公开(公告)号：EP2821016A4

公开(公告)日：2015-11-04

申请号：EP13754442

申请日：2013-02-26

Applicant: UNIV SAITAMA MEDICAL

Inventor： TOIDA MASAHIRO

IPC: A61B10/00 ,  A61B5/00 ,  G01B9/02 ,  G01N21/47 ,  G01N21/65

CPC classification number: A61B5/0075 ,  A61B5/0066 ,  G01B9/02029 ,  G01B9/02091 ,  G01N21/4795 ,  G01N21/65 ,  G01N33/50 ,  G01N2021/653 ,  G01N2201/06113 ,  G01N2201/0697

公开(公告)号：EP2936092A1

公开(公告)日：2015-10-28

申请号：EP13863946.3

申请日：2013-12-03

Applicant: Emx International, LLC

Inventor： LEE, Graybeal Daniel ,  ROGERS, Alan Carey

IPC: G01J3/42

CPC classification number: G01J3/10 ,  G01J3/0205 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0245 ,  G01J3/108 ,  G01J3/42 ,  G01N21/3504 ,  G01N21/39 ,  G01N2021/399 ,  G01N2201/06113 ,  G01N2201/0612 ,  G01N2201/0691 ,  G01N2201/0697 ,  G01N2201/08 ,  H01S5/3401

Abstract: An intracavity laser absorption infrared spectroscopy system for detecting trace analytes in vapor samples. The system uses a spectrometer in communications with control electronics, wherein the control electronics contain an analyte database that contains absorption profiles for each analyte the system is used to detect. The system can not only detect the presence of specific analytes, but identify them as well. The spectrometer uses a hollow cavity waveguide that creates a continuous loop inside of the device, thus creating a large path length and eliminating the need to mechanically adjust the path length to achieve a high Q-factor. In a preferred embodiment, the laser source may serve as the detector, thus eliminating the need for a separate detector.

公开(公告)号：EP2828650A1

公开(公告)日：2015-01-28

申请号：EP13714710.4

申请日：2013-03-13

Applicant: Canon Kabushiki Kaisha

Inventor： KUBOTA, Oichi

IPC: G01N29/06 ,  G01H9/00 ,  G01N29/07 ,  G01N29/11 ,  G01N29/24 ,  G01N29/34 ,  G01N21/17 ,  G01N21/35

CPC classification number: G01N21/3586 ,  G01H9/00 ,  G01N21/1717 ,  G01N21/4795 ,  G01N29/069 ,  G01N29/07 ,  G01N29/075 ,  G01N29/11 ,  G01N29/2418 ,  G01N29/343 ,  G01N2201/06113 ,  G01N2201/067 ,  G01N2201/0697 ,  G01N2291/011 ,  G01N2291/023 ,  G01N2291/10

Abstract: An electromagnetic wave pulse measuring device, includes an elastic vibration wave generating section which irradiates a predetermined area of a sample with an elastic vibration wave, an electromagnetic wave pulse generating section which irradiates the predetermined area, which is irradiated with the elastic vibration wave, with an electromagnetic wave pulse, and an electromagnetic wave pulse detecting section which measures a waveform of the electromagnetic wave pulse modulated in the predetermined area by the elastic vibration wave. The timing at which the electromagnetic wave pulse detecting section measures the waveform of the electromagnetic wave pulse is a timing at which a phase angle of the elastic vibration wave has a predetermined value when the elastic vibration wave generating section generates the elastic vibration wave.

公开(公告)号：EP2823286A1

公开(公告)日：2015-01-14

申请号：EP13710894.0

申请日：2013-03-07

Applicant: Imperial Innovations Limited

Inventor： FRENCH, Paul Michael William ,  McGINTY, James Andrew

IPC: G01N21/47 ,  G01N21/64

CPC classification number: G01N21/6486 ,  G01N21/47 ,  G01N21/4795 ,  G01N21/6408 ,  G01N21/6456 ,  G01N2201/06113 ,  G01N2201/0697 ,  G01N2201/08

Abstract: An optical projection tomography system comprises a support arranged to support an object (63) and to rotate the object between a plurality of orientations, a first imaging system (64) arranged to image the object from a first direction to form a first image, and a second imaging system arranged to image the object from a second direction to form a second image, data acquisition means (66, 67) arranged to acquire image data from the first and second images for each of the orientations and processing means arranged to process the image data to generate an image data set.

公开(公告)号：EP2810050A1

公开(公告)日：2014-12-10

申请号：EP13705115.7

申请日：2013-02-01

Applicant: Ecole Polytechnique ,  Centre National de la Recherche Scientifique

Inventor： MAHOU, Pierre ,  BEAUREPAIRE, Emmanuel, Jean-Marc ,  DEBARRE, Delphine ,  SUPATTO, Willy ,  MARTIN, Jean Louis

IPC: G01N21/64 ,  G02B21/00

CPC classification number: G01N21/6456 ,  G01N21/3151 ,  G01N21/6402 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2201/06113 ,  G01N2201/0668 ,  G01N2201/0697 ,  G02B17/023 ,  G02B21/16

Abstract: The present invention concerns a multicolour excitation module 1 for a multiphoton imaging system 100. Such a module is used for imaging a sample 7 comprising at least three chromophores. The module 1 comprises: a first femtosecond laser source 2, emitting a first excitation beam 20; a second femtosecond laser source 3 emitting a second excitation beam 30. The first excitation beam 20 comprises a so-called "pumping" portion, said pumping portion acting as a pump beam to synchronously excite the second laser source 3, and a so-called "excitation" portion. An optical delay line 4 is arranged to spatially and temporally superpose the second excitation beam 30 and the excitation portion of the first excitation beam, so as to excite at least a third of the chromophores by multiphoton absorption, said absorbed photons coming from the first and second excitation beams 20, 30. The invention also concerns the complete multiphoton imaging system 100, and a method implemented in this module 1.

公开(公告)号：EP2795390A1

公开(公告)日：2014-10-29

申请号：EP12816697.2

申请日：2012-12-03

Applicant: Ecole Polytechnique ,  Centre National de la Recherche Scientifique (CNRS)

Inventor： SCHANNE-KLEIN, Marie-Claire ,  BEAUREPAIRE, Emmanuel, Jean-Marc ,  STRUPLER, Mathias ,  DEBARRE, Delphine ,  OLIVIER, Nicolas ,  MAHOU, Pierre

IPC: G02B21/36 ,  G02B21/00

CPC classification number: G02B21/06 ,  G01N21/6486 ,  G01N21/65 ,  G01N33/4833 ,  G01N2021/653 ,  G01N2201/0697 ,  G02B21/0032 ,  G02B21/004 ,  G02B21/0076 ,  G02B21/26 ,  G02B21/365

Abstract: The invention relates to a nonlinear optical microscope using a Bessel laser beam so as to image a sample with good lateral resolution and extended field depth. This microscope incorporates a slide scanner. The sample is disposed on a slide, which is loaded automatically onto a motorized platen, so that the laser beam can sweep the entire slide. The useful signals originating from the sample are combined with the conventional image of the slide scanner so as to obtain a global image which clearly reveals, with good resolution, elements of interest.

Abstract translation: 提供非线性光学显微镜，包括脉冲激光束源; 用于调制脉冲激光束的空间分布的空间光调制器; 用于将调制束引导到用于携带样本的载玻片的目的; 以及用于收集源自样本的信号的检测器，其中空间光调制器被设计成调制物镜的后瞳孔上的脉冲激光束的强度和/或相位，以产生轴向延伸并限制在其中的光束 在被物镜聚焦之后的一个或两个横向方向，并且其中滑块被放置在组织学幻灯片扫描器组件的机动台上。

公开(公告)号：EP2778161A1

公开(公告)日：2014-09-17

申请号：EP12870663.7

申请日：2012-03-05

Applicant: Dalian Chromas Bioscience Co., Ltd. ,  Dalian Kerong Biology Technology Co., Ltd.

Inventor： PENG, Xiaojun ,  ZHANG, Hua ,  FAN, Jiangli ,  WANG, Jingyun

IPC: C07D401/12 ,  C07D403/12 ,  C07D471/04 ,  C09K11/06 ,  C12Q1/02

CPC classification number: G01N21/6486 ,  C07D401/12 ,  C07D403/12 ,  C07D471/04 ,  C07D471/06 ,  C09B57/00 ,  C09B57/08 ,  C09K11/02 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1029 ,  C09K2211/1044 ,  G01N21/6458 ,  G01N33/582 ,  G01N2201/06113 ,  G01N2201/0697

Abstract: The present invention provides a novel category of naphthalene-based two-photon fluorescent probes having a general formula I, wherein: X is selected from the X 1 , X 2 , X 3 and X 4 ; The mentioned two-photon fluorescent probes have a low fluorescence background in the non-tumor cells and tissues, and have a strong and specific fluorescent signal in the tumor cells and tissues. These probes have a certain level of water-solubility, while having good membrane permeability. In addition, they have a bigger effective two-photon absorption cross section. The compounds of the present invention also have a lower biotoxicity, phototoxicity and photobleaching. There is sufficient difference between the spectral range thereof and that of a biological sample.

Abstract translation: 本发明提供了具有I，worin通式基于萘的双光子荧光探针的新颖类别：X选自X1，X2，X3和X4中选择; 所提到的双光子荧光探针具有在非肿瘤细胞和组织的低荧光背景，并在肿瘤细胞和组织强烈和特定的荧光信号。 这些探针具有水溶性的一定的水平，同时具有良好的膜渗透性。 此外，一个全心全意更大有效双光子吸收横截面。 因此，本发明的化合物具有较低的生物毒性，光毒性和漂白。 有光谱范围其之间足够的差别，并做了一个生物样品。

公开(公告)号：EP2031371A3

公开(公告)日：2014-08-20

申请号：EP08015113.7

申请日：2008-08-27

Applicant: SYSMEX CORPORATION

Inventor： Ueno, Kunio

IPC: G01N15/14 ,  G01N21/53 ,  H01S3/13 ,  H01S5/06

CPC classification number: G01N15/1459 ,  G01N15/1434 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2201/0612 ,  G01N2201/0692 ,  G01N2201/0697 ,  H01S5/0427 ,  H01S5/0622 ,  H01S5/0652 ,  H01S5/0653 ,  H01S5/06832

Abstract: The present invention is to present a sample analyzer capable of automatically stabilizing the laser diode in multi-mode oscillation. A sample analyzer 1 comprises: a laser diode (LD) 501d for irradiating a sample with laser light; a photodiode (PD) 501e for detecting amount of light emitted from the LD 501d; a APC circuit 501b for outputting a direct current to be supplied to the LD 501d such that the amount of light emitted from the LD 501d is maintained at a predetermined amount, based on the amount of light detected by the PD 501e; a high frequency oscillation circuit 501f for superimposing a high frequency component on the direct current outputted from the APC circuit 501b; and a high frequency automatic adjustment circuit 501c for controlling amplitude of the high frequency component outputted from the high frequency oscillation circuit 501f according to magnitude of the direct current outputted from the APC circuit 501b such that the LD 501d oscillates in a multi-mode.

公开(公告)号：EP2676125A1

公开(公告)日：2013-12-25

申请号：EP12747710.7

申请日：2012-02-13

Applicant: Honeywell Asca, Inc.

Inventor： HUGHES, Michael Kon Yew ,  TIXIER, Sebastien

IPC: G01N21/35 ,  G01N21/89

CPC classification number: G01N21/3563 ,  G01N21/3559 ,  G01N21/359 ,  G01N21/86 ,  G01N21/8901 ,  G01N33/346 ,  G01N33/442 ,  G01N2021/8663 ,  G01N2021/869 ,  G01N2021/8917 ,  G01N2201/0697 ,  G01N2201/128 ,  G01N2201/13

Abstract: Radiation scattering is one of the main contributors to the uncertainty of near infrared (NIR) measurements. Enhanced absorption-measurement accuracy for NIR sensors is achieved by using a combination of NIR spectroscopy and time-of-flight techniques to select photons that are the result of a given mean free path within a moving sample target. By measuring absorption as a function of path length or by windowing signals that are attributable to excessive scattering of NIR radiation within the sample, this technique affords the calculation of more accurate and more universal calibrations. The NIR sensor employs short or ultra-short laser pulses to create NIR that is directed to the moving sample and emerging radiation is detected over time. Windowing effectively truncates non-contributing measurements.

公开(公告)号：EP1835323B1

公开(公告)日：2012-08-01

申请号：EP05793232.9

申请日：2005-10-14

Applicant: OSAKA UNIVERSITY

Inventor： FUJITA, Katsumasa ,  KAWATA, Satoshi ,  KOBAYASHI, Minoru ,  NAKAMURA, Osamu ,  NAKAMURA, Naoko

IPC: G02B21/16 ,  G01N21/64

CPC classification number: G01N21/6458 ,  G01N21/6408 ,  G01N21/6428 ,  G01N2201/0697 ,  G02B21/16

Abstract: A fluorescence microscope in which spatial resolution is enhanced by performing observation based on the saturation component of fluorescence. The fluorescence microscope comprises a light source (10) emitting laser light to serve as pumping light, an objective lens (13) for focusing the laser light and irradiating a sample with the focused laser light, a detector (22) for detecting fluorescence generated from the sample (14) by the laser light, and a stage (15) performing scanning while varying the relative position of the laser light and the sample (14). The sample is irradiated with laser light while varying the intensity of the laser light such that the fluorescence saturates when the intensity of laser light is the greatest, the fluorescence depending on the intensity of laser light is detected by the detector (22), and observation is performed based on the saturation component of fluorescence.