摘要:
There are described compounds of formula 1, in which Ra, Rb, Rc, Rd, Re, Rf and Rg, which may be the same or different, each represent hydrogen, amino, hydroxy, alkoxy, alkenyloxy, halogen, acyl, alkenyl, alkyl, or alkoxy substituted by phenyl,
Rh is hydrogen, alkyl or -COOH. X is a hydrocarbon chain containing from 2 to 10 carbon atoms and optionally substituted by a hydroxy group, A has no significance or represents Y, OY, or SY and Y represents a C 1 to 4 hydrocarbon chain which is optionally substituted by alkyl C 1 to 4, E and G, which may be the same or different, each represent -0-, -S- or -CH 2 -, provided that at least one of E and G is -0- or -S-, L, together with the carbon atoms to which it is attached, forms a benzene, furan, thiophene, indole, or pyran-2-one ring,
and pharmaceutically acceptable derivatives thereof.
摘要:
Methode de determination de la presence d'une enzyme dans un fluide biologique qui consiste a mettre en contact le fluide avec un substrat chromogene synthetique, qui est un derive d'un amino acide de 7-amino-4-trifluoromethylcoumarine, a incuber le fluide contenant le substrat pour effectuer l'hydrolyse enzymatique, et a determiner par fluorometrie la presence du chromophore libre de 7-amino-4-trifluoromethylcoumarine dans l'hydrolysat.
摘要:
Photoresponsive polymers that comprise a unit derived from an amide functional diol compound that includes a coumarin group are provided. Advantageously, the photoresponsive groups of the photoresponsive polymers may be used to control the viscosity of the photoresponsive polymer. The photoresponsize polymers may also include units derived from amide functional diol compounds with include a fatty acid chain or a polyethylene glycol chain. The photoresponsive polymers may be used for 3d printing. When an adhesive group is added to a photoresponsive polymer they may be used as an adhesive. Adhesive groups include catechol groups.
摘要:
Provided is a compound that comprises the structure: where SIG is a signaling molecule and R3 is a formyl, a succinyl, a methyl succinyl, or a myristoyl. Also provided is a kit is provided that comprises the above compound, with instructions for determining the presence of the enzyme. Additionally, a method is provided for determining whether a sample has an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an &egr;-amino of a lysine. Also provided is a method of determining whether a molecule inhibits an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an &egr;-amino of a lysine.
摘要:
The present invention relates to novel compounds, particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for ophthalmic devices as well as to ophthalmic devices comprising such compounds.
摘要:
Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor positive allosteric modulators (PAMS), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.