公开(公告)号：EP1229908A1

公开(公告)日：2002-08-14

申请号：EP00980405.5

申请日：2000-11-15

申请人： ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, Inc. ,  Marshall, Mark Steven ,  Sweeney, Christopher J. ,  Yip-Schneider, Michelle T. ,  Crowell, Pamela L.

发明人： MARSHALL, Mark, Steven ,  SWEENEY, Christopher J. ,  YIP-SCHNEIDER, Michelle, T. ,  CROWELL, Pamela, L.

IPC分类号： A61K31/19 ,  A61K31/405 ,  A61P35/00

CPC分类号： A61K45/06 ,  A61K31/00 ,  A61K31/192 ,  A61K31/405 ,  A61K31/4965 ,  A61K31/7068 ,  A61K2300/00

摘要： The invention provides a method comprising the use of non-steroidal antiinflammatory drugs (NSAIDs), particularly sulindac or its analogs to treat pancreatic cancer.

公开(公告)号：EP1227846A2

公开(公告)日：2002-08-07

申请号：EP00975626.3

申请日：2000-11-10

申请人： ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, Inc. ,  Clapp, Wade D. ,  Ingram, David A. ,  Marshall, Mark Steven

发明人： CLAPP, Wade, D. ,  INGRAM, David, A. ,  MARSHALL, Mark, Steven

IPC分类号： A61K45/00

CPC分类号： G01N33/6896 ,  A61K31/00 ,  A61K31/352 ,  A61K31/5377 ,  G01N2333/4703 ,  G01N2500/10

摘要： A method is provided to identify inhibitors of any one of Raf, MEK, extracellular signal regulated kinase 1 (ERK1), extracellular signal regulated kinase 2 (ERK2), phosphatidylinositol triphosphate kinase (PI3K), p21 activated kinase 2 (PAK2), p21 activated kinase 3 (PAK3), Rac, CDC42, p21 activated kinase 1 (PAK1), protein kinase B (PKB), Akt, and c-jun N-terminal kinase (JNK), or crosstalk between the PI3-K an the Ras-Raf-MEK-ERK pathway, useful to treat disorders such as neurofibromatosis type 1 or at least one clinical manifestation thereof.

公开(公告)号：EP1410031A2

公开(公告)日：2004-04-21

申请号：EP02756334.5

申请日：2002-06-28

申请人： ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, Inc.

发明人： NIE, Shuming ,  GAO, Xiaohu ,  HAN, Mingyong

IPC分类号： G01N33/544 ,  G01N33/58 ,  G01N33/543

CPC分类号： B82Y15/00 ,  G01N33/54393 ,  G01N33/544 ,  G01N33/588 ,  G06F19/00

摘要： The present invention provides a method of preparing a multicolor quantum dot-tagged bead, a multicolor quantum dot-tagged bead, a conjugate thereof, and a composition comprising such a bead or conjugate. Additionally, the present invention provides a method of making a conjugate thereof and methods of using a conjugate for multiplexed analysis of target molecules.

公开(公告)号：EP1242071A1

公开(公告)日：2002-09-25

申请号：EP00988155.8

申请日：2000-12-19

申请人： ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, Inc. ,  Nakshatri, Harikrishna ,  Sweeney, Christopher J.

发明人： NAKSHATRI, Harikrishna ,  SWEENEY, Christopher J.

IPC分类号： A61K31/34

CPC分类号： A61K31/365 ,  A61K31/00 ,  A61K2300/00

摘要： The invention provides a method comprising the use of parthenolide, including its analogs, to treat cancer or conditions characterized by abnormal angiogenesis.

公开(公告)号：EP1079704B1

公开(公告)日：2003-07-30

申请号：EP99923249.9

申请日：1999-05-20

申请人： ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, Inc.

发明人： STOOKEY, George, K.

IPC分类号： A23K1/18

CPC分类号： A61K8/365 ,  A23K20/26 ,  A23K50/40 ,  A23L29/035 ,  A61K8/24 ,  A61K8/362 ,  A61K2800/51 ,  A61Q11/00 ,  Y10S426/805 ,  Y10S426/807 ,  Y10S426/808 ,  Y10S426/81

摘要： The present invention provides a method to prevent, inhibit, or reduce dental calculus deposits or formation on the teeth of a dental calculus forming animal comprising exposing the teeth to a food product comprising an acidulent amount of phosphoric acid, wherein said food product further comprises an amount of a polycarboxylic acid sequestering agent effective to prevent, inhibit, or reduce dental calculus deposits or formation. The present invention further provides the food products and the method of preparing the food products of said method.

公开(公告)号：EP1303536A1

公开(公告)日：2003-04-23

申请号：EP01952590.6

申请日：2001-07-10

申请人： ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, INC. ,  Ludwig-Maximilians-Universität München

发明人： ECONS, Michael ,  WHITE, Ken ,  STROM, Tim, Matthias ,  MEITINGER, Thomas

IPC分类号： C07K14/435 ,  C07K14/47 ,  C07K14/475 ,  C07K14/50 ,  C07K16/22 ,  C07K16/26 ,  C12N5/10 ,  C12N15/12 ,  C12N15/16 ,  C12N15/18 ,  C12N15/62 ,  C12N15/63 ,  A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  A61K38/22 ,  A61K48/00 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/567

CPC分类号： C12Q1/6883 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/1825 ,  A61K48/00 ,  C07K14/50 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

摘要： The invention relates to novel nucleic acids encoding a fibroblast growth factor-23 (FGF23) and proteins encoded thereby, mutations in which are associated with autosomal dominant rickets (ADHR). The invention further relates to methods of diagnosing and treating hypophosphatemic and hyperphosphatemic disorders comprising inhibiting or stimulating, respectively, the biological activity of FGF23 in a patient. The invention also relates to methods of treating osteoporosis, dermatomyositis, and coronary artery disease comprising stimulating the biological activity of FGF23 in a patient.

公开(公告)号：EP1265987A2

公开(公告)日：2002-12-18

申请号：EP01916536.4

申请日：2001-03-12

申请人： ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, Inc.

发明人： FIELD, Loren, J.

IPC分类号： C12N5/06 ,  C12N5/10 ,  C12N15/10 ,  C12N15/66 ,  C12N15/67 ,  C07K14/47 ,  G01N33/48 ,  A61L27/24

CPC分类号： C12N5/0657 ,  A61K35/12 ,  C12N2506/02 ,  C12N2510/00

摘要： Described are conduction cardiomyocyte-enriched cellular populations, and methods and materials for obtaining the same. The populations may be used to engraft mammalian myocardial tissue, for example to provide biological pacemakers. Also described are restorative cellular myocardial tissue, for example to provide biological pacemakers. Also described are restorative cellular myocardial grafts for improving the contractile function of injured segments of myocardium, and articles adapted for heart implantation (e.g. conductive pacemaker leads), which includes coatings of viable cardiomyocytes and optionally a carrier for the cardiomyocytes.

公开(公告)号：EP1210405A2

公开(公告)日：2002-06-05

申请号：EP00941542.3

申请日：2000-06-19

申请人： ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, Inc.

发明人： FIELD, Loren, J. ,  PASUMARTHI, Kishore Babu S.

IPC分类号： C12N1/00 ,  C12N15/63 ,  C12N15/85 ,  C07H21/04

CPC分类号： C07K14/4738 ,  A01K67/0271 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2217/20 ,  A01K2227/105 ,  A01K2267/025 ,  A01K2267/03 ,  A61K38/00 ,  C12N5/0657 ,  C12N15/8509 ,  C12N2510/00 ,  C12N2799/021 ,  C12N2830/007 ,  C12N2830/008 ,  C12N2830/38 ,  C12N2830/85 ,  C12N2840/20 ,  C12N2840/203

摘要： Described are methods in vitro and in vivo which involve the use of increased cyclin D2 activity to activate the cell cycle of cardiomyocytes as a baseline measure and/or in response to stimuli. Also described are vectors useful for these purposes, and cardiomyocyte cells exhibiting an activated cell cycle. Transgenic cyclin D2 animal models are also described.

公开(公告)号：EP1468438A2

公开(公告)日：2004-10-20

申请号：EP03705647.0

申请日：2003-01-02

申请人： Advanced Research and Technology Institute, Inc.

发明人： HIEFTJE, Gary, M. ,  RAY, Steven, J.

IPC分类号： H01J49/16

CPC分类号： H01J49/107

摘要： A mass spectrometer and associated method of use where a first ion sample stream (32-l) and a second ion sample stream (32-h) are injected into a mass spectrometer where the ion streams ate reflected by a reflector (52) and detected simultaneously.

公开(公告)号：EP1233751A1

公开(公告)日：2002-08-28

申请号：EP00982263.6

申请日：2000-11-29

申请人： ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, Inc.

发明人： JOHNSON, Matthew, S. ,  MCLENNAN, Gordon

IPC分类号： A61K9/00 ,  A61K47/36

CPC分类号： A61K9/0024 ,  A61K47/36

摘要： Disclosed are compositions and methods for sustained percutaneous delivery of a biologically active substance in a timed-release manner. For example, the compositions and methods can involve percutaneous injection into the tissue surrounding the adventitia of a treated artery at the time of angioplasty, thereby significantly lessening smooth muscle cell proliferation, and thus intimal hyperplasia (IH) and restenosis.