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117 条记录 (耗时 0.015 秒)

    Novel glycoprotein and gene coding therefor
    82.
    发明公开
    Novel glycoprotein and gene coding therefor 失效
    糖蛋白和丹参

    公开(公告)号：EP0351313A2

    公开(公告)日：1990-01-17

    申请号：EP89401996.7

    申请日：1989-07-11

    申请人： Okada, Hidechika ,  Mitsubishi Chemical Corporation

    发明人： Okada, Hidechika ,  Okada, Noriko ,  Nagami, Yoichi ,  Takahashi, Kazuhiro ,  Takizawa, Hisao ,  Kondo, Jun

    IPC分类号： C07K15/00

    CPC分类号： C07K14/4703 ,  A61K38/00 ,  C07K14/8107 ,  Y10S530/827

    摘要： The present invention provides a glycoprotein derived from human cell membrane, which has a molecular weight of 20 to 25 Kd as estimated by SDS polyacrylamide gel electrophoresis, and contains N-glycoside type carbohydrate chain and phosphatidylinositol, and possesses an inhibitory activity to complement.mediated cell membrane damage. The present invention further provides a gene coding for the glycoprotein, and a method for the production of the glycoprotein and the gene therefor.

    摘要翻译： 本发明提供衍生自人细胞膜的糖蛋白，其通过SDS聚丙烯酰胺凝胶电泳估计的分子量为20〜25Kd，并含有N-糖苷型碳水化合物链和磷脂酰肌醇，并具有补体的抑制活性。 细胞膜损伤。 本发明还提供了编码糖蛋白的基因，以及糖蛋白的制造方法及其基因。

    IMMUNOSUPPRESSIVE FACTOR.
    83.
    发明公开
    IMMUNOSUPPRESSIVE FACTOR. 失效
    免疫抑制因子。

    公开(公告)号：EP0269742A4

    公开(公告)日：1989-12-12

    申请号：EP87902756

    申请日：1987-04-27

    申请人： YOSHITOMI PHARMACEUTICAL

    发明人： HASHIMOTO YOSHIYUKI ,  CHIBA KENJI KOYAMADAI ELEGANT ,  KOMATSU HIROTSUGU SANKOUDAI CO ,  OKUMOTO TAKEKI

    IPC分类号： C12P21/00 ,  A61K35/12 ,  A61K38/00 ,  A61P37/06 ,  C07K14/005 ,  C07K14/195 ,  C07K14/52 ,  C12R1/91 ,  C07K15/04 ,  C07K15/06

    CPC分类号： A61K38/1709 ,  A61K35/17 ,  Y10S530/827 ,  Y10S530/829

    摘要： Immunosuppressive factor of the following properties: (1) molecular weight: 45,000 to 65,000 and 150,000 to 200,000 according to gel filtration and 31,000 according to SDS-polyacrylamide gel electrophoresis; (2) isoelectric point: 4.6 to 4.8; (3) being elutable at a salt concentration of 0.31 to 0.32 M by FPLC-mono Q anion exchange chromatography; (4) not adsorbable to immobilized concanavalin A sepharose and Blue sepharose; (5) non-sensitive to deoxyribonuclease, ribonuclease, papain, and periodic acid, and sensitive to trypsin, alpha-chymotrypsin, and pronase; (6) stable at pH 2 to 10; (7) stable for a long time at 4°C and partly deactivated by heat treatment at 56°C or 90°C for 30 minutes; (8) not inhibitable by 2-mercaptoethanol, levamisole, N-acetyl-D-glucosamine, N-acetyl-D-galactosamine, alpha-methyl-D-mannose, L-arginine or L-ornithine; (9) inhibiting production of antibody; (10) inhibiting blastogenic transformation of lymphocytes; (11) inhibiting cell division and cell multiplication; and (12) having specific structural amino acids and specific contents thereof. This immunosuppressive factor has an excellent immunosuppressing effect and is useful as medicine or reagent.