公开(公告)号：EP0988534A1

公开(公告)日：2000-03-29

申请号：EP98930238.5

申请日：1998-06-12

申请人： Clinical Micro Sensors

发明人： O'CONNOR, Stephen, D. ,  KAYYEM, Jon, F. ,  MEADE, Thomas, J.

IPC分类号： G01N27/327 ,  G01N33/543 ,  G01N33/84 ,  G01N27/333

CPC分类号： G01N27/3277 ,  B82Y15/00 ,  B82Y30/00 ,  G01N33/5438 ,  G01N33/58 ,  G01N33/84 ,  G01N2458/30 ,  G01N2800/04

摘要： The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.

公开(公告)号：EP1802962B1

公开(公告)日：2018-06-06

申请号：EP05810138.7

申请日：2005-10-12

申请人： Ascensia Diabetes Care Holdings AG

发明人： WU, Huan-Ping

IPC分类号： G01N27/327 ,  C12Q1/00

CPC分类号： G01N27/3271 ,  B32B38/18 ,  B32B2307/202 ,  C12Q1/004 ,  C12Q1/005 ,  C12Q1/006 ,  C12Q1/6813 ,  C12Q1/6825 ,  G01N27/3272 ,  G01N27/3276 ,  G01N27/3277 ,  G01N27/40 ,  G01N33/5438

摘要： The present invention relates to improved electrochemical biosensor strips and methods for determining the concentration of an analyte in a sample. By selectively measuring a measurable species residing in a diffusion barrier layer, to the substantial exclusion of the measurable species residing exterior to the diffusion barrier layer, measurement errors introduced by sample constituents, such as red blood cells, and manufacturing variances may be reduced.

公开(公告)号：EP3311150A1

公开(公告)日：2018-04-25

申请号：EP16742450.6

申请日：2016-06-16

申请人： Ultradian Diagnostics LLC

发明人： WILLIS, John, Patrick

IPC分类号： G01N27/327 ,  A61B5/1486 ,  C12Q1/00

CPC分类号： A61B5/7275 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/14865 ,  A61B5/4839 ,  A61B5/4866 ,  A61B5/7203 ,  A61B5/7246 ,  A61B5/7253 ,  A61B5/7257 ,  C12Q1/006 ,  G01N27/3273 ,  G01N27/3277 ,  G01N2800/042 ,  G06F19/10 ,  G16H50/20

摘要： In vivo or in vitro sensors in combination with an electronic monitor enable the recognition, quantitation, and tracking of metabolic oscillations of living cells immobilized on or in close proximity to an analyte sensor providing methods, systems, and devices to monitor, probe, diagnose or treat abnormal metabolic states. The patterns or fingerprints of metabolic oscillations yield information about analyte concentration and the status of cellular metabolism. The analysis provides early recognition of abnormal metabolic states and provides treatment options that can avoid complications from metabolic disorders such as diabetes.

公开(公告)号：EP2673643B1

公开(公告)日：2018-04-04

申请号：EP12709137.9

申请日：2012-02-07

申请人： LUMIRADx UK LTD

发明人： LOWE, Philip ,  KEATCH, Steven, Alexander ,  MCGUIGAN, Brian

IPC分类号： B01L3/00 ,  G01N33/543 ,  C12Q1/00 ,  G01N27/327

CPC分类号： G01N33/5438 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/04 ,  B01L2200/0647 ,  B01L2200/16 ,  B01L2300/0645 ,  B01L2300/0864 ,  B01L2300/161 ,  B01L2400/043 ,  B01L2400/0688 ,  C12Q1/001 ,  C12Q1/006 ,  C12Y101/03004 ,  G01N27/3277 ,  G01N33/54326 ,  G01N33/54366 ,  G01N2333/904

摘要： A subtractive corrective assay device and methodology, whereby ail required binding and label detection reagents are initially located within the detection zone. Application of a magnetic field is used to selectively remove bound label from the detection zone by means of paramagnetic particles. The relationship between measured label concentration before and after the application of a magnetic field within the detection zone is used to accurately measure analyte concentration within the sample.

公开(公告)号：EP3290522A1

公开(公告)日：2018-03-07

申请号：EP17170521.3

申请日：2008-10-29

申请人： Roche Diabetes Care GmbH ,  F. Hoffmann-La Roche AG

发明人： Bhullar, Raghbir Sing ,  Celentano, Mike ,  El-Rahaiby, Said K.

IPC分类号： C12Q1/00 ,  G01N27/30 ,  G01N33/487

CPC分类号： G01N27/3277 ,  G01N27/3272 ,  G01N33/5438

摘要： The present invention provides an inventive biosensor that includes multiple regions in which the electrical pattern is formed from different electrically conductive materials. The present invention also provides an inventive method for mass producing biosensors as just described. In one embodiment of this method, first and second different electrically conductive materials are deposited side by side on a portion of an electrically insulating base material, and a plurality of electrical patterns is formed on the portion of the base material. Each electrical pattern includes a first region formed from the first electrically conductive material electrically connected to a second region formed from the second electrically conductive material. The electrically conductive materials can be deposited as layers on the base material and portions of the layers can be removed to form the electrical patterns, or, the electrical patterns can be formed by transferring the conductive material in the shape of the electrical pattern directly to the base material, such as by a laser direct transfer technique.

公开(公告)号：EP3278095A1

公开(公告)日：2018-02-07

申请号：EP16717283.2

申请日：2016-04-01

申请人： Université de Bourgogne ,  Centre Hospitalier Universitaire De Dijon ,  Institut National de la Recherche Agronomique (INRA)

发明人： DEQUAIRE-ROCHELET, Murielle ,  HARTMANN, Alain ,  NEUWIRTH, Catherine ,  CHANTEMESSE, Benoit

IPC分类号： G01N27/48 ,  C12Q1/04

CPC分类号： C12Q1/34 ,  C12Q1/04 ,  C12Y305/02006 ,  G01N27/3277 ,  G01N27/48 ,  G01N2333/195 ,  G01N2333/986

摘要： The present invention relates to an electrochemical method for determining,
in vitro , the presence of beta-lactamase-producing bacteria in a sample that may contain said bacteria.

公开(公告)号：EP1339495B1

公开(公告)日：2018-01-24

申请号：EP01997349.4

申请日：2001-11-26

申请人： Boehringer Ingelheim Vetmedica GmbH

发明人： MUND, Konrad ,  GUMBRECHT, Walter ,  STANZEL, Manfred ,  HINTSCHE, Rainer

IPC分类号： B01L3/00 ,  B01J19/00 ,  G01N27/327 ,  C40B60/14

CPC分类号： B01J19/0093 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00783 ,  B01J2219/00828 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01L3/502 ,  B01L3/50853 ,  B01L2200/0642 ,  B01L2200/0673 ,  B01L2300/0819 ,  B01L2300/0829 ,  C40B60/14 ,  G01N27/3277

公开(公告)号：EP2681543B1

公开(公告)日：2017-11-08

申请号：EP12714103.4

申请日：2012-02-28

申请人： Aytu BioScience, Inc.

发明人： BAR-OR, Raphael ,  BAR-OR, David ,  RAEL, Leonard, T.

IPC分类号： G01N27/403

CPC分类号： G01N27/3277 ,  G01N27/301 ,  G01N27/3272 ,  G01N27/403 ,  G01N27/4168 ,  G01N33/49

公开(公告)号：EP3084411A4

公开(公告)日：2017-09-20

申请号：EP14872472

申请日：2014-12-19

申请人： UNIV CALIFORNIA

发明人： REVZIN ALEXANDER ,  MATHARU ZIMPLE ,  YOU JUNGMOK ,  KWON LYDIA ,  LIU YING ,  SHIN DONG-SIK

IPC分类号： G01N27/327

CPC分类号： G01N33/5438 ,  B82Y30/00 ,  C08L65/00 ,  C12Q1/002 ,  C12Q1/003 ,  G01N27/3277 ,  G01N27/3278 ,  G01N33/54353 ,  G01N33/545 ,  G01N33/6866 ,  G01N2333/35 ,  G01N2333/57 ,  G01N2800/26

公开(公告)号：EP3060646A4

公开(公告)日：2017-06-21

申请号：EP14855736

申请日：2014-10-23

申请人： GENIA TECH INC

发明人： DAVIS RANDALL W ,  LIU EDWARD SHIAN ,  HARADA ERIC TAKESHI ,  AGUIRRE ANNE ,  TRANS ANDREW ,  POLLARD JAMES ,  CECH CYNTHIA

IPC分类号： C12M1/34 ,  B05D5/12 ,  C12Q1/68 ,  G01N33/487

CPC分类号： C12Q1/6869 ,  C12M1/34 ,  G01N27/3277 ,  G01N27/3278 ,  G01N27/44791 ,  G01N33/48721 ,  C12Q2565/607 ,  C12Q2565/631

摘要： This disclosure provides a biochip comprising a plurality of wells. The biochip includes a membrane that is disposed in or adjacent to an individual well of the plurality of wells. The membrane comprises a nanopore, and the individual well comprises an electrode that detects a signal upon ionic flow through the pore in response to a species passing through or adjacent to the nanopore. The electrode can be a non-sacrificial electrode. A lipid bilayer can be formed over the plurality of wells using a bubble.

摘要翻译： 本公开提供了包括多个井的生物芯片。 生物芯片包括设置在多个井的单个井中或与其相邻的膜。 所述膜包含纳米孔，并且所述单独的孔包含电极，所述电极响应于穿过或邻近所述纳米孔的物质而在离子流过所述孔时检测信号。 电极可以是非牺牲电极。 可以使用气泡在多个孔上形成脂质双分子层。