公开(公告)号：EP1344829A4

公开(公告)日：2005-01-05

申请号：EP01997561

申请日：2001-11-27

申请人： DNAVEC RESEARCH INC

发明人： YONEMITSU YOSHIKAZU ,  SUEISHI KATSUO ,  FUKUMURA MASAYUKI ,  HOU XIAOGANG ,  HASEGAWA MAMORU

IPC分类号： A61K48/00 ,  C07K14/50 ,  C12N15/86

CPC分类号： C12N15/86 ,  A61K48/00 ,  C07K14/50 ,  C12N2760/18843 ,  C12N2800/30

摘要： A paramyxovirus vector encoding an angiogenesis gene. Use of the paramyxovirus vector makes it possible to efficiently transfer the angiogenesis gene into an individual tissue. FGF2 gene administered in vivo expresses the angiogenesis gene accompanied by no edema in an ischemic tissue, thereby preventing necrosis due to the ischemia. This vector is appropriately usable in gene therapy targeting ischemic tissues.

公开(公告)号：EP1401855A4

公开(公告)日：2004-12-22

申请号：EP02746584

申请日：2002-06-17

申请人： CURAGEN CORP

发明人： SHIMKETS RICHARD A ,  JEFFERS MICHAEL E ,  PRAYAGA SUDHIRDAS K ,  BOLDOG FERENC L ,  YANG MEIJIA ,  BURGESS CATHERINE E ,  FERNANDES ELMA R ,  HERRMANN JOHN L ,  LAROCHELLE WILLIAM J ,  LICHENSTEIN HENRI S ,  GORMAN LINDA ,  ZHONG MEI ,  PADIGARU MURALIDHARA ,  PENA CAROL E A ,  ALSOBROOK JOHN P II ,  LEPLEY DENISE M ,  RIEGER DANIEL K ,  GROSSE WILLIAM M

IPC分类号： G01N33/50 ,  A61K38/27 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P1/00 ,  A61P9/00 ,  A61P17/02 ,  A61P17/14 ,  A61P35/00 ,  C07K14/50 ,  C07K16/22 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  A61K31/713 ,  A61K38/18 ,  C07K16/18 ,  C12N15/12

CPC分类号： C07K14/50

公开(公告)号：EP1404713A4

公开(公告)日：2004-09-22

申请号：EP01972731

申请日：2001-09-19

申请人： HUMAN DNA TECHNOLOGY INC ,  JANG HYUN JUN ,  KIM SOOGYUN

发明人： KIM SOOGYUN

IPC分类号： C12N15/09 ,  A61K8/00 ,  A61K8/64 ,  A61K38/00 ,  A61K48/00 ,  A61P17/14 ,  A61Q5/00 ,  A61Q7/00 ,  C07K14/47 ,  C07K14/50 ,  C12P21/02

CPC分类号： A61K8/64 ,  A61K38/00 ,  A61Q7/00 ,  C07K14/50 ,  G01N33/6893 ,  G01N33/74 ,  G01N2800/20

公开(公告)号：EP1374888A4

公开(公告)日：2004-07-07

申请号：EP02701642

申请日：2002-02-28

申请人： MITSUBISHI PHARMA CORP

发明人： IMAIZUMI REI

IPC分类号： A61K38/00 ,  A61P19/02 ,  A61P29/00 ,  A61P43/00 ,  C07K14/50 ,  C07K14/51 ,  A61K31/711 ,  A61K38/17 ,  A61K38/57 ,  A61K48/00

CPC分类号： C07K14/51 ,  A61K38/00 ,  C07K14/503

摘要： It is intended to provide remedies efficacious for arthritis deformans and rheumatoid arthritis. Namely, remedies for arthritis deformans and rheumatoid arthritis which contain, as the active ingredient, chondromodulin-I protein having an activity of proliferating articular cartilage cells either alone or in the coexistence with a basic fibroblast growth factor and an activity of inhibiting accelerated degradation of cartilage matrix.

公开(公告)号：EP1042348A4

公开(公告)日：2004-07-07

申请号：EP98920194

申请日：1998-04-29

申请人： NEXSTAR PHARMACEUTICALS INC

发明人： JANJIC NEBOJSA ,  GOLD LARRY

IPC分类号： C12Q1/68 ,  A61K31/7088 ,  A61K38/00 ,  A61K47/48 ,  A61K48/00 ,  A61K49/00 ,  A61P9/00 ,  A61P13/12 ,  A61P35/00 ,  C07H21/02 ,  C07H21/04 ,  C07K14/49 ,  C07K14/495 ,  C07K14/50 ,  C07K14/52 ,  C12N15/113 ,  C12N15/115 ,  C12P19/34

CPC分类号： C07K16/2803 ,  A61K38/00 ,  A61K47/544 ,  A61K47/60 ,  A61K2039/505 ,  C07K14/49 ,  C07K14/495 ,  C07K14/50 ,  C07K14/52 ,  C12N15/1136 ,  C12N15/115 ,  C12N2310/13 ,  C12N2310/317 ,  C12N2310/3183 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/351 ,  C12N2310/3515 ,  C12Q1/6811 ,  C40B30/04 ,  C12N2310/3521

公开(公告)号：EP1117421B1

公开(公告)日：2004-06-16

申请号：EP99945967.0

申请日：1999-10-05

申请人： Pharmexa A/S

发明人： STEINAA, Lucilla ,  MOURITSEN, Soren ,  NIELSEN, Klaus, Gregorius ,  HAANING, Jesper ,  LEACH, Dana ,  DALUM, Iben ,  GAUTAM, Anand ,  RASMUSSEN BIRK, Peter ,  KARLSSON, Gunilla

IPC分类号： A61K38/17 ,  A61K38/18 ,  C07K14/50 ,  C07K14/705 ,  C07K14/71 ,  C12N15/63 ,  C12N5/16 ,  C12N15/12

CPC分类号： C07K16/3069 ,  A61K39/0011 ,  C07K14/50 ,  C07K14/705 ,  C07K14/70539 ,  C07K14/71 ,  C07K2317/34 ,  C12N2799/021 ,  Y02A50/412

摘要： A method is disclosed for inducing cell-mediated immunity against cellular antigens. More specifically, the invention provides for a method for inducing cytotoxic T-lymphocyte immunity against weak antigens, notably self-proteins. The method entails that antigen presenting cells are induced to present at least one CTL epitope of the weak antigen and at the same time presenting at least one foreign T-helper lymphocyte epitope. In a preferred embodiment, the antigen is a cancer specific antigen, e.g. PSM, Her2, or FGF8b. The method can be exercised by using traditional polypeptide vaccination, but also by using live attenuated vaccines or nucleic acid vaccination. The invention furthermore provides immunogenic analogues of PSM, Her2 and FGF8b, as well as nucleic acid molecules encoding these analogues. Also vectors and transformed cells are disclosed. The invention also provides for a method for identification of immunogenic analogues of weak or non-immunogenic antigens.

公开(公告)号：EP0950100B1

公开(公告)日：2004-02-11

申请号：EP97937200.0

申请日：1997-08-13

申请人： HUMAN GENOME SCIENCES, INC.

发明人： DUAN, Roxanne ,  RUBEN, Steven, M. ,  JIMENEZ, Pablo ,  RAMPY, Mark, A. ,  MENDRICK, Donna ,  ZHANG, Jun ,  NI, Jian ,  MOORE, Paul, A. ,  COLEMAN, Timothy, A. ,  GENTZ, Reiner L.

IPC分类号： C12N15/12 ,  C07K14/50 ,  A61K38/18 ,  C07K16/22 ,  G01N33/566 ,  A61K48/00

CPC分类号： C07K14/50 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

公开(公告)号：EP1140964A4

公开(公告)日：2003-06-18

申请号：EP99966224

申请日：1999-12-14

申请人： UNIV MIAMI ,  FIBROGEN INC

发明人： GROTENDORST GARY R ,  NEFF THOMAS B

IPC分类号： C12N15/09 ,  A61K31/7088 ,  A61K31/7105 ,  A61K38/00 ,  A61K38/04 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P1/16 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P9/14 ,  A61P11/00 ,  A61P13/12 ,  A61P17/00 ,  A61P17/02 ,  A61P19/02 ,  A61P19/04 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P37/02 ,  A61P43/00 ,  C07K14/47 ,  C07K14/475 ,  C07K14/50 ,  C07K16/22 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/50 ,  G01N33/566 ,  C07H21/00

CPC分类号： C07K16/22 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/475

公开(公告)号：EP1311699A2

公开(公告)日：2003-05-21

申请号：EP01974582.7

申请日：2001-08-17

申请人： Ozawa, Keiya ,  Shimpo, Masahisa ,  Ikeda, Uichi ,  Maeda, Yoshikazu ,  Shimada, Kazuyuki

发明人： Ozawa, Keiya ,  Shimpo, Masahisa ,  Ikeda, Uichi ,  Maeda, Yoshikazu ,  Shimada, Kazuyuki

IPC分类号： C12N15/864 ,  C12N15/12 ,  C07K14/50 ,  C07K14/52 ,  C07K14/515 ,  A61K48/00

CPC分类号： C12N15/86 ,  A61K38/1825 ,  A61K38/1866 ,  A61K38/1891 ,  A61K48/00 ,  A61K48/0075 ,  C07K14/52 ,  C12N2750/14143

摘要： The use of recombinant adeno-associated virus (rAAV) virions for delivery of genes encoding angiogenic factors to muscle tissue is disclosed. The invention describes such methods of delivery and also describes methods for treating an ischemic condition such as myocardial ischemia. The methods include direct delivery of rAAV virions to a muscle via intramuscular injection and indirect delivery to a muscle via an injection into a blood vessel supplying blood to the muscle. The invention provides for sustained expression of the rAAV virion-delivered angiogenic factor gene or genes, which subsequently leads to a quantifiable therapeutic angiogenic factor gene or genes, which subsequently leads to a quantifiable therapeutic effect, namely an increase in new blood vessel formation resulting in an increase in blood flow to the ischemic muscle tissue.

公开(公告)号：EP1303536A1

公开(公告)日：2003-04-23

申请号：EP01952590.6

申请日：2001-07-10

申请人： ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, INC. ,  Ludwig-Maximilians-Universität München

发明人： ECONS, Michael ,  WHITE, Ken ,  STROM, Tim, Matthias ,  MEITINGER, Thomas

IPC分类号： C07K14/435 ,  C07K14/47 ,  C07K14/475 ,  C07K14/50 ,  C07K16/22 ,  C07K16/26 ,  C12N5/10 ,  C12N15/12 ,  C12N15/16 ,  C12N15/18 ,  C12N15/62 ,  C12N15/63 ,  A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  A61K38/22 ,  A61K48/00 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/567

CPC分类号： C12Q1/6883 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/1825 ,  A61K48/00 ,  C07K14/50 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

摘要： The invention relates to novel nucleic acids encoding a fibroblast growth factor-23 (FGF23) and proteins encoded thereby, mutations in which are associated with autosomal dominant rickets (ADHR). The invention further relates to methods of diagnosing and treating hypophosphatemic and hyperphosphatemic disorders comprising inhibiting or stimulating, respectively, the biological activity of FGF23 in a patient. The invention also relates to methods of treating osteoporosis, dermatomyositis, and coronary artery disease comprising stimulating the biological activity of FGF23 in a patient.