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公开(公告)号：EP1794137A4
公开(公告)日：2009-12-02
申请号：EP05799606
申请日：2005-09-26
IPC分类号： C07D267/22 , A61K31/33 , A61K31/365 , A61K31/4178 , A61K31/5377 , A61P35/00 , C07D245/00 , C07D281/18 , C07D291/00 , C07D327/00 , C07D337/16 , C07D343/00 , C07D411/00 , C07D487/00 , C07D497/00 , C07D513/00
CPC分类号： A61K31/33 , A61K31/365 , A61K31/4178 , A61K31/5377 , C07D493/04
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公开(公告)号：EP1485462B1
公开(公告)日：2007-12-12
申请号：EP03719319.0
申请日：2003-02-25
CPC分类号： C12N1/20 , C12N15/52 , C12P17/162 , C12P17/167 , C12P17/181
摘要： The present invention provides a generalized oxygen-limited cultivation method for myxobacterial strains engineered to heterologously express polyketides synthase (PKS) gene clusters under various oxygen tension conditions, modulating the polyketide congener distribution.
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公开(公告)号：EP1224300B9
公开(公告)日：2007-09-26
申请号：EP00972384.2
申请日：2000-10-27
发明人： SANTI, Daniel , PECK, Larry , DAYEM, Linda , KEALEY, James
摘要： Recombinant host cells that comprise recombinant DNA expression vectors that drive expression of a product and a precursor for biosynthesis of that product can be used to produce useful products such as polyketides in host cells that do not naturally produce the product or produce the product or precursor at low levels due to the absence of the precursor or the presence of the precursor in rate limiting amounts.
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公开(公告)号：EP1576140A4
公开(公告)日：2007-08-08
申请号：EP03798802
申请日：2003-09-26
摘要： The invention provides strategies, methods, vectors, reagents, and systems for production of synthetic genes, production of libraries of such genes, and manipulation and characterization of the genes and corresponding encoded polypeptides. In one aspect, the synthetic genes can encode polyketide synthase polypeptides and facilitate production of therapeutically or commercially important polyketide compounds.
摘要翻译： 本发明提供了用于生产合成基因的策略，方法，载体，试剂和系统，这些基因文库的生产以及基因和相应编码多肽的操作和表征。 一方面，合成基因可编码聚酮化合物合酶多肽并促进产生治疗或商业上重要的聚酮化合物。
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公开(公告)号：EP1244800B1
公开(公告)日：2007-03-14
申请号：EP00990461.6
申请日：2000-10-30
发明人： KATZ, Leonard , LIU, Lu , CHUNG, Loleta, M.
IPC分类号： C12N15/76 , C07D498/18 , A61K31/435
CPC分类号： C07D498/18 , C12N9/1029 , C12N15/52 , C12P17/188
摘要： Recombinant host cells that produce rapamycin analogues are constructed by deleting or modifying rapamycin biosynthetic gene cluster genes and are useful in the production of compounds used as antifungals, anticancers, immunosuppressants, and neurotrophins.
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公开(公告)号：EP1754700A2
公开(公告)日：2007-02-21
申请号：EP06120607.4
申请日：2000-01-27
IPC分类号： C07C327/30 , C12P17/08 , C07D239/38
CPC分类号： C07C327/30
摘要： Facile methods for preparing diketide and triketide thioesters are disclosed. The resulting thioesters may be used as intermediates in the synthesis of desired polyketides, and may contain functional groups which ultimately reside in side chains on the resulting polyketide and thus can be used further to manipulate the polyketide so as to form derivatives. The polyketides produced may also be tailored by glycosylation, hydroxylation and the like. New polyketides and their derivatives and tailored forms are thereby produced.
摘要翻译： 公开了制备二酮化合物和三酮化物硫酯的简便方法。 所得硫酯可用作合成所需聚酮化合物的中间体，并且可以含有最终存在于所得聚酮化合物上的侧链中的官能团，因此可以进一步用于操作聚酮化合物以形成衍生物。 产生的聚酮化合物也可以通过糖基化，羟基化等来定制。 由此生产新的聚酮化合物及其衍生物和定制的形式。
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公开(公告)号：EP1740713A2
公开(公告)日：2007-01-10
申请号：EP05767675.1
申请日：2005-04-05
CPC分类号： C12N15/1031 , C12N15/1058 , C12N15/52 , C12N15/64 , C12N15/66
摘要： The invention provides strategies, methods, vectors, reagents, and systems for production of synthetic genes, production of libraries of such genes, and manipulation and characterization of the genes and corresponding encoded polypeptides. In one aspect, the synthetic genes can encode polyketide synthase polypeptides and facilitate production of therapeutically or commercially important polyketide compounds.
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公开(公告)号：EP1471923A4
公开(公告)日：2006-01-11
申请号：EP03713257
申请日：2003-01-17
发明人： ASHLEY GARY , SHAW SIMON JAMES , LI YANDONG
IPC分类号： A61K31/7048 , A61P1/00 , A61P3/10 , A61P31/04 , C07H17/08
CPC分类号： C07H17/08 , Y02P20/582
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公开(公告)号：EP1551378A2
公开(公告)日：2005-07-13
申请号：EP03773239.3
申请日：2003-10-09
IPC分类号： A61K31/00
CPC分类号： A61K45/06 , A61K31/427 , A61K31/7088 , A61K2300/00
摘要： Methods and compositions for treating hyperproliferative diseases using combinations of one or more epothilones and one or more nucleoside analogs. In some embodiments, the combination includes epothilone D and 5-fluorouracil or 5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-cytidine.
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公开(公告)号：EP1282626A2
公开(公告)日：2003-02-12
申请号：EP01935329.1
申请日：2001-05-10
发明人： Chu, Daniel , Fardis, Maria , Khosla, Chaitan , Reeves, Christopher , Santi, Daniel , Schirmer, Andreas
IPC分类号： C07D498/18 , C12P17/18
CPC分类号： C07D498/18
摘要： The present invention relates to novel polyketides, host cells that produce the novel compounds, and methods for their use. The compounds of the present invention are cyclic polyketides (also referred to as a 'macrolides' or 'macrolactones') that include Formula (I) as part of their structure and bind to a FK binding protein wherein R?4 and R5¿ are each selected from the group consisting of hydrogen, methyl, ethyl, and methoxy, provided that at least one of R?4 and R5¿ is hydrogen, methyl, or ethyl. As will be explained in greater detail below, the compounds of the present invention have properties such as favorable P450 enzyme activity profiles that are desirable for use of these compounds as drugs.
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