摘要:
The present invention provides a cosmetic composition that can effectively improve melasma and a cosmetic composition that can effectively reduce skin dullness. The cosmetic composition for improving melasma comprises a purine nucleic acid-related substance and a cosmetically acceptable carrier, and exhibits an excellent melasma improving effect due to the action of the purine nucleic acid-related substance contained. The cosmetic composition for reducing skin dullness comprises a purine nucleic acid-related substance and a cosmetically acceptable carrier, and exhibits an excellent effect of reducing skin dullness due to the action of the purine nucleic acid-related substance contained.
摘要:
The present invention provides an industrially advantageous method of producing aminophenol compounds represented by the formula (1) by a simple and easy procedure at a high yield and a high purity. The present invention provides a method of producing an aminophenol compound represented by the formula (1): (wherein each of R1 and R2, which may be the same or different, is a hydrogen atom, a substituted or unsubstituted lower alkyl group or the like; R1 and R2, taken together with the adjacent nitrogen atom, may form a 5- or 6-membered heterocycle with or without other intervening heteroatoms; the heterocycle may be substituted by 1 to 3 substituents selected from the group consisting of a hydroxyl group, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aryloxy group and the like; and the hydroxyl group in the formula (1) is substituted on the 2- or 4-position to the amino group on the phenyl ring), which comprises allowing a cyclohexanedione compound represented by the formula (2) to react with an amine compound represented by the formula (3) (wherein R1 and R2 are as defined above), under a neutral or basic condition.
摘要:
A peptide comprising the amino acid sequence represented by SEQ ID NO:1; a peptide comprising the amino acid sequence represented by SEQ ID NO:2; or a mutant peptide comprising an amino acid sequence derived from an amino acid sequence represented by SEQ ID NO:1 or 2 by addition, deletion or substitution of one or more amino acids and being capable of forming a complex with an HLA-A2402 molecule that can be recognized by HLA-A2402-restricted cytotoxic T lymphocytes or being capable of inducing the same. Such a peptide is useful as a cancer vaccine for epithelial cancer patients having HLA-A2402.
摘要:
A method of softening beans and the beans softened by the said method are provided. The method uses two or more types of enzymes selected from cellulase, hemicellulase and pectinase to produce softened beans having a compressive strength of 6.0 × 10 4 N/m 2 or lower and retaining the original shapes.
摘要翻译:提供了一种软化豆类和通过所述方法软化的豆的方法。 该方法使用选自纤维素酶,半纤维素酶和果胶酶的两种或更多种酶产生抗压强度为6.0×10 4 N / m 2或更低的软化豆并保持原始形状。
摘要:
An object of the invention is to provide an equol-containing fermented soybean hypocotyl material that is useful for foods, pharmaceutical preparations, cosmetic products, etc. The equol-containing fermented soybean hypocotyl material of the invention is obtained by fermenting soybean hypocotyls using at least one microorganism having an equol-producing ability by utilizing at least one daidzein compound selected from the group consisting of diadzein glycosides, daidzein, and dihydrodaidzein.
摘要:
A controlled release sterile freeze-dried aripiprazole formulation is provided which is formed of aripiprazole of a desired mean particle size and a vehicle therefor, which upon constitution with water and intramuscular injection releases aripiprazole over a period of at least about one week and up to about eight weeks. A method for preparing the controlled release freeze-dried aripiprazole formulation, and a method for treating schizophrenia employing the above formulation are also provided.
摘要:
An object of the present invention is to provide a carbonated beverage containing soybean powder or soymilk, wherein the carbonated beverage is provided with a refreshing carbonic acid flavor as well as nutrients and good flavor derived from soybeans, and the soybean-derived ingredient is stably maintained without becoming coagulated even when the content of the soybean-derived ingredient is high. By adjusting the pH of the carbonated beverage containing soybean powder and/or soymilk to 5.7 or higher, it is possible to stably maintain the soybean-derived ingredient without coagulation, and to provide the beverage with a refreshing carbonic acid flavor as well as nutrients and good flavor derived from soybeans.
摘要:
A heterocyclic compound or a salt thereof represented by the formula (I): where R 2 represents a hydrogen atom or a lower alkyl group; A represents a lower alkylene group or a lower alkenylene group; and R 1 represents a cylo C3-C8 alkyl group. The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.