公开(公告)号：EP0959881A1

公开(公告)日：1999-12-01

申请号：EP97946641.0

申请日：1997-11-12

申请人： Sugen, Inc.

发明人： TANG, Peng, C. ,  HARRIS, G., David

IPC分类号： A61K31 ,  A61P31 ,  A61P35 ,  C07D209

CPC分类号： A61K31/4045 ,  A61K31/404 ,  C07D209/12 ,  C07D209/42

摘要： The present invention relates to novel synthetic methods for the preparation of indolylquinones. The methods of the present invention are directed to synthetic reactions involving indoles and halo-quinones in solvent and in the presence of a metal carbonate. The invention also relates to bis- and mono- indolylquinones of high purity and pharmaceutical compositions containing the same.

摘要翻译： 本发明涉及制备吲哚基醌的新合成方法。 本发明的方法涉及在溶剂中和在金属碳酸盐存在下涉及吲哚和卤代醌的合成反应。 本发明还涉及高纯度的双 - 和单 - 吲哚基醌及含有其的药物组合物。

公开(公告)号：EP0954297A1

公开(公告)日：1999-11-10

申请号：EP97913665.0

申请日：1997-10-06

申请人： SHAMAN PHARMACEUTICALS, INC.

发明人： KHANDWALA, Atul, S. ,  LUO, Jian

IPC分类号： A61K45 ,  A61K31 ,  A61P3 ,  A61P43

CPC分类号： A61K31/05 ,  Y10S514/866

摘要： This invention is directed to methods for treatment of non-insulin-dependent diabetes mellitus, for reducing blood glucose levels, or hyperglycemia. The methods entail administering to a mammal in need of such treatment a therapeutically effective amount of a composition whose active ingredient consists essentially of a compound of structure (I) or a pharmaceutically acceptable salt thereof. In the compound R and R' are independently H or a C1-C20 alkyl or C2-C20 alkenyl group which may be substituted or unsubstituted. Alternatively, R and R' are such that together a cycloalkyl or cycloalkenyl ring is formed. In the chain linking the two phenolic derivatives each of (C(R)=C(R')) or (C(R)(R')) are the same or different. A and A' are independently C2-C20 acylamino, C2-C20 acyloxy, C2-C20 alcanoyl, C2-C20 alkoxycarbonyl, C1-C20 alkoxyl, C1-C20 alkylamino, C2-C20 alkyl carboxyl, amino, C2-C20 carbalkoxyl, carboxyl, cyano, halo, hydroxy. B and B' are independently H, C2-C20 alkanoyl, C3-C20 alkenoyl, C2-C20 alkenyl, C2-C20 alkoxycarbonyl, C1-C20 alkyl, aroyl, aralkanoyl, C2-C20 carbamoyl, or phosphate. The invention is also directed to methods of treatment using a bisphenolic compound in conjunction with another hypoglycemic or hypolipidemic agent.

公开(公告)号：EP0951294A1

公开(公告)日：1999-10-27

申请号：EP97951010.0

申请日：1997-12-12

申请人： Beaulieu, André

发明人： BEAULIEU, André ,  PAQUIN, Robert

IPC分类号： A61K38 ,  A61K9 ,  A61K47 ,  A61P17 ,  C07K14

CPC分类号： A61K9/08 ,  A61K9/0014 ,  A61K38/27 ,  A61K38/39 ,  A61K47/02 ,  A61K47/10 ,  A61K47/32 ,  A61K47/38 ,  C07K14/78

摘要： Aqueous, non-buffered solutions containing high concentrations of fibronectin and other wound healing promoters are produced, which can then be used to make topical gel and cream formulations with high concentrations wound healing promoters. The formulations are used for the healing of cutaneous wounds. The formulations provide slow release and increased contact time of fibronectin and of other wound healing promoters to the wound site leading to the effective absorption of the promoters.

公开(公告)号：EP0932681A2

公开(公告)日：1999-08-04

申请号：EP97910873.0

申请日：1997-10-07

申请人： CORIXA CORPORATION

发明人： REED, Steven, G. ,  SKEIKY, Yasir, A., W. ,  DILLON, Davin, C. ,  CAMPOS-NETO, Antonio ,  HOUGHTON, Raymond ,  VEDVICK, Thomas, S. ,  TWARDZIK, Daniel, R. ,  LODES, Michael, J.

IPC分类号： A61K ,  C07H ,  C07K ,  C12N ,  G01N ,  G01N33 ,  A61K39 ,  A61K48 ,  A61P31 ,  C07K14 ,  C07K19 ,  C12N1 ,  C12N5 ,  C12N15 ,  C12P21 ,  C12Q1 ,  A61K38

CPC分类号： C07K14/35 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00

摘要： Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.

公开(公告)号：EP0923366A1

公开(公告)日：1999-06-23

申请号：EP98908860.0

申请日：1998-03-03

申请人： E-L Management Corp.

发明人： MAMMONE, Thomas ,  INGRASSIA, Michael

IPC分类号： A61K8 ,  A61K31 ,  A61P17 ,  A61Q1 ,  A61Q17 ,  A61Q19

CPC分类号： A61Q1/10 ,  A61K8/606 ,  A61Q1/02 ,  A61Q1/04 ,  A61Q1/06 ,  A61Q1/12 ,  A61Q17/04 ,  A61Q19/08

摘要： The present invention relates to a protection-effective amount of UV-damaged RNA fragments, in combination with a cosmetically or pharmaceutically acceptable carrier. The compositions are useful in the prevention of skin damage to UV radiation and in preventing photoaging.

摘要翻译： 本发明涉及保护有效量的UV损伤的RNA片段，与化妆品或药学上可接受的载体组合。 该组合物可用于防止紫外线辐射的皮肤损伤和防止光老化。

公开(公告)号：EP0915903A1

公开(公告)日：1999-05-19

申请号：EP97930083.0

申请日：1997-06-16

申请人： Biodynamics Associates

发明人： HARNEY, Peter, D.

IPC分类号： C12N15 ,  C07H21

CPC分类号： C12N15/64 ,  C07H21/00 ,  C12N15/1093 ,  C12N15/66

摘要： The invention provides a highly efficient, rapid, and cost effective method of linking nucleic acid components in a predetermined order to produce a nucleic acid multicomponent construct. Such a method and multicomponent construct are illustrated in the figure. The invention further provides nucleic acid components, each nucleic acid component comprising a double stranded nucleic acid molecule having at least one single stranded 5' or 3' terminal sequence, the terminal sequence having sufficient complementarity to either a terminal sequence in a separate nucleic acid component or a sequence in a linking nucleic acid molecule so as to allow for specific annealing of complementary sequences and linkage of the components in a predetermined order. Kits containing reagents required to practice the method of the invention are also provided.

公开(公告)号：EP0914691A1

公开(公告)日：1999-05-12

申请号：EP97917849.0

申请日：1997-04-04

申请人： Handy & Harman

发明人： SOUZA, Therese, R. ,  MOLVAR, Allen, E.

IPC分类号： C25D15 ,  C25D5 ,  H05K3

CPC分类号： C25D15/02 ,  C25D5/10 ,  H05K3/244 ,  H05K3/3473

摘要： The present invention relates to composite articles including a surface layer (4) of tin, lead, silver or an alloy thereof that contains co-deposited non-ionic polymeric particles to provide a reduced-friction deposit that has an initially low coefficient of friction and low insertion force and fretting corrosion in separable electronic connectors, and to methods for preparing the plated articles. The polymeric particles have a size between about 0.1 to 0.45 ν in diameter to reduce the coefficient of friction of the resultant deposit to about 0.45 or below. Also, the deposit has excellent electrical properties and can be successfully soldered. The invention also relates to a solution for plating the surface layer (4) of the composite articles, which surface layer (4) reduces insertion force and fretting corrosion of separable electronic connectors.

公开(公告)号：EP0914155A1

公开(公告)日：1999-05-12

申请号：EP97917121.0

申请日：1997-03-25

申请人： Pacific Northwest Cancer Foundation

发明人： MURPHY, Gerald, P. ,  BOYNTON, Alton, L. ,  HOLMES, Eric, H. ,  TINO, William, T.

IPC分类号： G01N33 ,  A61K39 ,  A61K45 ,  A61K51 ,  A61P13 ,  A61P35 ,  C07K16 ,  C12N5 ,  C12N15 ,  A61K38

CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K2317/34 ,  C12N2799/026

摘要： The present invention relates to monoclonal antibodies that bind to the extracellular domain of prostate specific membrane antigen (PSMA), hybridoma cell lines producing the antibodies, and methods of using such antibodies for diagnosis and treatment of cancer. In particular, it relates to three monoclonal antibodies reactive with PSMA expressed on the cell surface and in sera of prostate cancer patients. Additionally, the present invention relates to a novel protein variant (PSM') of PSMA detected by an antibody of the invention. The hydrolase activity of PSMA and PSM' allows the use of an immunoenzymatic assay for their detection.

公开(公告)号：EP0910347A2

公开(公告)日：1999-04-28

申请号：EP97918279.0

申请日：1997-04-30

申请人： University of Strathclyde

发明人： GRAHAM, Neil, Bonnette

IPC分类号： A61K9

CPC分类号： A61K9/0004

摘要： A delivery device under osmotic control when in contact with a liquid comprising an enclosure having an enclosure wall and at least an aperture through the wall, wherein the osmotically active material is present within the enclosure, and the apertures being sized such that when the device is in contact with liquid, osmotically controlled flow of solution from the enclosure through the aperture occurs.

公开(公告)号：EP0910330A1

公开(公告)日：1999-04-28

申请号：EP98911725.0

申请日：1998-03-17

申请人： Revlon Consumer Products Corporation

发明人： HAWKINS, Geoffrey, R. ,  DOLAK, Terence, M. ,  GUTKOWSKI, Glenn, A.

IPC分类号： A61K ,  A61K8 ,  A61Q5 ,  A61Q17 ,  C09B67

CPC分类号： A61Q5/10 ,  A61K8/496 ,  A61Q17/04

摘要： A composition for oxidative dyeing of hair comprising, by weight of the total composition; 0.0001-20 % of at least one primary intermediate and at least one coupler for the formation of oxidation dyes, 0.01-10 % of a 2-hydroxyphenyl benzotriazole compound which absorbs ultraviolet radiation in the wavelength range of 200 to 400 nanometers, 0.5-20 % surfactant, and 10-65 % water; a two component kit containing the hair dye composition and a developer, and a method for oxidative dyeing of hair with said kit.