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1.发明授权
公开(公告)号：EP1104479B1
公开(公告)日：2006-10-18
申请号：EP99939728.4
申请日：1999-08-11
发明人： TURPEN, Thomas, H. , GARGER, Stephen, J. , MCCULLOCH, Michael, J. , CAMERON, Terri, I. , SAMONEK-POTTER, Michelle, L. , HOLTZ, R., Barry
IPC分类号： C12N15/82 , C12P21/02 , C12P1/00 , C07K14/415
CPC分类号： C12Y302/01045 , C07K14/415 , C07K14/47 , C07K14/57 , C07K16/00 , C07K2317/13 , C07K2317/622 , C12N9/2402 , C12N9/2422 , C12N9/2465 , C12N15/8257 , C12N15/8258 , C12Y302/01022
摘要： A method for extracting proteins from the intercellular space of plants is provided. The method is applicable to the large scale isolation of many active proteins of interest synthesized by plant cells. The method may be used commercially to recover recombinantly produced proteins from plant hosts thereby making the large scale use of plants as sources for recombinant protein production feasible.
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公开(公告)号：EP1003498A1
公开(公告)日：2000-05-31
申请号：EP98912089.4
申请日：1998-03-25
CPC分类号： C07C205/59 , A61K31/085 , A61K31/09 , A61K31/095 , A61K31/10 , A61K31/11 , A61K31/12 , A61K31/192 , A61K31/235 , A61K31/65 , A61K41/0038 , C07C45/29 , C07C47/575 , C07C65/24 , Y02A50/401
摘要： The present invention relates, inter alia, to compounds that bind tubulin and exhibit anti-mitotic properties and to methods of using such compounds to inhibit abnormal cell mitosis and, in particular, to inhibit tumor cell growth. In addition, methods are presented of treating mammalian diseases associated with undesired and uncontrolled angiogenesis.
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公开(公告)号：EP0999281A1
公开(公告)日：2000-05-10
申请号：EP99124656.2
申请日：1989-02-24
发明人： Grill, Laurence K. , Erwin, Robert L. , Berliner, David L. , Hubbard, Ernest T., Jr. , Turpen, Thomas H.
IPC分类号： C12N15/86 , C12N5/10 , A01K67/027
CPC分类号： C12N15/8257 , C07K14/005 , C12N9/0071 , C12N9/1074 , C12N9/6459 , C12N15/8203 , C12N15/8258 , C12N15/86 , C12N2770/32622 , C12N2770/32722 , C12N2830/002 , C12N2830/55 , C12Y114/18001 , C12Y302/01031 , C12Y304/21069
摘要： The present invention relates to viral vectors which are biologically contained, self-replicating and capable of the non-nuclear chromosomal transformation of a host. The viral vectors may contain a heterologous coding sequence adjacent a viral promoter. The invention further relates to viruses containing the viral vectors which a transmissible, i.e. infective. The invention also relates to production cells which are capable of producing the viruses or parts thereof. Host cells are infected by the viruses of the invention. A process for the production of a desired product by growing the infected hosts is also within the scope of the present invention.
摘要翻译： 本发明涉及生物地包含，自我复制并能够进行宿主的无核染色体转化的病毒载体。 病毒载体可以含有与病毒启动子相邻的异源编码序列。 本发明还涉及含有病毒载体的病毒，其是可传染的，即感染性的。 本发明还涉及能够产生病毒或其部分的生产细胞。 宿主细胞被本发明的病毒感染。 通过生长受感染宿主生产所需产物的方法也在本发明的范围内。
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公开(公告)号：EP0752006A1
公开(公告)日：1997-01-08
申请号：EP95912818.0
申请日：1995-03-08
发明人： HOLTZ, Richard, Barry , McCULLOCH, Michael, Jay , GARGER, Stephen, John , TEAGUE, Richard, King , PHILLIPS, Harriet, Flannery
IPC分类号： C12P7
摘要： Green note compound, such as cis-3-hexen-1-ol, is provided by subjecting linolenic acid and a fresh watermelon foliage to shearing in the presence of an aqueous liquid and yeast. Enzymes within the plant material (i.e., lipoxygenase and hydroperoxide lyase) and the yeast act to cause the linolenic acid to be converted to green note alcohol at a relatively high yield. Green note compound can be provided naturally using a continuous or batch process.
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5.发明公开Melanins with improved ability to inhibit HIV replication 失效Melanine mit verb desserten HIV replikationshemmenden Eigenschaften
公开(公告)号：EP1095652A2
公开(公告)日：2001-05-02
申请号：EP01102345.4
申请日：1998-02-04
IPC分类号： A61K31/195 , A61K31/40 , A61K31/785
CPC分类号： A61K31/787 , A61K31/00 , C12P17/00
摘要： Novel enzymatically produced melanins are described that are useful in the treatment of HIV infection. The novel melanins are optionally modified to contain chemical moieties such as halogens, sulfates, or sulfonyl groups. Additionally, the novel enzymatically synthesized melanins may be modified, or further modified, by chemical oxidation.
摘要翻译： 描述了新的酶促产生的黑色素，其可用于治疗HIV感染。 任选地修饰新颖的黑色素以含有化学部分，例如卤素，硫酸酯或磺酰基。 此外，新的酶促合成的黑色素可以通过化学氧化进行修饰或进一步修饰。
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公开(公告)号：EP1087017A2
公开(公告)日：2001-03-28
申请号：EP00127988.4
申请日：1995-05-26
CPC分类号： C12N15/1137 , C07K14/005 , C07K14/415 , C07K14/70571 , C12N9/00 , C12N9/0059 , C12N9/0071 , C12N9/0083 , C12N9/1074 , C12N9/1085 , C12N9/14 , C12N9/16 , C12N9/18 , C12N9/20 , C12N9/6459 , C12N9/78 , C12N9/84 , C12N15/8203 , C12N15/8216 , C12N15/8218 , C12N15/8249 , C12N15/825 , C12N15/8289 , C12N15/86 , C12N2710/22043 , C12N2710/22062 , C12N2750/12043 , C12N2770/00022 , C12N2770/00043 , C12N2770/00051 , C12N2770/32643 , C12N2770/32662 , C12N2770/32722 , C12N2770/32743 , C12N2770/32762 , C12N2770/36143 , C12N2770/36162 , C12N2799/021 , C12N2810/609 , C12P41/003 , C12Y114/18001 , C12Y302/01031 , C12Y304/21069 , G01N2333/4353
摘要： The present invention concerns a viral genetic vector derived from a positive single-stranded virus capable of replication in the cytoplasm of a plant cell. Furthermore, the invention concerns a method of producing a plant cell having reduced expression of a gene of interest and it concerns the plant cell itself. In addition, the present invention concerns a plant comprising a plurality of the plant cells.
摘要翻译： 本发明涉及来自能够在植物细胞的细胞质中复制的阳性单链病毒的病毒遗传载体。 此外，本发明涉及一种生产具有降低目标基因表达的植物细胞的方法，并涉及植物细胞本身。 此外，本发明涉及包含多个植物细胞的植物。
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7.发明公开METHOD OF DETERMINING THE FUNCTION OF NUCLEOTIDE SEQUENCES AND THE PROTEINS THEY ENCODE BY TRANSFECTING THE SAME INTO A HOST 审中-公开用于确定编码通过转染核酸序列和蛋白质的功能在来宾
公开(公告)号：EP1045899A2
公开(公告)日：2000-10-25
申请号：EP99903208.9
申请日：1999-01-15
发明人： DELLA-CIOPPA, Guy , ERWIN, Robert, L. , FITZMAURICE, Wayne, P. , HANLEY, Kathleen, M. , KUMAGAI, Monto, H. , LINDBO, John, A. , McGEE, David, R. , PADGETT, Hal, S. , POGUE, Gregory, P.
CPC分类号： C12N15/1079 , A01H1/04 , C12Q1/68
摘要： The present invention provides methods for rapidly determining the function of nucleic acid sequences by transfecting the same into a host organism to effect expression. Phenotypic and biochemical changes produced thereby are then analyzed to ascertain the function of the nucleic acids which have been transfected into the host organism. The invention also provides methods for silencing endogenous genes by transfecting hosts with nucleic acid sequences to effect expression of the same. The present invention also provides methods for selecting desired functions of RNAs and proteins by the use of virus vectors to express libraries of nucleic acid sequence variants. Moreover, the present invention provides methods for inhibiting an endogenous protease of a plant host.
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8.发明公开
公开(公告)号：EP1014964A1
公开(公告)日：2000-07-05
申请号：EP98904832.7
申请日：1998-02-04
IPC分类号： A61K31/195 , A61K31/40 , A61K31/785
CPC分类号： A61K31/787 , A61K31/00 , C12P17/00
摘要： Novel enzymatically produced melanins are described that are useful in the treatment of HIV infection. The novel melanins are optionally modified to contain chemical moieties such as halogens, sulfates, or sulfonyl groups. Additionally, the novel enzymatically synthesized melanins may be modified, or further modified, by chemical oxidation.
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公开(公告)号：EP1013771A1
公开(公告)日：2000-06-28
申请号：EP99124650.5
申请日：1989-02-24
发明人： Grill, Lawrence K. , Erwin, Robert L. , Berliner, David L. , Hubbard, Ernest T.,Jr. , Turpen, Thomas H.
CPC分类号： C12N15/8257 , C07K14/005 , C12N9/0071 , C12N9/1074 , C12N9/6459 , C12N15/8203 , C12N15/8258 , C12N15/86 , C12N2770/32622 , C12N2770/32722 , C12N2830/002 , C12N2830/55 , C12Y114/18001 , C12Y302/01031 , C12Y304/21069
摘要： The present invention relates to viral vectors which are biologically contained, self-replicating and capable of the non-nuclear chromosomal transformation of a host. The viral vectors may contain a heterologous coding sequence adjacent a viral promoter. The invention further relates to viruses containing the viral vectors which a transmissible, i.e. infective. The invention also relates to production cells which are capable of producing the viruses or parts thereof. Host cells are infected by the viruses of the invention. A process for the production of a desired product by growing the infected hosts is also within the scope of the present invention.
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10.发明公开Melanins with improved ability to inhibit HIV replication 失效Melanine mit verb desserten HIV replikationshemmenden Eigenschaften
公开(公告)号：EP1096021A2
公开(公告)日：2001-05-02
申请号：EP01102344.7
申请日：1998-02-04
IPC分类号： C12P17/00
CPC分类号： A61K31/787 , A61K31/00 , C12P17/00
摘要： Novel enzymatically produced melanins are described that are useful in the treatment of HIV infection. The novel melanins are optionally modified to contain chemical moieties such as halogens, sulfates, or sulfonyl groups. Additionally, the novel enzymatically synthesized melanins may be modified, or further modified, by chemical oxidation.
摘要翻译： 描述了可用于治疗HIV感染的酶促产生的酪氨酸生成的黑色素。 任选地将黑色素修饰成含有化学部分，例如卤素，硫酸酯或磺酰基。 另外，酶促合成的黑色素可以通过化学氧化进行改性或进一步修饰。
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