公开(公告)号：EP1161988A2

公开(公告)日：2001-12-12

申请号：EP01116443.1

申请日：1999-08-12

申请人： SYMYX TECHNOLOGIES

发明人： Turner, Howard ,  Dales, G. Cameron ,  Van Erden, Lynn ,  Van Beek, Johannes A. M. ,  Hajduk, Damian A. ,  Nielsen, Ralph B. ,  Mansky, Paul ,  Matsiev, Leonid ,  Wang, Pei ,  McFarland, Eric

IPC分类号： B01J19/00

CPC分类号： B01L3/50851 ,  B01F15/00207 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00056 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  G01K13/00 ,  G01N21/253

摘要： A method for parallel processing of a plurality of reaction mixtures and for monitoring the consumption or production of a gas-phase component of the reaction mixtures, the method comprising reacting the reaction mixtures in a plurality of vessels such that the pressure in the vessels changes as the gas-phase component of the reaction mixtures is consumed or produced, sensing the pressure within the vessels, passing the gas-phase component of the reaction mixture into or out of the vessels in response to the pressure sensed within the vessels, and recording the pressure changes within each of the vessels.

摘要翻译： 一种用于反应混合物中的多个并行处理和用于监测反应混合物的气相组分的消耗或生产的方法，包括在容器的多元反应的反应混合物的方法检测所做的压力在血管中的变化如 反应混合物的气相组分被消耗或产生，感测所述容器内的压力，使所述反应混合物的气相组分流入或流出所述容器的响应于血管内感测到的压力，并记录该 在每个容器的压力的变化。

公开(公告)号：EP1055452A2

公开(公告)日：2000-11-29

申请号：EP00110336.5

申请日：2000-05-13

申请人： Mettler-Toledo GmbH

发明人： Harness, James R. ,  Haidle, Rudy H. ,  Markus, Larry W. ,  Gallup, David A. ,  Grzybowski, Andrew J.

IPC分类号： B01J19/00

CPC分类号： G01N11/14 ,  B01F13/0818 ,  B01F15/00123 ,  B01F15/00246 ,  B01F2013/1091 ,  B01J3/04 ,  B01J3/048 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00335 ,  B01J2219/00337 ,  B01J2219/00344 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01L7/00 ,  C40B60/14 ,  G01N2035/00534

摘要： A reaction block assembly of reaction vessels for conducting chemical reactions under pressure. The assembly includes a heat conductive reactive block having reaction vessel receiving openings formed in the block. A heat exchanger is mounted in heat transfer engagement with some of the exterior walls of the reaction block. The heat exchangers can operate in different modes, to provide a heat differential across the reaction block. A reaction vessel is positioned in each reaction vessel receiving opening in the block. A cap is attached to each reaction vessel and a cannula opening is formed in each cap. A cannula passage is connected at one end to a cannula opening in each cap and it has a septum at the other end. A valve controls each cannula passage. An operating mechanism is provided for opening and closing each cannula passage controlling valve. The reaction block assembly may be used to determine when the reaction of a solution in a reaction vessel is completed. This is accomplished by using a calibration curve comparing the frequency of rotation of the stirring bar with the viscosity of the reaction solution in which the frequency is inversely proportional to the viscosity. The time interval at which the stir bar decouples from rotation with the driving magnet is determined. This time interval of decoupling is compared with the calibration table to determine the viscosity of the solution at the time the reaction was completed which takes place at the time the stir bar was decoupled.

公开(公告)号：EP0821619A4

公开(公告)日：1999-06-02

申请号：EP96911797

申请日：1996-04-17

申请人： ONTOGEN CORP

发明人： CARGILL JOHN ,  MAIEFSKI ROMAINE R

IPC分类号： C12N15/09 ,  B01J19/00 ,  C07H21/00 ,  C07K1/04 ,  C12M1/00 ,  C40B50/14 ,  C40B60/14 ,  C40B70/00 ,  G01N35/02 ,  B01J8/06 ,  B01L3/14

CPC分类号： C07H21/00 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00315 ,  B01J2219/00335 ,  B01J2219/00373 ,  B01J2219/00416 ,  B01J2219/00418 ,  B01J2219/00423 ,  B01J2219/00454 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00542 ,  B01J2219/00545 ,  B01J2219/00547 ,  B01J2219/00549 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00686 ,  C07K1/045 ,  C40B50/14 ,  C40B60/14 ,  C40B70/00 ,  G01N35/028

摘要： Method and apparatus for generation of chemical libraries are described. The apparatus includes a reaction block (140) which supports replaceable reaction chambers. Each reaction block is fitted with four sets of twelve reaction chambers. Reaction chambers are provided with s-shaped trap tubes which run into drain tubes. The reaction block is provided with gas lines and a septum seal such that gas pressurization empties the reaction chambers into the drain tubes. The drain tubes are arranged so as to mate directly with a standard 96 well microtiter plate for the collection of material. A docking station (300) secures registration of reaction blocks and introduces gases and liquids into the reaction blocks (140). An inert atmosphere is maintained in the reaction block by a top and an optional bottom seals. A needle (20) pipettes reagents from reagent containers (44) into reaction chambers. A container rack (90) keeps reagent containers securely in place.

公开(公告)号：EP0876208A1

公开(公告)日：1998-11-11

申请号：EP96943189.0

申请日：1996-12-24

申请人： RHONE-POULENC AGROCHIMIE

发明人： VIAL, Jean ,  ORTHOLAND, Jean-Yves ,  CALLEJA, Marcel

IPC分类号： B01D29 ,  B01D35 ,  B01J4 ,  B01J19 ,  G01N1 ,  C40B60

CPC分类号： G01N35/1079 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00335 ,  B01J2219/00373 ,  B01J2219/00414 ,  B01J2219/00423 ,  B01J2219/005 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00686 ,  C40B60/14 ,  G01N1/34 ,  Y10T436/25375 ,  Y10T436/2575

摘要： A device for separating the liquid and solid constituents in a chemical reaction medium (1), comprising a metal filtering needle (12) with lateral holes (5) able to pass through polymer- or rubber-like membranes without losing their impermeability to gas (2), a source of suction (7) able to draw liquid out of an enclosed space (8), a channel for evacuating liquid (6) and an end piece (4).

公开(公告)号：EP0848721A1

公开(公告)日：1998-06-24

申请号：EP96929937.0

申请日：1996-09-06

申请人： PATHOGENESIS CORPORATION

发明人： BAKER, William, R. ,  TOWELL, J., Andrew ,  HARNESS, James, R.

IPC分类号： C12N15 ,  B01J19 ,  B01L3 ,  B01L7 ,  C08F2 ,  C12M1 ,  C40B60

CPC分类号： B01L3/50851 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00335 ,  B01J2219/00373 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01L3/50853 ,  B01L7/52 ,  C40B60/14

摘要： A method and device (2) for the simultaneous production of chemical compounds in an array which is capable of providing a very broad range of reaction environments including reaction temperatures of -40 °C to 150 °C, reflux condensation, and a selective gas environment. The invention also allows the addition of several reagents (4) during the course of the production process. The device (2) is comprised of a number of different block sections (6, 24, 18) which are fastened together to provide the required reaction environment.

公开(公告)号：EP0529504B1

公开(公告)日：1998-05-13

申请号：EP92114165.1

申请日：1992-08-19

申请人： SHIMADZU CORPORATION

发明人： Nokihara, Kiyoshi ,  Hazama, Makoto ,  Yamamoto, Rintaro ,  Nakamura, Shin

IPC分类号： B01J19/00 ,  C07K1/04

CPC分类号： B01J19/004 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00288 ,  B01J2219/00308 ,  B01J2219/00373 ,  B01J2219/00423 ,  B01J2219/00493 ,  B01J2219/005 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00725 ,  C07K1/045 ,  C40B40/10 ,  C40B60/14