公开(公告)号：EP1260267A3

公开(公告)日：2005-09-21

申请号：EP02017947.9

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES

Inventor： Turner, Howard ,  Dales, Cameron G. ,  Van Erden, Lynn ,  Van Beek, Johannes A.M. ,  Hajduk, Damian A. ,  Nielsen, Ralph B. ,  Mansky, Paul ,  Matsiev, Leonid ,  Wang, Pei ,  McFarland, Eric

IPC: B01J19/00

CPC classification number: B01L3/50851 ,  B01F15/00207 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00056 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  G01K13/00 ,  G01N21/253

Abstract: A method of processing reaction mixtures in parallel, comprising: forming chemical reaction mixtures in a plurality of reactor vessels of a parallel reactor apparatus said apparatus comprising sensors for providing measured values relating to chemical reactions in said reactor vessels, and a processor for receiving data relating to said measured values; sealing the reaction mixture in each reactor vessel against fluid communication with the other vessels and at a pressure different than ambient pressure; injecting a fluid into at least one of the reactor vessels while the reaction mixture in said at least one vessel is sealed and at a pressure different than ambient pressure; agitating the reaction mixtures for at least a portion of the sealing step; and using the processor to receive said data relating to said measured values of the chemical reactions in said reactor vessels.

公开(公告)号：EP1184073B1

公开(公告)日：2005-10-12

申请号：EP01116401.9

申请日：1999-08-12

Applicant: Symyx Technologies, Inc.

Inventor： Turner, Howard ,  Dales, G. Cameron ,  Van Erden, Lynn ,  Van Beek, Johannes A.M. ,  Hajduk, Damian A. ,  Nielsen, Ralph B. ,  Mansky, Paul ,  Matsiev, Leonid ,  Wang, Pei ,  McFarland, Eric

IPC: B01J19/00 ,  G05D21/00

CPC classification number: B01L3/50851 ,  B01F15/00207 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00056 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  G01K13/00 ,  G01N21/253

公开(公告)号：EP1161988A2

公开(公告)日：2001-12-12

申请号：EP01116443.1

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES

Inventor： Turner, Howard ,  Dales, G. Cameron ,  Van Erden, Lynn ,  Van Beek, Johannes A. M. ,  Hajduk, Damian A. ,  Nielsen, Ralph B. ,  Mansky, Paul ,  Matsiev, Leonid ,  Wang, Pei ,  McFarland, Eric

IPC: B01J19/00

CPC classification number: B01L3/50851 ,  B01F15/00207 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00056 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  G01K13/00 ,  G01N21/253

Abstract: A method for parallel processing of a plurality of reaction mixtures and for monitoring the consumption or production of a gas-phase component of the reaction mixtures, the method comprising reacting the reaction mixtures in a plurality of vessels such that the pressure in the vessels changes as the gas-phase component of the reaction mixtures is consumed or produced, sensing the pressure within the vessels, passing the gas-phase component of the reaction mixture into or out of the vessels in response to the pressure sensed within the vessels, and recording the pressure changes within each of the vessels.

Abstract translation: 一种用于反应混合物中的多个并行处理和用于监测反应混合物的气相组分的消耗或生产的方法，包括在容器的多元反应的反应混合物的方法检测所做的压力在血管中的变化如 反应混合物的气相组分被消耗或产生，感测所述容器内的压力，使所述反应混合物的气相组分流入或流出所述容器的响应于血管内感测到的压力，并记录该 在每个容器的压力的变化。

公开(公告)号：EP1161988B1

公开(公告)日：2004-10-13

申请号：EP01116443.1

申请日：1999-08-12

Applicant: Symyx Technologies, Inc.

Inventor： Turner, Howard ,  Dales, G. Cameron ,  Van Erden, Lynn ,  Van Beek, Johannes A.M. ,  Hajduk, Damian A. ,  Nielsen, Ralph B. ,  Mansky, Paul ,  Matsiev, Leonid ,  Wang, Pei ,  McFarland, Eric

IPC: B01J19/00 ,  G05D16/00

CPC classification number: B01L3/50851 ,  B01F15/00207 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00056 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  G01K13/00 ,  G01N21/253

公开(公告)号：EP1161988A3

公开(公告)日：2002-03-27

申请号：EP01116443.1

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES

Inventor： Turner, Howard ,  Dales, G. Cameron ,  Van Erden, Lynn ,  Van Beek, Johannes A. M. ,  Hajduk, Damian A. ,  Nielsen, Ralph B. ,  Mansky, Paul ,  Matsiev, Leonid ,  Wang, Pei ,  McFarland, Eric

IPC: B01J19/00 ,  G05D16/00

CPC classification number: B01L3/50851 ,  B01F15/00207 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00056 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  G01K13/00 ,  G01N21/253

Abstract: A method for parallel processing of a plurality of reaction mixtures and for monitoring the consumption or production of a gas-phase component of the reaction mixtures, the method comprising reacting the reaction mixtures in a plurality of vessels such that the pressure in the vessels changes as the gas-phase component of the reaction mixtures is consumed or produced, sensing the pressure within the vessels, passing the gas-phase component of the reaction mixture into or out of the vessels in response to the pressure sensed within the vessels, and recording the pressure changes within each of the vessels.

公开(公告)号：EP1184074A2

公开(公告)日：2002-03-06

申请号：EP01116411.8

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES

Inventor： Turner, Howard ,  Dales, G. Cameron ,  Van Erden, Lynn ,  Van Beek, Johannes A.M. ,  Hajduk, Damian A. ,  Nielsen, Ralph B. ,  Mansky, Paul ,  Matsiev, Leonid ,  Wang, Pei ,  Mcfarland, Eric

IPC: B01J19/00 ,  B01F15/00 ,  B01F7/16 ,  F28F27/00 ,  G01K13/00

CPC classification number: B01L3/50851 ,  B01F15/00207 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00056 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  G01K13/00 ,  G01N21/253

Abstract: Apparatus for parallel processing of reaction mixtures comprising a reactor block having a series of wells therein extending from an exterior surface of the block, a removable plate removably secured to the reactor block face-to-face with said exterior surface, the removable plate having openings therein in registry with the wells in the reactor block, removable liners in the wells for containing the reaction mixtures, a temperature control system for regulating the temperature of the reaction mixtures, and a stirring system attached to the removable plate and removable with the removable plate for agitating the reaction mixtures, the stirring system comprising spindles extending into respective wells, each of the spindles having a first end and a second end, stirring blade attached to the first end of each of the spindles, a drive mechanism located external to the vessels that is adapted to rotate the spindles, and magnetic feed through devices for magnetically coupling the drive mechanism to the second end of each of the spindles.

Abstract translation: 用于平行处理反应混合物的设备，其包括反应器块体，反应器块体中具有从块体的外表面延伸的一系列孔，与所述外表面面对面地可移除地固定到反应器块体的可移除板，可移除板具有开口 其中与反应器块中的井配准，井中用于容纳反应混合物的可移除衬里，用于调节反应混合物温度的温度控制系统，以及连接到可移除板并可用可移除板移除的搅拌系统 用于搅动反应混合物，搅拌系统包括延伸到各自井中的主轴，每个主轴具有第一端和第二端，搅拌叶片连接到每个主轴的第一端，驱动机构位于容器外部 适用于旋转主轴，以及用于磁性耦合驱动机构的磁性馈送装置 对每个锭子的第二端有害。

公开(公告)号：EP1174183B1

公开(公告)日：2004-10-20

申请号：EP01116442.3

申请日：1999-08-12

Applicant: Symyx Technologies, Inc.

Inventor： Turner, Howard ,  Dales, G. Cameron ,  Van Erden, Lynn ,  Van Beek, Johannes A. M. ,  Hajduk, Damian A. ,  Nielsen, Ralph B. ,  Mansky, Paul ,  Matsiev, Leonid ,  Wang, Pei ,  McFarland, Eric

IPC: B01J19/00 ,  B01F15/00 ,  B01F7/16 ,  F28F27/00 ,  G01K13/00

CPC classification number: B01L3/50851 ,  B01F15/00207 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00056 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  G01K13/00 ,  G01N21/253

公开(公告)号：EP1184073A3

公开(公告)日：2002-04-17

申请号：EP01116401.9

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES

Inventor： Turner, Howard ,  Dales, G. Cameron ,  Van Erden, Lynn ,  Van Beek, Johannes A.M. ,  Hajduk, Damian A. ,  Nielsen, Ralph B. ,  Mansky, Paul ,  Matsiev, Leonid ,  Wang, Pei ,  McFarland, Eric

IPC: B01J19/00 ,  G05D21/00

CPC classification number: B01L3/50851 ,  B01F15/00207 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00056 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  G01K13/00 ,  G01N21/253

Abstract: A reactor control system which monitors sensors providing measured values relating to a plurality of reactor vessels of a combinatorial reactor when used in a combinatorial chemical reaction, said system comprising: (a) a receiver for receiving the measured value associated with the contents of each of the plurality of reactor vessels during the course of the combinatorial chemical reaction; and (b) a display for simultaneously displaying during the course of the combinatorial chemical reaction the received measured values, said display comprising a tabular array corresponding to the plurality of reactor vessels.

Abstract translation: 一种用于并行处理多个反应混合物并用于监测反应混合物的气相组分的消耗或产生的方法，所述方法包括使反应混合物在多个容器中反应，使得容器中的压力变为 消耗或产生反应混合物的气相组分，感测容器内的压力，响应于在容器内感测到的压力将反应混合物的气相组分进入或流出容器，并记录 每个容器内的压力变化。

公开(公告)号：EP1174183A2

公开(公告)日：2002-01-23

申请号：EP01116442.3

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES

Inventor： Turner, Howard ,  Dales, G. Cameron ,  Van Erden, Lynn ,  Van Beek, Johannes A. M. ,  Hajduk, Damian A. ,  Nielsen, Ralph B. ,  Mansky, Paul ,  Matsiev, Leonid ,  Wang, Pei ,  McFarland, Eric

IPC: B01J19/00 ,  B01F15/00 ,  B01F7/16 ,  F28F27/00 ,  G01K13/00

CPC classification number: B01L3/50851 ,  B01F15/00207 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00056 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  G01K13/00 ,  G01N21/253

Abstract: A parallel reactor for simultaneously processing a plurality of reaction mixtures, the reactor comprising: vessels for containing the reaction mixtures, and multi-piece spindles for stirring the reaction mixtures in the vessels, each multi-piece spindle comprising a metal upper spindle portion, a plastic stirrer, and a coupling for releasably coupling the plastic stirrer to the metal upper spindle portion in a position wherein the stirrer extends down into a respective vessel, the plastic stirrer being removable from the coupling after a mixing operation to permit replacement of the stirrer.

公开(公告)号：EP1184074B1

公开(公告)日：2004-06-09

申请号：EP01116411.8

申请日：1999-08-12

Applicant: Symyx Technologies, Inc.

Inventor： Turner, Howard ,  Dales, G. Cameron ,  Van Erden, Lynn ,  Van Beek, Johannes A.M. ,  Hajduk, Damian A. ,  Nielsen, Ralph B. ,  Mansky, Paul ,  Matsiev, Leonid ,  Wang, Pei ,  Mcfarland, Eric

IPC: B01J19/00 ,  B01F13/08

CPC classification number: B01L3/50851 ,  B01F15/00207 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00056 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  G01K13/00 ,  G01N21/253