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公开(公告)号：EP2718428A4
公开(公告)日：2015-07-01
申请号：EP12801020
申请日：2012-06-13
申请人： MEDICAGO INC
IPC分类号： A61K39/00 , A61K39/205 , A61K39/295 , A61P31/16 , A61P37/04 , C07K14/005 , C07K14/11 , C12N7/00 , C12N15/82 , C12P17/06
CPC分类号： C07K14/005 , A61K39/12 , A61K39/205 , A61K2039/517 , A61K2039/5258 , A61K2039/55505 , C12N15/8258 , C12N2750/12043 , C12N2760/20123 , C12N2760/20134
摘要： A method of producing a virus like particle (VLP) in a plant is provided. The method comprises introducing a first nucleic acid into the plant, or portion of the plant. The first nucleic acid comprising a first regulatory region active in the plant operatively linked to a nucleotide sequence encoding a native rabies virus structural protein. The nucleotide sequence may further comprise one or more than one amplification element. Optionally, a second nucleic acid might be introduced into the plant, or portion of the plant. The second nucleic acid comprising a second regulatory region active in the plant and operatively linked to a nucleotide sequence encoding a matrix protein, for example but not limited to a rabies matrix protein. The plant or portion of the plant is incubated under conditions that permit the expression of the nucleic acids, thereby producing the VLP.
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公开(公告)号：EP2718428B1
公开(公告)日：2018-03-07
申请号：EP12801020.4
申请日：2012-06-13
申请人： Medicago Inc.
IPC分类号： C12N15/82 , A61K39/205 , A61K39/12
CPC分类号： C07K14/005 , A61K39/12 , A61K39/205 , A61K2039/517 , A61K2039/5258 , A61K2039/55505 , C12N15/8258 , C12N2750/12043 , C12N2760/20123 , C12N2760/20134
摘要： A method of producing a virus like particle (VLP) in a plant is provided. The method comprises introducing a first nucleic acid into the plant, or portion of the plant. The first nucleic acid comprising a first regulatory region active in the plant operatively linked to a nucleotide sequence encoding a native rabies virus structural protein. The nucleotide sequence may further comprise one or more than one amplification element. Optionally, a second nucleic acid might be introduced into the plant, or portion of the plant. The second nucleic acid comprising a second regulatory region active in the plant and operatively linked to a nucleotide sequence encoding a matrix protein, for example but not limited to a rabies matrix protein. The plant or portion of the plant is incubated under conditions that permit the expression of the nucleic acids, thereby producing the VLP.
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公开(公告)号：EP2718428A1
公开(公告)日：2014-04-16
申请号：EP12801020.4
申请日：2012-06-13
申请人： Medicago Inc.
IPC分类号： C12N7/01 , A01H5/00 , A61K39/205 , A61P31/14 , C07K14/145 , C07K16/10 , C12N15/00 , C12N15/47 , C12N15/82 , C12N7/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/205 , A61K2039/517 , A61K2039/5258 , A61K2039/55505 , C12N15/8258 , C12N2750/12043 , C12N2760/20123 , C12N2760/20134
摘要： A method of producing a virus like particle (VLP) in a plant is provided. The method comprises introducing a first nucleic acid into the plant, or portion of the plant. The first nucleic acid comprising a first regulatory region active in the plant operatively linked to a nucleotide sequence encoding a native rabies virus structural protein. The nucleotide sequence may further comprise one or more than one amplification element. Optionally, a second nucleic acid might be introduced into the plant, or portion of the plant. The second nucleic acid comprising a second regulatory region active in the plant and operatively linked to a nucleotide sequence encoding a matrix protein, for example but not limited to a rabies matrix protein. The plant or portion of the plant is incubated under conditions that permit the expression of the nucleic acids, thereby producing the VLP.
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公开(公告)号：EP2761007A1
公开(公告)日：2014-08-06
申请号：EP12781171.9
申请日：2012-09-24
CPC分类号： C12N15/8261 , C07K14/21 , C12N15/52 , C12N15/8203 , C12N15/86 , C12N2750/12022 , C12N2750/12043 , Y02A40/146
摘要： The present invention provides means and methods for producing plants with enhanced growth and yield. Particularly, the present invention provides plants to which an expression construct comprising the entire prn operon was introduced, wherein said plants produce pyrrolnitrin and show enhanced growth and yield production compared to corresponding control plants not harboring the prn operon.
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公开(公告)号：EP1087017A3
公开(公告)日：2001-11-28
申请号：EP00127988.4
申请日：1995-05-26
CPC分类号： C12N15/1137 , C07K14/005 , C07K14/415 , C07K14/70571 , C12N9/00 , C12N9/0059 , C12N9/0071 , C12N9/0083 , C12N9/1074 , C12N9/1085 , C12N9/14 , C12N9/16 , C12N9/18 , C12N9/20 , C12N9/6459 , C12N9/78 , C12N9/84 , C12N15/8203 , C12N15/8216 , C12N15/8218 , C12N15/8249 , C12N15/825 , C12N15/8289 , C12N15/86 , C12N2710/22043 , C12N2710/22062 , C12N2750/12043 , C12N2770/00022 , C12N2770/00043 , C12N2770/00051 , C12N2770/32643 , C12N2770/32662 , C12N2770/32722 , C12N2770/32743 , C12N2770/32762 , C12N2770/36143 , C12N2770/36162 , C12N2799/021 , C12N2810/609 , C12P41/003 , C12Y114/18001 , C12Y302/01031 , C12Y304/21069 , G01N2333/4353
摘要： The present invention concerns a viral genetic vector derived from a positive single-stranded virus capable of replication in the cytoplasm of a plant cell. Furthermore, the invention concerns a method of producing a plant cell having reduced expression of a gene of interest and it concerns the plant cell itself. In addition, the present invention concerns a plant comprising a plurality of the plant cells.
摘要翻译： 本发明涉及源自能够在植物细胞的细胞质中复制的阳性单链病毒的病毒遗传载体。 此外，本发明涉及生产目的基因表达降低的植物细胞的方法，其涉及植物细胞本身。 另外，本发明涉及包含多个植物细胞的植物。
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公开(公告)号：EP1087017A2
公开(公告)日：2001-03-28
申请号：EP00127988.4
申请日：1995-05-26
CPC分类号： C12N15/1137 , C07K14/005 , C07K14/415 , C07K14/70571 , C12N9/00 , C12N9/0059 , C12N9/0071 , C12N9/0083 , C12N9/1074 , C12N9/1085 , C12N9/14 , C12N9/16 , C12N9/18 , C12N9/20 , C12N9/6459 , C12N9/78 , C12N9/84 , C12N15/8203 , C12N15/8216 , C12N15/8218 , C12N15/8249 , C12N15/825 , C12N15/8289 , C12N15/86 , C12N2710/22043 , C12N2710/22062 , C12N2750/12043 , C12N2770/00022 , C12N2770/00043 , C12N2770/00051 , C12N2770/32643 , C12N2770/32662 , C12N2770/32722 , C12N2770/32743 , C12N2770/32762 , C12N2770/36143 , C12N2770/36162 , C12N2799/021 , C12N2810/609 , C12P41/003 , C12Y114/18001 , C12Y302/01031 , C12Y304/21069 , G01N2333/4353
摘要： The present invention concerns a viral genetic vector derived from a positive single-stranded virus capable of replication in the cytoplasm of a plant cell. Furthermore, the invention concerns a method of producing a plant cell having reduced expression of a gene of interest and it concerns the plant cell itself. In addition, the present invention concerns a plant comprising a plurality of the plant cells.
摘要翻译： 本发明涉及来自能够在植物细胞的细胞质中复制的阳性单链病毒的病毒遗传载体。 此外，本发明涉及一种生产具有降低目标基因表达的植物细胞的方法，并涉及植物细胞本身。 此外，本发明涉及包含多个植物细胞的植物。
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公开(公告)号：EP2861737A1
公开(公告)日：2015-04-22
申请号：EP13807501.5
申请日：2013-06-19
CPC分类号： C12N15/8203 , C12N9/22 , C12N15/902 , C12N2750/12043 , C12N2999/007
摘要： Systems and methods for gene targeting in plants, including systems and methods that include the use of geminiviruses and customizable endonucleases.
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公开(公告)号：EP0832191A4
公开(公告)日：2000-11-15
申请号：EP96919165
申请日：1996-06-06
申请人： BIOSOURCE TECH INC
发明人： DONSON JON , DAWSON WILLIAM O , GRANTHAM GEORGE L , TURPEN THOMAS H , TURPEN ANN M , GARGER STEPHEN J , GRILL LAURENCE K
IPC分类号： A01K67/027 , C07K14/08 , C07K14/095 , C07K14/415 , C12N5/10 , C12N9/00 , C12N9/02 , C12N9/10 , C12N9/14 , C12N9/16 , C12N9/18 , C12N9/20 , C12N9/24 , C12N9/72 , C12N9/78 , C12N9/84 , C12N15/00 , C12N15/09 , C12N15/113 , C12N15/12 , C12N15/40 , C12N15/82 , C12N15/83 , C12N15/86 , C12P21/02 , C12P41/00 , C12R1/91 , C12R1/92 , C12N5/00
CPC分类号： C07K14/005 , C07K14/415 , C12N9/00 , C12N9/0059 , C12N9/0071 , C12N9/0083 , C12N9/1074 , C12N9/14 , C12N9/16 , C12N9/18 , C12N9/20 , C12N9/6459 , C12N9/78 , C12N9/84 , C12N15/1137 , C12N15/8203 , C12N15/8216 , C12N15/8218 , C12N15/8249 , C12N15/825 , C12N15/8289 , C12N15/86 , C12N2710/22043 , C12N2710/22062 , C12N2750/12043 , C12N2770/00043 , C12N2770/00051 , C12N2770/32643 , C12N2770/32662 , C12N2770/32743 , C12N2770/32762 , C12N2770/36143 , C12N2770/36162 , C12N2810/609 , C12P41/003 , C12Y114/18001 , C12Y204/01019 , C12Y302/01031 , C12Y304/21069
摘要： The present invention relates to a recombinant viral nucleic acid selected from a (+) sense, single stranded RNA virus possessing a native subgenomic promoter encoding for a first viral subgenomic promoter, a nucleic acid sequence that codes for a viral coat protein whose transcription is regulated by the first viral subgenomic promoter, a second viral subgenomic promoter and a second nucleic acid sequence whose transcription is regulated by the second viral subgenomic promoter. The first and second viral subgenomic promoters of the recombinant viral nucleic acid do not have homologous sequences relative to each other. The recombinant viral nucleic acid provides the particular advantage that it systematically transcribes the second nucleic acid in the host. Host organisms encompassed by the present invention include procaryotes and eucaryotes, particularly animals and plants. The present invention also relates to viruses containing the viral vectors which are infective, production cells which are capable of producing the viruses or parts thereof, a host infected by the viruses of the invention, the gene products produced by expression of the viral nucleic acids and a process for the production of a desired product by growing the infected hosts.
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公开(公告)号：EP0832191A1
公开(公告)日：1998-04-01
申请号：EP96919165.0
申请日：1996-06-06
发明人： DONSON, Jon , DAWSON, William, O. , GRANTHAM, George, L. , TURPEN, Thomas, H. , TURPEN, Ann, M. , GARGER, Stephen, J. , GRILL, Laurence, K.
CPC分类号： C07K14/005 , C07K14/415 , C12N9/00 , C12N9/0059 , C12N9/0071 , C12N9/0083 , C12N9/1074 , C12N9/14 , C12N9/16 , C12N9/18 , C12N9/20 , C12N9/6459 , C12N9/78 , C12N9/84 , C12N15/1137 , C12N15/8203 , C12N15/8216 , C12N15/8218 , C12N15/8249 , C12N15/825 , C12N15/8289 , C12N15/86 , C12N2710/22043 , C12N2710/22062 , C12N2750/12043 , C12N2770/00043 , C12N2770/00051 , C12N2770/32643 , C12N2770/32662 , C12N2770/32743 , C12N2770/32762 , C12N2770/36143 , C12N2770/36162 , C12N2810/609 , C12P41/003 , C12Y114/18001 , C12Y204/01019 , C12Y302/01031 , C12Y304/21069
摘要： The present invention relates to a recombinant viral nucleic acid selected from a (+) sense, single stranded RNA virus possessing a native subgenomic promoter encoding for a first viral subgenomic promoter, a nucleic acid sequence that codes for a viral coat protein whose transcription is regulated by the first viral subgenomic promoter, a second viral subgenomic promoter and a second nucleic acid sequence whose transcription is regulated by the second viral subgenomic promoter. The first and second viral subgenomic promoters of the recombinant viral nucleic acid do not have homologous sequences relative to each other. The recombinant viral nucleic acid provides the particular advantage that it systematically transcribes the second nucleic acid in the host. Host organisms encompassed by the present invention include procaryotes and eucaryotes, particularly animals and plants. The present invention also relates to viruses containing the viral vectors which are infective, production cells which are capable of producing the viruses or parts thereof, a host infected by the viruses of the invention, the gene products produced by expression of the viral nucleic acids and a process for the production of a desired product by growing the infected hosts.
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公开(公告)号：EP2861737A4
公开(公告)日：2016-02-10
申请号：EP13807501
申请日：2013-06-19
申请人： UNIV MINNESOTA
发明人： VOYTAS DANIEL F , BALTES NICHOLAS J
CPC分类号： C12N15/8203 , C12N9/22 , C12N15/902 , C12N2750/12043 , C12N2999/007
摘要： Systems and methods for gene targeting in plants, including systems and methods that include the use of geminiviruses and customizable endonucleases.
摘要翻译： 植物中基因靶向的系统和方法，包括使用双因子病毒和可定制的内切核酸酶的系统和方法。
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