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81.发明授权METHOD FOR OBTAINING DELIPIDATED HEPATITIS B ANTIGENIC AGGREGATES AND THEIR USE THEREOF 有权程序用于获得乙型肝炎及其使用DELIPIDIERTER抗原骨料
公开(公告)号：EP1346727B1
公开(公告)日：2010-04-28
申请号：EP01998363.4
申请日：2001-11-29
发明人： AGUILAR RUBIDO, Julio, César , PENTON ARIAS, Eduardo , TLEUGULOVA, Dina , SEWER MENSIES, Minerva , MUZIO GONZALEZ, Verena, Lucila , GUILL NENIETO, Gerardo, Enrique , SIMON BERNARD, Iloki, Assanga , CRUZ RICONDO, Luis, Javier , FALCON CAMA, Viviana , TAMBARA HERNANDEZ, Yanet
IPC分类号： A61K39/12 , A61K39/29 , A61K39/295 , B01D15/08
CPC分类号： A61K39/292 , A61K39/12 , A61K2039/54 , A61K2039/543 , A61K2039/545 , A61K2039/55505 , A61K2039/575 , C12N2730/10134
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公开(公告)号：EP1693378B1
公开(公告)日：2009-09-30
申请号：EP04802607.4
申请日：2004-12-02
发明人： PAJON FEYT, Rolando , GUILLEN NIETO, Gerardo Enrique , SARDINAS GARCIA, Gretel, Calle Jorge 18 , BETANCOURT NUNEZ, Lázaro Hiram , CASTELLANOS SERRA, Lila, Rosa , PERERA NEGRIN, Yasser , GARCIA DIAZ, Darién , NIEBLA PEREZ, Olivia , CABALLERO MENENDEZ, Evelin , GONZALEZ BLANCO, Sonia
IPC分类号： C07K14/22 , C12N15/31 , A61K39/095 , C12N1/21 , G01N33/569 , C12Q1/68 , A61K48/00
CPC分类号： C07K14/22 , A61K39/00 , A61K2039/523 , A61K2039/53
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83.发明公开USE OF EPIDERMAL GROWTH FACTOR FOR THE MORPHOFUNCTIONAL RESTORATION OF PERIPHERAL NERVES IN DIABETIC NEUROPATHY 有权VERWENDUNG DES EPIDERMALEN WACHSTUMSFAKTORS ZUR MORPHOFUNKELLELLEN WIEDERHERSTELLUNG VON PERIPHEREN NERVEN BEI DIABETISCHER NEUROPATHIE
公开(公告)号：EP2075004A1
公开(公告)日：2009-07-01
申请号：EP07817382.0
申请日：2007-10-01
发明人： FERNÁNDEZ MONTEQUÍN, José, Ignacio , HERRERA MARTINEZ, Luis, Saturnino , BERLANGA ACOSTA, Jorge, Amador , GARCIA DEL BARCO HERRERA, Diana , CIBRIAN VERA, Danay , GUILLEN NIETO, Gerardo, Enrique , UBIETA GÓMEZ, Raimundo , GONZALEZ BLANCO, Sonia , SÁEZ MARTÍNEZ, Vivian María
CPC分类号： A61K38/1808 , A61K9/16 , C07K14/485 , Y10S930/12
摘要： The present invention is relevant to human medicine, and, in particular, to the use of Epidermal Growth Factor (EGF) in a pharmaceutical composition, said composition is administered through infiltration at the periphery of nerve trunks and/or ganglia, for the morphofunctional restoration of peripheral nerves in painful, sensitive-motor neuropathy, as well as ischemic neuritis. It is also relevant to an EGF containing composition, where this molecule can be formulated together with anesthetic or analgesic drugs, or encapsulated in microspheres, and their use for the morphofunctional restoration of peripheral nerves in painful, sensitive-motor neuropathy, as well as in ischemic neuritis.
摘要翻译： 本发明涉及人类药物，特别是涉及在药物组合物中使用表皮生长因子（EGF），所述组合物通过渗透在神经干和/或神经节周围进行形态功能恢复 的周围神经在痛苦，敏感运动神经病，以及缺血性神经炎。 它也与含EGF的组合物有关，其中该分子可与麻醉剂或镇痛药一起配制或包封在微球中，以及它们用于在疼痛，敏感运动神经病变以及周围神经中形态功能恢复的用途 缺血性神经炎。
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84.发明公开CHIMERIC VACCINE ANTIGENS AGAINST CLASSICAL SWINE FEVER VIRUS 有权CHIMÄREVAKZINE-ANTIGENE GEGEN DAS KLASSISCHE SCHWEINEFIEBER-VIRUS
公开(公告)号：EP1994943A2
公开(公告)日：2008-11-26
申请号：EP07711102.9
申请日：2007-02-28
发明人： TOLEDO ALONSO, Jorge, Roberto , SÁNCHEZ RAMOS, Oliberto , BARRERA VALLE, Maritza, Isidra , FIGUEROA BAILE, Nancy, Elena , PRIETO CARRATALÁ, Yanet , RODRÍGUEZ MOLTÓ, María, Pilar , FRÍAS LEPOUREAU, María, Teresa , BORROTO NORDELO, Carlos, Guillermo
IPC分类号： A61K39/12 , C07K14/18 , C07K19/00 , C07K14/705
CPC分类号： C07K14/005 , A01K2267/01 , A61K39/12 , A61K2039/55 , A61K2039/552 , A61K2039/55566 , A61K2039/57 , A61K2039/6031 , C07K14/70575 , C07K16/1081 , C07K2317/76 , C07K2319/21 , C07K2319/74 , C12N2710/10343 , C12N2770/24322 , C12N2770/24334
摘要： The current invention describes chimeric vaccine antigens against the virus that causes the Classic Swine Fever (CSFV). Such vaccine antigens are based on viral subunits coupled to proteins able to stimulate cellular and humoral immune system. Chimeric antigens can be produced in expression systems that guarantee a correct tertiary structure folding of the chimeric molecules, which constitute the essence of the current invention. The vaccine formulations containing such chimeric antigens induce an early and potent immune response on vaccinated pigs and confer full protection against CSFV. Moreover, the resultant vaccine formulations prevent the viral transmission from sows to their offspring. The chimeric antigens, as well as the resultant vaccine formulations, can be applied in animal health as vaccines for preventive use in swine.
摘要翻译： 本发明描述了针对导致经典猪瘟（CSFV）的病毒的嵌合疫苗抗原。 这样的疫苗抗原基于与能够刺激细胞和体液免疫系统的蛋白质偶联的病毒亚基。 嵌合抗原可以在保证构成本发明精华的嵌合分子的正确三级结构折叠的表达系统中产生。 含有这种嵌合抗原的疫苗制剂在接种疫苗的猪上诱导早期有效的免疫应答并赋予对CSFV的完全保护。 此外，所得疫苗制剂防止病毒从母猪传播到其后代。 嵌合抗原以及得到的疫苗制剂可以在动物健康中作为预防用于猪的疫苗使用。
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85.发明公开DENGUE VIRUS CAPSID PROTEIN WHICH INDUCES A PROTECTIVE RESPONSE AND PHARMACEUTICAL COMPOSITION 有权登革病毒 - CAPSID-PROTEIN ZUR INDUKTION EINERSCHÜTZENDENREAKION UND PHARMAZEUCHSCHE ZUSAMMENSETZUNG
公开(公告)号：EP1944038A1
公开(公告)日：2008-07-16
申请号：EP06791279.0
申请日：2006-09-18
发明人： LAZO VAZQUEZ, Laura , HERMIDA CRUZ, Lisset , LOPEZ ABARRATEGUI, Carlos , SIERRA VAZQUEZ, Beatriz de la Caridad , VAZQUEZ RAMUNDO, Susana , VALDEZ PRADO, Iris , GUILLEN NIETO, Gerardo, Enrique , GUZMAN TIRADO, María, Guadalupe , ZULUETA MORALES, Aída
IPC分类号： A61K39/12 , A61K39/295 , C07K14/18
CPC分类号： A61K39/12 , A61K2039/55505 , A61K2039/55566 , C07K14/005 , C12N2770/24122 , C12N2770/24134 , Y02A50/386
摘要： This invention describe the a pharmaceutical compound having the capsid protein of Dengue virus capable of induce in the receptor a protective immune response before the viral challenge without inducing the Abdependent enhancement phenomenon.
摘要翻译： 本发明描述了具有登革热病毒衣壳蛋白的药物化合物，其能够在病毒攻击之前在受体中诱导保护性免疫应答，而不诱导依赖性增强现象。
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公开(公告)号：EP1892245A2
公开(公告)日：2008-02-27
申请号：EP06753157.4
申请日：2006-05-05
发明人： RODRIGUEZ FERNANDEZ, Rolando Eduardo , VERA ALVAREZ, Roberto , DE LA NUEZ VEULENS, Ania , MAZOLA REYES, Yuliet , PEREA RODRÍGUEZ, Silvio, Ernesto , ACEVEDO CASTRO, Boris Ernesto , MUSACCHIO LASA, Alexis , UBIETA GÓMEZ, Raimundo
IPC分类号： C07F9/22 , C07D487/04 , C07D239/42 , C07D239/36 , C07D233/54 , C07D235/14 , C07D215/18 , C07D213/82 , C07D207/36 , C07C237/30 , C07C327/44 , C07C313/06 , C07C275/36 , C07C275/22 , C07C275/18
CPC分类号： C07C211/14 , C07C237/06 , C07C237/22 , C07C243/28 , C07C255/42 , C07C257/14 , C07C271/22 , C07C271/64 , C07C275/08 , C07C275/16 , C07C275/24 , C07C281/12 , C07C317/28 , C07C327/42 , C07C337/08 , C07D207/34 , C07D209/14 , C07D213/81 , C07D213/82 , C07D215/46 , C07D233/88 , C07D233/91 , C07D235/14 , C07D239/36 , C07D239/46 , C07D239/54 , C07D251/22 , C07D307/52 , C07D487/04 , C07F9/224
摘要： Chemical compounds identified by in silico molecular modelling, and having an structure that allows the blocking of the phosphorylation event, through the interaction of such compounds with the phosphorylation domain or its milieu in the substrates of the Casein Kinase 2 enzyme. This invention comprises also the pharmaceutical compositions containing such compounds, and their use in the preparation of medicines for the treatment of diseases related with neoplasic processes.
摘要翻译： 化学化合物通过硅胶分子模拟鉴定，并具有允许阻断磷酸化事件的结构，通过这些化合物与酪蛋白激酶2酶底物中磷酸化结构域或其环境的相互作用。 本发明还包含含有这些化合物的药物组合物及其在制备用于治疗与新生物相关疾病的药物中的用途。
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87.发明公开Method for the identification and relative quantification of proteins based on the selective isolation of RRNK peptides for the simplification of complex mixtures of proteins 审中-公开基于肽的选择性分离的蛋白质的鉴定和相对定量方法PRNK对于复杂的蛋白质混合物的简化
公开(公告)号：EP1795896A2
公开(公告)日：2007-06-13
申请号：EP06077074.0
申请日：2006-11-22
发明人： Puente, Aniel Sanchez , Gonzalez Lopez, Luis Javier , Gil Valdés, Jeonvanis , Betancourt Nunez, Lazaro Hiram , Besada Pérez, Vladimir Armando , Fernandez de Cossio Dorta-Duque, Jorge , Alvarez Gil, Félix Modesto , Padron Palomares, Gabriel Ramon , Gomez, Yassel Ramos
IPC分类号： G01N33/50
CPC分类号： G01N33/6848 , G01N33/6842
摘要： A method based on the selective isolation of peptides originated by the cleavage at the C-terminal end of the arginine residues and do not possess lysine inside their sequences (péptidos RRnK), is described. The method is based on the blocking of amino groups of the LEP peptides and the separation of the RRnK peptides and the modified peptides by using a chromatography column or a chemical reaction of the modified peptides with a solid support. The method simplifies the complex mixtures of peptides by isolating selectively an average of 4 peptides/protein and it guarantees a coverage of 88% of the proteomes, its specificity and selectivity are very high (>95%), it is compatible with different types of isotopic labeling ( 13 C, 18 O or 15 N) and it is useful for the determination of the differential expression of proteins without the necessity of using the two-dimensional electrophoresis.
摘要翻译： 基于源自通过在精氨酸残基的C末端裂解肽的选择性分离和方法不具有它们的序列（péptidosRRnK）的内部赖氨酸，进行说明。 该方法是基于LEP肽的氨基基团的阻断和肽RRnK和修饰的肽通过使用层析柱或修饰的肽与固体支持物的化学反应的分离。 该方法通过对平均四种肽/蛋白质的选择性分离简化的肽的复合物的混合物和它保证的蛋白质组的88％的覆盖率，其特异性和选择性都很高（> 95％），它与不同类型的相容 同位素标记（13 C，18 O或15 N），它是为蛋白质的差异表达的所述确定而无需使用二维电泳的必要性是有用的。
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88.发明授权
公开(公告)号：EP1477181B1
公开(公告)日：2006-12-06
申请号：EP03744706.7
申请日：2003-01-22
发明人： ESTRADA GARCIA, Mario, Pablo, Ave.31 e/158 y 190 , MARTINEZ RODRIGUEZ, Rebeca, Ave.31 e/158 y 190 , ARENAL CRUZ, Amilcar, Circunvalacion norte , PIMENTEL PEREZ, Rafael, Marcos, Circunvalacion n. , MORALES ROJAS, Antonio, Ave.31 e/158 y 190 , PIMENTEL VAZQUEZ, Eulogio, Circunvalacion norte , ESPINOSA VAZQUEZ, Alexander , GARCIA MOLINA, Carmen, Aday, Circunvalacion norte , CABRERA GONZALEZ, Edenaida, Circunvalacion norte , VINJOY CAMPA, Mirta, C. Alegria e/ Ata. y Georgia , TOLEDO PEREZ, Sergio , CARRILLO FARNES, Olimpia , ZALDIVAR MUNOZ, Claudina
CPC分类号： C07K7/06 , A23K20/147 , A23K20/168 , A23K20/184 , A23K50/80 , A61K38/08 , A61K38/25
摘要： The invention is related with the chemical synthesis for increase the growth rate in marketable fish and custracean. The aim of this invention is supply GHRP-6 to induce directly or indirectly the release of growthing hormone or like, to produce the increase of circulating growthing hormone level in the blood of the fishes. The peptide is stable, soluble and biologically active. The peptide is able to stimulate growth, improve the larvae quality, and increase the defense against pathogen agents, the dry weight, the protein concentration and the RNA in muscle of fish and crustaceans.
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89.发明公开Method of selective peptide isolation for the identification and quantitative analysis of proteins in complex mixtures 审中-公开对于肽的用于在复杂的混合物的蛋白质的鉴定和定量分析选择性分离方法
公开(公告)号：EP1589341A3
公开(公告)日：2006-04-26
申请号：EP04078150.2
申请日：2004-11-17
发明人： Betancourt Nunez, Lazaro Hiram , Fernandez de Cossio Dorta-Duque, Jorge , Besada Pérez, Vladimir Armando , Gil Valdés, Jeovanis, Calle Camilo Cienfuegos Edif , Conzales Lopez, Luis Javier , Padron Palomares, Gabriel Ramon , Pajon Feyt, Rolando , Alvarez Gil, Felix Modesto
IPC分类号： G01N33/68
CPC分类号： G01N33/6848 , C12Q1/37
摘要： The present invention describes a method of selective peptide isolation for the identification and quantitative analysis of proteins in complex mixture. The method comprises the selective isolation from every protein of those peptides that neither contain arginine nor histidine (NHNR peptides), and the determination of the relative concentrations of one or several proteins in different samples from the ratio between the areas of the estimated theoretical spectra for the NHNR peptides labeled with different isotopes in each sample. The determination of the relative concentration of proteins is valid for any type of isotopic label of the NHNR peptides. The method avoids the separation and purification of the proteins present in a complex mixture, and the analysis of all peptides generated from the enzymatic digest of the samples. The method is applicable to the identification of proteins with vacunal, therapeutic and diagnostic aims.
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90.发明授权Method for obtaining recombinant surface antigen of hepatitis B virus (HEP B) of higher immunogenic capacity and use thereof in a vaccine preparation 失效一种用于生产具有增强的免疫原性的能力和使用的，重组的乙肝表面抗原的疫苗制剂的方法
公开(公告)号：EP0864649B1
公开(公告)日：2006-04-26
申请号：EP98202021.6
申请日：1991-10-07
发明人： Muzio, González, Verena L. , Penton Arias, Eduardo , Fontirrochi Escobar, Giuvel , Nazábal Gálvez, Marcelo , González Griego, Marta de Jesus , Beldarrain Iznaga, Alejandro , Padron Gonzalez, Guillermo Julio , Ramirez Albajes, Victoria , Garcia Pena, Arnaldo , Ruiz Cruz, Carlos Enrique , Izquierdo Lopez, Gladys Mabel , Herrera Martinez, Luis Saturnino , Duarte Cano, Carlos Antonio , Pérez Suarez, Lilia Luisa , Garcia Suárez, José , de la Riva de la Riva, Gustavo Alberto , Santiago Avila, Ramon Alexis , Ayon Zorrilla, Filiberto Rosendo , Paez Meireles, Rolando , Agraz Fierro, Alberto , Diaz Betancourt, Raul Enrique , Quinones Maya, Yair
CPC分类号： C07K14/005 , A61K39/00 , C07K16/082 , C12N15/815 , C12N2730/10122
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