公开(公告)号：EP0128318B1

公开(公告)日：1987-06-16

申请号：EP84104830.9

申请日：1984-04-30

申请人： MILES LABORATORIES, INC.

发明人： Charlton, Steven C. ,  Fleming, Roger L. ,  Lau, Arthur L. Y.

IPC分类号： C07C119/00 ,  G01N33/84

CPC分类号： G01N33/84

公开(公告)号：EP0103247B1

公开(公告)日：1987-05-06

申请号：EP83108720.0

申请日：1983-09-05

申请人： MILES LABORATORIES, INC.

发明人： Sommer, Ronald G. ,  Greenquist, Alfred C.

IPC分类号： C12Q1/56 ,  G01N33/52

CPC分类号： G03F7/70216 ,  C12Q1/56 ,  G01N33/526 ,  G01N2333/8128 ,  G01N2400/40 ,  Y10S435/805

公开(公告)号：EP0184017A3

公开(公告)日：1987-03-18

申请号：EP85114165

申请日：1985-11-07

申请人： MILES LABORATORIES, INC.

发明人： Boguslawski, Sophie J. ,  DeReimer Anderson, Leslie H.

IPC分类号： C12Q01/68

CPC分类号： C12Q1/6832 ,  Y10S435/803 ,  Y10S435/81

摘要： The rate of hybridization between two complementary polynucleotide segments in an aqueous medium is increased by the presence of the anionic polymers polyacrylate and polymethacrylate. The acceleration effect is particularly useful in nucleic acid hybridization assays involving immobilization of sample nucleic acids and the use of labeled probes. Nonspecific binding of probe to nitrocellulose supports is substantially lower in the presence of the present polymers than in the presence of the prior art accelerator dextran sulfate. Polyacrylate is particularly advantageous since it has been found to be effective at low concentrations and is significantly less expensive than the prior art compound.

公开(公告)号：EP0156261A3

公开(公告)日：1987-03-11

申请号：EP85102983

申请日：1985-03-15

申请人： MILES LABORATORIES, INC.

发明人： Buckler, Robert T. ,  Hatch, Robert P.

IPC分类号： C07D215/54 ,  C07D215/38 ,  C07D491/06 ,  C07D471/06 ,  C12Q01/28 ,  G01N33/52 ,  C07D311/00 ,  C07D221/00

CPC分类号： C07D407/12 ,  C07D215/38 ,  C07D215/54 ,  C07D491/06 ,  C07F9/60 ,  C12Q1/28 ,  C12Q2326/00

摘要： Fluorogenic indicator compounds responsive to the presence of hydrogen peroxide and methods and test compositions for determining hydrogen peroxide in a test sample. Preferred indicator compounds are 3,4-dihydrocoumarin derivatives and 3,4-dihydro-2-quinolone derivatives, especially those having a dialkylamino group at the 7-position. Such particularly preferred compounds are of the formula:
wherein R' is hydrogen, cyano, or -COOR 6 , -CONHR 6 or -CON(R*) 2 whee R 6 is hydrogen, alkyl, alkenyl, or aryl; R 3 and R 4 are lower alkyl; and Y is =0 or =N- R ' where R 5 is hydrogen or lower alkyl. The indicator compounds yield highly fluorescent products upon oxidation by hydrogen peroxide in the presence of a peroxidatively active substance and are useful in analytical systems which generate hydrogen peroxide in response to an analyte under determination in a test sample.

公开(公告)号：EP0104527B1

公开(公告)日：1987-02-25

申请号：EP83108977.6

申请日：1983-09-12

申请人： MILES LABORATORIES, INC.

发明人： Albarella, James Paul

IPC分类号： G01N33/53 ,  C07J41/00 ,  C07K15/02

CPC分类号： G01N33/531 ,  C07J41/0005 ,  G01N33/9453 ,  Y10S436/80 ,  Y10S436/817 ,  Y10S530/806

公开(公告)号：EP0079502B1

公开(公告)日：1987-02-04

申请号：EP82109958.7

申请日：1982-10-28

申请人： MILES LABORATORIES, INC.

发明人： Oberhardt, Bruce J.

IPC分类号： G01N27/30 ,  G01N27/48 ,  G01N33/48

CPC分类号： C12Q1/002 ,  G01N27/3271

公开(公告)号：EP0156256A3

公开(公告)日：1987-01-14

申请号：EP85102948

申请日：1985-03-14

申请人： MILES LABORATORIES, INC.

发明人： Siddigi, Sultan M.

IPC分类号： G01N33/52 ,  G01N31/22

CPC分类号： G01N21/8483 ,  G01N33/521

摘要： The substrate of conventional reagent test devices is replaced by polyester screen material having a nominal filter rating of from about 80 to about 130 microns such that liquid present in the reagent matrix material of the test device is retained therein and prevented from running over onto other reagent matrix areas present on the same reagenttest device.

公开(公告)号：EP0166294A3

公开(公告)日：1986-12-17

申请号：EP85107171

申请日：1985-06-11

申请人： MILES LABORATORIES, INC.

发明人： Elliott, Roderick Douglas ,  Gardiner, Phillip John

IPC分类号： A61M15/00

CPC分类号： A61M15/0065 ,  A61M11/003 ,  A61M15/0066 ,  A61M2202/064

摘要： An inhalation device for dispensing medicament is described having a vertically rotatable medicament delivery member positioned between a medicament storage chamber and an air inhalation chamber where the medicament is suspended in air for subsequent inhalation by a patient.

公开(公告)号：EP0143393A3

公开(公告)日：1986-10-08

申请号：EP84113715

申请日：1984-11-14

申请人： MILES LABORATORIES, INC.

发明人： Brown, Karen K. ,  Cooper, Harold

IPC分类号： A61K31/73

CPC分类号： A61K31/715

摘要： Hyaluronic acid having controlled molecular weight and substantially free of protein and nucleic acids can be prepared from a hyaluronidase-negative or hyaluronidase inhibited microbiological source and product is especially useful as a joint replacement fluid in mammals.

公开(公告)号：EP0130520B1

公开(公告)日：1986-09-24

申请号：EP84107255.6

申请日：1984-06-25

申请人： MILES LABORATORIES, INC.

发明人： Gantzer, Mary Lou

IPC分类号： C12Q1/28 ,  G01N33/52

CPC分类号： C12Q1/28 ,  C12Q2326/12 ,  Y10S436/904