公开(公告)号：EP1167357A4

公开(公告)日：2002-06-05

申请号：EP00915361

申请日：2000-04-06

申请人： SANKYO CO

发明人： FUJITA TAKASHI ,  WADA KUNIO ,  OGUCHI MINORU ,  HONMA HIDEHITO ,  FUJIWARA TOSHIHIKO ,  IWABUCHI HARUO

IPC分类号： A61K31/4184 ,  A61K31/7056 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P25/00 ,  A61P27/12 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D235/06 ,  C07D235/12 ,  C07D471/04 ,  C07H17/02 ,  C07D235/16 ,  A61K31/437 ,  A61K31/4439 ,  C07D401/12

CPC分类号： C07D471/04 ,  C07D235/06 ,  C07D235/12 ,  C07H17/02

摘要： α-Substituted carboxylic acid derivatives represented by general formula (I), pharmacologically acceptable salts of the same, or pharmacologically acceptable esters or amides thereof, which are useful as therapeutic and/or preventive agents for diabetes, impaired glucose tolerance, diabetes in pregnancy, and so on; wherein R1 is alkyl or the like; R2 is hydrogen or the like; R3 is hydrogen or the like; A is =CH- or the like; B is oxygen or the like; W1 is C1-C8 alkylene; W2 is a single bond or C1-C8 alkylene; X is hydrogen or the like; Y is oxygen or the like; and Z1 is alkoxy or the like.

公开(公告)号：EP0930076A4

公开(公告)日：2001-10-04

申请号：EP97930762

申请日：1997-07-11

申请人： SANKYO CO

发明人： TSUJITA YOSHIO ,  FUJIWARA TOSHIHIKO ,  SADA TOSHIO ,  MAEDA NAOYUKI

IPC分类号： A61K31/41 ,  A61K31/33 ,  A61K31/39 ,  A61K31/4178 ,  A61K31/425 ,  A61K31/427 ,  A61K31/44 ,  A61K31/55 ,  A61K45/06 ,  A61P9/10 ,  A61P43/00

CPC分类号： A61K31/4178 ,  A61K31/425 ,  A61K31/427 ,  A61K31/44 ,  A61K31/55 ,  A61K45/06 ,  Y10S514/824 ,  A61K31/415 ,  A61K2300/00

摘要： Compound CS-866, (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-Ä2'-(1H-tetrazol-5-yl)biphenyl- 4-ylmethylÜimidazole-5-carboxylate, is useful in the preparation of a medicament for use in the prophylaxis or treatment of arteriosclerosis.

摘要翻译： 包含选自血管紧张素II受体拮抗剂和血管紧张素转换酶抑制剂的一种或多种药物和选自胰岛素抗性改善剂的一种或多种药物作为活性成分的药物组合物。 由于显示出抑制动脉硬化进展的优异效果，因此这些组合物可用作药物，特别是用于预防或治疗动脉硬化的药物。

公开(公告)号：EP0916651A4

公开(公告)日：2001-09-12

申请号：EP97908566

申请日：1997-04-01

申请人： SANKYO CO

发明人： YANAGISAWA HIROAKI ,  TAKAMURA MAKOTO ,  FUJITA TAKASHI ,  FUJIWARA TOSHIHIKO

IPC分类号： C07C251/50 ,  A61K31/15 ,  A61K31/195 ,  A61K31/415 ,  A61P31/10 ,  C07C251/54 ,  C07C251/58 ,  C07C259/02 ,  C07C317/32 ,  C07C323/45 ,  C07C323/62 ,  C07D213/36 ,  C07D213/53 ,  C07D233/61 ,  C07D233/64 ,  C07D277/26 ,  C07D307/52 ,  C07D263/32 ,  C07D263/34 ,  C07D333/22

CPC分类号： C07D213/53 ,  C07C251/54 ,  C07C251/58 ,  C07C323/62

摘要： Phenylalkylcarboxylic acid derivatives represented by general formula (I) and pharmacologically acceptable salts and esters thereof (wherein R1 represents alkyl, etc.; R2 represents alkylene; R3 represents hydrogen, etc.; X represents (un)substituted aryl, etc.; Y represents oxygen, etc.; Z represents alkylene, etc.; and W represents alkyl, etc.), useful as a remedy or preventive for hyperglycemia and the like.

摘要翻译： （I）表示的苯基烷基羧酸衍生物及其药理学上可接受的盐和酯（其中R1表示烷基等; R2表示亚烷基; R3表示氢等; X表示（未）取代的芳基等; Y表示 氧等; Z代表亚烷基等; W代表烷基等），用作治疗或预防高血糖症等。

公开(公告)号：EP0945065A4

公开(公告)日：2001-07-18

申请号：EP97911458

申请日：1997-11-06

申请人： SANKYO CO

发明人： HORIBE YOSHIMICHI ,  AMAGASA TADASHI ,  SATO KAZUO ,  TSUKIYAMA TAKAHIRO

IPC分类号： A01N37/00 ,  A01N37/06 ,  A01N43/16 ,  A01N43/40 ,  A01N43/54 ,  A01N43/58 ,  A01N43/70 ,  A01N57/12 ,  A01N57/20 ,  A01N59/06 ,  A01P13/02 ,  A01P21/00

CPC分类号： A01N57/20 ,  A01N2300/00

摘要： Crop-selective herbicides prepared by mixing a first non-selective herbicidal component selected from among glyphosate, glyphosine, bialaphos and glufosinate with a second component selected from among phosphorous acid derivatives, chitosans, metal salts of isopropyl phosphate, metal salts of organic acids and so on, and, if necessary, a third component such as a fungicide. By virtue of the second component, the herbicides do not completely kill weeds in spite of the action of the non-selective herbicidal component but can retard the growth of weeds, so that the herbicides are applicable to hillsides and usable as crop-selective herbicides reduced in the chemical damage to useful crops.

公开(公告)号：EP0885891A4

公开(公告)日：2001-02-21

申请号：EP97903623

申请日：1997-02-27

申请人： SANKYO CO

发明人： KOJIMA KOICHI ,  SAKAI JUNICHI ,  SAMATA NAOZUMI ,  KOZUKA MASAO ,  YOSHIMI KENJI ,  KANEKO TSUGIO

IPC分类号： A61K31/42 ,  A61K31/422 ,  A61P25/16 ,  A61P25/28 ,  C07D261/10 ,  C07D261/12 ,  C07D413/04 ,  C07D417/04 ,  A61K31/425

CPC分类号： C07D413/04 ,  C07D261/12

摘要： Isoxazole derivatives represented by general formula (I), which have an excellent monoamine oxidase inhibitory activity and are useful for the treatment or prevention of nervous diseases such as depression, wherein R1 represents optionally substituted aryl or optionally substituted heteroaryl; R2 represents hydrogen, halogeno, optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, alkoxy, cyano, carboxy, alkanoyl, alkoxycarbonyl, or optionally substituted carbamoyl; R3 represents optionally substituted amino or saturated heterocyclic group; X represents oxygen or sulfur; and n is an integer of 2 to 6.

公开(公告)号：EP1018544A4

公开(公告)日：2000-09-06

申请号：EP98928613

申请日：1998-06-22

申请人： NITTETSU MINING CO LTD ,  SANKYO CO

发明人： INABA KAZUHIRO ,  SHIRATORI MAMORU-SANKYO COMPAN ,  ICHIKAWA MASATO-SANKYO COMPANY

IPC分类号： C12M1/16 ,  B01L9/00 ,  B01L99/00 ,  B65G57/30 ,  B65G59/06 ,  C12M1/22 ,  C12M1/26 ,  C12M1/34 ,  G01N35/00 ,  G01N35/04 ,  C12M1/00 ,  G01N1/00

CPC分类号： B01L9/52 ,  B01L99/00 ,  B01L2300/0803 ,  B65G57/302 ,  B65G59/067 ,  C12M23/10 ,  C12M23/48 ,  G01N2035/00049 ,  G01N2035/00089

摘要： A stocker (1) for laboratory dishes (S), comprising a pair of dish receiving metal members (7) which are provided on edges of a plurality of drop holes (6) made in a bottom plate (2) in such a manner that these metal members can be turned upward only, and which support bottom portions of the dishes (S), a plurality of support rods (9) provided on circumferential portions of the drop holes (6) and supporting outer circumferential surfaces of the dishes (S) piled on the drop holes, a handle (5) provided above a central portion of the bottom plate via a rod (3), an automatic dish take-out unit (20) adapted to urge up the dish receiving metal members (7) from the drop holes (6) and take out the dishes from a lower side thereof, and an automatic laboratory dish supply unit (40) adapted to store laboratory dishes by urging up the dish receiving metal members (7) while pressing the dishes (S) upward into the drop holes (6), whereby it becomes possible to store a plurality of the dishes at once and take out the dishes simply without disarraying the dishes in store.

公开(公告)号：EP0900797A4

公开(公告)日：2000-07-19

申请号：EP97919696

申请日：1997-04-25

申请人： SANKYO CO

发明人： KAWAMOTO ISAO ,  MORIMOTO MUNETSUGU ,  ISHIKAWA KATSUYA ,  KOJIMA KATSUHIKO ,  SHIMOJI YASUO ,  OHYA SATOSHI

IPC分类号： A61K31/403 ,  A61P31/04 ,  C07D477/20 ,  C07D487/04 ,  A61K31/40

CPC分类号： C07D477/20

摘要： Constitution: 1-Methylcarbapenem compounds of general formula (I) and pharmacologically acceptable salts and derivatives thereof, wherein R1 is hydrogen or lower alkyl; R2 is hydrogen or lower alkyl; and R3 is hydrogen, lower alkyl, substituted lower alkyl, cycloalkyl or -C(=NH)R4 (wherein R4 is hydrogen, lower alkyl or amino). Effect: these compounds exhibit excellent antibacterial activity and are useful as preventive or therapeutic agents for infectious diseases.

公开(公告)号：EP0676398A3

公开(公告)日：1998-07-01

申请号：EP95302409

申请日：1995-04-11

申请人： SANKYO CO

发明人： FUJITA TAKASHI ,  FUJIMOTO KOICHI ,  YOSHIOKA TAKAO ,  YANAGISAWA HIROAKI ,  FUJIWARA TOSHIHIKO ,  HORIKOSHI HIROYOSHI ,  OGUCHI MINORU ,  WADA KUNIO

IPC分类号： C07D263/44 ,  A61K31/33 ,  A61K31/425 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P5/00 ,  C07D209/08 ,  C07D209/10 ,  C07D209/12 ,  C07D209/36 ,  C07D277/34 ,  C07D413/10 ,  C07D413/12 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/49

CPC分类号： C07D413/12 ,  C07D209/08 ,  C07D209/10 ,  C07D209/12 ,  C07D209/36 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

摘要： Compounds of formula (I): [wherein: X represents an unsubstituted or substituted indolyl, indolinyl, azaindolyl, azaindolinyl, imidazopyridyl or imidazopyrimidinyl group; Y represents an oxygen or sulphur atom; Z represents a 2,4-dioxothiazolidin-5-ylidenylmethyl, 2,4-dioxothiazolidin-5-ylmethyl, 2,4-dioxooxazolidin-5-ylmethyl, 3,5-dioxooxadiazolidin-2-ylmethyl or
N -hydroxyureidomethyl group; R represents a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, a hydroxy group, a nitro group, an aralkyl group or a unsubstituted or substituted amino group; and
m is an integer of from 1 to 5] have hypoglycemic and anti-diabetic activities.

公开(公告)号：EP0773214A4

公开(公告)日：1998-04-15

申请号：EP95921111

申请日：1995-06-07

申请人： UBE INDUSTRIES ,  SANKYO CO

发明人： KIMURA TOMIO ,  KATSUBE TETSUSHI ,  NISHIGAKI TAKASHI

IPC分类号： C07D401/04 ,  A61K31/4709 ,  A61P31/18 ,  C07D215/56 ,  C07D295/00 ,  A61K31/495 ,  A61K31/55

CPC分类号： C07D215/56

摘要： An 8-trifluoromethylquinolinecarboxylic acid derivative represented by general formula (I) or a pharmacologically acceptable salt or ester thereof wherein: R1 represents lower alkyl, halogenated lower alkyl or cycloalkyl; R2 represents a phenyl group which may be substituted by R0, a five- or six-membered heteroaromatic monocyclic group which may be substituted by R0 and bears one or two heteroatoms selected from among N, O and S, or a fused heteroaromatic group composed of the above heteroaromatic monocycle and a benzene ring; R0 represents halogen, lower alkyl, fluorinated lower alkyl, lower alkoxy or lower alkylthio; R3 represents hydrogen or lower alkyl; and m represents an integer of 2 or 3.

公开(公告)号：EP0657443A4

公开(公告)日：1995-09-06

申请号：EP93919582

申请日：1993-08-27

申请人： SANKYO CO

发明人： TERADA ATSUSUKE SANKYO COMPANY ,  IIZUKA YOSHIO SANKYO COMPANY L ,  WACHI KAZUYUKI SANKYO COMPANY ,  FUJIBAYASHI KENJI SANKYO COMPA

IPC分类号： A61K31/54 ,  A61P25/04 ,  A61P29/00 ,  C07D20060101 ,  C07D279/12 ,  C07D417/06

CPC分类号： C07D279/12

摘要： An optically active carboxamide derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein R1 represents hydrogen or halogen; R2 represents halogen; R3 represents pyrrolidino or piperidino; Y represents methylene or carbonyl; and n represents 1 or 2. The compound has an excellent analgesic effect, thus being useful as an analgesic.