公开(公告)号：EP3204518B1

公开(公告)日：2019-07-10

申请号：EP15849044.1

申请日：2015-10-08

申请人： Invitae Corporation

发明人： OLIVARES, Eric

IPC分类号： C12Q1/68 ,  C12Q1/6806 ,  C12Q1/6809 ,  C12Q1/6832 ,  C12Q1/6853 ,  C12Q1/6858 ,  C12Q1/686 ,  C12Q1/6874 ,  C12Q1/6883 ,  C40B30/04 ,  C40B40/06 ,  C40B70/00 ,  C40B40/08

公开(公告)号：EP2279291B1

公开(公告)日：2019-07-03

申请号：EP09729677.6

申请日：2009-04-09

申请人： Cornell University ,  Purdue Research Foundation

发明人： BARANY, Francis ,  PINGLE, Maneesh ,  BERGSTROM, Donald ,  GARDINA, Sarah, Filippa

IPC分类号： C40B50/00 ,  C40B50/04 ,  C07D233/64 ,  C07D307/92 ,  C07D309/30 ,  C07D319/24 ,  C07D493/22 ,  C07F5/02 ,  C07H7/02 ,  C07H9/02 ,  C40B30/04 ,  A61K47/54 ,  A61K31/69

公开(公告)号：EP2877574B1

公开(公告)日：2019-05-15

申请号：EP13823740.9

申请日：2013-07-24

申请人： Glycosyn LLC

发明人： HEIDTMAN, Matthew, Ian ,  MERIGHI, Massimo ,  MCCOY, John, M.

IPC分类号： C12N15/52 ,  C40B30/02 ,  G06F19/16 ,  C12P19/18 ,  C12N9/10 ,  C12N15/72

公开(公告)号：EP2245571B1

公开(公告)日：2019-04-10

申请号：EP09708274.7

申请日：2009-02-05

申请人： Zymeworks Inc.

发明人： LARIO, Paula, I. ,  MULLEGGER, Johannes ,  DIXIT, Surjit, B. ,  RODINGER, Tomas ,  TAN, Powell, Patrick, Cheng

IPC分类号： G06F19/16 ,  G06F19/00 ,  C12N15/11 ,  C12N15/00 ,  C07K14/00 ,  C40B30/02 ,  G01N33/68

公开(公告)号：EP3443149A1

公开(公告)日：2019-02-20

申请号：EP17781661.8

申请日：2017-04-13

申请人： University Health Network (UHN)

发明人： PUGH, Trevor John ,  MULDER, David Thomas ,  MAHE, Etienne Raymond G. A.

IPC分类号： C40B40/06 ,  C12N15/10 ,  C12N15/12 ,  C12N15/13 ,  C12Q1/68 ,  C40B30/04

公开(公告)号：EP3434769A1

公开(公告)日：2019-01-30

申请号：EP18193568.5

申请日：2010-10-27

申请人： Novartis AG

发明人： LOEW, Andreas ,  VASH, Brian Edward

IPC分类号： C12N15/10 ,  C40B30/04 ,  C40B40/02 ,  C40B50/02

摘要： The invention pertains to a natural-variant combinatorial library of fibronectin Type 3 domain (Fn3) polypeptides useful in screening for the presence of one or more polypeptides having a selected binding or enzymatic activity. The library polypeptides include (a) regions A, AB, B, C, CD, D, E, EF, F, and G having wildtype amino acid sequences of a selected native fibronectin Type 3 polypeptide or polypeptides, and (b) loop regions AB, CD, and EF having selected lengths (Bottom Loops). The Fn3 may also have loop regions BC, DE, and FG having wildtype amino acid sequences, having selected lengths, or mutagenized amino acid sequences (Top Loops).

公开(公告)号：EP3429472A1

公开(公告)日：2019-01-23

申请号：EP17767645.9

申请日：2017-03-17

申请人： Takeda Pharmaceutical Company Limited

发明人： FFRENCH-MULLEN, Jarlath ,  LAI, Eric

IPC分类号： A61B5/16 ,  C12Q1/68 ,  C40B30/04

公开(公告)号：EP3423463A1

公开(公告)日：2019-01-09

申请号：EP17759041.1

申请日：2017-03-01

申请人： Fusion Genomics Corporation

发明人： Zhan, Shing H. ,  Kwok, Brian S. ,  Qadir, Mohammad

IPC分类号： C07H21/00 ,  C07H21/04 ,  C12N15/10 ,  C12Q1/68 ,  C40B30/04 ,  G06F19/10 ,  G06F19/20

公开(公告)号：EP3417048A1

公开(公告)日：2018-12-26

申请号：EP17752613.4

申请日：2017-02-17

申请人： University Health Network

发明人： JAFFRAY, David A. ,  WOUTERS, Bradly G. ,  JAFFRAY, Alexander Ralph Lino ,  ELLIOTT, Ryan Steven

IPC分类号： C12M1/34 ,  C12M1/42 ,  C12Q1/00 ,  C12Q1/02 ,  G06F19/00 ,  G21K5/04 ,  C40B30/06

CPC分类号： C12M1/34 ,  C12M1/42 ,  C12M41/48 ,  G01N33/5011 ,  G01N2510/00 ,  G01N2800/40 ,  G01N2800/52 ,  G06F19/00 ,  G21K5/08

摘要： A high throughput automated assay platform for temporal image processing of cell growth and colony formation before and after radiation therapy treatments. The platform is designed to compute and monitor a therapeutic protocol by measuring sensitivity of cell growth to treatment based on a radiation therapy protocol. The platform is designed to detect relationships between the temporal images being tracked to colony formation behaviour.

公开(公告)号：EP3411517A1

公开(公告)日：2018-12-12

申请号：EP17746659.6

申请日：2017-02-06

申请人： University Health Network

发明人： WANG, Jean ,  DICK, John ,  NG, Stanley ,  MINDEN, Mark ,  MITCHELL, Amanda ,  CHEN, Weihsu, Claire ,  ZANDSTRA, Peter ,  KENNEDY, James

IPC分类号： C40B40/06 ,  C12Q1/68 ,  C40B30/04 ,  C40B40/08 ,  G01N33/48 ,  G06F19/10 ,  G06F19/20

CPC分类号： G01N33/57426 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  C40B40/06 ,  C40B40/08 ,  G01N2800/52 ,  G06F19/10 ,  G06F19/20

摘要： There is described herein a method of prognosing or classifying a subject with acute myeloid leukemia (AML) comprising: (a) determining the expression level of at least 3 genes in a test sample from the subject selected from the group consisting of DNMT3B, ZBTB46, NYNRIN, ARHGAP22, LAPTM4B, MMRN1, DPYSL3, KIAAQ125. CDK6, CPXM1, SOCS2, SMIM24, EMP1, NGFRAP1, CD34, AKR1C3, GPR56; and (b) comparing expression of the at least 3 genes in the test sample with reference expression levels of the at least 3 genes from control samples from a cohort of patients; wherein a difference or similarity in the expression of the at least 3 genes in the test sample and the reference expression levels is used to prognose or classify the subject with AML into a low risk group or a high risk group for worse survival.