公开(公告)号：EP1945659A2

公开(公告)日：2008-07-23

申请号：EP06826359.9

申请日：2006-10-19

申请人： University of Florida Research Foundation, Incorporated ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  Cornell Research Foundation, Inc. ,  Intervet Inc.

发明人： CRAWFORD, Patti, C. ,  GIBBS, Paul, J. ,  DUBOVI, Edward, J. ,  DONIS, Ruben, O. ,  KATZ, Jacqueline ,  KLIMOV, Alexander, I. ,  KAKSHMANAN, Nallakannu, P. ,  LUM, Melissa, Anne ,  GOOVAERTS, Daniel, Ghislena, Emiel ,  MELLENCAMP, Mark, William ,  CASTLEMAN, William L. ,  COX, Nancy J.

IPC分类号： C07K14/11 ,  A61K39/145 ,  C12N7/00

CPC分类号： A61K39/145 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/552 ,  A61K2039/55555 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2760/16121 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16143 ,  G01N33/56983 ,  G01N2333/11 ,  G01N2500/10 ,  G01N2800/12

摘要： The subject invention pertains to isolated influenza virus, notably the viral isolate designated as canine/Miami/05, that is capable of infecting canids and causing respiratory disease in the canid. The subject invention also pertains to compositions and methods for inducing an immune response against an influenza virus of the present invention. The subject invention also pertains to compositions and methods for identifying a virus of the invention and diagnosing infection of an animal with a virus of the invention.

公开(公告)号：EP1937311A2

公开(公告)日：2008-07-02

申请号：EP06825277.4

申请日：2006-09-28

申请人： The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services

发明人： BIRAGYN, Arya ,  MATSUSHIMA, Kouji ,  BATAAR, Dolgor

IPC分类号： A61K47/48

CPC分类号： A61K38/465 ,  A61K38/195 ,  A61K38/45 ,  A61K45/06 ,  A61K47/6415 ,  A61K47/642 ,  C07K14/521 ,  C07K14/523 ,  C07K14/7158 ,  C07K2319/55 ,  C12N9/1077 ,  C12N9/22 ,  C12Y204/02036 ,  C12Y301/27 ,  C12Y301/27005

摘要： The instant invention provides methods and compositions for modulation of the immune system. Specifically, the invention provides methods and compositions for increasing T cell mediated immune response useful in the treatment of cancer and chronic infection.

摘要翻译： 本发明提供了用于调节免疫系统的方法和组合物。 具体地，本公开提供了用于增加可用于治疗癌症和慢性感染的T细胞介导的免疫应答的方法和组合物。

公开(公告)号：EP1924604A1

公开(公告)日：2008-05-28

申请号：EP06789775.1

申请日：2006-08-15

申请人： The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services

发明人： DIMITROV, Dimiter, S. ,  FENG, Yang

IPC分类号： C07K16/26 ,  A61K39/395 ,  G01N33/574

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/55 ,  G01N2333/65

摘要： Disclosed herein are isolated monoclonal human antibodies that specifically bind insulin-like growth factor II (IGF-II) with an equilibrium dissociation constant (Kd) of 1 nM or less, wherein the antibodies bind IGF-I with an equilibrium dissociation constant (Kd) of 1 mM or greater. The antibodies inhibit phosphorylation of the insulin-like growth factor receptor. Nucleic acids encoding these antibodies, expression vectors including these nucleic acids, and isolated host cells that express the nucleic acids are also disclosed. The antibodies can be used to detect human IGF-II in a sample. Methods of diagnosing a tumor are disclosed herein that utilize these antibodies. Methods of treating a subject with a tumor are also disclosed.

公开(公告)号：EP1921989A2

公开(公告)日：2008-05-21

申请号：EP06813476.6

申请日：2006-08-14

申请人： The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services

发明人： PLENZ, Dietmar

IPC分类号： A61B5/0476

CPC分类号： G06F19/34 ,  A61B5/0476 ,  A61B5/4094

摘要： Method and system for determining a cognitive enhancement and/or anti-epileptic effect comprising: detecting synchronized neuronal activity in neuronal tissue (601), monitoring spreading of the synchronized neuronal activity (602), determining a parameter (604, 605) indicative of the closeness of the synchronized neuronal activity to the critical state and comparing (613) the parameter to a predetermined value.

公开(公告)号：EP1912635A2

公开(公告)日：2008-04-23

申请号：EP06800452.2

申请日：2006-07-27

申请人： The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services

发明人： POMMIER, Yves ,  SHOEMAKER, Robert, H. ,  SCUDIERO, Dominic ,  CURRENS, Michael ,  CARDELINA, John ,  JOBSON, Andrew

IPC分类号： A61K31/17 ,  A61K31/175 ,  A61K31/4184 ,  A61P9/10 ,  A61P3/10 ,  A61P35/00 ,  A61P29/00

CPC分类号： A61K31/17 ,  A61K31/175 ,  A61K31/4184 ,  C07C251/44 ,  C07C281/16 ,  C07C2603/18

摘要： Described herein are Chk2 -inhibitor compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.

公开(公告)号：EP1411124B1

公开(公告)日：2008-04-09

申请号：EP03022671.6

申请日：1997-02-06

申请人： The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services

发明人： Wang, Rong-Fu ,  Rosenberg, Steven A.

IPC分类号： C12N15/12 ,  C07K14/705 ,  A61K39/00 ,  C07K16/28 ,  C12N5/08 ,  G01N33/574 ,  A01K67/027 ,  A61P35/00

CPC分类号： C12N9/0059 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/51 ,  C07K14/4748 ,  C12N9/0071 ,  C12N9/90 ,  C12N2799/021 ,  Y10S435/96 ,  Y10S435/975 ,  Y10S530/828

公开(公告)号：EP1898935A2

公开(公告)日：2008-03-19

申请号：EP06760547.7

申请日：2006-05-25

申请人： The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services

发明人： TSENG, Christopher, K. ,  MARQUEZ, Victor, E.

IPC分类号： A61K31/7072 ,  A61P31/20

CPC分类号： A61K31/7072

摘要： A method for the prevention or treatment of poxvirus infection by administering an effective amount of an antiviral agent comprising cyclopropanated carbocyclic 2'-deoxynucleoside to an individual in need thereof is provided.

公开(公告)号：EP1877082A2

公开(公告)日：2008-01-16

申请号：EP05817336.0

申请日：2005-06-16

申请人： The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services

发明人： XU, He ,  KIRK, Allan, D.

IPC分类号： A61K39/00

CPC分类号： A61K39/0008 ,  A61K2039/5154 ,  A61K2039/5158 ,  C07K16/28

摘要： The invention relates to compositions containing antibodies that can bind activated lymphocytes and/or activated monocytes. The invention also provides methods for making these antibodies and methods for using these antibodies to treat or prevent undesirable immune responses.

公开(公告)号：EP1861424A2

公开(公告)日：2007-12-05

申请号：EP05858301.4

申请日：2005-11-04

申请人： The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services

发明人： DIMITROV, Diviter, S. ,  ZHONGYU, Zhu ,  BRODER, Christopher, C.

IPC分类号： C07K16/10 ,  A61K39/395

CPC分类号： C07K16/1203 ,  A61K51/1009 ,  A61K2039/505 ,  C07K16/1027 ,  C07K2317/21 ,  C07K2317/51 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56983 ,  G01N33/6893 ,  G01N2333/115 ,  G01N2469/10

摘要： The present invention relates to monoclonal antibodies that bind or neutralize Hendra or Nipah virus. The invention provides such antibodies, fragments of such antibodies retaining Hendra or Nipah virus-binding ability, fully human antibodies retaining Hendra or Nipah virus-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.

摘要翻译： 本发明涉及结合或中和Hendra或Nipah病毒的单克隆抗体本发明提供了这样的抗体，这种抗体的片段，其保留了Hendra或Nipah病毒结合能力，完全人体抗体保留了Hendra或Nipah病毒结合能力，以及药物组合物，包括 这样的抗体本发明还提供了编码本发明的抗体的分离的核酸和用其转化的宿主细胞。 另外，本发明提供了使用本发明的抗体和核酸的预防，治疗和诊断方法

公开(公告)号：EP1861123A2

公开(公告)日：2007-12-05

申请号：EP06735517.2

申请日：2006-02-16

申请人： The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services

发明人： TERABE, Masaki ,  TAKAKU, Shun ,  BERZOFSKY, Jay A.

IPC分类号： A61K39/395 ,  A61K39/00 ,  A61K39/12 ,  A61K41/00 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P37/04 ,  C07K16/22 ,  C07K14/025

CPC分类号： A61K39/39 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/3955 ,  A61K39/39558 ,  A61K2039/5152 ,  A61K2039/55516 ,  A61K2039/55522 ,  A61K2039/55566 ,  A61K2039/585 ,  C07K16/22 ,  C12N2710/20022 ,  C12N2710/20034 ,  A61K2300/00

摘要： Methods are provided herein for synergistically affecting tumor growth in a subject, involving the administration to the subject of an agent that blocks the TGF- β signaling pathway in combination with an immunogenic agent. The agent that blocks the TGF-β signaling pathway is believed to inhibit the immunosuppressive effects of TGF-β, while the immunogenic agent is believed to enhance an immune response. Surprisingly, the combination of such elements produces a synergistic effect. In one embodiment, the administration of the IDl 1.16 anti-TGF-β antibody in combination with the human papilloma virus E7(49-57) peptide enhances tumor regression and tumor-specific CTL response in the subject. In another embodiment, the administration of the IDl 1.16 anti-TGF-β antibody in combination with irradiated CT26 cells enhances tumor regression in the subject. The method of administering the combination of agents to the subject is more effective than the administration of each agent individually, or the sum of their individual effects.