Abstract:
An apparatus for use in parallel reaction of materials. The apparatus includes a base (32) having a plurality of reaction wells, each of the reaction wells (30) having a closed lower end (84) and open upper end for receiving reactant materials. A cover (34) is configured for sealing engagement with the base to form a housing enclosing the plurality of reaction wells and defining a common pressure chamber (26) in communication with the reaction wells. The apparatus further includes a flow restriction device (92) positioned adjacent to the open ends of the reaction wells to provide communication between the reaction wells and the pressure chamber while reducing cross-talk between the reactants and an inlet port (70) in communication with the pressure chamber for supplying pressurized fluid to the chamber to pressurize the reaction wells. The housing is configured to sustain a pressure substantially above atmospheric pressure.
Abstract:
A method for parallel processing of a plurality of reaction mixtures and for monitoring the consumption or production of a gas-phase component of the reaction mixtures, the method comprising reacting the reaction mixtures in a plurality of vessels such that the pressure in the vessels changes as the gas-phase component of the reaction mixtures is consumed or produced, sensing the pressure within the vessels, passing the gas-phase component of the reaction mixture into or out of the vessels in response to the pressure sensed within the vessels, and recording the pressure changes within each of the vessels.
Abstract:
A method for parallel processing of a plurality of reaction mixtures and for monitoring the consumption or production of a gas-phase component of the reaction mixtures, the method comprising reacting the reaction mixtures in a plurality of vessels such that the pressure in the vessels changes as the gas-phase component of the reaction mixtures is consumed or produced, sensing the pressure within the vessels, passing the gas-phase component of the reaction mixture into or out of the vessels in response to the pressure sensed within the vessels, and recording the pressure changes within each of the vessels.
Abstract:
Apparatus for parallel processing of reaction mixtures comprising a reactor block having a series of wells therein extending from an exterior surface of the block, a removable plate removably secured to the reactor block face-to-face with said exterior surface, the removable plate having openings therein in registry with the wells in the reactor block, removable liners in the wells for containing the reaction mixtures, a temperature control system for regulating the temperature of the reaction mixtures, and a stirring system attached to the removable plate and removable with the removable plate for agitating the reaction mixtures, the stirring system comprising spindles extending into respective wells, each of the spindles having a first end and a second end, stirring blade attached to the first end of each of the spindles, a drive mechanism located external to the vessels that is adapted to rotate the spindles, and magnetic feed through devices for magnetically coupling the drive mechanism to the second end of each of the spindles.
Abstract:
Methodologies for the synthesis, screening and characterisation of organometallic compounds and catalysts (eg homogenous catalysts), including combinatorial synthesis, screening and characterisation of libraries of supported and unsupported organometallic compounds and catalysts (eg homogenous catalysts). The methods can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (eg homogeneous catalysts), but also as additives and therapeutic agents.
Abstract:
A method of processing reaction mixtures in parallel, comprising: forming chemical reaction mixtures in a plurality of reactor vessels of a parallel reactor apparatus said apparatus comprising sensors for providing measured values relating to chemical reactions in said reactor vessels, and a processor for receiving data relating to said measured values; sealing the reaction mixture in each reactor vessel against fluid communication with the other vessels and at a pressure different than ambient pressure; injecting a fluid into at least one of the reactor vessels while the reaction mixture in said at least one vessel is sealed and at a pressure different than ambient pressure; agitating the reaction mixtures for at least a portion of the sealing step; and using the processor to receive said data relating to said measured values of the chemical reactions in said reactor vessels.