公开(公告)号：EP1816136A4

公开(公告)日：2008-08-27

申请号：EP05807057

申请日：2005-11-17

申请人： BANYU PHARMA CO LTD

发明人： MATSUDA MASAO ,  TOKITA SHIGERU ,  KANATANI AKIO ,  KANESAKA MAKI

IPC分类号： C07K7/02 ,  A61K38/00 ,  A61P3/04 ,  A61P3/10 ,  A61P5/06 ,  A61P25/06 ,  A61P25/18 ,  A61P25/20 ,  A61P29/00 ,  G01N33/15 ,  G01N33/50

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K7/02 ,  G01N2333/726 ,  G01N2500/02 ,  G01N2800/042 ,  G01N2800/044 ,  G01N2800/2864 ,  G01N2800/303

摘要： A compound represented by Trp-Tyr-Lys-(X) n -Gly-Arg-Ala­Ala-Gly-Leu-Leu-Ser-Gly-Leu-NH 2 or a pharmaceutically acceptable salt thereof is a GPR7-selective ligand. [In the formula, n is an integer of 2-10; and X's each independently represents -NH-(CH 2 ) m -CO- (wherein m is an integer of 2-6), the group represented by the formula (1) (wherein l is 0 or 1) which may be substituted, etc.]

公开(公告)号：EP1938818A2

公开(公告)日：2008-07-02

申请号：EP08150436.7

申请日：2002-06-19

申请人： Axelar AB

发明人： Larsson, Olle ,  Axelson, Magnus

IPC分类号： A61K31/36 ,  A61K31/365 ,  A61P5/06 ,  A61P9/10 ,  A61P17/06 ,  A61P35/00

CPC分类号： C07D493/04 ,  A61K31/34 ,  A61K31/36 ,  A61K31/365 ,  C07D317/54 ,  C07D317/70

摘要： The invention refers to the use of specific cyclolignans, wherein the carbon atoms in positions 9 and 9' have cis configuration, for inhibition of the insulin-like growth factor-1 receptor. Said compounds can be used for treatment of IGF-1R dependent diseases, such as cancer, psoriasis, artherosclerosis and acromegaly. A preferred compound is picropodophyllin.

公开(公告)号：EP1420800A4

公开(公告)日：2008-01-23

申请号：EP02747109

申请日：2002-08-02

申请人： FLOREY HOWARD INST

发明人： ALBISTON ANTHONY L ,  MCDOWALL SHARON G ,  MENDELSOHN FREDERICK A O ,  CHAI SIEW YEEN

IPC分类号： C12N15/09 ,  A61K31/7088 ,  A61K31/713 ,  A61K35/76 ,  A61K38/00 ,  A61K38/08 ,  A61K38/39 ,  A61K38/43 ,  A61K38/55 ,  A61K45/00 ,  A61K48/00 ,  A61P3/00 ,  A61P3/06 ,  A61P3/10 ,  A61P5/06 ,  A61P5/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P15/04 ,  A61P15/06 ,  A61P15/08 ,  A61P17/02 ,  A61P21/04 ,  A61P25/00 ,  A61P25/02 ,  A61P25/16 ,  A61P25/28 ,  A61P25/30 ,  A61P35/00 ,  A61P39/02 ,  A61P43/00 ,  C07K7/04 ,  C07K14/54 ,  C12N5/06 ,  C12N5/10 ,  C12Q1/02 ,  C12Q1/37 ,  C12Q1/68 ,  G01N33/50 ,  A61K38/11

CPC分类号： A61K38/39 ,  A61K31/713 ,  A61K38/08 ,  C07K14/54 ,  G01N33/5035 ,  G01N2333/72 ,  G01N2500/00 ,  G01N2500/04

公开(公告)号：EP1197496B8

公开(公告)日：2007-10-03

申请号：EP00946453.8

申请日：2000-07-24

申请人： Kangawa, Kenji

发明人： KANGAWA, Kenji ,  KOJIMA, Masayasu ,  HOSODA, Hiroshi ,  MATSUO, Hisayuki ,  MINAMITAKE, Yoshiharu c/o Asubio Pharma Co., Ltd.,

IPC分类号： C12N15/12 ,  C07K14/47 ,  C07K14/46 ,  C07K14/465 ,  C07K14/575 ,  C07K16/18 ,  C12P21/02 ,  A61K38/18 ,  A61P5/06 ,  A61P19/08

CPC分类号： C07K14/575 ,  A01K2217/05 ,  A61K9/0019 ,  A61K38/00 ,  A61K47/42 ,  A61K48/00 ,  C07K14/461 ,  C07K14/463 ,  C07K14/465 ,  C07K14/47 ,  C07K14/4702

摘要： The present invention provides a novel peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP1795598A1

公开(公告)日：2007-06-13

申请号：EP07006224.5

申请日：2000-07-24

申请人： Kangawa, Kenji

发明人： Kangawa, Kenji ,  Kojima, Masayasu ,  Hosoda, Hiroshi ,  Matsuo, Hisayuki ,  Minamitake, Yoshiharu

IPC分类号： C12N15/12 ,  C07K14/47 ,  C07K14/46 ,  C07K14/465 ,  C07K14/575 ,  C07K16/18 ,  C12N1/21 ,  C12P21/02 ,  A61K38/18 ,  A61P5/06 ,  A61P19/08 ,  A61K45/00 ,  A61K48/00

CPC分类号： C07K14/575 ,  A01K2217/05 ,  A61K9/0019 ,  A61K38/00 ,  A61K47/42 ,  A61K48/00 ,  C07K14/461 ,  C07K14/463 ,  C07K14/465 ,  C07K14/47 ,  C07K14/4702

摘要： The present invention provides a novel peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP1471891A4

公开(公告)日：2007-04-11

申请号：EP03713410

申请日：2003-02-07

申请人： ALKERMES INC ,  SERONO INTERNAT S A

发明人： TRACY MARK A ,  COSTANTINO HENRY R ,  FIGUEIREDO MARIA ,  WARD KEVIN L ,  SCHER DAVID S

IPC分类号： A61K9/14 ,  A61K38/24 ,  A61K9/00 ,  A61K9/16 ,  A61K9/19 ,  A61K9/22 ,  A61K9/26 ,  A61K47/02 ,  A61K47/04 ,  A61K47/26 ,  A61K47/34 ,  A61P5/06 ,  A61P5/10 ,  A61P15/00 ,  A61P15/08

CPC分类号： A61K9/1647 ,  A61K9/0019 ,  A61K9/1611 ,  A61K9/1623 ,  A61K9/1694 ,  A61K9/19 ,  A61K38/24 ,  A61K47/02 ,  A61K47/26

公开(公告)号：EP1676862A1

公开(公告)日：2006-07-05

申请号：EP04773541.0

申请日：2004-09-24

申请人： KYOWA HAKKO KOGYO CO., LTD.

发明人： SHITARA, Kenya, c/o BioFrontier Laboratories ,  NAKAMURA, Kazuyasu, c/o BioFrontier Laboratories ,  OHKI, Yuji, c/o BioFrontier Laboratories

IPC分类号： C07K16/26 ,  C12N15/13 ,  C12N1/21 ,  C12N1/19 ,  C12N1/15 ,  C12N5/10 ,  C12P21/08 ,  A61K39/395 ,  A61P3/10 ,  A61P5/06 ,  A61P35/00 ,  G01N33/15 ,  G01N33/50

CPC分类号： C07K16/2896 ,  C07K2317/73

摘要： It is demanded that pharmaceutical agents for therapeutic treatment of diseases such as cancer, acromegaly and diabetic complications, of which IGF is involved in the progress of the conditions.
The present invention provides a recombinant antibody or an antibody fragment thereof which specifically binds to human insulin-like growth factor-I (hereinafter referred to as hIGF-I) and human insulin-like growth factor-II (hereinafter referred to as hIGF-II) to inhibit the biological activities of human IGF-I and human IGF-II, a transformant producing the antibody or the antibody fragment thereof, a process for producing the antibody or the antibody fragment thereof, and a medicament comprising the antibody or the antibody fragment thereof as the active ingredient therein.

摘要翻译： 需要用于治疗癌症，肢端肥大症和糖尿病并发症等疾病的药剂，其中IGF参与病情进展。 本发明提供与人胰岛素样生长因子-I（以下称为hIGF-1）和人胰岛素样生长因子-II特异性结合的重组抗体或其抗体片段（以下称为hIGF-II ）以抑制人IGF-I和人IGF-II的生物活性，产生抗体或其抗体片段的转化体，制备抗体或其抗体片段的方法，以及包含抗体或抗体片段的药物 作为其中的活性成分。

公开(公告)号：EP1133522B1

公开(公告)日：2006-07-05

申请号：EP99963962.8

申请日：1999-11-23

申请人： The Administrators of The Tulane Educational Fund

发明人： SCHALLY, Andrew, V. ,  VARGA, Jozsef ,  ZARANDI, Marta

IPC分类号： C07K14/60 ,  A61K38/27 ,  A61P35/00 ,  A61P5/06

CPC分类号： C07K14/60 ,  A61K38/00

摘要： There is provided a novel series of synthetic analogs of hGH-RH(1-29)NH2. These analogs inhibit the activity of endogenous hGH-RH, and therefore prevent the relase of growth hormone. The stronger inhibitory potencies of the new analogs, as compared to previously described ones, results from replacement of various amino acids.

公开(公告)号：EP1644342A1

公开(公告)日：2006-04-12

申请号：EP04756667.4

申请日：2004-07-06

申请人： NEUROCRINE BIOSCIENCES, INC.

发明人： HUANG, Charles, Q. ,  CHEN, Chen ,  CHEN, Yongsheng ,  GUO, Zhiqiang ,  WADE, Warren ,  ROWBOTTOM, Martin ,  RUETER, Jaimie, K.

IPC分类号： C07D239/54 ,  C07D403/12 ,  A61K31/513 ,  A61P5/06 ,  C07D241/00 ,  C07D239/00 ,  C07D207/00

CPC分类号： C07D239/54 ,  C07D403/12

摘要： GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein n, R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

公开(公告)号：EP1509612A4

公开(公告)日：2005-07-20

申请号：EP03719433

申请日：2003-03-21

申请人： DRUGTECH CORP

发明人： LEVINSON R SAUL ,  RILEY THOMAS C

IPC分类号： A61K9/133 ,  A61K9/127 ,  A61K38/00 ,  A61K38/22 ,  A61K38/27 ,  A61K45/00 ,  A61P5/06 ,  A61P19/10 ,  C12N15/88

CPC分类号： A61K9/1272 ,  A61K9/127 ,  A61K9/1271