-
1.发明公开
公开(公告)号：EP0824529A1
公开(公告)日：1998-02-25
申请号：EP96914169.0
申请日：1996-05-02
申请人： Dr. Karl Thomae GmbH
发明人： MÜLLER, Peter , HURNAUS, Rudolf , MAIER, Roland , MARK, Michael , EISELE, Bernhard , BUDZINSKI, Ralph-Michael , THOMAS, Leo , HALLERMAYER, Gerhard
CPC分类号： C07D263/56 , A23K20/137 , C07D277/64 , C07D277/66 , C07D277/68 , C07D277/74 , C07D277/76 , C07D417/04 , C07D417/12
摘要： The invention concerns benzothiazoles and benzoxazoles of generale formula (I), in which R1 to R3, X, Z and n are as defined in claim 1, their enantiomers, diastereomers and salts thereof, in particular physiologically tolerated acid addition salts, which exhibit biosynthesis of cholesterol. The invention also concerns drugs containing these compounds, their use and methods of preparing them.
-
公开(公告)号：EP0632241B1
公开(公告)日：1997-08-06
申请号：EP94108192.9
申请日：1994-05-27
申请人： Dr. Karl Thomae GmbH
CPC分类号： F26B3/30 , F26B11/049 , F26B11/0495
-
公开(公告)号：EP0781325A1
公开(公告)日：1997-07-02
申请号：EP95933363.0
申请日：1995-09-12
申请人： Dr. Karl Thomae GmbH
发明人： SCHORN, Peter , VOIGT, Hans , NOE, Wolfgang
CPC分类号： C12M37/02 , C12M33/04 , G01N1/10 , G01N1/14 , G01N2001/1427 , G01N2001/1436
摘要： The invention concerns a sampling device in which the boundary with the microbiologically contaminated environment takes the form of a sterile protective gas stream with 'laminar air flow' characteristics underneath a housing bell (7); the connection point between the inner tube (11) and the sample tube (10) is at a point inside or just underneath the bell (7), with or without a fixed connection, and for automatic operation just underneath the bell (7) without a fixed connection.
-
4.发明公开
公开(公告)号：EP0777667A1
公开(公告)日：1997-06-11
申请号：EP95929874.0
申请日：1995-08-16
申请人： Dr. Karl Thomae GmbH
CPC分类号： C07D223/16 , C07D401/14 , C07D403/04
摘要： Cyclic urea derivatives having the general formula (I), in which R1 to R9, Ra, Rb, A, D, E and F have the definitions given in the first claim, their tautomers, their stereoisomers, including their mixtures and their salts, in particular their physiologically acceptable salts with inorganic or organic acids or bases, have valuable pharmacological and other properties, preferably aggregation-inhibiting effects. Also disclosed are medicaments containing said compounds, their use and a process for producing the same.
-
5.发明公开Piperazinderivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendungen und Verfahren zu ihrer Herstellung 失效的含有这些化合物的药物的哌嗪衍生物，它们的用途和它们的制备方法
公开(公告)号：EP0718287A3
公开(公告)日：1997-01-29
申请号：EP95120118.5
申请日：1995-12-19
申请人： Dr. Karl Thomae GmbH
发明人： Pieper, Helmut, Dr. Dipl.-Ing. , Austel, Volkhard, Prof. Dr. Dipl.-Chem. , Himmelsbach, Frank, Dr. Dipl.-Chem. , Linz, Günther, Dr. Dipl.-Chem. , Guth, Brian, Dr. , Weisenberger, Johannes, Dr. Dipl.-Chem.
IPC分类号： C07D213/74 , A61K31/415
CPC分类号： C07D213/74 , C07D211/34 , C07D211/58 , C07D401/12
摘要： Die vorliegende Erfindung betrifft Piperazinderivate der allgemeinen Formel
in der
R a , Y₁ bis Y₃ und E wie Anspruch 1 definiert sind, deren Tautomere, deren Stereoisomere, einschließlich ihrer Gemische, und deren Salze, insbesondere deren Salze mit physiologisch verträglichen Säuren oder Basen, welche wertvolle pharmakologische Eigenschaften aufweisen, vorzugsweise aggregationshemmende Wirkungen, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung.-
6.发明授权
公开(公告)号：EP0508370B1
公开(公告)日：1996-07-03
申请号：EP92105989.5
申请日：1992-04-07
申请人： Dr. Karl Thomae GmbH
发明人： Eberlein, Wolfgang, Dr. , Mihm, Gerhard, Dr. , Engel, Wolfhard, Dr. , Rudolf, Klaus, Dr. , Doods, Henri, Dr. , Ziegler, Harald, Dr. , Entzeroth, Michael, Dr.
IPC分类号： C07D471/04 , C07D487/04 , C07D495/04 , C07D243/38 , A61K31/55
CPC分类号： C07D401/06 , C07D471/04 , C07D487/04 , C07D495/04
-
7.发明授权Neue Pyridylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung 失效，含有这些化合物的，新的吡啶基衍生物和它们的制备方法制药
公开(公告)号：EP0487095B1
公开(公告)日：1996-02-28
申请号：EP91119889.3
申请日：1991-11-21
申请人： Dr. Karl Thomae GmbH
发明人： Soyka, Rainer, Dr. Dipl.-Chem. , Eisert, Wolfgang, Arzt. Prof. Dr. Dr. Dr. , Müller, Thomas, Dr. Arzt und Dipl.-Chem. , Weisenberger, Johannes, Dr. Dipl.-Chem.
IPC分类号： C07D213/55 , C07D409/12 , C07D401/12 , A61K31/44
CPC分类号： C07D401/12 , C07D213/55
-
8.发明公开
公开(公告)号：EP0680469A1
公开(公告)日：1995-11-08
申请号：EP94905073.0
申请日：1994-01-18
申请人： Dr. Karl Thomae GmbH
发明人： RUDOLF, Klaus , EBERLEIN, Wolfgang , ENGEL, Wolfhard , MIHM, Gerhard , DOODS, Henri , WIELAND, Heike-Andrea , WILLIM, Klaus-Dieter , KRAUSE, Jürgen , DOLLINGER, Horst , ESSER, Franz , SCHNORRENBERG, Gerd , ENTZEROTH, Michael , WIENEN, Wolfgang
IPC分类号： A61K31 , A61K38 , A61P9 , A61P43 , C07C237 , C07C255 , C07C257 , C07C259 , C07C261 , C07C275 , C07C279 , C07C307 , C07C311 , C07D209 , C07D211 , C07D213 , C07D215 , C07D223 , C07D233 , C07D235 , C07D249 , C07D271 , C07D295 , C07D333 , C07D401 , C07D471 , C07K5
CPC分类号： C07D233/64 , A61K38/00 , C07C237/22 , C07C237/42 , C07C255/60 , C07C257/12 , C07C257/14 , C07C257/18 , C07C259/10 , C07C259/18 , C07C261/04 , C07C275/40 , C07C279/14 , C07C279/18 , C07C279/36 , C07C307/02 , C07C307/10 , C07C311/08 , C07C311/19 , C07C311/39 , C07C311/42 , C07C2601/08 , C07C2601/14 , C07C2603/18 , C07C2603/74 , C07D209/16 , C07D209/42 , C07D209/44 , C07D213/38 , C07D215/38 , C07D223/20 , C07D233/24 , C07D233/48 , C07D233/72 , C07D233/88 , C07D235/06 , C07D249/12 , C07D249/14 , C07D271/07 , C07D295/15 , C07D333/20 , C07D471/04 , C07K5/06095
摘要： New aminoacid derivates have the general formula: T-Z-NR?1-(R2CR3¿)-CO-Y-(CH¿2?)n-R, in which R, R?1 to R3¿, T, Z, Y and n are defined as in the first claim. They represent valuable NPY-antagonistic active substances. Also disclosed are their diastereomers, their enantiomers and their salts, in particular their physiologically tolerable salts with inorganic or organic acids or bases, as well as medicaments containing these compounds, their use and a process for preparing the same.
摘要翻译： 氨基酸衍生物，适合于治疗肥胖症。 以下化合物是示范性的类：（R）-N 2 - （二苯基）-N - [（4-羟基苯基）甲基] -argininamide乙酸盐。
-
9.发明授权Aryliden-1-azacycloalkane und Arylalkyl-1-azacycloalkane, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung 失效亚芳基-1-氮杂环烷烃和芳基烷基-1-氮杂环烷烃，它们的盐，以及含有这些化合物，它们的用途和它们的制备方法的药物。
公开(公告)号：EP0596326B1
公开(公告)日：1995-08-23
申请号：EP93116959.3
申请日：1993-10-20
申请人： Dr. Karl Thomae GmbH
发明人： Maier, Roland, Dr. Dipl.-Chem. , Müller, Peter, Dr. Dipl.-Chem. , Woitun, Eberhard, Dr. Dipl.-Chem. , Hurnaus, Rudolf, Dr. Dipl.-Chem. , Mark, Michael, Dr. , Eisele, Bernhard, Dr. Dipl.-Chem. , Budzinski, Ralph-Michael, Dr. Dipl.-Bio. , Hallermayer, Gerhard, Dr. Dipl.-Chem.
IPC分类号： C07D401/10 , C07D401/14 , C07D413/10 , C07D417/10 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/445 , A61K31/455
CPC分类号： C07D403/10 , C07D413/10 , C07D413/14 , C07D417/10
-
公开(公告)号：EP0457035B1
公开(公告)日：1995-08-02
申请号：EP91105898.0
申请日：1991-04-13
申请人： Dr. Karl Thomae GmbH
发明人： Bergemann, Klaus, Dr. Dipl.-Chem. , Bader, Georg , Berthold, Wolfgang, Dr. , Werner, Rolf-Günter, Prof. Dr. Dipl.-Mikrobiologe
CPC分类号： A61L2/0088 , A61L2/0023 , C12N1/08
-
-
-
-
-
-
-
-
-
搜索结果
533 条记录 (耗时 0.037 秒)
