公开(公告)号：EP0819700B1

公开(公告)日：2006-12-13

申请号：EP97660081.7

申请日：1997-07-09

申请人： Määttä, Jorma ,  Hinkkanen, Ari

发明人： Määttä, Jorma ,  Hinkkanen, Ari

IPC分类号： C07K1/14 ,  C07K14/47

CPC分类号： C07K14/4713 ,  A61K38/00 ,  Y10S530/839

公开(公告)号：EP0801679B1

公开(公告)日：2005-03-09

申请号：EP95917195.0

申请日：1995-04-27

申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

发明人： RODRIGUEZ, Moses ,  MILLER, David, J.

IPC分类号： C12N15/13 ,  A61K39/395 ,  C07K16/18 ,  C12N5/20 ,  C12N5/06

CPC分类号： C07K16/18 ,  A61K38/00 ,  Y10S530/809 ,  Y10S530/839 ,  Y10S530/863

摘要： Monoclonal IgM antibodies which promote central nervous system remyelination when given to a mammal afflicted with a demyelinating disease are disclosed. These antibodies show multi-organ autoreactivity, and recognize both surface and cytoplasmic determinants on glial cells.

摘要翻译： 公开了当给予患有脱髓鞘疾病的哺乳动物时促进中枢神经系统髓鞘再生的单克隆IgM抗体。 这些抗体显示多器官自身反应性，并识别胶质细胞上的表面和细胞质决定因素。

公开(公告)号：EP0692490B1

公开(公告)日：2004-11-03

申请号：EP95102535.2

申请日：1990-06-04

申请人： SCIOS INC.

发明人： Schilling, James W., Jr. ,  Ponte, Phyllis A. ,  Cordell, Barbara

IPC分类号： C07K14/81 ,  A61K38/55

CPC分类号： C12N15/86 ,  A61K38/00 ,  A61K2123/00 ,  C07K14/4711 ,  C07K14/8114 ,  C07K16/18 ,  C07K16/38 ,  C12N15/71 ,  C12N2710/24143 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/6896 ,  G01N2800/2821 ,  Y02A50/406 ,  Y10S435/91 ,  Y10S530/839

摘要： An analog of human amyloid plaque core protein protease inhibitor wherein the amino acid corresponding to arginine at position 13 in the sequence is substituted with an aromatic amino acid, said analog exhibiting chymotrypsin inhibitory activity or is substituted with a neutral hydrophobic amino acid, said analog exhibiting human elastase inhibitory activity and method of producing them. Use of the protease inhibitor in the manufacture of a medicament for use in treating acute pancreatitis and method of recovering purified protease inhibitor.

公开(公告)号：EP0610254B1

公开(公告)日：2004-09-01

申请号：EP92921022.7

申请日：1992-09-17

申请人： Amgen Inc.,

发明人： LIN, Leu-Fen, H. ,  COLLINS, Franklin, D. ,  DOHERTY, Daniel, H. ,  LILE, Jack ,  BEKTESH, Susan

IPC分类号： C12N15/12 ,  C12N1/21 ,  C12N5/10 ,  C07H15/12 ,  C12P21/06 ,  C12N1/22 ,  A61K39/395 ,  A61K9/00

CPC分类号： A61K9/0085 ,  A61K38/00 ,  C07K14/475 ,  Y10S530/809 ,  Y10S530/839

摘要： A novel neurotrophic factor referred to as glial derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth conditioned medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequenced. A gene encoding GDNF has been subcloned into a vector, and the vector has been used to transform a host cell in order to produce biologically active GDNF in a recombinant DNA process.

公开(公告)号：EP1418834A2

公开(公告)日：2004-05-19

申请号：EP02750216.0

申请日：2002-07-19

申请人： The Mount Sinai School of Medicine of New York University

发明人： GOOD, Paul, F. ,  KOHTZ, D., Stave

IPC分类号： A61B1/00

CPC分类号： C07K16/44 ,  C07K2317/77 ,  G01N33/6896 ,  G01N2800/2821 ,  G01N2800/2835 ,  Y10S530/839

摘要： The present invention relates to a method for diagnosing Alzheimer's disease and Parkinson's disease in a subject by analyzing the expression of Semaphorin 3 and downstream effectors. It also provides a method for identifying a substance useful in the prevention or treatment of Alzheimer's disease and Parkinson's disease, and a method of using such substance in the treatment of Alzheimer's disease and Parkinson's disease.

公开(公告)号：EP1243652A2

公开(公告)日：2002-09-25

申请号：EP02009293.8

申请日：1992-09-17

申请人： Amgen Inc.,

发明人： Lin, Leu-Fen H. ,  Collins, Franklin D. ,  Doherty, Daniel H. ,  Lile, Jack

IPC分类号： C12N15/12 ,  C07K14/475 ,  A61K38/18 ,  C12N15/63 ,  C12N1/21 ,  C12N5/10 ,  C07K16/18 ,  A61K48/00 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28

CPC分类号： A61K9/0085 ,  A61K38/00 ,  C07K14/475 ,  Y10S530/809 ,  Y10S530/839

摘要： A novel neurotrophic factor referred to as glial derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth conditioned medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequenced. A gene enconding GDNF has been subcloned into a vector, and the vector has been used to transform a host cell in order to produce biologically active GDNF in a recombinant DNA process.

摘要翻译： 已经鉴定了一种称为神经胶质神经营养因子（GDNF）的新型神经营养因子，并从B49胶质母细胞瘤细胞的无血清生长条件培养基中分离出来。 编码GDNF的大鼠和人基因已被克隆并测序。 将包含GDNF的基因亚克隆到载体中，并且该载体已经用于转化宿主细胞，以便在重组DNA过程中产生生物活性的GDNF。

公开(公告)号：EP0584452B1

公开(公告)日：2002-07-31

申请号：EP93105718.6

申请日：1993-04-07

申请人： AMERICAN CYANAMID COMPANY

发明人： Vitek, Michael Peter ,  Jacobsen, Jack Steven

IPC分类号： C12N15/12 ,  C12N15/62 ,  C07K2/00 ,  C12N5/10

CPC分类号： C07K14/4711 ,  C07K2319/00 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821 ,  Y10S530/839

公开(公告)号：EP1013270A2

公开(公告)日：2000-06-28

申请号：EP00101570.0

申请日：1993-12-02

申请人： Alkermes Controlled Therapeutics, Inc.

发明人： Auer, Henry ,  Khan, M. Amin ,  Bernstein, Howard

IPC分类号： A61K9/16 ,  A61K38/27

CPC分类号： B82Y5/00 ,  A61K9/1611 ,  A61K9/1647 ,  A61K9/1694 ,  A61K38/27 ,  Y10S514/839 ,  Y10S530/839 ,  Y10T428/2985

摘要： Growth hormone polymeric controlled release systems are described wherein the growth hormone retains good biological activity and is released over an extended period of time following administration by injection. In the preferred embodiment, human growth hormone polymeric microspheres are made using very cold temperatures to freeze the polymer-growth hormone mixtures into polymeric microspheres with very high retention of biological activity and material. Sustained release of biologically active growth hormone is achieved when the microspheres are tested in vivo , extending over a period of greater than one day to several months. Altered release can be achieved by inclusion of degradation modifiers, pore forming agents, and stabilizers of the growth hormone.

摘要翻译： 描述了生长激素聚合物控制释放系统，其中生长激素保持良好的生物活性并且通过注射施用后在延长的时间段内释放。 在优选的实施方案中，使用非常低的温度制备人生长激素聚合物微球，以将聚合物 - 生长激素混合物冻结成具有非常高的生物活性和材料保留的聚合物微球体。 当体内测试微球体时，持续释放生物活性生长激素，延长时间大于1天至数月。 改变的释放可以通过包含降解改性剂，成孔剂和生长激素的稳定剂来实现。

公开(公告)号：EP0982988A4

公开(公告)日：2000-04-05

申请号：EP98919778

申请日：1998-04-28

申请人： UNIV MARYLAND

发明人： FASANO ALESSIO

IPC分类号： C12N15/09 ,  A61K31/05 ,  A61K31/135 ,  A61K31/137 ,  A61K31/167 ,  A61K31/221 ,  A61K31/427 ,  A61K31/43 ,  A61K31/431 ,  A61K31/4468 ,  A61K31/472 ,  A61K31/475 ,  A61K31/485 ,  A61K31/5377 ,  A61K31/545 ,  A61K31/5517 ,  A61K31/568 ,  A61K31/704 ,  A61K31/7076 ,  A61K38/00 ,  A61K38/16 ,  A61K38/21 ,  A61K38/28 ,  A61K45/00 ,  A61K47/42 ,  A61K47/48 ,  C07K14/47 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00

CPC分类号： C07K14/4716 ,  A61K38/28 ,  A61K47/62 ,  C07K14/4705 ,  Y10S530/839 ,  Y10S530/844

公开(公告)号：EP0930365A2

公开(公告)日：1999-07-21

申请号：EP99101562.9

申请日：1992-05-01

申请人： YALE UNIVERSITY ,  INDIANA UNIVERSITY FOUNDATION

发明人： The designation of the inventor has not yet been filed

IPC分类号： C12N15/12 ,  C07K14/435 ,  C12N15/62 ,  C07K16/18

CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00 ,  Y10S530/839

摘要： The present invention provides a substantially purified fragment of a Serrate protein, which is characterized by the ability in vitro, when expressed on the surface of a first cell, to bind to a Notch protein expressed on the surface of a second cell, as well as derivatives and analog of this fragment able to bind to a second protein selected from the group consisting of a Notch, a Delta and a Serrate protein.
The nucleic acid sequence encoding said protein as well as vectors and recombinant cells containing the same are described. A method of producing a fragment of a Serrate protein is also disclosed.

摘要翻译： 本发明提供了一种基本上纯化的丝氨酸蛋白片段，其特征在于当在第一细胞表面表达时结合在第二细胞表面上表达的Notch蛋白的体外能力，以及 该片段的衍生物和类似物能够结合选自Notch，Delta和Serrate蛋白质的第二种蛋白质。 描述了编码所述蛋白质的核酸序列以及含有该蛋白质的载体和重组细胞。 还公开了一种产生丝氨酸蛋白片段的方法。