公开(公告)号：EP3433384A1

公开(公告)日：2019-01-30

申请号：EP17712142.3

申请日：2017-03-21

申请人： YUN NV ,  Universiteit Antwerpen

发明人： LEBEER, Sarah ,  CLAES, Ingmar ,  OERLEMANS, Eline ,  VAN DEN BROEK, Marianne

IPC分类号： C12R1/25 ,  A61K35/747 ,  C12N1/20 ,  C12R1/225

公开(公告)号：EP3432865A1

公开(公告)日：2019-01-30

申请号：EP17713625.6

申请日：2017-03-24

申请人： Universiteit Gent

发明人： VERVAET, Chris ,  REMON, Jean Paul ,  VERSTRAETE, Glenn

IPC分类号： A61K9/16 ,  A61K45/06 ,  A61K9/20 ,  A61K9/50 ,  A61K31/135

公开(公告)号：EP3194405B1

公开(公告)日：2018-12-26

申请号：EP15766801.3

申请日：2015-09-17

申请人： Oncodesign S.A.

发明人： HOFLACK, Jan ,  BLOM, Petra ,  LAVERGNE, Olivier ,  GOMEZ, Sylvie

IPC分类号： C07D487/22 ,  C07D498/22 ,  A61K31/529 ,  A61P25/28

CPC分类号： C07D498/22 ,  C07D487/22

摘要： The present invention relates to novel macrocyclic compounds of formula (I) and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of LRRK2 (Leucine-Rich Repeat Kinase 2). Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine or diagnostic agent, in particular for the treatment and/or diagnosis of diseases characterized by LRRK2 kinase activity such as neurological disorders including Parkinson's disease and Alzheimer's disease.

公开(公告)号：EP3403068A1

公开(公告)日：2018-11-21

申请号：EP17706135.5

申请日：2017-01-12

申请人： Katholieke Universiteit Leuven KU Leuven Research & Development ,  Universiteit Hasselt

发明人： AMELOOT, Marcel ,  BOVÉ, Hannelore ,  NAWROT, Tim ,  ROEFFAERS, Maarten ,  STEUWE, Christian ,  VANDEVEN, Martin

IPC分类号： G01N21/63 ,  G01N15/06

摘要： The present invention is based on non-incandescence related emission generation by carbonaceous particles (e.g. carbon black (CB) and black carbon (BC) particles) under illumination with pulsed light. The pulse duration is sufficiently short to trigger an instantaneous sample response without emission of heat-induced sample incandescence. The unique property of the described emission by carbonaceous particles upon pulsed illumination allows label-free optical detection and localization of carbonaceous particles in fluids, cells and tissues of biological and carrier media of non-biological origin. A method for analysing carbonaceous particles in fluids, cells and tissues of biological and carrier media of non-biological origin is also disclosed. An apparatus for analysing carbonaceous particles in fluids, cells and tissues of biological and carrier media of non-biological origin is disclosed that includes: a measurement specimen distribution section for distributing a liquid control sample and a predefined aliquot of liquid sample together with sheath fluid; an optical detecting section comprising of a femtosecond pulsed laser for illumination of the measurement specimen, a forward light receiving element for detecting forward light emitted from the specimen, and a backward light receiving element for detecting backward emitted light from the specimen; and a measurement section for measuring carbonaceous particles in liquids, cells and tissues, based on light detected by the optical detecting section.

公开(公告)号：EP3390546A1

公开(公告)日：2018-10-24

申请号：EP16826513.0

申请日：2016-12-15

申请人： Michelman, Inc.

发明人： COLLINS, Talia McKinney ,  SMALLWOOD, Kenneth Scott ,  TURNBULL, Robert

IPC分类号： C09D11/00 ,  C09D11/02 ,  C09D11/10 ,  C08F210/02 ,  C08F210/04 ,  C08F210/06 ,  C08F220/08 ,  C09D133/02 ,  C08F220/04 ,  C08F220/06

CPC分类号： C09D123/0876 ,  C08F220/04 ,  C08F220/06 ,  C09D11/00 ,  C09D11/02 ,  C09D11/10 ,  C09D133/02 ,  D21H19/12

摘要： Various embodiments provided herein include a primer coating formulation that includes an aqueous dispersion comprising a metal salt and a copolymer of ethylene and one or more acid-based monomers. Also described are embodiments of an aqueous dispersion including a blend a co-binder and ethylene copolymerized with an acid-based monomer neutralized to form an ionomer. Embodiments provided herein also provide a method including applying to a substrate an aqueous dispersion comprising ethylene copolymerized with an acid- based monomer neutralized to form an ionomer.

公开(公告)号：EP2731663B1

公开(公告)日：2018-10-17

申请号：EP11743474.6

申请日：2011-07-15

申请人： Peters, Jean-Pierre

发明人： Peters, Jean-Pierre

IPC分类号： A61M5/00 ,  A61M39/28 ,  A61M39/24 ,  A61M39/10 ,  A61M39/26

CPC分类号： A61M39/24 ,  A61M5/007 ,  A61M39/1011 ,  A61M39/26 ,  A61M39/288 ,  A61M2039/1033

摘要： A disposable set (5) for establishing a fluid connection between a fluid dispensing unit (17) and a dosing device adapted to dispense the fluid into a patients' vein, the disposable set comprising a length of a tubing (15) for establishing a fluid connection from the fluid dispensing unit towards and into the dosing device, wherein the tubing (15) comprises a first (1) and a second (10) tubing part, and a releasable connection (11,12), wherein the first tubing part (1) comprises two or more one-way valves (3, 24) which are provided to prevent a backflow from the patient in the direction of the fluid dispensing unit (17) in the closed position of the releasable connection.

公开(公告)号：EP3384948A1

公开(公告)日：2018-10-10

申请号：EP17164862.9

申请日：2017-04-04

申请人： Medec Benelux NV

发明人： BRAEM, Kristof

IPC分类号： A61M16/00 ,  A61M16/20 ,  G01F25/00

CPC分类号： A61M16/202 ,  A61M16/00 ,  A61M16/04 ,  A61M16/06 ,  A61M16/0858 ,  A61M16/1045 ,  A61M2016/0036 ,  A61M2205/3334 ,  A61M2205/3375 ,  A61M2205/3653 ,  A61M2205/50 ,  A61M2205/70 ,  A61M2205/702 ,  A61M2205/75 ,  A61M2230/432 ,  G01F25/0007

摘要： The invention relates to respiration systems (10) comprising a flow sensor (20) and a ventilator (30) for delivering gas to the patient (5) via the flow sensor (20). More particularly, the invention relates to calibrating the flow sensor (20) of such respiration system (10) in an automated manner, substantially improving the workflow, decreasing risk of human error and enhancing the quality of the obtained calibration data, including subsequent control and information capturing. A fully automated manner is further provided by not disconnecting the patient (5) while continuing ventilation.

公开(公告)号：EP3384011A1

公开(公告)日：2018-10-10

申请号：EP16804820.5

申请日：2016-12-01

申请人： Katholieke Universiteit Leuven ,  Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)

发明人： VERFAILLIE, Cathérine ,  BOON, Ruben ,  SANCHO BRU, Pau ,  COL LOPERENA, Mar ,  PEREA SANCHEZ, Luis

IPC分类号： C12N5/075 ,  C12N5/077

CPC分类号： C12N5/067 ,  C12N5/0672 ,  C12N2501/113 ,  C12N2501/119 ,  C12N2501/155 ,  C12N2501/385 ,  C12N2501/999 ,  C12N2506/45 ,  C12N2513/00

摘要： The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express a hepatic stellate phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other applications, for treatment of liver deficiencies, liver metabolism studies, and liver toxicity studies, fibrogenic studies, or to support hepatocyte function in co-culture setting.

公开(公告)号：EP2793036B1

公开(公告)日：2018-09-26

申请号：EP12845674.6

申请日：2012-10-26

申请人： Valadão Abi-Ackel, Marcos ,  Loiola Pereira Campos, Inácio

发明人： Valadão Abi-Ackel, Marcos ,  Loiola Pereira Campos, Inácio

IPC分类号： G01R21/00 ,  G01R22/10 ,  H02J13/00 ,  H04Q9/02 ,  H04W84/02

CPC分类号： G01R21/00 ,  G01R19/2513 ,  G01R22/066 ,  H01H47/002 ,  H02J13/00 ,  H04Q9/00 ,  H04Q2209/40 ,  H04Q2209/60 ,  H04Q2209/84 ,  H05B37/034 ,  Y10T307/858

摘要： The present invention relates to a system for controlling, measuring and monitoring the secondary electric power distribution grid with remote fraud and power theft detection, readings, power cuts-off, reconnection and client load control, besides continuous monitoring of the electric grid parameters, providing diagnostics on the status of the grid and public lighting from an assigned Command Central, located at the secondary busbar of the distribution transformer, and Measuring Modules at clients installations.

公开(公告)号：EP3362436A1

公开(公告)日：2018-08-22

申请号：EP16775090.0

申请日：2016-09-14

申请人： Universiteit Antwerpen

发明人： MAES, Bert ,  WYBON, Clarence ,  CHEN, Chen ,  BHEETER, Charles Beromeo ,  SERGUEEV, Serguei

IPC分类号： C07D213/80 ,  C07C67/20 ,  C07D213/81 ,  C07D213/90

CPC分类号： C07D213/90 ,  C07C67/20 ,  C07D213/80 ,  C07D213/81 ,  C07C69/78

摘要： The present invention relates to a catalytic method for the conversion of amide-containing compouds by means of a build-in directing group and upon the action of a heteronucleophilic compound (in se an amine (RNH2 or RNHR') or an alcohol (ROH) or a thiol (RSH)) in the presence of a metal catalyst to respectively esters, thioesters, carbonates, thiocarbonates and to what is defined as amide-containing compounds (such as carboxamides, urea, carbamates, thiocarbamates). The present invention also relates to these amide-containing compounds having a build-in directing group (DG), as well as the use of such directing groups in the catalytic directed cleavage of N-DG amides with the use of heteronucleophiles (in se an amine (RNH2 or RNHR') or an alcohol (ROH) or thiol (RSH)).