面部区域的表面法线图像和照明特征，所述提取基于照度补偿模型; 基于反照率图像，表面法线图像和照明特征来生成照明恢复图像; 并且基于训练图像和照明恢复图像来训练照明补偿模型。

公开(公告)号：EP2803988B1

公开(公告)日：2017-04-12

申请号：EP14176968.7

申请日：2009-09-01

申请人： The Governing Council of the University of Toronto

发明人： Soleymani, Leyla ,  Fang, Zhichao ,  Kelley, Shana ,  Sargent, Edward ,  Taft, Bradford

IPC分类号： G01N27/327 ,  G01N27/30 ,  G01N27/403 ,  G01N27/416 ,  G01N33/53 ,  C12Q1/68 ,  C12Q1/00 ,  C40B60/00 ,  G01N33/543

CPC分类号： G01N27/3272 ,  G01N27/30 ,  G01N27/3275 ,  G01N27/3278 ,  G01N33/5438 ,  Y10S977/754 ,  Y10S977/925